Target gene expression regulation developmental. Medical search. Frequent questions

Recent work has shown that these proteins are also involved in hormonal regulation of breast cancer cells. (ucsc.edu)
These targets include mRNA, which codes for proteins, as well as a number of functional non-coding RNAs. (wikipedia.org)
Some binding proteins such as neuronal specific RNA-binding proteins, namely NOVA1, control the alternative splicing of a subset of hnRNA by recognizing and binding to a specific sequence in the RNA (YCAY where Y indicates pyrimidine, U or C). These proteins then recruit splicesomal proteins to this target site. (wikipedia.org)
In this work, we present a different paradigm for predicting miRNA-regulated genes based on the encoded proteins. (frontiersin.org)
Although dominant mutations are often not informative of the normal gene function, E(spl) turned out to encode a family of seven paralogous basic helix-loop-helix proteins of utmost importance in the implementation of the Notch signal in the receiving cell. (nih.gov)
In this review, we will focus on the regulation of E(spl) expression and on the function of E(spl) proteins. (nih.gov)
Learn more about ACD's new Co-detection Assays which will allow researchers to simultaneously examine cell-type specific gene expression and identify cellular sources of secreted proteins. (acdbio.com)
Within this conserved region is a consensus site for myocyte enhancer factor 2 (MEF2) proteins that we show is bound efficiently by MEF2 and is required for transgene expression in all three muscle lineages in vivo. (ox.ac.uk)
These compounds generally penetrate cell membranes, act on specific target proteins in cells, regulate intracellular signaling pathways, and cause some changes in cell phenotype. (chemscene.com)
The coiled-coil domain is a structural motif found in proteins that are involved in a diverse array of biological functions such as the regulation of gene expression, cell division, membrane fusion and drug extrusion and delivery. (antikoerper-online.de)
Polycomb and Trithorax group proteins maintain stable epigenetic memory of gene expression states for some genes, but many targets show highly dynamic regulation. (bvsalud.org)
Research reported in The Plant Cell shows that microRNAs control the accumulation of transcription factor proteins that regulate the expression of genes in the auxin response pathway. (sciencedaily.com)
Messenger RNA (mRNA) molecules are encoded by genes and are themselves templates for the proteins that carry the main metabolic functions in a cell. (sciencedaily.com)
There are many AGO1-like proteins in animals and other eukaryotes as well, indicating that the RNA-induced silencing complex is of ancient evolutionary origin, and that microRNA-mediated regulation of gene expression is shared among many eukaryotes. (sciencedaily.com)
The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. (elifesciences.org)
Transcription factors help to regulate gene expression-turning genes on or off and dialing up or down their level of activity-often in partnership with the proteins that they bind. (mit.edu)
They anchor themselves and their partner proteins to DNA at binding sites in genetic regulatory sequences, bringing together the components that are needed to make gene expression happen. (mit.edu)
At the Trinh laboratory, we employ experimental and computational approaches to understand how proteins and RNAs act at chromatin level to control activities of key genes involved in normal myeloid cell maturation, leukemia development, myeloid cell - cancer cell communication in the tumor microenvironment, as well as drug response. (virginia.edu)
Runx proteins are essential for a number of developmental processes and are aberrantly expressed in many human cancers. (elsevierpure.com)

We present a mathematical model comprising a Polycomb/Trithorax response element (PRE/TRE) coupled to a promoter and including Drosophila developmental timing. (bvsalud.org)
Fruitless isoforms and target genes specify the sexually dimorphic nervous system underlying Drosophila reproductive behavior. (ox.ac.uk)
Male courtship behavior in Drosophila is in large part regulated by the gene fruitless (fru). (ox.ac.uk)
This important study advances our understanding of the functions and regulation of the Drosophila transcriptional regulator Bonus, an ortholog of mammalian TIF1 family members. (elifesciences.org)
We are a hybrid computational and experimental lab who couple genome-scale computational and experimental analysis of gene regulation in Drosophila melanogaster and Saccharomyces cerevisiae with extensive analysis of comparative sequence data and experimental analysis of species closely related to these model systems. (berkeley.edu)
We now have extensive comparative sequence data for fruitflies (12 Drosophila genomes) and yeasts (many fungal genomes), and are using these data to characterize how the individual building blocks of regulatory sequences (transcription factor binding sites) and higher order structures (e.g. developmental enhancers) evolve. (berkeley.edu)
My lab is applying the high-resolution fluorescent imaging methods developed for D. melanogaster to systematically analyze gene expression, and dissect regulatory networks, in other Drosophila species and in several inbred lines of D. melanogaster . (berkeley.edu)
The detailed experimental data we are generating for D. melanogaster , and the genome sequences of 12 Drosophila species are a tremendous resource for studying the evolution of gene regulation. (berkeley.edu)
To take advantage of sequence diversity outside of the genus Drosophila, we are sequencing developmentally important loci from several non-Drosophilid fly families to provide insights into the underlying principles of gene regulation. (berkeley.edu)
Ecdysone- and NO-mediated gene regulation by competing EcR/Usp and E75A nuclear receptors during Drosophila development. (jefferson.edu)
Regulation of a duplicated locus: Drosophila sloppy paired is replete with functionally overlapping enhancers. (jefferson.edu)
sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein. (jefferson.edu)
Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila. (jefferson.edu)

