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  • vitro
  • Possess experience with well-validated in vitro assays and in vivo models. (sbir.gov)
  • In vitro assays with rat mesenchymal stem cells (rMSCs) and rat endothelial progenitor cells (rEPCs) also showed that rMSCs attached and proliferated on the materials influenced by the calcium content in the environment. (rsc.org)
  • vivo
  • In vivo assays showed that hybrid composite PLA-ORMOGLASS fibers were able to promote the formation of blood vessels. (rsc.org)
  • analytic
  • Such industrial scale assays as these are often done in well equipped laboratories and with automated organization of the procedure-from ordering an assay to pre-analytic sample processing (sample collection, necessary manipulations e.g. spinning for separation or other processes, aliquoting if necessary, storage, retrieval, pipetting/aspiration etc. (wikipedia.org)
  • An assay (analysis) is never an isolated process and must be combined with pre- and post-analytic procedures. (wikipedia.org)
  • Similarly, after the assay, the result may be documented, verified and transmitted/communicated in steps that are called post-analytic steps. (wikipedia.org)
  • i.e. not only analytic variations and errors intrinsic to the assay itself but also variations and errors involved in preanalytic and post analytic steps. (wikipedia.org)
  • Since the assay itself (the analytic step) gets much attention, steps that get less attention by the chain of users, i.e. the preanalytic and the post analytic steps, are often less stringently regulated and generally more prone to errors - e.g. preanalytic steps in medical laboratory assays may contribute to 32-75% of all lab errors. (wikipedia.org)
  • Ligand binding assays (LBA) is an assay, or an analytic procedure, whose procedure or method relies on the binding of ligand molecules to receptors, antibodies or other macromolecules. (wikipedia.org)
  • This type of analytic test can be used to test for the presence of target molecules in a sample that are known to bind to the receptor. (wikipedia.org)
  • reactants
  • Essential aspects of binding assays include, but are not limited to, the concentration level of reactants or products (see radioactive section), maintaining the equilibrium constant of reactants throughout the assay, and the reliability and validity of linked reactions. (wikipedia.org)
  • therapeutic
  • Identify a therapeutic target and explain in detail the mechanism by which their drug will exhibit efficacy in preventing or treating cancer-or cancer treatment-related cachexia. (sbir.gov)
  • While a number of approaches toward the identification and development of hits exist, the most successful techniques are based on chemical and biological intuition developed in team environments through years of rigorous practice aimed solely at discovering new therapeutic agents. (wikipedia.org)
  • quantitative
  • Quantitative structure-activity relationship models (QSAR models) are regression or classification models used in the chemical and biological sciences and engineering. (wikipedia.org)
  • On the other hand, older generation qualitative assays, especially bioassays, may be much more gross and less quantitative (e.g., counting death or dysfunction of an organism or cells in a population, or some descriptive change in some body part of a group of animals). (wikipedia.org)
  • drugs
  • Target identification is the first step in developing new antimalarial drugs. (fiocruz.br)
  • It includes synthetic and computational aspects of the study of existing drugs and agents in development in relation to their bioactivities (biological activities and properties), i.e., understanding their structure-activity relationships (SAR). (wikipedia.org)
  • bound
  • 15. The use according to any preceding claim, with detection of a change between unbound probe and bound probe arising from a change in conformation or local environment on binding of probe to target. (google.co.uk)
  • Identification
  • Identification of targets of this ncRNA associated with cancer can suggest that networks of these linked to oncogenes or tumor suppressors play pivotal roles in cancer development. (mdpi.com)
  • The discovery process begins with the identification of appropriate targets or desired activities in biological assays (e.g., neuroprotection or cytotoxicity). (frontiersin.org)
  • involve
  • Elucidation of the mode of action of anesthetic agents has shown that anesthesia can involve mitochondrial targets, leak currents, and gap junctions. (frontiersin.org)
  • But generally, assays involve biological material or phenomena which tend to be intrinsically more complex either in composition or in behavior or both. (wikipedia.org)
  • reaction
  • The underlying problem is therefore how to define a small difference on a molecular level, since each kind of activity, e.g. reaction ability, biotransformation ability, solubility, target activity, and so on, might depend on another difference. (wikipedia.org)
  • typically
  • A target is typically selected on the basis of accumulated evidence linking it mechanistically to a disease, for example, mutation of the transmembrane conductance regulator in cystic fibrosis. (frontiersin.org)
  • tissue
