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Tandem Repeat SequencesRepetitive Sequences, Nucleic AcidMolecular Sequence DataBase SequenceMinisatellite RepeatsTrinucleotide RepeatsRepetitive Sequences, Amino AcidAmino Acid SequenceInverted Repeat SequencesCloning, MolecularMicrosatellite RepeatsDNA, SatelliteDNASequence Analysis, DNASequence Homology, Nucleic AcidPolymerase Chain ReactionPolymorphism, GeneticTrinucleotide Repeat Expansion
GenomeGenomesExon sequencesGenesPhylogeneticRepetitive sequencesCopiesAmino acidDivergenceProteinsEvolutionaryNucleotideChromosomesGeneSpeciesMutationConsistsMolecularCytogeneticElusiveMicrosatelliteVariationHumansProtein sequenceConsensus sequenceClinicalImplicationsMutabilityDomainsLongBacterialElementsTranscriptionPropertiesSimilarShownStructure
Genome13
  • Multilocus variable-number tandem-repeat analyses (MLVA) is based on variation in repeat number in tandemly repeated DNA elements on multiple loci in the genome of C. burnetii and might be more discriminatory than multispacer sequence typing ( 13 , 15 ). (cdc.gov)
  • Any cytogenetic investigation regarding NOR variability, telomere sequence and genome size in the Indian species becomes the most promising field to decipher chromosome evolution against the background of species diversity and evolution, especially in the Indian subcontinent. (pensoft.net)
  • Here we have mapped sites of DNA replication initiation across the T. cruzi genome using Marker Frequency Analysis, which has previously only been deployed in two related trypanosomatids. (biomedcentral.com)
  • The mitochondrial (mt) genome sequence of insects possesses numerous evolutionary traits. (bvsalud.org)
  • To better understand the evolution of mt genomes within the family Miridae, the complete mt genome of the predatory Japanese plant bug Stethoconus japonicus Schumacher was sequenced before undertaking a comparative analysis of all reported plant bug mt genomes. (bvsalud.org)
  • Phylogenetic relationships of 15 bugs were eventually analyzed based on Maximum likelihood (ML) and Bayesian inference (BI) methods using 17 mt genome sequences. (bvsalud.org)
  • The sequence of the human nuclear genome has been completed in draft form by an international public consortium consisting of 16 sequencing centers and associated computational facilities [ 1 ]. (biomedcentral.com)
  • As of late 2000, the public human sequence was primarily based on approximately 24,000 accessioned bacterial artificial chromosome (BAC) clones covering 97% of the euchromatic portion of the genome [ 6 ]. (biomedcentral.com)
  • Thirty percent of the genome is in finished form, including the entire sequence of chromosomes 21 and 22 [ 7 ]. (biomedcentral.com)
  • Recently, the consortium has distributed a working draft assembly of the entire genome that removes redundancies, orients sequence fragments and clearly indicates gaps arising from sequencing and assembly. (biomedcentral.com)
  • The current coverage is, however, sufficient for the Human Genome Project to enter a new phase, in which the entire sequence can be analyzed to identify genes, regulatory regions and other genomic elements and structures. (biomedcentral.com)
  • The assembly provides simplified descriptions of the genome, as disparate data sources such as GenBank and numerous expressed sequence tag (EST) and protein databases are unified. (biomedcentral.com)
  • There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. (lookformedical.com)
Genomes2
  • of tandem repeats within their genomes [6, 17]. (scirp.org)
  • Similar sequence with variable number of tandemly repeated units from intra-genus CRs is a distinct characteristic of plant bug mt genomes. (bvsalud.org)
Exon sequences1
  • While whole gene duplications and deletions are relatively well-studied, the biology of subexonic ( i.e. , within coding exon sequences), copy number variation remains elusive. (nature.com)
Genes9
  • Therefore comparative genomic analysis of T . equi was undertaken to: 1) identify genes contributing to immune evasion and persistence in equid hosts, 2) identify genes involved in PBMC infection biology and 3) define the phylogenetic position of T . equi relative to sequenced apicomplexan parasites. (biomedcentral.com)
  • Comparative genomic analysis of T . equi revealed the phylogenetic positioning relative to seven apicomplexan parasites using deduced amino acid sequences from 150 genes placed it as a sister taxon to Theileria spp . (biomedcentral.com)
  • Our analysis identified 50 genes that will be useful for definitive phylogenetic classification of T . equi and closely related organisms. (biomedcentral.com)
  • An analysis of VFA biosynthesis pathways showed that genes required for the synthesis of acetate were present in a range of species, except for Elusimicrobiota and Euryarchaeota . (biomedcentral.com)
  • The putative origins identified in T. cruzi show a notable enrichment of GC content, a preferential position at subtelomeric regions, coinciding with genes transcribed towards the telomeres, and a pronounced enrichment within coding DNA sequences, most notably in genes from the Dispersed Gene Family 1 (DGF-1). (biomedcentral.com)