Cancer research at UC Santa Cruz includes faculty in a wide range of departments, including Applied Math and Statistics, Biomolecular Engineering, Chemistry and Biochemistry, Electrical Engineering, Microbiology and Environmental Toxicology, and Molecular, Cell, and Developmental Biology. (ucsc.edu)
We ask fundamental questions in chromatin biology and seek to understand how these multifaceted regulations are dysregulated in human cancers. (childrensnational.org)
Detlef Weigel received his PhD in 1988 from the Max Planck Institute for Developmental Biology. (elifesciences.org)
Since 2002, he has been director of the Department of Molecular Biology at the Max Planck Institute for Developmental Biology. (elifesciences.org)
He serves on the Editorial Boards of Annual Review of Cell and Developmental Biology and Genome Biology. (elifesciences.org)
She is currently a Senior Investigator leading the Chromosome Structure and Epigenetics Mechanism Unit within the Laboratory of Receptor Biology and Gene Expression at the Center for Cancer Research of the NCI/NIH in Bethesda. (elifesciences.org)
Using a combination of chromatin biochemistry, computational modelling, atomic force microscopy (AFM), genetics, genomics and cell biology, Dr. Dalal and colleagues are investigating whether chromatin adopts alternate structural conformations in cancer cells, the functional consequences of large-scale chromosomal alterations upon the cancer epigenome, and identifying small molecules which can target these structures or processes. (elifesciences.org)
This Special Issue of "Genes" seeks reviews and original papers covering a wide range of topics related to microRNA biology, such as regulation of expression in various disorders (cancer, metabolism, autoimmunity to mention but a few), genetics of microRNAs and their target sites, functional analysis of microRNA function and studies of interactions between microRNAs and target genes. (mdpi.com)
We then apply our algorithm to a large compendium of 19,801 microarrays and identify genes specifically expressed in 30 diverse cell types of widespread importance in human biology, demonstrating that CellMapper can be readily used for cell types from many different tissues. (biomedcentral.com)
Development: For advances in developmental biology and stem cells. (lu.se)

Post-transcriptional regulation in multicellular organisms is mediated by microRNAs. (frontiersin.org)
MicroRNAs (miRNAs) post-transcriptionally regulate genes across all animals and plants. (frontiersin.org)
MicroRNAs are tiny ribonucleic acid (RNA) molecules (~22 nucleotides long) that recently have been found to play important roles in regulating gene expression in eukaryotic organisms, including plants and animals. (sciencedaily.com)
Research conducted by three independent groups and reported in The Plant Cell shows that fundamental developmental processes controlled by the plant hormone auxin are regulated by microRNAs in the model plant Arabidopsis thaliana. (sciencedaily.com)
mRNAs corresponding to several regulatory genes that mediate auxin responses contain short stretches of sequence that are complementary to microRNAs, and therefore have been considered potential targets of microRNA-mediated regulation. (sciencedaily.com)
Arabidopsis ago1 mutants lacking the AGO1 protein have numerous severe developmental defects, supporting the notion that regulation by microRNAs is critical for normal plant growth. (sciencedaily.com)
Since the first microRNA was identified in 1993 by Victor Ambros and colleagues (the lin-4 heterochronic gene in C. Elegans ), more than 24,000 microRNAs have now been identified. (mdpi.com)
MicroRNAs constitute a pervasive post-transcriptional filter on protein or mRNA expression levels that are likely to control developmental timing, cellular differentiation, stress responses, metabolism and proliferation. (mdpi.com)
Recently, research on the roles of microRNAs (miR) in cancer prognosis has formed an important area of research as differential expression of miRNAs has been observed in different cancers. (geneticsmr.com)
MicroRNAs are a class of endogenous, small non-coding RNAs (20-24 nucleotides) with critical roles in the post-transcriptional regulation of gene expression [ 1 ]. (biomedcentral.com)
Since microRNAs (miRNAs) are developmentally regulated and required for CD8+ T cell function, we hypothesized that defective CD8+ T cell memory formation in early life may be due to differences in miRNA expression patterns between neonatal and adult CD8+ T cells. (cornell.edu)

