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Gene RearrangementDNA, MitochondrialGenes, MitochondrialPhylogenyRNA, TransferGene Rearrangement, B-Lymphocyte, Light ChainGene Rearrangement, T-LymphocyteGene Rearrangement, B-Lymphocyte, Heavy ChainGene Rearrangement, gamma-Chain T-Cell Antigen ReceptorBase SequenceGenome, MitochondrialGene Rearrangement, B-LymphocyteMolecular Sequence DataGene Rearrangement, beta-Chain T-Cell Antigen ReceptorRNA, Transfer, Amino Acid-SpecificGene Rearrangement, delta-Chain T-Cell Antigen ReceptorGenes, ImmunoglobulinMitochondriaAnticodonGene OrderGene Rearrangement, alpha-Chain T-Cell Antigen ReceptortRNA MethyltransferasesImmunoglobulin Heavy ChainsNucleic Acid ConformationRNA, Transfer, Amino AcylElectron Transport Complex IVPolymerase Chain ReactionEvolution, MolecularGenes, T-Cell Receptor gammaTranscription, GeneticBlotting, SouthernGenesRNA, Transfer, SerImmunoglobulin kappa-ChainsTranslocation, GeneticCytochromes bRNA, Transfer, LeuRNA, RibosomalSequence Analysis, DNAMutationCodonRNA, Transfer, ArgImmunoglobulin Joining RegionRNA, Transfer, GlyRNA, Transfer, IleB-LymphocytesSaccharomyces cerevisiaeMitochondrial ProteinsNADH DehydrogenaseRecombination, GeneticImmunoglobulin Variable RegionCloning, MolecularRNA, FungalClone CellsNucleic Acid HybridizationRNA, Transfer, ValRNA, Transfer, AlaImmunoglobulin lambda-ChainsIn Situ Hybridization, FluorescenceRNA, Transfer, GluReceptors, Antigen, T-CellAmino Acid SequenceRNAImmunoglobulin Light ChainsReceptors, Antigen, T-Cell, gamma-deltaRNA, Transfer, TrpRNA, Transfer, ProSequence Homology, Nucleic AcidRNA, Transfer, PheDNA, NeoplasmDNA Restriction EnzymesRNA EditingRNA Polymerase IIISpecies SpecificityRestriction MappingChromosome MappingRNA, Transfer, MetGenetic VariationCell NucleusModels, GeneticImmunoglobulin mu-ChainsMyeloid-Lymphoid Leukemia ProteinDNALymphoma, T-CellIntronsRNA, MessengerBase CompositionTranscription FactorsVDJ RecombinasesGenes, FungalRNA, Transfer, ThrImmunoglobulin J-ChainsLymphoma, B-CellSequence AlignmentLymphomaRNA, Transfer, TyrEscherichia coliDNA PrimersRNA, Transfer, GlnSuppression, Genetic
GenomesMtDNAProteinsProteinRibosomalRRNAsPlant mitochondrial genomeSequencesMaternally inherited mitochondrialIntergenic regionsKnown as mitochondrialMutations in mitochondrialDiseasesMitogenomeVarious mitochondrialPutativeReactive oxygenRRNANuclearGenomicSpeciesEvolutionaryRNAsGeneticsExpressionDysfunctionDistantly relatedMolecularRecombinationIntronsMammalianCOX1Candidate GenesRibosomesChromosomeAnnotationDeletionSequenceDouble-strandedPhenotypesIntronImplicationsTranscriptionHypotheticalMetabolicDisordersDisorderDeletionsBacterialOxidative phosphorylationHomeostasisComplete
Genomes13
  • About 2000 completely sequenced mitochondrial genomes are available from the NCBI RefSeq data base together with manually curated annotations of their protein-coding genes, rRNAs, and tRNAs. (scienceopen.com)
  • We present an in silico approach for the reconstruction of complete mitochondrial genomes of non-model organisms directly from next-generation sequencing (NGS) data-mitochondrial baiting and iterative mapping (MITObim). (scienceopen.com)
  • The method is straightforward even if only (i) distantly related mitochondrial genomes or (ii) mitochondrial barcode sequences are available as starting-reference sequences or seeds, respectively. (scienceopen.com)
  • The approach overcomes the limitations of traditional strategies for obtaining mitochondrial genomes for species with little or no mitochondrial sequence information at hand and represents a fast and highly efficient in silico alternative to laborious conventional strategies relying on initial long-range PCR. (scienceopen.com)
  • 3] SHAO R,AOKI Y,MITANI H,et al.The mitochondrial genomes of soft ticks have an arrangement of genes that has remained unchanged for over 400 million years[J]. Insect Molecular Biology ,2004,13(3):219-224. (chvm.net)
  • The lack of restorer lines for the newly identified male-sterility led us to predict that it might be a complete cytoplasmic male-sterility without restorer-of-fertility genes in nuclear genomes. (springer.com)
  • In view to find putative mitochondrial genes in alternative reading frames on both coding and "presupposed" non-coding strands, numerous complete mtDNA genomes have been analyzed. (biomedcentral.com)
