• vitro
  • Possess experience with well-validated in vitro assays and in vivo models. (sbir.gov)
  • In vitro assays with rat mesenchymal stem cells (rMSCs) and rat endothelial progenitor cells (rEPCs) also showed that rMSCs attached and proliferated on the materials influenced by the calcium content in the environment. (rsc.org)
  • vivo
  • In vivo assays showed that hybrid composite PLA-ORMOGLASS fibers were able to promote the formation of blood vessels. (rsc.org)
  • pharmacology
  • Through collaborations with biological researchers and/or research projects carried out within the Beeler Group, students will learn methods for biological assays, pharmacology, and target identification. (bu.edu)
  • An assay is an investigative (analytic) procedure in laboratory medicine, pharmacology, environmental biology and molecular biology for qualitatively assessing or quantitatively measuring the presence, amount, or functional activity of a target entity (the analyte). (wikipedia.org)
  • Medicinal chemistry and pharmaceutical chemistry are disciplines at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with design, chemical synthesis and development for market of pharmaceutical agents, or bio-active molecules (drugs). (wikipedia.org)
  • therapeutic
  • Identify a therapeutic target and explain in detail the mechanism by which their drug will exhibit efficacy in preventing or treating cancer-or cancer treatment-related cachexia. (sbir.gov)
  • While a number of approaches toward the identification and development of hits exist, the most successful techniques are based on chemical and biological intuition developed in team environments through years of rigorous practice aimed solely at discovering new therapeutic agents. (wikipedia.org)
  • quantitative
  • Quantitative structure-activity relationship models (QSAR models) are regression or classification models used in the chemical and biological sciences and engineering. (wikipedia.org)
  • On the other hand, older generation qualitative assays, especially bioassays, may be much more gross and less quantitative (e.g., counting death or dysfunction of an organism or cells in a population, or some descriptive change in some body part of a group of animals). (wikipedia.org)
  • synthetic
  • It includes synthetic and computational aspects of the study of existing drugs and agents in development in relation to their bioactivities (biological activities and properties), i.e., understanding their structure-activity relationships (SAR). (wikipedia.org)
  • methodology
  • While each paper shared the core principles of combining CRISPR mediated perturbation with scRNA-seq, their experimental, technological and analytical approaches differed in several aspects, to explore distinct biological questions, demonstrating the broad utility of this methodology. (wikipedia.org)
  • Identification
  • Identification of targets of this ncRNA associated with cancer can suggest that networks of these linked to oncogenes or tumor suppressors play pivotal roles in cancer development. (mdpi.com)
  • Target identification is the first step in developing new antimalarial drugs. (fiocruz.br)
  • drug
  • This might have translated later (possibly after the 14th century) into a generalized meaning of analysis,[citation needed] e.g. of an important or principal component of a target inside a mixture such as an active ingredient of a drug inside the inert excipients in a pharmacological formulation which originally used to be measured by its actual action on an organism (e.g. lethal dose or inhibitory dose). (wikipedia.org)
  • suitable
  • 10 The suitable biological performance of these scaffolds was mainly attributed to their stiffness and the ions released from the glass, in particular calcium ions, as well as the intrinsic surface properties of the materials. (rsc.org)
  • This delivers label-free, non-activated cells suitable for immunologic or cell biological assays. (wikipedia.org)
  • development
  • The goal of this SBIR contract topic is to provide support for the development of targeted agents, including small molecules and biologics, to prevent or treat cachexia related to cancer and/or cancer therapy, including chemotherapy and/or radiotherapy. (sbir.gov)
  • Provide preliminary data or cite literature to support the role of the target in the development of cancer-or cancer treatment-related cachexia. (sbir.gov)
  • Although biological assays have been the cornerstone of endocrinologic measurements, the development of the radioimmunoassay (RIA) completely changed the field of endocrinology (1). (thefreedictionary.com)
  • Those assays that are very highly commercially demanded have been well investigated in research and development sectors of professional industries, undergone generations of development and sophistication, and become copyrighted intellectual properties via highly competitive process patenting. (wikipedia.org)
  • fragments
  • This technology is known as Fab-TACS (Traceless Affinity Cell Selection) and is based on Strep-tagged Fab fragments, which reversibly capture and release the target cells. (wikipedia.org)
  • functional
  • The assay usually aims to measure an intensive property of the analyte and express it in the relevant measurement unit (e.g. molarity, density, functional activity in enzyme international units, degree of some effect in comparison to a standard, etc. (wikipedia.org)
  • Complex
  • STATs then interact directly or indirectly, via their transactivation domain, with components of the RNA polymerase II complex to activate transcription of target genes. (aacrjournals.org)
  • Therapy
  • These data suggest survivin might provide a new target for cancer therapy that would discriminate between transformed and normal cells. (wikipedia.org)
  • manipulation
  • Given the larger and growing focus on targeting RNAs for disease therapeutics, what we do know about the intrinsic biology of these small RNAs (miRNA) and long non-coding RNA (lncRNA) makes them potentially attractive targets for pharmacologic manipulation and prognosis markers. (mdpi.com)
  • Analysis
  • and (g) determining a spatial pattern of the biological target abundance, expression and/or activity in the sample based on the analysis of step (f). (patentsencyclopedia.com)
  • test the quality of", from Anglo-French assaier, from assai (n.), from Old French essai "trial", and the noun assay thus means "trial, test of quality, test of character", mid-14th century, from Anglo-French assai and the meaning "analysis" is from the late 14th century. (wikipedia.org)
  • For assay of currency coins, this literally meant analysis of the purity of the gold or silver or whatever precious component was used to represent the true value of the coin. (wikipedia.org)
  • An assay (analysis) is never an isolated process and must be combined with pre- and post-analytic procedures. (wikipedia.org)
  • laboratory
  • Since the assay itself (the analytic step) gets much attention, steps that get less attention by the chain of users, i.e. the preanalytic and the post analytic steps, are often less stringently regulated and generally more prone to errors - e.g. preanalytic steps in medical laboratory assays may contribute to 32-75% of all lab errors. (wikipedia.org)
  • further
  • Further ligand optimisation cycles generated new prospects for docking and biological assays. (fiocruz.br)
  • The information communication (e.g. request to perform an assay and further information processing) or specimen handling (e.g. collection, transport and processing) that are done until the beginning of an assay are the preanalytic steps. (wikipedia.org)
  • often
  • Such industrial scale assays as these are often done in well equipped laboratories and with automated organization of the procedure-from ordering an assay to pre-analytic sample processing (sample collection, necessary manipulations e.g. spinning for separation or other processes, aliquoting if necessary, storage, retrieval, pipetting/aspiration etc. (wikipedia.org)
  • specific
  • Mature miRNAs regulate mRNA target degradation or translational repression by mediating sequence-specific targeting of its mRNA [ 7 , 8 ]. (mdpi.com)
  • system
  • The goal of the program is to provide a system that can rapidly detect and identify the presence of a typical threat cloud and provide a countermeasure to that cloud that will kill it before it reaches the intended target. (wikipedia.org)
  • field
  • Assays have become a routine part of modern medical, environmental, pharmaceutical, forensic and many other businesses at various scales from industrial to curbside or field level. (wikipedia.org)
  • data
  • Demonstrate ownership of, or license for, at least one lead agent (e.g., compound or antibody) with preliminary data showing that the agent hits the identified target. (sbir.gov)
  • important
  • It is very important to consider that the number of miRNA binding sites can vary in the target mRNA affecting efficiency of translational repression [ 9 ]. (mdpi.com)
  • The most important aspects in quality control of chemotaxis assays were described by H. Harris in the 1950s. (wikipedia.org)