Auxin influences development by affecting the expression of numerous genes that control the processes of cell division and cell expansion in specific plant tissues at specific stages during the plant life cycle - e.g. for leaves, roots, and floral organs to develop in the correct patterns and correct time sequence. (sciencedaily.com)
Based on these results and prior studies, increased AQP9 expression may lead to increased arsenic transport in the female fetal placenta, which in turn may alter the expression patterns of key developmental genes that we have previously shown to be associated with arsenic exposure. (biomedcentral.com)
We found that known C(4) genes were recruited to photosynthesis from different expression domains in C(3), including typical housekeeping gene expression patterns in various tissues as well as individual heterotrophic tissues. (nih.gov)
Comparison of gene expression patterns with anatomy during leaf ontogeny provided insight into genetic features of Kranz anatomy. (nih.gov)
Therefore, it is important to describe their mechanisms of actions, expression patterns and possible target genes and cellular pathways with which they interact. (mdpi.com)
We are working on a toolbox of deep learning algorithms that can elucidate predictive relationships between sequence of non-coding gene regulatory elements, protein-DNA binding events, and expression patterns of their target genes. (ipk-gatersleben.de)
Expression analysis of the miR172-targeted euAP2s in nine different tissues showed diverse spatiotemporal expression patterns. (biomedcentral.com)
The human brain provides a clear example: many brain cell types display abnormal gene expression patterns when grown in culture [ 2 ] and must be acutely isolated from intact brain tissue to insure physiological relevance. (biomedcentral.com)
For each of the approximately 40 transcription factors critical in shaping anterior-posterior and dorsal-ventral patterns, our goals are to: 1) measure the factor s in vitro affinity to each of its potential target sequences, 2) identify the genomic regions bound by each factor in living embryos, 3) determine the expression pattern of the factor and its targets in three-dimensions at cellular resolution. (berkeley.edu)
Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)

This synthetic genetic interaction is seen at the level of single genes and acts downstream of promoter nucleosome reorganization. (sdbonline.org)
We train our algorithms on large resources of genetic variation, DNA binding and gene expression data across multiple species, tissues and treatments. (ipk-gatersleben.de)
We use our toolbox to estimate the regulatory impact of structural genetic variation, highlight gene candidates in GWAS studies and design gene editing strategies for gene expression modulation. (ipk-gatersleben.de)
Our other focus is are methods for integration of multi-omic data and identification of causal/predictive interactions between genetic variation, gene expression, metabolite levels and emergence of crop quality traits. (ipk-gatersleben.de)
Here, we collaborate with multiple labs interested in elucidation of molecular mechanisms of genetic associations or identification of molecular traits for targeted breeding. (ipk-gatersleben.de)
Using mouse models with distinct deletions in an intergenic region controlling imprinting across the Dlk1-Dio3 domain, we link changes in genetic and epigenetic states to allelic-expression and phenotypic outcome in vivo. (nature.com)
Emergence can result from mutations in housekeeping structural or regulatory genes or from acquiring foreign genetic information. (cdc.gov)
With the advances in BMT and gene therapy, patients now have a better likelihood of developing a functional immune system in a previously lethal genetic disease. (medscape.com)

Production of NO during early developmental stages is required for formation of multi-ciliated cells, ionocytes and small secretory cells by regulation of epidermal specific gene expression. (labgenexp.eu)
Recently it has become clear that a subset of CpG islands in embryonic stem cells can act as polycomb response elements and are recognized by the polycomb silencing systems to regulate the expression of genes involved in pluripotency and early developmental transcription programs. (nih.gov)

Reversal of aberrant epigenetic events, including those that modulate the transcriptional activity of genes associated with various signaling pathways, holds the prospect of influencing multiple stages of tumorigenesis. (oregonstate.edu)
Bonus has been implicated in embryonic development and organogenesis and shown to regulate several signaling pathways, however, its targets and mechanism of action remained poorly understood. (elifesciences.org)

In eukaryotes, the complex regulation of temporal- and tissue-specific gene expression is controlled by the binding of transcription factors to enhancers, which in turn interact with the promoter of their target gene(s) via the formation of a chromatin loop . (ens-lyon.fr)
The researchers found that RNA binding keeps transcription factors near their DNA binding sites for longer, helping to fine tune gene expression. (mit.edu)
This rethinking of how transcription factors work may lead to a better understanding of gene regulation, and may provide new targets for RNA-based therapeutics. (mit.edu)
When transcription factors had their ARMs mutated so they couldn't bind RNA, those transcription factors were less effective in finding their target sites, remaining at those sites and regulating genes. (mit.edu)
APETALA2 -like genes encode plant-specific transcription factors, some of which possess one microRNA172 (miR172) binding site. (biomedcentral.com)
One-third of the 471 genes predicted to encode transcription factors are differentially expressed during sexual development of S. commune . (nature.com)
MiR-29, on the other hand, is more abundant in adult CD8+ T cells and regulates the expression of transcription factors involved in effector and memory cell differentiation. (cornell.edu)