  • Plant mitochondrial (mt) genomes possess several complex features, including a variable size, a dynamic genome structure, and complicated patterns of gene loss and gain throughout evolutionary history. (springeropen.com)
  • 1997 ). The comparative analysis of plant mt genomes enhances our understanding of genome rearrangement and DNA transfer mechanisms, and of phylogenetic diversity. (springeropen.com)
  • With the development of next generation sequencing (NGS) technologies, such as the Roche and Illumina platforms, new strategies are being used to characterize plant mitochondrial genomes. (springeropen.com)
  • In this study, we analyzed all genes from sequenced plastid genomes to unearth any neglected cases of HGT and to obtain a measure of the overall extent of HGT to the plastid. (biomedcentral.com)
  • Though most chloroplast genes are believed to have been transferred to the nucleus during evolution, their genomes have maintained fairly conserved structures and gene contents throughout their evolutionary lineage 1 . (plos.org)
  • The cp genomes of land plants usually contain approximately 110-120 genes, which mostly participate in photosynthesis or gene expression 4 , 5 . (plos.org)
MtDNA13
  • This genetic material is known as mitochondrial DNA or mtDNA. (medlineplus.gov)
  • A rapid diagnostic 'mulitplex' one-step polymerase chain reaction protocol (RD-PCR) was developed using cytochrome oxidase subunit 1 (COX1) mitochondrial DNA (mtDNA) to discriminate between S. haematobium and S. bovis. (imperial.ac.uk)
  • A number of maternally inherited mitochondrial diseases with distinct clinical phenotypes have been associated with point mutations in mtDNA, all of which result in neurologic or neuromuscular disorders. (celljournal.org)
  • Several studies showed that mutations in the tRNA genes of mtDNA could cause mitochondrial disease due to the decreased synthesis of mitochondrial DNA coded proteins. (celljournal.org)
  • A patient having clinical, biochemical, and histochemical abnormalities compatible with mitochondrial disease but without rearrangements in her mtDNA, was subjected to study for point mutations in the mitochondrial tRNA genes. (celljournal.org)
  • A New Point Mutation In MtDNA TRNA Ser (UCN) Gene In A Cardiomyopathic Patient', Cell Journal (Yakhteh) , 1(1), pp. 19-26. (celljournal.org)
  • Background Mitochondrial DNA (mtDNA) diseases are rare disorders whose prevalence is estimated around 1 in 5000. (bmj.com)
  • Methods We analysed the whole mtDNA in a cohort of 743 patients suspected of manifesting a mitochondrial disease, after excluding deletions and common mutations. (bmj.com)
  • The human mitochondrial genome is encoded in multiple copies of ~16.6 kb circular double-stranded DNA molecules (mtDNA) present in mitochondrial nucleoids in the mitochondrial matrix. (nature.com)
  • Furthermore, instead of 5S rRNA, structurally similar mtDNA-encoded tRNAs occupy an equivalent region in the central protuberance of the mtLSU. (nature.com)
  • The 145 kb target space comprised 653 exons from nuclear genes (138 kb) and two mtDNA regions (7 kb). (massgenomics.org)
  • These subcellular organelles contain a genome that differs from the nuclear genome and is referred to as mitochondrial DNA (mtDNA). (biomedcentral.com)
  • These essential subcellular organelles contain mitochondrial DNA (mtDNA), which is an extrachromosomal genetic element. (biomedcentral.com)
Proteins9
  • The mitochondrial genes associated with cytochrome c oxidase deficiency provide instructions for making proteins that are part of a large enzyme group (complex) called cytochrome c oxidase (also known as complex IV). (medlineplus.gov)
  • Two genes encoding putative internalin proteins were chosen for further study. (omictools.com)
  • Here, a genome-wide analysis of the human mitochondrial transcriptome shows that 2'- O -methylation is limited to residues of the mitoribosomal large subunit (mtLSU) 16S mt-rRNA, introduced by MRM1, MRM2 and MRM3, with the modifications installed by the latter two proteins being interdependent. (nature.com)
  • The candidates included 103 genes that (i) encoded known complex I proteins, (ii) were implicated in the disease, or (iii) were identified by phylogenetic profiling. (massgenomics.org)
  • Immunohistochemical analyses using an anti-Gau monoclonal antibody revealed strict co-localization of Gau proteins and a mitochondrial marker. (biomedcentral.com)
