Targets hepatocyte nuclear factor 1. Medical search. Frequent questions

MODY can result from mutations in any one of the six different genes, one of which encodes the glycolytic enzyme Glucokinase, associated with MO-DY2 and the other five encode transcription factors HNF4-alpha associated with MODY 1, HNF1-alpha associated with MODY 3, IPF with MODY 4, HNF1-Beta with MODY 5 and NeuroD1 with MO-DY6. (scirp.org)
Studies related to mutations in the MODY genes have led to a better understanding of the genetic causes of the Beta cell dysfunction as genetic factors plays a great role in this disorder. (scirp.org)
ObjectiveThe aim of this study was to document the association between pancreatic agenesis or hypoplasia and multicystic renal dysplasia related to transcription factor 2 (TCF2) or hepatocyte nuclear factor 1 beta mutations. (cyp17-signal.com)
Heterozygosity for mutations suggest a role of nongenetic factors or other genes involved in renal glucose transport. (medscape.com)
AIMS/HYPOTHESIS:Mutations in the hepatocyte nuclear factor 1-alpha gene (HNF-1alpha, now known as the transcription factor 1 gene [TCF1]) cause the most common monogenic form of diabetes, MODY3, but it is not known if common variants in HNF-1a are associated with decreased transcriptional activity or phenotypes related to type 2 diabetes, or whether they predict future type 2 diabetes. (ox.ac.uk)
To determine whether KLF15 binding to CP35 would be specific, we synthesized CP35-2m, which had mutations in the two potential KLF15-binding sites (Supporting Fig. 1). (agckinases.com)
The generalized aminoaciduria seen in patients with hepatocyte nuclear factor-1alpha mutations is a feature of all patients with diabetes and is associated with glucosuria. (cdc.gov)

depending on the HNF1B isoform, the result may be to activate or inhibit transcription of target genes. (wikipedia.org)
Objective: To investigate the mutation pattern in the different transcription factor genes with special reference to HNF1-alpha which are highly penetrant with 63% mutation carriers manifesting clinical diabetes by the age of 25 years. (scirp.org)
The best known of the human env-derived genes is syncytin-1, or ERVWE1, which originated from a human endogenous retrovirus (HERV) of the HERV-W family inserted on chromosome 7q21 in human-pre-hominoids 40-45 million years ago [ 11 , 10 ]. (ecancer.org)
Unphosphorylated β-catenin accumulates in the nuclear and interacts with TCF/LEF factors to stimulate the transcription of the downstream target genes of Wnt/β-catenin signaling. (esmed.org)
Ipi3p also functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex which is definitely recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes [10]. (irjs.info)
This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. (hindawi.com)
These findings indicate miR-34a along with its putative target genes could play a role in RCC tumorigenesis and progression. (hindawi.com)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
Targeted resequencing of phosphorus metabolism?related genes in 86 patients with hypophosphatemic rickets/osteomalacia. (cdc.gov)
The receptors function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner. (embl.de)
FXR, and possibly other nuclear receptors, may promote homeostasis not only by regulating expression of appropriate metabolic target genes but also by driving homeotrophic liver growth. (nih.gov)
Similarly, lncRNA H19 also was reported to promote osteogenic differentiation of rat ectomesenchymal stem cells through enhancing the expressions of osteogenic markers, beta-catenin, and target genes of Wnt/beta-catenin signaling pathway partly through sponging miR-22 and miR-141 [ 12 ]. (biomedcentral.com)

Here, we characterized mechanisms of hepatic and ectopic fVII (FVII) gene expression to identify molecular targets enabling selective inhibition of the ectopic expression. (figshare.com)
Unlike hepatic expression, hepatocyte nuclear factor-4 binding to the promoter is not required for ectopic FVII expression, although Sp1 binding is essential. (figshare.com)
Hepatic cytochrome P450s, phase II enzymes and nuclear receptors are downregulated in a Th2 environment during Schistosoma mansoni infection. (harvard.edu)
Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha. (harvard.edu)
The Onecut homeodomain transcription factor hepatic nuclear factor 6 (Hnf6) is necessary for proper development of islet β-cells. (diabetesjournals.org)
Hepatic differentiation was assessed based on increased albumin and hepatocyte nuclear factor 4α, as hepatocyte markers, and decreased cytokeratin 19 and SOX9, as stem/progenitor cell markers. (elsevierpure.com)
Long noncoding RNA NEAT1 (nuclear-enriched abundant transcript 1) inhibited hepatocyte proliferation in fulminant hepatic failure via strengthened recruitment of EZH2 to the LATS2 (large tumor-suppressor kinase 2) promoter region [ 18 ]. (biomedcentral.com)