In the latter section, we will present some of the best-studied developmental events where E(spl) function has been analysed as well as the molecular mechanism of E(spl) activity that has transpired. (nih.gov)
We performed gene-agnostic screening of the non-coding regions to discover new molecular causes of congenital hyperinsulinism. (exeter.ac.uk)
In time series experiments, we characterize the molecular events determing developmental and stress responses events in time. (ipk-gatersleben.de)
The aims are to identify actionable molecular targets and diagnostic biomarkers, and to develop innovative therapeutic strate-gies for diseases such as cancer. (virginia.edu)
We are driven by a desire to understand the molecular basis of organismal diversity, and the belief that many differences in physiology, morphology and behavior arise from changes in gene regulation. (berkeley.edu)

According to the Eukaryotic RBP Database (EuRBPDB), there are 2961 genes encoding RBPs in humans. (wikipedia.org)

The HRC gene encodes the histidine-rich calcium-binding protein, which is found in the lumen of the junctional sarcoplasmic reticulum (SR) of cardiac and skeletal muscle and within calciosomes of arterial smooth muscle. (ox.ac.uk)
The complex then cleaves the mRNA into smaller pieces, thereby preventing translation of the protein it encodes, and thus inhibiting or "silencing" gene expression. (sciencedaily.com)
Comparative analyses of its 38.5-megabase genome, which encodes 13,210 predicted genes, reveal the species's unique wood-degrading machinery. (nature.com)

The proximal promoter lies just 5' to the coding region for the gene and is active only in thymocytes. (rupress.org)
As previously reported, transgenic mice bearing functional proximal promoter sequence juxtaposed with the SV40 large T antigen gene invariably develop lymphoid tumors confined to the thymus. (rupress.org)
In the current work, transgenic mice bearing a 2.6-kb fragment of the human distal promoter fused to the SV40 large T antigen gene express large T antigen in thymocytes and in peripheral lymphoid cells, and develop tumors of both the thymus and the peripheral lymphoid organs. (rupress.org)
With the exception of a single short interval that serves as a target for binding of nuclear factors, significant sequence similarity is not seen when the distal and proximal promoter sequences are compared. (rupress.org)
Hence, developmentally regulated, lineage-specific transcription of the lck gene is mediated by distinct promoter sequences that appear to be capable of functioning independently. (rupress.org)
Brca1 expression is regulated by a bidirectional promoter that is shared by the Nbr1 gene in mouse. (nih.gov)
3) Are all enhancer-promoter interactions functional, and how does the activity of an enhancer relate to the expression of the gene it interacts with? (ens-lyon.fr)
CoAA also blocked Runx2-mediated repression of the Axin2 promoter, a novel Runx target gene. (elsevierpure.com)
After implantation, a secondary DMR is established at the promoter of the Gtl2 gene, sustaining its repression from the paternal allele. (nature.com)

Moreover, AQP9 expression associated with that of a subset of female-specific arsenic-responsive genes. (biomedcentral.com)
Swr1 is required for the deposition of histone H2AZ at specific chromosome locations in vivo, and Swr1 and H2AZ commonly regulate a subset of yeast genes. (sdbonline.org)
Through a physical interaction with the polycomb repressive complex 1 (PRC1), KDM2B targets PRC1 to CpG islands where it contributes to H2AK119ub1 and gene repression at a subset of polycomb targets. (nih.gov)
In the subset of VPA targeted genes, 114 were downregulated whilst 217 genes were upregulated. (plos.org)
In the subset of LiCl targeted genes, 73 were downregulated and 91 were upregulated. (plos.org)

My lab studies how the genomic sequences that control gene expression function and evolve. (berkeley.edu)

3 Institute of Developmental Genetics, Cluster of Excellence on Plant Sciences, Heinrich-Heine-University, 40225 Düsseldorf, Germany. (nih.gov)

However, the principles that determine if a gene is regulated by miRNAs are poorly understood. (frontiersin.org)
Mature miRNAs act via complementarity with their target mRNAs. (frontiersin.org)
However, targeting of miRNAs to structural genes involved in Z-discs have not been investigated. (geneticsmr.com)
Surprisingly, our results indicated that differences in miRNA expression profiles were most pronounced prior to immunological challenge, suggesting that developmentally-regulated miRNAs do not operate by altering the fate of effector cells at the peak of the response. (cornell.edu)