  • Typical triploblastic animal mtDNAs contain genes that encode the large and small subunit ribosomal RNAs, 22 transfer RNAs (tRNAs), and 13 proteins that are all components of the oxidative phosphorylation process: ATPase subunits 6 and 8 (ATP6 and 8), cytochrome b (Cyt b), cytochrome c oxidase subunits 1-3 (Cox1-3) and NADH dehydrogenase subunits 1-6 and 4L (ND1-6 and 4L). (biomedcentral.com)
  • More than half of all human genes are alternatively spliced, so it is expected that alternative pre- mRNA splicing will be responsible for the identification of more than 90 percent of all human proteins. (genomicglossaries.com)
  • Note that by convention gene names are italicized and the proteins they make are not. (cancerquest.org)
  • Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
Protein22
  • We sequenced the complete mt genome of W. compar and conducted phylogenetic analyses using concatenated coding sequences of 12 protein-coding genes (PCGs) by maximum likelihood and Bayesian inference. (nature.com)
  • The complete mt genome is 14,373 bp in size and comprises 36 genes, including 12 protein-coding, two rRNA and 22 tRNA genes. (nature.com)
  • All protein-coding genes had a typical ATN initiation codon, and only 2 protein-coding genes had an incomplete termination codon T. Out of the 13 protein-coding genes, the 5 most frequently used codons ended in A/U, with only 1 codon ending in G/C had an relative synonymous codon usage value >1. (bvsalud.org)
  • The mitogenome of M. sexmaculata is a circular molecule of 16,663 bp with 75.00% AT content, containing 13 protein-coding genes (PCGs), 22 tRNAs, 2 rRNAs, and one non-coding control region. (scienceopen.com)
  • Brown GG, Formanova N, Jin H, Wargachuk R, Dendy C, Patil P, Laforest M, Zhang J, Cheung WY, Landry BS (2003) The radish Rfo restorer gene of Ogura cytoplasmic male sterility encodes a protein with multiple pentatricopeptide repeats. (springer.com)
  • Results of kinase inhibitors on viral RNA replication The immunofluorescence detection of viral capsid protein presented a qualitative indication of no matter whether a given kinase inhibitor affected the initiation of the infection processes leading to viral gene expression. (mirnaassay.com)
  • Reducing equivalents produced in the Krebs cycle and in the beta-oxidation spirals are passed along a series of protein complexes embedded in the inner mitochondrial membrane (the electron transport chain). (medlink.com)
  • The mitogenome is 16,401 bp in length and consisted of 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes, and a control region. (pensoft.net)
  • One basic problem is how a decrease in tRNA levels, by downregulating Pol III efficiency, influences the expression pattern of protein-coding genes. (mdpi.com)
  • While RNA makes up most of the composition of bacterial and cytosolic eukaryotic ribosomes, mammalian mitochondrial ribosomes present a more elaborate protein shell, which aids coping with the oxidative microenvironment. (nature.com)
  • The number of mitochondrial protein genes is believed to vary from 3 to 67, while the tRNA gene content varies from 0 to 27 [ 2 ]. (biomedcentral.com)
  • The S. purpurea mt genome contains 52 genes: 31 protein-coding, 18 tRNAs, and three rRNAs. (springeropen.com)
  • Because alternative RNA splicing allows different types of mRNA molecules to be created from a single gene, it generates the diversity of protein function and structure that is essential to complex organisms. (genomicglossaries.com)
  • Highly specific and effective gene silencing of any disease can be achieved by an accurate knowledge of the target mRNA sequence and rational design of its complementary antisense agents for the downregulation of its protein message. (genomicglossaries.com)
  • Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
  • Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
  • As an example TP 53 refers to the gene and p53 refers to the protein. (cancerquest.org)
  • This includes gene, protein and metabolic networks, cellular architecture and intracellular dynamics, cell communication and motility, cell division and differentiation, tissue formation and organogenesis, tissue and organ functions, changes in population characteristics as a consequence of interaction of organisms with their physical environment, with individuals of their own species, and with organisms of other species. (nih.gov)