  • Moreover, analysis showed that while expression of many genes on the monosomic Ch5 is altered in accordance with the chromosome ploidy, expression of a large fraction of genes is increased to the normal diploid level, presumably compensating for gene dose. (biomedcentral.com)
  • However, reduction to a single consensus sequence permits placement of genes and other chromosomal structures in their proper positional context. (biomedcentral.com)
  • Public attention surrounding completion of the draft human sequence has fostered the impression that we are entering a 'post-genomic' era, and that description of genes and their functions is straightforward. (biomedcentral.com)
  • Sequences of DNA in the genes that are located between the EXONS. (lookformedical.com)
Phylogenetic3
  • Molecular phylogenetic analyses indicate an intermediate position for T . equi between B . bovis and Theileria spp. (biomedcentral.com)
  • According to our phylogenetic analyses, the group constitutes a well-supported monophylum containing several distinct evolutionary lineages with high haplotype diversity. (podarcis.de)
  • Phylogenetic analyses showed that no single species tree can efficiently represent all species relationships, suggesting high levels of repeatedly occurring gene flow. (biomedcentral.com)
Repetitive sequences1
Copies6
  • These domains are found in the N terminus of proteins and consists of tandemly repeated copies of an around 80 amino acids region. (wikipedia.org)
  • Repeats present in 4 or more copies in proteins. (embl.de)
  • 王海震 , 苏小运 , 曹瑞兵 , 陈溥言 , , 2004: Construction and Expression of the Prokaryotic Expressing Vector Containing Tandemly Linked 2 Copies of the A and D Antigenic Domains of the CSFV E2 Gene, Virologica Sinica, 19, 171-173. (virosin.org)
  • The Alu sequence family (named for the restriction endonuclease cleavage enzyme Alu I) is the most highly repeated interspersed repeat element in humans (over a million copies). (lookformedical.com)
  • Sequences of DNA or RNA that occur in multiple copies. (lookformedical.com)
  • TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES). (lookformedical.com)
Amino acid2
  • The tetratricopeptide repeat (TPR) is a degenerate 34 amino acid sequence identified in a wide variety of proteins, present in tandem arrays of 3-16 motifs, which form scaffolds to mediate protein-protein interactions and often the assembly of multiprotein complexes. (embl.de)
  • Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
Divergence1
  • The study highlighted several mechanisms underlying species diversification, including selection acting on existing standing variation, high rates of gene duplication, novel microRNAs and rapid sequence divergence in otherwise conserved non-coding elements. (biomedcentral.com)
Proteins2
  • The detailed sequence analysis of Doublecortin and Doublecortin-like proteins allowed the identification of a tandem repeat of evolutionarily conserved Doublecortin (DC) domains. (wikipedia.org)
  • Western blot analysis showed that stromal cells of lung tumours were characterised by a statistically considerably lower phrase level of the p16 proteins as likened with that in regular lung stromal cells. (immune-source.com)
Evolutionary1
  • On a broader scale, our study highlights variable subexonic repeats as a primary source for modular evolutionary innovation that lead to rapid functional adaptation. (nature.com)
Nucleotide3
  • Whereas most analyses in cichlids focused on nucleotide substitutions across species to investigate the genetic bases of this explosive radiation, to date, no study has investigated the contribution of structural variants (SVs) in the evolution of adaptive traits across the three Great Lakes of East Africa. (biomedcentral.com)
  • It is also called nucleotide sequence. (lookformedical.com)
  • Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. (lookformedical.com)
Chromosomes1
  • The terminal regions of human chromosomes are known to contain specialised DNA sequences and may be vulnerable to rearrangements causing human genetic diseases and particularly idiopathic mental impairment. (bmj.com)
Gene7
  • The salivary MUC7 gene provides an opportunity for studying such variation, as it harbors copy number variable subexonic repeat sequences that encode for densely O-glycosylated domains (PTS-repeats) with microbe-binding properties. (nature.com)
  • Here, we focus on the salivary mucin-7 gene ( MUC7 ) to study the evolution and functional impact of subexonic repeats. (nature.com)
  • These repeats can be particularly well studied in this gene because the repeats are relatively short and few in number compared to other mucins. (nature.com)
  • 彭艳华 , 杨复华 , 齐义鹏 , 黄永秀 , 1999: Location，Sequence and Promoter Structure of Apoptosis-Inhibiting Gene of Leucania seperate Nuclear Polyhedrosis Virus, Virologica Sinica, 14, 58-71. (virosin.org)
  • 芦银华 , 陈德胜 , 华修国 , 黄伟坚 , 谈国蕾 , 陈溥言 , 2002: Sequence Analysis of ORF2 Gene of Type 2 Porcine Circovirus and Construction of Eukaryotic Expressing Vector of ORF2, Virologica Sinica, 17, 87-91. (virosin.org)