Our method, CellMapper, strongly outperforms previous computational algorithms to predict cell type-specific expression, especially for rare and difficult-to-isolate cell types. (biomedcentral.com)
One promising solution has been the development of computational methods to infer cell type-specific expression information directly from heterogeneous samples [ 8 - 19 ], such as undissociated tissue. (biomedcentral.com)

It is these differentially expressed genes that frequently control cell differentiation, define cell-specific phenotypes, and provide the core signature of cell identity. (biomedcentral.com)
By focusing on identifying differentially expressed genes, it turns a more complex model-fitting problem into a classification problem [ 9 ], opening the door to algorithms that may be more sensitive, especially for rare and difficult-to-isolate cell types. (biomedcentral.com)

This process effectively changes the RNA sequence from that encoded by the genome and extends the diversity of the gene products. (wikipedia.org)
Our work provides a simple unifying framework for a rich repertoire of PRE/TRE functions, and thus provides insights into genome-wide Polycomb/Trithorax regulation. (bvsalud.org)
Integrated multi-omics analyses and genome-wide association studies reveal prime candidate genes of metabolic and vegetative growth variation in canola. (ipk-gatersleben.de)
In this study, 19 euAP2 and four miR172 genes were identified in the B. napus genome. (biomedcentral.com)
Whole genome duplication (WGD) or segmental duplication events played a major role in the expansion of the euAP2 gene family. (biomedcentral.com)
Finally, we explore a clinically relevant application to prioritize candidate genes in loci identified by genome-wide association studies (GWAS). (biomedcentral.com)
We focus on short evolutionary timescales where it is possible to couple specific changes in genome sequences with alterations in gene regulation and expression. (berkeley.edu)
Unexpectedly, we also find that CpG islands are occupied by low levels of PRC1 throughout the genome, suggesting that the KDM2B-PRC1 complex may sample CpG island associated genes for susceptibility to polycomb mediated silencing. (nih.gov)

2011. Dietary factors and epigenetic regulation for prostate cancer prevention. . (oregonstate.edu)
Epigenetic regulation of gene expression is an essential mechanism that guides cell differentiation during development. (elifesciences.org)
Mammalian parental imprinting is a form of epigenetic regulation that causes genes to be expressed from only one chromosome homolog according to parent-of-origin 1 , 2 . (nature.com)

and 3) non-histone targets of histone-modifying enzymes. (childrensnational.org)
Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane. (oregonstate.edu)
Perturbation of normal histone acetylation status can result in undesirable phenotypic changes, including developmental disorders and cancer. (oregonstate.edu)
Histone deacetylase (HDAC) inhibitors may be useful for cancer prevention and therapy by virtue of their ability to 'reactivate' the expression of epigenetically silenced genes, including those involved in differentiation, cell cycle regulation, apoptosis, angiogenesis, invasion, and metastasis. (oregonstate.edu)
The variant histone H2A.Z regulates gene transcription, and deletion of the gene encoding H2A.Z strongly increases the requirement for SNF/SWI and SAGA. (sdbonline.org)
The conserved histone variant H2AZ has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. (sdbonline.org)
Recent studies have revealed that variants of histone H2A and histone H3 play important roles not only in gene expression but also in the repair of DNA breaks and the assembly of chromosome centromeres. (sdbonline.org)
CoAA repressed Runx factor-dependent activation of reporter genes in a histone deacetylaseindependent manner. (elsevierpure.com)

HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo. (ox.ac.uk)
Thus, these studies identify the HRC enhancer as the first MEF2-dependent, CArG-independent transcriptional target in smooth muscle and represent the first analysis of the transcriptional regulation of an SR gene in vivo. (ox.ac.uk)
Importantly, we have identified for the first time, by means of the DamID technique, direct Fru transcriptional target genes. (ox.ac.uk)

Osteoblast differentiation of rabbit adipose-derived stem cells by polyethylenimine-mediated BMP-2 gene transfection in vitro. (geneticsmr.com)
The aim of this study was to examine the efficiency of polyethylenimine-mediated transfection of the human bone morphogenetic protein-2 (BMP-2) gene into rabbit adipose-derived stem cells (ADSCs), and its effect on osteoblast differentiation. (geneticsmr.com)
MiR172 and its target genes play key roles in flowering time and floral organ differentiation. (biomedcentral.com)
Measuring gene expression in specific cellular subsets is key to understanding cellular function and differentiation and how these processes are disrupted during disease pathogenesis. (biomedcentral.com)

on the other hand, it confirmed that AP2 genes negatively regulate flowering time in Arabidopsis. (biomedcentral.com)