Members of the family of nuclear receptors, the three peroxisome proliferator-activated receptors (PPARs), PPARα, PPARβ/δ, and PPARγ take part in the modulation of these pathways. (encyclopedia.pub)
Free circulating insulin activates insulin receptors on the surface of target cells eliciting a signaling cascade initiated by the activation of insulin receptor substrates (IRS 1-4) followed by phosphorylation of phosphoinositide 3-kinase (PI3K), which manages metabolic response including PDK1 and Akt stimulation by phosphorylation. (encyclopedia.pub)
Essential FA, mainly polyunsaturated fatty acids (PUFA), may modulate gene expression in diverse biological processes thought regulating transcription factors (TF), including peroxisome proliferator receptors (PPAR) , liver X receptors (LXR) , and sterol regulatory element-binding proteins ( SREBP ) 3 . (nature.com)
In the past decade, accumulating evidence revealed that nuclear receptors (NRs) modulated Wnt/β-catenin signaling activity via binding to diverse members of this pathway. (esmed.org)
5] Xiao X, Wang P, Chou K-C. Recent progresses in identifying nuclear receptors and their families. (esmed.org)
6] Helsen C, Claessens F. Looking at nuclear receptors from a new angle. (esmed.org)
Steroid or nuclear hormone receptors constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. (embl.de)
The DNA-binding domains of nuclear receptors consist of two zinc-nucleated modules and a C-terminal extension, where residues in the first zinc module determine the specificity of the DNA recognition and residues in the second zinc module are involved in dimerisation. (embl.de)
Transcription factors 3: nuclear receptors. (embl.de)
Analytes include soluble growth and differentiation factors, extracellular matrix components, proteases, membrane-bound receptors, and intracellular signaling molecules. (rndsystems.com)

Common culture formats used for in vitro enzyme induction studies comprise conventional and sandwich cultures, the former referring to plated hepatocytes maintained on rigid substratum (e.g., collagen), whereas in the latter cells are "sandwiched" by an additional layer of either collagen or a composite of extracellular matrix proteins, such as Matrigel ( LeCluyse, 2001 ). (aspetjournals.org)
Assay conditions, such as culture format and duration, media supplements etc., were reported previously to alter the phenotype and induction response of cultured hepatocytes ( LeCluyse, 2001 ). (aspetjournals.org)

Methods: In our study enzyme amplification (PCR) of the 10 target exons of the said gene with simultaneous mutation detection in them by PCR-SSCP (Polymerase chain reaction-single strand conformational polymorphism) reaction analysis method was attempted by screening of exon 1 - 10 with respect to normal healthy controls without Diabetes Mellitus. (scirp.org)
1998).Linkage and molecular scaning analysis of MODY 3/hepatocyte nuclear factor 1-alpha gene in typical familial type 2 diabetes: Evidence for novel mutation in exon 8 and 10. (scirp.org)
C5a 2 receptor is associated with 1 mutation . (guidetopharmacology.org)
Hepatocyte nuclear factor-4-α is associated with 5 mutation . (guidetopharmacology.org)

Insulin signaling affects multiple downstream pathways including mitogen-activated protein kinase (MAPK), which controls growth, sterol regulatory element-binding protein 1 (SREBP-1), which stimulates the synthesis of lipid and cholesterol as well as the family of Forkhead (FOXO) transcription factors regulating metabolism and autophagy [ 9 ] [ 10 ] . (encyclopedia.pub)
We conclude that targeted absolute LC-MS/MS quantification of drug-metabolizing enzymes and transporters can broaden the scope and significantly increase the impact of in vitro drug metabolism studies, such as induction, as an important supplement or future alternative to mRNA and activity data. (aspetjournals.org)
The use of hepatocytes provides, among others, the advantage of including active drug transport mechanisms as well as effects of drug metabolites that are formed during the experimental incubation period by phase I and II metabolism. (aspetjournals.org)
To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. (nature.com)
Our findings unveil Sirt2 as an unexpected actionable target for reprogramming T cell metabolism to augment a broad spectrum of cancer immunotherapies. (biomed.news)