  • In addition, initial sequence analysis reveals highly ordered chromosomal landscapes associated with paralogous gene clusters and distinct functional compartments. (biomedcentral.com)
  • Sequence homology is an indication of the genetic relatedness of different organisms and gene function. (lookformedical.com)
Species2
  • In this study, a shotgun metagenomic analysis of the microbes adhering to plant fiber in the camel rumen was undertaken to identify the key species contributing to lignocellulose degradation and short chain volatile fatty acids (VFA) fermentation. (biomedcentral.com)
  • However, Bayesian and maximum likelihood from sequencing data demonstrated the occurrence of a single species, Cichla kelberi. (bvsalud.org)
Mutation1
  • Launch Reduction of the DNA mismatch fix (MMR) program by (epi-) hereditary adjustments network marketing leads to an elevated mutation price in brief, repeated sequences tandemly, called microsatellites. (immune-source.com)
Consists1
  • The TPR motif consists of 3-16 tandem-repeats of 34 amino acids residues, although individual TPR motifs can be dispersed in the protein sequence. (embl.de)
Molecular1
  • At present, DNA molecular marker techniques are widely applied in the fields of germplasm identification, phylogenetics, and genetic structural analysis. (biomedcentral.com)
Cytogenetic1
  • Similarly, formerly independent maps, based on cytogenetic banding patterns, meiotic crossovers and radiation hybrids, may be placed within the single consensus sequence. (biomedcentral.com)
Elusive1
  • In all other eukaryotes, clear consensus sequences for origins are elusive, perhaps indicating there are no cis elements to initiate replication in most of these cells and organisms. (biomedcentral.com)
Microsatellite1
  • A total of 17 different minisatellite and microsatellite repeat markers have been described ( 11 ). (cdc.gov)
Variation2
  • However, there is no study to our knowledge that specifically investigated the evolution of copy number variable subexonic repeats from their initial emergence as functional units to the adaptive constraints and mutational properties that contributed to their extant variation in primates. (nature.com)
  • MUC7 provides an opportunity to assess the broader implications of subexonic repeat variation within the context of the functional evolution of the mucin functional group and primate salivary adaptation. (nature.com)
Humans1
  • First, MUC7 carries subexonic repeats that are 69 bp (23 amino acids) long and are copy number variable in humans 5 . (nature.com)
Protein sequence1
  • The two DUX4‐fl isoforms produce the same protein sequence and differ only in the splicing of the 3′UTR. (comprehensivephysiology.com)
Consensus sequence1
  • Sequence alignment of the TPR domains reveals a consensus sequence defined by a pattern of small and large amino acids. (embl.de)
Clinical1
  • Multispacer sequence typing is based on DNA sequence variations in 10 short intergenic regions and can be performed on isolated C. burnetii strains or directly on extracted DNA from clinical samples ( 12 , 14 , 15 ). (cdc.gov)
Implications1
  • The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. (embl.de)
Mutability1
  • A recent study has shown that, despite the high intrinsic mutability of subexonic repeats, the vast majority of thousands of subexonic repeats remain strongly conserved among mammals 4 . (nature.com)
Domains2
  • Second, the subexonic repeats of MUC7 code for densely O-glycosylated proline-, threonine-, and serine-rich (PTS) tandem repeat domains. (nature.com)
  • Comparison of 4qA, 4qB, and 10q D4Z4 repeat sequence domains. (comprehensivephysiology.com)
Long6
  • Zheng Hou , Zheng Zhou , Zonglin Wang , Gengfu Xiao , 2016: Assembly of long DNA sequences using a new synthetic Escherichia coli -yeast shuttle vector, Virologica Sinica, 31, 160-167. (virosin.org)
  • The control region is 1,717 bp and contains a long tandem repeat sequence of a 165 bp unit repeated six times. (bvsalud.org)
  • TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. (lookformedical.com)
  • They also have an open reading frame that is related to the reverse transcriptase of retroviruses but they do not contain LTRs (long terminal repeats). (lookformedical.com)
  • Highly repeated sequences, 100-300 bases long, which contain RNA polymerase III promoters. (lookformedical.com)
  • Long terminal repeats (LTRs) similar to those from retroviruses are contained in retrotransposons and retrovirus-like elements. (lookformedical.com)
Bacterial1
  • DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom. (lookformedical.com)
Elements1
Transcription1
  • The region of DNA which borders the 3' end of a transcription unit and where a variety of regulatory sequences are located. (lookformedical.com)
Properties1
  • MUC7 comprises a number of interesting properties that could make it a model for studying subexonic repeats ( Fig. 1A ). (nature.com)
Similar1
  • somewhat similar sequences of about 110 amino acids each. (wikipedia.org)
Shown2
Structure1
  • Adjacent TPR motifs are packed together in a parallel arrangement such that a tandem TPR motif structure is composed of a regular series of antiparallel alpha-helices. (embl.de)