Resistance to antimicrobial drugs in bacteria can result from mutations in housekeeping structural or regulatory genes. (cdc.gov)

Expression and estrogen sensitivity of target genes and nuclear receptor coregulators were altered at mRNA and protein levels in adult uterus, prostate and brain. (researchgate.net)
The plants showed increased accumulation of ARF17 mRNA and altered levels of mRNAs corresponding to several genes that may be regulated by ARF17. (sciencedaily.com)
Dr. Bellini and her colleagues found that the mutant plants over-accumulate ARF17 mRNA within the hypocotyl, pointing to ARF17 as a major regulator of adventitious rooting and microRNA-mediated regulation as a major regulator of ARF17. (sciencedaily.com)
Alternative splicing of pre-mRNA is a post-transcriptional modification essential for the regulation of gene expression and function. (biomedcentral.com)

We demonstrate a clinically relevant application to prioritize candidate genes in disease susceptibility loci identified by GWAS. (biomedcentral.com)

We further show that the evolutionary conservation among paralogs does not imply any coherence in miRNA regulation. (frontiersin.org)
We conclude that duplicated paralogous genes that often changed their function, also diverse in their tendency to be miRNA regulated. (frontiersin.org)
We conclude that protein function is informative across species in predicting post-transcriptional miRNA regulation in living cells. (frontiersin.org)
Their ability to maintain cell and tissue homeostasis is critical, with many miRNA genes implicated in human diseases such as metabolic, inflammatory, and neurodegenerative diseases ( Vishnoi and Rani, 2017 ). (frontiersin.org)
Here, we describe a highly expressed miRNA, miR-432, in pig embryonic skeletal muscle, which appeared to target myozenin1 (MYOZ1), a protein involved in the muscular sarcomere microstructure. (geneticsmr.com)

Although RBPs have a crucial role in post-transcriptional regulation in gene expression, relatively few RBPs have been studied systematically.It has now become clear that RNA-RBP interactions play important roles in many biological processes among organisms. (wikipedia.org)
This determined how hierarchical interactions between regulatory elements orchestrate robust parent-specific expression, with implications for non-imprinted gene regulation. (nature.com)

Together, our work identified Bonus as a regulator of tissue-specific gene expression and revealed the importance of SUMOylation as a regulator of complex formation in the context of transcriptional repression. (elifesciences.org)

Treatment with VPA and LiCl resulted in the differential expression of 331 and 164 genes respectively. (plos.org)

Her lab focuses on mutations that cause changes in gene expression by affecting a process called alternative splicing of RNA. (ucsc.edu)
These changes in gene expression alter cell metabolism, tissue re-modeling, and even organismal responses such as increases in heart rate and ventilation. (nobelprize.org)

This study explores the use of a simple human neurosphere-based in vitro model to characterise the pharmacological and toxicological effects of LiCl and VPA using gene expression changes linked to phenotypic alterations in cells. (plos.org)

CpG island elements are associated with most mammalian gene promoters, yet how they contribute to gene regulation remains poorly understood. (nih.gov)

While imprinting perturbations are widely associated with developmental abnormalities, the intricate regional interplay between imprinted genes makes interpreting the contribution of gene dosage effects to phenotypes a challenging task. (nature.com)
Yet, the intricate form of epigenetic control over the parent-specific expression of multiple genes in an imprinted cluster poses difficulties when trying to decipher the relative contribution of changes in imprinted gene dosage to the resulting physiological phenotypes. (nature.com)

2006) Exposure to lead and the developmental origin of oxidative DNA damage in the aging brain. (edu.pl)
In a previous report using the resources of the New Hampshire Birth Cohort Study (NHBCS), we found that low-to-moderate i n utero exposure to arsenic, a highly toxic and widespread pollutant, was associated with altered expression of several key developmental genes in the fetal portion of the placenta. (biomedcentral.com)
Multivariable linear regression analysis was used to examine their relationship with arsenic exposure and with key developmental genes, after stratification by fetal sex. (biomedcentral.com)
We found that maternal arsenic exposure was strongly associated with expression of the AQP9 gene, encoding an aquaglyceroporin transporter, in female but not male fetal placenta. (biomedcentral.com)
Gene ontology (GO) term enrichment analysis was used to highlight the most relevant GO terms associated with a given gene list following toxin exposure. (plos.org)
MRLs are derived when reliable and sufficient data exist to identify the target organ(s) of effect or the most sensitive health effect(s) for a specific duration within a given route of exposure. (cdc.gov)
Differential gene regulation in human small airway epithelial cells grown in monoculture versus coculture with human microvascular endothelial cells following multiwalled carbon nanotube exposure. (cdc.gov)
16 , 17 In particular, transgenic zebrafish lines that express nfsB in β cells, cardiomyocytes, or other cell types have been established, and their exposure to the metronidazole leads to the targeted loss of these cells. (cdc.gov)