JASPAR and TFSEARCH were used to analyze the potential transcription factor binding sites in the promoter region of chicken VNN1 and miRanda was used to search miRNA binding sites in 3' untranslated region (3'UTR) of chicken VNN1. (koreascience.kr)
SNHG1 directly interact with the histone methyltransferase enhancer of the zeste homolog 2 (EZH2) and modulate the histone methylation of promoter of Kruppel-like factor 2 (KLF2) and altered the progress osteogenic differentiation of PDLSCs. (biomedcentral.com)

Nkx2-1: a novel tumor biomarker of lung cancer[J]. Journal of Zhejiang University Science B, 2012, 13(11): 855-866. (zju.edu.cn)
Pancreatic cancer is a highly invasive type of malignant tumor with a very poor prognosis [ 1 ] . (jcancer.org)
1 ) report that serum levels and temporal velocities of multiple cytokine and growth factors interleukin IL-6, IL-8, growth regulated oncogene 1 (GRO-1), vascular endothelial growth factor (VEGF), and hepatocyte growth factor (HGF), secreted by tumor and stromal cells and modulated by transcription factor nuclear factor κB (NF-κB), predict chemoradiation response and survival in patients with advanced-stage oropharyngeal carcinoma. (aacrjournals.org)
The generalized biological basis and scientific rationale of this study rest on known tumor/host cell biology showing that the interaction of tumor and stromal cells leads to the secretion of multiple growth factors and cytokines that modulate and promote cell growth, inflammation, and angiogenesis within the tumor microenvironment ( 2 - 4 ) and hence is related to tumor proliferation, invasion, and metastasis ( 5, 6 ). (aacrjournals.org)
The current study builds on previously reported data from these and other investigators that increased expression of a number of cytokines and growth factors is observed in HNSCC cell lines and tumor tissues ( 7 - 15 ). (aacrjournals.org)
In addition, building on previous observations that increases or decreases in the levels of IL-6, IL-8, GRO-1, VEGF, and HGF in post-chemoradiation serum samples were associated with tumor progression or reduction in individual patients, these investigators further reasoned that longitudinal monitoring of a panel of these NF-κB-modulated proteins could potentially serve as additional serum biomarker predictors of response, relapse, and survival. (aacrjournals.org)
Elimination of the primary tumor, either by irradiation or by surgery, shifts the balance towards pro-angiogenesis and growth of the lung metastases (Table 1 ) (Camphausen et al. (biomedcentral.com)
Hypoxia stimulates hypoxia inducible factor (HIF)-dependent expression of CXCL12 and KITL promoting mobilization from the bone marrow and recruitment to primary tumor and metastatic sites of CXCR4 + CD11b + bone marrow-derived cells and KITbCD11b + cells assisting vasculogenesis and metastasis respectively (Kuonen et al. (biomedcentral.com)
Nussе and Varmus identified components of the Wnt/β-catenin pathway in 1982 in a study of oncogenic breast tumor viral diseases (MMTV) [1]. (chemdiv.com)

Conclusion Our findings demonstrate that exosome-transmitted miR-224-5p promotes p53-dependent cell proliferation by targeting ULK2 in CRC, which may offer promising targets for CRC prevention and therapy. (besjournal.com)

MATE transporters efflux organic cations in exchange with protons across the luminal membrane of renal proximal tubule cells and the canalicular membrane of hepatocytes, thereby enabling excretion of organic cations into urine and bile. (proteasepathway.com)
Renal cell carcinoma (RCC) accounts for approximately 3% of human malignancies, and its incidence appears to be increasing globally [ 1 ]. (hindawi.com)
The prevalence of CKD is SAV1 normally estimated to become 8C16% world-wide.1 The amount of sufferers requiring renal replacement therapies has increased tremendously within the last decade also, with 500 currently,000 sufferers on dialysis in america alone. (ap26113.com)

FFA4 is a potential drug target in type 2 diabetes mellitus. (guidetopharmacology.org)