  • This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. (nih.gov)
  • We aimed to evaluate quantitative real-time PCR (qPCR) targeting three protein-coding genes of Histoplasma capsulatum (100-kDa, H and M antigens) for detection of this fungus in formalin-fixed paraffin-embedded (FFPE) samples from patients with proven histoplasmosis. (cdc.gov)
Ribosomal1
  • The remaining genes provide instructions for making molecules called transfer RNA (tRNA) and ribosomal RNA (rRNA), which are chemical cousins of DNA. (medlineplus.gov)
RRNAs1
  • Similar to other systems, the mitochondrial ribosome is composed of a small (mtSSU) and a large (mtLSU) subunit, with their core rRNAs, 12S and 16S mitochondrial (mt-) rRNAs, respectively, surrounded by MRPs (30 for the mtSSU and 52 for the mtLSU). (nature.com)
Plant mitochondrial genome2
  • Abdelnoor RV, Yule R, Elo A, Christensen AC, Meyer-Gauen G, Mackenzie SA (2003) Substoichiometric shifting in the plant mitochondrial genome is influenced by a gene homologous to MutS. (springer.com)
  • Albert B, Godelle B, Gouyon PH (1998) Evolution of the plant mitochondrial genome: dynamics of duplication and deletion of sequences. (springer.com)
Sequences5
  • We assembled a complete mitogenome of the intertidal spider Desis jiaxiangi and performed comparative mitochondrial analyses of data set comprising of Desis jiaxiangi and other 45 previously published spider mitogenome sequences, including that of Argyroneta aquatica . (biomedcentral.com)
  • Comparative genomic analysis of T . equi revealed the phylogenetic positioning relative to seven apicomplexan parasites using deduced amino acid sequences from 150 genes placed it as a sister taxon to Theileria spp . (biomedcentral.com)
  • Summary: Comparative genomics remains a pivotal strategy to study the evolution of gene organization, and this primacy is reinforced by the growing number of full genome sequences available in public repositories. (omictools.com)
  • The mitochondrial sequences are highly informative phylogenetic markers, but have been mostly neglected due to technical difficulties. (biomedcentral.com)
  • Our search relied primarily on phylogenetic analyses, but also involved scrutiny of each potential case (including generation of new gene sequences from phylogenetically relevant taxa) to rule out artifacts and various types of homoplasy. (biomedcentral.com)
Maternally inherited mitochondrial1
  • Initially these disorders were named according to symptoms (later the cause was found to be mitochondrial dysfunction and more specifically maternally inherited mitochondrial DNA variations). (medlink.com)
Intergenic regions2
  • The arrangement between genes is relatively compact, with a total of 10 gene intergenic regions and 12 gene overlap regions. (bvsalud.org)
  • Moreover, the transferred gene has physically replaced the native rpl36 gene, yet flanking genes and intergenic regions show no sign of HGT. (biomedcentral.com)
Known as mitochondrial1
  • Expression of this genome entails several, highly regulated processes, with newly synthesised transcripts being cleaved, chemically modified, polyadenylated and further matured in neighbouring structures known as mitochondrial RNA granules (MRGs). (nature.com)
Mutations in mitochondrial1
  • After reminding the reader of the basic concepts of mitochondrial genetics, she offers examples of disorders due to mutations in mitochondrial DNA and mutations in nuclear DNA. (medlink.com)
Diseases4
  • In this review of what is probably the most heterogeneous group of human diseases (the mitochondrial diseases including encephalomyopathies), the author tries to offer the clinician a rational diagnostic framework. (medlink.com)
  • Studies of the gau ORF will shed light on the origin of novel genes and their functions in organelles and could also have medical implications for human diseases that are caused by mitochondrial dysfunction. (biomedcentral.com)
  • presents an opportunity to manipulate gene expression within the cells to treat various diseases, and acts as a powerful tool for studying gene function utilizing antisense agents to manage the diseases by regulating the expression of the specific factor that actually causes the particular disease. (genomicglossaries.com)