To provide a solid experimental foundation for our evolutionary studies, we are working with several other labs in Berkeley to systematically dissect gene expression and regulation in the early D. melanogaster embryo. (berkeley.edu)

These changes were correlated with dramatic development defects in leaves, roots, and flowers, showing that microRNA-mediated regulation of ARF17 is essential for normal plant development. (sciencedaily.com)
We found that knockdown of Bonus in early oogenesis results in severe defects in ovarian development and in ectopic expression of genes that are normally repressed in the germline, demonstrating its essential function in the ovary. (elifesciences.org)

The phytochemical 3,3'-diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells. (oregonstate.edu)
We demonstrated that these mutations resulted in expression of HK1 in the pancreatic beta-cells causing inappropriate insulin secretion and congenital hyperinsulinism. (exeter.ac.uk)
Altered expression of developmental factors and cell cycle genes is associated with a higher degree of endoreduplication in enlarged C(4) bundle sheath cells. (nih.gov)
The reduced expression of most of these genes in htz1Delta cells was reversed by the deletion of SIR2 (sir2Delta) suggesting that H2A.Z antagonizes telomeric silencing. (sdbonline.org)
Suppression of the biological activity of neuroglioma cells by down-regulation of miR-1. (geneticsmr.com)
A major goal of this grant is to identify the key gene regulatory networks that underlie cell-intrinsic differences between neonatal and adult CD8+ T cells. (cornell.edu)
MiR-130 is preferentially expressed in neonatal CD8+ T cells and targets a number of genes involved in negative regulation of T cell proliferation or apoptosis. (cornell.edu)
We propose that the miR-29/miR-130 axis acts as a developmental rheostat for adjusting the activation threshold of CD8+ T cells, controlling the balance between rapid effector cells (neonates) and long-lived memory cells (adults). (cornell.edu)
We show that a set of somatic lineage regulators (including Hox, Gata and Sox factors) that carry bivalent chromatin enriched in H3K27me3 and H3K4me2 are selectively targeted by Suv39h1-mediated H3K9me3 and de novo DNA methylation in extra-embryonic versus embryonic (pluripotent) lineages, as assessed both in blastocyst-derived stem cells and in vivo. (cnrs.fr)
Suppression of CoAA expression by RNA interference reduced osteosarcoma cell viability in vitro, suggesting that it contributes to the proliferation and/or survival of osteoblast lineage cells. (elsevierpure.com)
Animal cells undergo fundamental shifts in gene expression when there are changes in the oxygen levels around them. (nobelprize.org)
Of particular interest is their contribution to Developmental Neurotoxicity (DNT) as well as their potential impact on stem cells. (plos.org)
When a microRNA is present in the cell, it binds to the target sites and downregulates GFP expression, while in cells that do not express the microRNA GFP, it is expressed. (lu.se)

Gene expression is tightly regulated with many genes exhibiting cell-specific silencing when their protein product would disrupt normal cellular function. (exeter.ac.uk)
Through the combined work of these three laureates it was thus demonstrated that the response by gene expression to changes in oxygen is directly coupled to oxygen levels in the animal cell, allowing immediate cellular responses to occur to oxygenation through the action of the HIF transcription factor. (nobelprize.org)
This neurosphere model might provide the basis of a human-based cellular approach for the regulatory exploration of developmental impact of potential toxic chemicals. (plos.org)
not unique for the embryonic system but are shared by other ogenesis regulation must consider different scales of multi-cellular modeling areas. (lu.se)
This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. (cancerindex.org)

We present a sensitive approach to predict genes expressed selectively in specific cell types, by searching publicly available expression data for genes with a similar expression profile to known cell-specific markers. (biomedcentral.com)
Tissues with complex three-dimensional morphology, significant depth, or rapid movement are challenging to selectively target by optical techniques. (cdc.gov)

Multi-Walled Carbon Nanotube-Induced Gene Expression Biomarkers for Medical and Occupational Surveillance. (cdc.gov)

A cis-regulatory element (CRE) analysis suggested that the euAP2 s were involved in the response to light, hormones, stress, and developmental processes including circadian control, endosperm and meristem expression. (biomedcentral.com)

Importantly, this has revealed a new disease mechanism for non-coding mutations that cause inappropriate expression of a disallowed gene. (exeter.ac.uk)