Here, we report the use of a targeted liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) method for concurrent quantification of multiple cytochrome P450 (P450), UDP-glucuronosyltransferase (UGT), and transporter proteins in cultured primary human hepatocytes. (aspetjournals.org)
Immune checkpoint inhibitors (ICIs) targeting immune checkpoint proteins, such as CTLA-4 and PD-1/PD-L1, have demonstrated remarkable and durable clinical responses in various cancer types. (biomed.news)
Autophagy is a homeostatic process regulating turnover of impaired proteins and organelles, and p62 (sequestosome-1, SQSTM1) functions as the autophagic receptor in this process. (elsevierpure.com)
Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2) . (rndsystems.com)

RESULTS:Certain combinations of the I27L and A98V polymorphisms in the HNF-1alpha gene showed decreased transcriptional activity on the target promoters glucose transporter 2 (now known as solute carrier family 2 [facilitated glucose transporter], member 2) and albumin in both HeLa and INS-1 cells. (ox.ac.uk)

Induction via nuclear receptor activation can significantly alter those levels, with the coregulation of multiple enzymes and transporters occurring to different extents. (aspetjournals.org)
Recently, a molecular evolution study of the HERV-W provirus in several ape species and 24 humans demonstrated the conservation of syncytin-1, as well as its retention of receptor-mediated fusogenic activity [ 14 ]. (ecancer.org)
Liver X receptor as a drug target for the treatment of breast cancer. (esmed.org)
With respect to cadherin 1 (CDH1) and fibroblast growth factor receptor 2 (FGFR2), the mutational rates for non-neoplastic colorectal mucosa were similar to those in sporadic CRC. (iiarjournals.org)
Here, we identify a role for nuclear receptor-dependent bile acid signaling in normal liver regeneration. (nih.gov)
Elevated bile acid levels accelerate regeneration, and decreased levels inhibit liver regrowth, as does the absence of the primary nuclear bile acid receptor FXR. (nih.gov)
If those measures are not sufficient for glycemic control, patients may be prescribed non- insulin antihyperglycemic medications (eg, injectable glucagon -like peptide-1 [GLP-1] receptor agonists), insulin , or a combination of these medications. (msdmanuals.com)

Although there are often found on insulin-like growth factor-1 binding protein excretion or indirectly. (lorenzopetrantoni.com)

Pediatric Diabetes, 1, 88-117. (scirp.org)
Common variants in HNF-1 alpha and risk of type 2 diabetes. (ox.ac.uk)
This disease ranges from 1% to 5% in all cases of diabetes and is less affected by behavior and environment. (pfmjournal.org)
however, it remains challenging to distinguish MODY from type 1 and 2 diabetes due to the lack of a single diagnostic criteria and genetic testing. (pfmjournal.org)
Challenges faced when implementing precision medicine in diabetes are disease heterogeneity, various genetic influences, difficulties of accurate diagnosis, limitations of current treatment, and social, environmental, and psychological factors [ 6 ]. (pfmjournal.org)
Patients with type 1 diabetes mellitus are treated with insulin and also benefit from diet and exercise. (msdmanuals.com)
The anti-CD3 monoclonal antibody teplizumab can delay progression to symptomatic type 1 diabetes in patients who are presymptomatic and have mild glucose elevations and autoantibodies. (msdmanuals.com)
Insulin replacement in type 1 diabetes should ideally mimic beta-cell function to provide basal and prandial requirements (physiologic replacement or basal-bolus dosing). (msdmanuals.com)

The levels of metabolizing enzymes and transporters expressed in hepatocytes are decisive factors for hepatobiliary disposition of most drugs. (aspetjournals.org)
However, higher in vitro expression was observed for drug transporters, especially for multidrug resistance protein 1 and breast cancer resistance protein. (aspetjournals.org)

α-1,2-mannosyltransferase (ALG9) germline variants are linked to autosomal dominant polycystic kidney disease (ADPKD). (bvsalud.org)

Also, we identified miR-504 as a target of LINC00673 in pancreatic cancer and LINC00673 can be used as a novel therapeutic target for the pancreatic cancer. (jcancer.org)
Finally, we also discuss the contribution of ADAM17 as a potential therapeutic target in cardiovascular disorder and the neurogenic component of these cardiovascular diseases. (frontiersin.org)

[ 1 ] The incidence of salivary gland neoplasms as a whole is approximately 5.5 cases per 100,000 individuals in the United States, with malignant neoplasms accounting for 0.9 cases per 100,000. (medscape.com)
1] The incidence of salivary gland neoplasms as a whole is approximately 1.5 cases per 100,000 individuals in the United States. (medscape.com)