  • This group includes lysosomal storage disorders, various mitochondrial diseases, other neurometabolic disorders, and several other miscellaneous disorders. (medscape.com)
Mitogenome2
  • All the 22 typical animal tRNA genes are found in M. sexmaculata mitogenome, and most of the tRNAs could be folded into the classic cloverleaf secondary structure. (scienceopen.com)
  • Understanding the forces that drive the evolution of the mitochondrial genome (mitogenome) provides crucial information, as this evolution is affected by a range of factors that in turn influence the information content of the genome. (biomedcentral.com)
Various mitochondrial1
  • 16S and 12S), which are essential for various mitochondrial functions [ 9 ]. (biomedcentral.com)
Putative2
  • T . equi has lost the putative genes for host cell transformation, or the genes were acquired by T . parva and T . annulata after divergence from T . equi . (biomedcentral.com)
  • This putative gene has been named gau for g ene a ntisense u biquitous in mtDNAs. (biomedcentral.com)
Reactive oxygen2
  • As a result, reactive oxygen species easily damage mitochondrial DNA, causing cells to malfunction and ultimately to die. (medlineplus.gov)
  • Cell damage was assessed using MTT assays, and the lactate dehydrogenase (LDH) release rate and flow cytometry were used to detect the accumulation of reactive oxygen species (ROS) and mitochondrial membrane potential respectively. (sdbonline.org)
RRNA1
  • Depending on the organism and availability, mt-tRNA Val or mt-tRNA Phe are incorporated, most likely due to their genomic proximity to mt-rRNA genes and consequent near stoichiometric presence of their transcripts 4 , 8 . (nature.com)
Nuclear1
  • In areas where human and cattle schistosomiasis overlap and are transmitted in close proximity, this mitochondrial assay will be a valuable identification tool for epidemiological studies, especially when used in conjunction with other nuclear diagnostic markers. (imperial.ac.uk)
Genomic2
  • Therefore comparative genomic analysis of T . equi was undertaken to: 1) identify genes contributing to immune evasion and persistence in equid hosts, 2) identify genes involved in PBMC infection biology and 3) define the phylogenetic position of T . equi relative to sequenced apicomplexan parasites. (biomedcentral.com)
  • The mitochondrial (mt) genome has drawn increased attention during the genomic and now post-genomic eras owing to its maternal pattern of inheritance and unique evolutionary features, and is often used for the phylogenetic study of plants (Gualberto et al. (springeropen.com)
Species5
  • Surprisingly, Pirata subpiraticus , Hypochilus thorelli , and Argyroneta aquatica each had a higher Ka/Ks value in the 13 PCGs dataset among 46 taxa with complete mitogenomes, and these three species also showed positive selection signal in the nd6 gene. (biomedcentral.com)
  • Here we generated and characterized the mitochondrial (mt) genome of 14 specimens of the S. talpa species-group and evaluated its species limits with the cox1 barcoding locus. (unam.mx)
  • Comparative analysis of the mitogenomes in the FOSC revealed ongoing mitochondrial recombination within, but not between phylogenetic species. (biomedcentral.com)
  • The genome of F. oxysporum resembles the genome of heterothallic species, both mating types can be found in populations, the mating type genes are expressed and introns are correctly spliced from the transcript [ 7 ]. (biomedcentral.com)
  • Most, if not all of these transfers seem to be the result of a gene being transferred from the mitochondrial genome of one species to that of another. (biomedcentral.com)
Evolutionary2
  • Arrieta-Montiel M, Lyznik A, Woloszynska M, Janska H, Tohme J, Mackenzie S (2001) Tracing evolutionary and developmental implications of mitochondrial stoichiometric shifting in the common bean. (springer.com)
  • Information regarding gene content, polycistronic transcription units, sequence insertion or deletion, transition or transversion, and nucleotide repeats may help resolve evolutionary relationships in the kingdom Plantae (Viridiplantae) 6 , 7 , 8 . (plos.org)
RNAs2
Genetics1
  • De novo sequencing,assembly and analysis of salivary gland transcriptome of Haemaphysalis flava and identification of sialoprotein genes[J]. Infection,Genetics and Evolution ,2015,32(1):135-142. (chvm.net)