One in eight women in the United States will develop breast cancer in her lifetime, yet only about 15 percent of these cancers have been linked to inherited gene mutations. (ucsc.edu)
Dr. Yu's research group aims to answer the fundamental question: How can chromatin-associated molecules be targeted to stop aggressive cancers? (childrensnational.org)

1 In particular, morpholino oligonucleotides (MOs) have been used to block the expression of targeted genes in several invertebrate and vertebrate models. (cdc.gov)

Co-activator activator (CoAA) is a nuclear protein that regulates gene expression, RNA splicing and is overexpressed in many human tumors. (elsevierpure.com)

Family history of immune conditions and autism spectrum and developmental disorders: Findings from the study to explore early development. (cdc.gov)

MCE owns a unique collection of 17212 compounds with confirmed biological activities and clear targets. (chemscene.com)
This requirement poses a severe limitation for most biological applications, as it is difficult to curate such a large list of established marker genes for even well-studied cell types and impossible for many others. (biomedcentral.com)

Using NanoString technology, we further analyzed the fetal placenta samples from the NHBCS for the expression of genes encoding arsenic transporters and metabolic enzymes. (biomedcentral.com)

Phosphorodiamidate morpholino oligonucleotides are widely used to interrogate gene function in whole organisms, and light-activatable derivatives can reveal spatial and temporal differences in gene activity. (cdc.gov)

Dr. Yu's research group studies regulations of gene expression at the chromatin level. (childrensnational.org)

These arrays contain oligonucleotide probes that span exon-exon junctions, and probes positioned within exons to determine individual exon levels and overall transcript expression. (biomedcentral.com)
Alternative splicing results in multiple transcript variants of this gene. (cancerindex.org)

with these three reports, we are beginning to understand the consequences of this regulation for the development of the plant. (sciencedaily.com)
Fru target genes overwhelmingly represent genes previously reported to be involved in the nervous system development, such as CadN, lola and pdm2. (ox.ac.uk)
Tumor-specific variations in splicing may generate new epitopes that can serve as a starting point for immune therapy or targeted delivery, as well as for the development of new diagnostic or prognostic tools [ 6 ]. (biomedcentral.com)
The miR172 and its target euAP2 genes are involved in the process of phase transformation and flower organ development in many plants. (biomedcentral.com)
Most euAP2 genes were highly expressed in the floral organs, suggesting their specific functions in flower development. (biomedcentral.com)
Runx factors bind DNA and co-factors to activate or repress genes crucial for bone formation, hematopoiesis, and neuronal development. (elsevierpure.com)

All RBPs bind RNA, however they do so with different RNA-sequence specificities and affinities, which allows the RBPs to be as diverse as their targets and functions. (wikipedia.org)
The HRC enhancer contains a small, highly conserved sequence that is required for expression in all three muscle lineages. (ox.ac.uk)
A sequence analysis suggested that 17 euAP2 genes were targeted by Bna-miR172 in the 3′ coding region. (biomedcentral.com)
While it is impractical to repeat every experiment done in D. melanogaster in every other strain and species, we are extending several classes of experiment to selected strains and species so that we can better understand regulatory variation at each of its multiple levels: how sequence variation affects binding, how binding variation affects expression, and how expression variation affects phenotype. (berkeley.edu)

AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. (bvsalud.org)

One of these targets is the transcription factor AUXIN RESPONSE FACTOR17 (ARF17), which is thought to repress the expression of a number of other genes involved in auxin responses. (sciencedaily.com)

A special issue of Genes (ISSN 2073-4425). (mdpi.com)

Anatomy22

Organisms13

Diseases5

Chemicals and Drugs93

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes88

Disciplines and Occupations3

Information Science6

Health Care2

Proteins19

Drosophila13

Biology10

MicroRNAs11

Patterns10

Genetic8

Early developmental2

Pathways2

Transcription Factors7

Molecular5

Humans1

Encodes3

Promoter9

Subset5

Genomic1

Genetics1

MiRNAs4

Computational2

Differentially expressed2

Genome8

Epigenetic regulation3

Histone8

Transcriptional target3

Differentiation4

Negatively regulate1

Regulatory genes1

MRNA4

Candidate genes1

MiRNA5

Interactions2

Repression1

Differential expression1

Changes in gene expression2

Phenotypic1

Poorly understood1

Phenotypes2

Exposure8

Embryo1

Defects2

Cells13

Cellular5

Selectively2

Biomarkers1

Processes1

Mutations that cause1

Cancers2

Invertebrate1

Regulates gene1

Disorders1

Biological2

Metabolic1

Reveal1

Chromatin level1

Transcript2

Development6

Sequence4

Nuclear1

Auxin1

ISSN1