During the progression of colitis, genetic alterations associated with mucosal permeability [ e.g. those in extracellular matrix protein 1 ( ECM1 ), cadherin 1 ( CDH1 ), and hepatocyte nuclear factor 4 alpha ( HNF4A )] have been observed and considered to confer the risk of severe UC ( 11 , 12 ). (iiarjournals.org)
Hepatocyte nuclear factor 4 alpha (HNF4A) has been suggested as a potential marker in these cases. (biomedcentral.com)
HNF4A is a nuclear transcription factor that binds DNA as a homodimer. (biomedcentral.com)
To demonstrate that HNF4A can serve as a biomarker, it is crucial to (1) increase the size of patient cohorts and (2) investigate populations with different genetic backgrounds. (biomedcentral.com)

Taken together, SNHG1 inhibited the osteogenic differentiation of PDLSCs through EZH2-mediated H3K27me3 methylation of KLF2 promotor and provided a novel class of therapeutic targets for regenerate dental tissues. (biomedcentral.com)

Accordingly, the impact of CR on plasma IGF-1 and insulin level is compromised in mice deficient for Bmal1 [ 16 ] . (encyclopedia.pub)
Insulin secreted upon refeeding-after-fasting stimulates Per2 and reduces Rev-erbα expression in hepatocytes [ 18 ] . (encyclopedia.pub)
Final hba1c reduc- tion, as described in insulin-treated type 1. (lorenzopetrantoni.com)
Sustained expression of Hnf6 also results in downregulation of the β-cell-specific transcription factor MafA and a decrease in total pancreatic insulin. (diabetesjournals.org)

Direct protein quantification was applied successfully to study in vitro induction in sandwich cultured primary hepatocytes in a 24-well format using the prototypical inducers rifampicin, omeprazole, and phenobarbital. (aspetjournals.org)
The approval status of the ligand is shown, along with curator comments and an indication of whether the target is considered the primary target of the ligand. (guidetopharmacology.org)
however, the prognosis and treatment substantially differ among patients who present with (1) both primary tumors (BC and gastric) and (2) primary BC and metastases to stomach. (biomedcentral.com)

In general, P450 and UGT expression was lower in hepatocyte cultures than that in liver, and CYP2C9 was found to be the most abundant P450 isoform expressed in cultured hepatocytes. (aspetjournals.org)

HNF1 homeobox B (hepatocyte nuclear factor 1 homeobox B), also known as HNF1B or transcription factor 2 (TCF2), is a human gene. (wikipedia.org)

The sandwich culture format and 0.1 μM DEX in media retained the protein expression in the hepatocytes closest to the levels found in liver. (aspetjournals.org)
Western blotting was performed to examine the protein expression levels of endoplasmic reticulum stress (ERS)‑associated factors. (spandidos-publications.com)

Of specific relevance, these investigators have previously observed increased levels of factors IL-6, IL-8, GRO-1, VEGF, and HGF in the sera of HNSCC patients compared with disease-free control subjects ( 9, 12, 16 - 20 ), consistent with previous and related studies ( 9, 21 - 24 ). (aacrjournals.org)

Nuclear factor I/thyroid transcription factor 1 interactions modulate surfactant protein C transcription. (zju.edu.cn)

Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonarry neuroendocrine tumors. (zju.edu.cn)
This theory holds that tumors arise from 1 of 2 undifferentiated stem cells: the excretory duct reserve cell or the intercalated duct reserve cell. (medscape.com)

1 , 2 In recent years, mammalian cell-derived exosomes (a type of extracellular vesicle) have been widely used in the field of biomedicine, including diagnosis, regulation of disease progression and drug delivery. (dovepress.com)

A large number of studies have demonstrated that the synergistic collaboration of a number of microRNAs (miRNAs), their growth factors and their downstream agents is required for the initiation and completion of pathogenesis in the liver. (wjgnet.com)
EZH2 (enhancer of the zeste homolog 2) which was characterized as a histone methylase was also found to interact with lncRNAs and then impact the transcription of downstream factors [ 17 ]. (biomedcentral.com)

In this review, we summarize the role of this transcription factor in the development, diagnosis , and prognosis of lung cancer in the hope of providing insights into the utility of Nkx2-1 as a novel biomarker of lung cancer . (zju.edu.cn)
Recent studies reported microRNAs as promising biomarkers for early cancer detection, accurate prognosis, and molecular targets for future treatment. (hindawi.com)