Expression8
  • Genome-wide transcript analysis showed that B. anthracis undergoes considerable changes in gene expression during growth in iron-depleted media, including the regulation of known and candidate virulence factors. (omictools.com)
  • The Rac1 inhibitor NSC23766 did not block viral gene expression at any time level. (mirnaassay.com)
  • The PI3K inhibitors LY294002 and wortmannin had been effective in diminishing viral gene expression only when extra at 0 or two hpi, with the time range of effectiveness just like that with the ERK inhibitor. (mirnaassay.com)
  • MK 2206, another Akt inhibitor, did not have an impact on viral gene expression, suggesting that block ade of Akt had minor impact on HAstV1 infection. (mirnaassay.com)
  • Not remarkably, drugs that didn't inhibit viral gene expression-inhibitors of MAPK p38s, JNK, Akt, and PKA -had no measurable result within the extent of viral RNA replica tion. (mirnaassay.com)
  • this involves the possible import of the cytosolic AGR tRNA into the mitochondria and/or the expression of mt antisense tRNAs with anticodons recognizing AGR codons according to an alternative genetic code that is induced by the presence of suppressor tRNAs. (biomedcentral.com)
  • A biological process that is crucial for gene expression in most animal life, including humans. (genomicglossaries.com)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Dysfunction1
  • GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)
Distantly related1
  • Interestingly, this rpl36 gene is a distantly related paralog of the rpl36 type found in other plastids and most eubacteria. (biomedcentral.com)
Molecular2
  • In this study, the mitochondrial genome of Eulaelaps silvestris, which parasitizes Apodemus chevrieri, was sequenced and assembled to fill the gap in understanding the molecular evolution of the genus Eulaelaps. (bvsalud.org)
  • Meanwhile, the PCR amplification profile of molecular markers for the classification of radish mitochondrial genome types revealed that the new MS radish contained a novel mitotype. (springer.com)
Recombination2
  • Bellaoui M, Martin-Canadell A, Pelletier G, Budar F (1998) Low-copy-number molecules are produced by recombination, actively maintained and can be amplified in the mitochondrial genome of Brassicaceae: relationship to reversion of the male sterile phenotype in some cybrids. (springer.com)
  • This suggests that gene replacement somehow occurred by recombination at the very ends of rpl36 , without the level and length of similarity normally expected to support recombination. (biomedcentral.com)
Introns1
Mammalian1
  • The mammalian mitochondrial ribosome is endowed with a number of specific features. (nature.com)
COX14
  • En este trabajo se caracteriza el genoma mitocondrial de 14 ejemplares del grupo de especies S. talpa y se evalúan sus límites de especie utilizando el marcador mitocondrial cox1 . (unam.mx)
  • Despite a disparity in gene content, all mtDNAs encode at least two components of the mitochondrial electron transport chain, including cytochrome c oxidase I (Cox1). (biomedcentral.com)
  • A positionally conserved ORF has been found on the complementary strand of the cox1 genes of both eukaryotic mitochondria (protist, plant, fungal and animal) and alpha-proteobacteria. (biomedcentral.com)
  • This search has led to the observation of an unknown, positionally conserved open reading frame (ORF) on the complementary strand of eukaryotic cox1 genes. (biomedcentral.com)
Candidate Genes2
  • Instead of employing a whole-genome or exome strategy, they performed deep resequencing of carefully-chosen candidate genes in pools of ~20 samples. (massgenomics.org)
  • Next-generation sequencing of the whole exome is useful for testing for multiple candidate genes simultaneously or for discovering new, rare disorders. (medlink.com)
Ribosomes1
  • Almost half of these MRPs are evolutionarily exclusive to mitochondrial ribosomes, some of which were repurposed and accreted during reductive genome evolution 4 , 5 . (nature.com)
Chromosome1
  • This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. (cancerindex.org)
Annotation1
Deletion1
  • Deletion of either gene (GBAA0552 or GBAA1340) resulted in attenuation in a murine model of infection. (omictools.com)
Sequence2