  • The Canadian team of organic chemists and enzymologists developed drug design motifs, and pursued preparative chemistry, enzymology, molecular biology, and tissue culture studies that were interfaced with biological assays and pharmacokinetic studies carried out in Syntex, Palo Alto, CA. (thefreedictionary.com)
  • gene
  • However, for many CNS disorders, the identity of the targets directly mediating the disorder (e.g., defective gene products or disease-causing variants) or even the extended pathways that could be targeted for ameliorative effects are not known with any certainty. (frontiersin.org)
  • It also is a direct target gene of the Wnt pathway and is upregulated by beta-catenin. (wikipedia.org)
  • biologics
  • The goal of this SBIR contract topic is to provide support for the development of targeted agents, including small molecules and biologics, to prevent or treat cachexia related to cancer and/or cancer therapy, including chemotherapy and/or radiotherapy. (sbir.gov)
  • complex
  • Here, we review the innovative use of simple model organisms, especially Caenorhabditis elegans , to gain fresh insights into the complex biological effects of approved CNS medications. (frontiersin.org)
  • STATs then interact directly or indirectly, via their transactivation domain, with components of the RNA polymerase II complex to activate transcription of target genes. (aacrjournals.org)
  • suitable
  • 10 The suitable biological performance of these scaffolds was mainly attributed to their stiffness and the ions released from the glass, in particular calcium ions, as well as the intrinsic surface properties of the materials. (rsc.org)
  • This delivers label-free, non-activated cells suitable for immunologic or cell biological assays. (wikipedia.org)
  • development
  • Provide preliminary data or cite literature to support the role of the target in the development of cancer-or cancer treatment-related cachexia. (sbir.gov)
  • Although biological assays have been the cornerstone of endocrinologic measurements, the development of the radioimmunoassay (RIA) completely changed the field of endocrinology (1). (thefreedictionary.com)
  • Those assays that are very highly commercially demanded have been well investigated in research and development sectors of professional industries, undergone generations of development and sophistication, and become copyrighted intellectual properties via highly competitive process patenting. (wikipedia.org)
  • Through the development of RIA technology, researchers have been able to move beyond the use of radioactivity, and instead, use liquid- and solid-phase, competitive, and immunoradiometric assays. (wikipedia.org)
  • fragments
  • This technology is known as Fab-TACS (Traceless Affinity Cell Selection) and is based on Strep-tagged Fab fragments, which reversibly capture and release the target cells. (wikipedia.org)
  • GQSAR allows flexibility to study various molecular fragments of interest in relation to the variation in biological response. (wikipedia.org)
  • functional
  • The assay usually aims to measure an intensive property of the analyte and express it in the relevant measurement unit (e.g. molarity, density, functional activity in enzyme international units, degree of some effect in comparison to a standard, etc. (wikipedia.org)
  • biology
  • Given the larger and growing focus on targeting RNAs for disease therapeutics, what we do know about the intrinsic biology of these small RNAs (miRNA) and long non-coding RNA (lncRNA) makes them potentially attractive targets for pharmacologic manipulation and prognosis markers. (mdpi.com)
  • Therapy
  • These data suggest survivin might provide a new target for cancer therapy that would discriminate between transformed and normal cells. (wikipedia.org)
  • Analysis
  • and (g) determining a spatial pattern of the biological target abundance, expression and/or activity in the sample based on the analysis of step (f). (patentsencyclopedia.com)
  • test the quality of", from Anglo-French assaier, from assai (n.), from Old French essai "trial", and the noun assay thus means "trial, test of quality, test of character", mid-14th century, from Anglo-French assai and the meaning "analysis" is from the late 14th century. (wikipedia.org)
  • For assay of currency coins, this literally meant analysis of the purity of the gold or silver or whatever precious component was used to represent the true value of the coin. (wikipedia.org)
  • This might have translated later (possibly after the 14th century) into a generalized meaning of analysis,[citation needed] e.g. of an important or principal component of a target inside a mixture such as an active ingredient of a drug inside the inert excipients in a pharmacological formulation which originally used to be measured by its actual action on an organism (e.g. lethal dose or inhibitory dose). (wikipedia.org)
  • bind
  • Furthermore, the company offers Aptamers, small DNA, RNA (or peptide) molecules that show the ability to bind to specific target molecules. (wikipedia.org)
  • especially
  • And the third response is a more pragmatic one - the worry that whether these prices are appropriate or not, they end up looking like a tempting political target, especially in the current environment (more on that in a later post today). (sciencemag.org)
  • aspects
  • The most important aspects in quality control of chemotaxis assays were described by H. Harris in the 1950s. (wikipedia.org)