Life Sci, 2021 Jan 1. (nih.gov)

Actionable targets that rescue the effector activity of antitumor T cells remain elusive. (biomed.news)
Speaking more specifically, β-catenin is an integral structural component of cadherin-based adhesive junctions as well as it a key nuclear effector of canonical in nucleus Wnt signaling. (chemdiv.com)

Identification of c-MYC as a target of the APC pathway. (esmed.org)
p62 also functions as a hub for intracellular signaling such as that in the mammalian target of rapamycin (mTOR) pathway. (elsevierpure.com)
The Part 1 post was concerned principally with interventions that address the mTOR pathway, a growth pathway also of great interest from the viewpoint of longevity. (anti-agingfirewalls.com)

Members of the ADAM family contribute to various physiological and pathophysiological processes by modulation of molecules like growth factors or cytokines. (frontiersin.org)

An analysis of an interactome for apoptosis factor, Ei24/PIG8, using the inducible expression system and shotgun proteomics. (nih.gov)

thyroid transcription factor-1), is a tissue-specific transcription factor of the thyroid, lung, and ventral forebrain. (zju.edu.cn)

Functional interaction of β-catenin with the transcription factor LEF-1. (esmed.org)
These ligands have been curated as having an association to the disease and possess interaction data with the target in GtoPdb. (guidetopharmacology.org)

A Systematic Review of Mesenchymal Epithelial Transition Factor (MET) and Its Impact in the Development and Treatment of Non-Small-Cell Lung Cancer. (lu.se)

The direct interconnection between CR and circadian rhythms has been evinced by the fact that Igf-1 expression is regulated by both CR and the circadian clock [ 14 ] . (encyclopedia.pub)
Interestingly, Igf-1 expression is rhythmic and shows sexual dimorphism [ 14 ] . (encyclopedia.pub)
Cultured hepatocytes offer the possibility to assess long-term effects, such as enzyme induction (i.e., changes of the expression levels of molecular entities of the hepatocytes). (aspetjournals.org)
Transcription factors (TFs) drive gene expression programs that shape specific phenotypes [ 3 ], and are frequently dysregulated in cancer [ 4 ]. (aging-us.com)

These observations, together with their finding that the levels of several of these factors can be jointly modulated in HNSCC by the transcription factor NF-κB, led these investigators to hypothesize that the circulating levels of these factors could be combined into a biologically rational biomarker panel for more accurately predicting response, relapse, and survival in individual patients. (aacrjournals.org)

The counts of targets and ligands of immunological relevance associated to the disease are also shown. (guidetopharmacology.org)

This study advances our knowledge of transcriptional MRs potentially involved in HCC development and progression that may be targeted by specific interventions. (aging-us.com)

as a proto-oncogene was recently characterized and the gene is implicated as a contributory factor in lung cancer development. (zju.edu.cn)

The study also reported that recurrence risk factors for these lesions included positive and uncertain resection margins, as well as younger age at diagnosis. (medscape.com)

One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
In this combined immunodeficiency (SCID) cancer is low in these species (as it chapter, some aspects of this issue mice, in which the human target is in humans), which renders cancer are discussed. (who.int)
However, except non-primate species often do not mour viruses is often problematic, for Epstein-Barr virus (EBV), which accurately reflect the mechanism of Part 1 · Chapter 9. (who.int)

Anatomy20

Organisms8

Diseases5

Chemicals and Drugs96

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes50

Disciplines and Occupations1

Information Science3

Health Care1

Mutations7

Genes12

Hepatic7

Receptors10

20012

Mutation4

Metabolism5

Promoter2

Tumor9

Proliferation1

Renal3

Type 2 diabet1

Proteins4

Albumin1

Receptor7

Excretion1

Diabetes8

Transporters2

Variants1

Therapeutic target2

Neoplasms2

HNF4A4

Differentiation1

Insulin4

Primary3

Isoform1

TCF21

Protein expression2

VEGF1

Modulate1

Tumors2

Extracellular1

Downstream2

Prognosis2

20211

Effector2

Pathway3

Cytokines1

Inducible1

Tissue-specific transcription factor1

Interaction2

Transition1

Expression4

Biomarker1

Ligands1

Development and progression1

Oncogene1

Recurrence1

Species3