Loading...


  • variety
  • Several prominent projects include discovery of epigenetic modulators for cancer, inflammatory disease and neuroscience as well as programs centered on a variety of targets in mucopolysaccharidosis, addiction, schizophrenia, fragile X, obesity, Alzheimer's, Parkinson's, among many others. (wikipedia.org)
  • treat
  • The sugar transporter receptor, i.e., "transceptor" GLUT2, may constitute a drug target to treat eating disorders and associated metabolic diseases, particularly by modulating its receptor function without affecting vital sugar provision by its transporter function. (physiology.org)
  • ability
  • The protective effect of many HLA class I alleles on HIV-1 pathogenesis and disease progression is, in part, attributed to their ability to target conserved portions of the HIV-1 genome that escape with difficulty. (jove.com)
  • include
  • Other risk factors include betel quid, certain types of human papillomavirus, radiation exposure, certain workplace exposures, and Epstein-Barr virus. (wikipedia.org)
  • systems
  • This article presents a review of the literature on haptic feedback systems for microrobotics, categorizing it according to the type of haptic technology employed. (frontiersin.org)
  • ophthalmology
  • QR-421a is part of ProQR's growing ophthalmology pipeline which also includes lead candidate, QR-110 for Leber's congenital amaurosis 10 currently in clinical trials, and three additional pipeline programs, QR-411 that addresses another genetic mutation resulting in Usher syndrome type 2A, QRX-1011 for Stargardt's disease and QRX-504 for Fuchs endothelial corneal dystrophy. (sofinnova.fr)
  • The Anne Bates Leach Eye Hospital annually serves 160,000 outpatients of ophthalmology and other specialties, largely for microsurgery procedures. (wikipedia.org)
  • virtually
  • Recent advances in the use of designer nucleases such as zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) 9 system for site-specific genome engineering open the possibility to perform rapid targeted genome modification in virtually any laboratory species without the need to rely on embryonic stem (ES) cell technology. (jove.com)
  • experiment
  • A genome editing experiment typically starts with identification of designer nuclease target sites within a gene of interest followed by construction of custom DNA-binding domains to direct nuclease activity to the investigator-defined genomic locus. (jove.com)
  • In an exemplar experiment, a target category was first displayed, followed by a sequence of 8 nouns. (jove.com)
  • In a second exemplar experiment, the same design was used, except that 1) the memory task was counterbalanced into two groups with SOAs of either 120 or 240 msec and 2) three memory tasks followed the sequence and tested remembrance for nontarget nouns in the sequence that could be anywhere from 3 items prior the target noun position to 3 items following the target noun position. (jove.com)
  • therapy
  • Acute pain services are provided by the Department to post-operative, burn and trauma patients in hospital using continuous epidural, perineural and patient-controlled analgesia catheters and multimodal drug therapy. (shreekrishnahospital.org)
  • stem
  • Embryonic stem cells, derived from the blastocyst stage early mammalian embryos, are distinguished by their ability to differentiate into any cell type and by their ability to propagate. (wikipedia.org)
  • include
  • Other risk factors include betel quid, certain types of human papillomavirus, radiation exposure, certain workplace exposures, and Epstein-Barr virus. (wikipedia.org)
  • However
  • However, with the typical procedure of AB experiments, it is not possible to examine how the processing of non-target items in RSVP may be affected by attention. (jove.com)
  • another
  • Two 2-alternative forced choice memory tasks followed the response to determine if participants remembered the words immediately before or after the target, as well as a random word from another part of the sequence. (jove.com)
  • changes
  • The types of sensation that allow for detecting these changes can be categorized as tactile, thermal, aural, or olfactory. (oxfordre.com)