  • LI Z B.Study on ITS sequence and the entire mitochondrial genome sequence of Haemaphysalis flava and Haemaphysalis longicornis [D].Changsha:Hunan Agricultural University,2018. (chvm.net)
  • This hypothesis could be tested by purifying the gau gene product and determining its sequence. (biomedcentral.com)
Double-stranded1
  • The E. silvestris mitochondrial genome is a double-stranded DNA molecule with a length of 14 882 bp, with a distinct AT preference for base composition and a notably higher AT content than GC content. (bvsalud.org)
Phenotypes1
  • MTND5 and MTND6 genes were identified as 'hotspots' of mutations, with Leigh syndrome accounting for the large majority of associated phenotypes. (bmj.com)
Intron1
  • The evidence found thus far for HGT to the plastid proceeded from studies of a particular gene or intron. (biomedcentral.com)
Implications1
  • Recognition of a single-gene disorder as causal for a patient's 'multiple sclerosis-like' phenotype is critically important for accurate direction of patient management, and evokes broader genetic counselling implications for affected families. (medscape.com)
Transcription1
  • These events are dependent on the proper levels of transcription and translation of certain genes. (cancerquest.org)
Hypothetical1
  • Unlike the gene arrangement order of the arthropod hypothetical ancestor, the E. silvestris mitochondrial genome underwent fewer rearrangements, mainly near tRNA genes and control regions. (bvsalud.org)
Metabolic1
  • The positive selection signals in the nd4 and nd6 genes might enable a better understanding of the spider metabolic adaptations in relation to different environments. (biomedcentral.com)
Disorders5
  • Mitochondrial disorders describe a broad range of disorders that have multiple genetic causes and variable symptoms and signs. (medlink.com)
  • The named and biochemical disorders may or may not have been caused by their initially described genetic variation, but potentially by other gene variations. (medlink.com)
  • In general, mitochondrial disorders are disorders of energy production. (medlink.com)
  • Several single gene disorders share clinical and radiologic characteristics with multiple sclerosis and have the potential to be overlooked in the differential diagnostic evaluation of both adult and paediatric patients with multiple sclerosis. (medscape.com)
  • Here we review single gene disorders that have the potential to mimic multiple sclerosis, provide an overview of clinical and investigational characteristics of each disorder, and present guidelines for when clinicians should suspect an underlying heritable disorder that requires diagnostic confirmation in a patient with a definite or probable diagnosis of multiple sclerosis. (medscape.com)
Disorder2
  • Categorizing and describing a mitochondrial disorder is complicated in part because there are 3 ways to do so. (medlink.com)
  • This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. (cancerindex.org)
Deletions1
  • As people age, mitochondrial DNA accumulates damaging mutations, including deletions and other changes. (medlineplus.gov)
Bacterial3
  • A single new case, a bacterial rpl36 gene transferred into the ancestor of the cryptophyte and haptophyte plastids, appears to be a true HGT event. (biomedcentral.com)
  • The plastid acquisition of a bacterial rpl36 gene via HGT provides the first strong evidence for a sister-group relationship between haptophyte and cryptophyte plastids to the exclusion of heterokont and alveolate plastids. (biomedcentral.com)
  • Moreover, the bacterial gene has replaced the native plastid rpl36 gene by an uncertain mechanism that appears inconsistent with existing models for the recombinational basis of gene conversion. (biomedcentral.com)
Oxidative phosphorylation1
Homeostasis1
  • This work identifies a key checkpoint during mtLSU assembly, essential to maintain mitochondrial homeostasis. (nature.com)
Complete3
  • This study aimed to determine the complete mitochondrial (mt) genome of W. compar and reconstruct its phylogenetic relationship with other nematodes. (nature.com)
  • We sequenced the complete mitochondrial genome of Menochilus sexmaculata (Fabricius, 1781) and compared it with that of other insects. (scienceopen.com)
  • In the present study, the complete mitochondrial genome of P. flavomaculatus was sequenced and analyzed. (pensoft.net)