• mutations
  • Mutations in HIV epitopes recognized by cytotoxic T lymphocytes (CTL) could be a major contributing factor because they result in T cell mediated immune responses with limited effectiveness. (pitt.edu)
  • Protocols
  • Detailed protocols are now available that can be used to label lymphocytes (and other cell types) with a high degree of reliability and precision. (wikipedia.org)
  • molecule
  • When synthesized as a soluble molecule fused to the Fc of IgG, it is used as a biologic therapy in rhematic diseases, because it blocks a costimulatory molecule on B lymphocytes. (drugs.com)
  • cell
  • These observations permit the development of new T-cell vaccine strategies capable of inducing an MUC1-specific cytotoxic T cell response in cancer patients. (hindawi.com)
  • Mechanistically, T cell receptor engagement facilitated STAT4-dependent Munc13-4 expression in naive CD8 + T lymphocytes. (rupress.org)
  • novel
  • The intronic sequence acted as an overall enhancer of Munc13-4 expression in cytotoxic lymphocytes in addition to representing an alternative promoter encoding a novel Munc13-4 isoform. (rupress.org)
  • The action of leucyl-leucine methyl ester on cytotoxic lymphocytes requires uptake by a novel dipeptide-specific facilitated transport system and dipeptidyl peptidase I-mediated conversion to membranolytic products. (rupress.org)
  • found
  • In this regard, Leu-Leu-OMe was found to be incorporated by lymphocytes and monocytes via a saturable facilitated transport mechanism with characteristics distinct from previously characterized mammalian dipeptide transport processes. (rupress.org)