• tolerability
  • To evaluate the pharmacokinetic (PK) and tolerability profiles of a new tablet formulation of tacrolimus and its interindividual variability (IIV) in the systemic exposure, and to compare them with those of the conventional capsule formulation, a randomized, open-label, two-treatment, two-period, two-sequence, crossover study was performed in 47 healthy males. (dovepress.com)
  • Thus, the tablet formulation of tacrolimus has smaller IIV in the systemic exposure than capsule, while having comparable PK and tolerability profiles, which may render it as a better treatment option for organ transplant patients. (dovepress.com)
  • drug
  • Is tacrolimus available as a generic drug? (medicinenet.com)
  • A similar pattern of renal injury from cyclosporine is seen with the use of tacrolimus, thereby suggesting a drug class effect. (uptodate.com)
  • See also: Immunosuppressants in the treatment of dermatitis In January 2006, the United States Food and Drug Administration (FDA) announced that Elidel packaging would be required to carry a black box warning regarding the potential increased risk of lymph node or skin cancer, as for the similar drug tacrolimus. (wikipedia.org)
  • capsules
  • Mylan Institutional has tacrolimus 5 mg capsules in 100 count unit-dose on back order and the company cannot estimate a release date. (drugs.com)
  • transplant
  • The use of sub-potent tacrolimus in compounded drugs for transplant recipients may lead to sub-therapeutic tacrolimus blood levels and an unacceptable increased risk of solid organ transplant rejection. (drugs.com)
  • Subsequently
  • Dogs receiving just the aqueous carrier were subsequently treated with tacrolimus, and STT increased 5 mm/min in 9 dogs (18/20 eyes) after administration. (vetcontact.com)
  • inflammation
  • In recent years, tacrolimus has been used to suppress the inflammation associated with ulcerative colitis (UC), a form of inflammatory bowel disease. (wikipedia.org)
  • effective
  • Although almost exclusively used in trial cases only, tacrolimus has shown to be significantly effective in the suppression of outbreaks of UC. (wikipedia.org)
  • concentration
  • Whole-blood tacrolimus concentration was determined using liquid chromatography-tandem mass spectrometry. (dovepress.com)
  • The maximum whole-blood tacrolimus concentration (C max ) and the area under the whole-blood tacrolimus concentration-time curve from 0 hour to the last quantifiable concentration (AUC last ) were compared between the two formulations. (dovepress.com)
  • mice
  • There were two studies involving MRL/lpr and B/W F1 mice, where tacrolimus was administered to the mice with spontaneous lupus nephritis [ 4 ]. (hindawi.com)
  • twice
  • Conclusions: Twice daily administration of 0.02% tacrolimus in aqueous suspension effectively increased tear production in dogs with KCS. (vetcontact.com)
  • study
  • Histopathological study showed that tacrolimus significantly inhibited glomerular hypercellularity and crescent formation. (hindawi.com)
  • In the controlled study, STT increased by 5 mm/min in 7/10 dogs (14/20 eyes) that received tacrolimus and in none of the 10 dogs that received aqueous carrier alone. (vetcontact.com)