• Systemic sclerosis, also called scleroderma, is an immune-mediated rheumatic disease that is characterised by fibrosis of the skin and internal organs and vasculopathy. (nih.gov)
  • Systemic sclerosis is a form of scleroderma that can not only affect the skin and underlying tissue, but also the internal organs. (23andme.com)
  • Systemic sclerosis is a generalized form of scleroderma which affects multiple organs at a time and if not treated timely can cause various complications. (selfgrowth.com)
  • Systemic sclerosis is known as scleroderma or progressive systemic sclerosis, or CREST syndrome. (selfgrowth.com)
  • Updates in Systemic Sclerosis Treatment and Applicability to Pediatric Scleroderma. (scleroderma.org)
  • Systemic sclerosis (SSc) differs from localized scleroderma in prognosis as well as clinical expression. (skintherapyletter.com)
  • Systemic scleroderma is a rare disease in which visceral manifestations occur, particularly peripheral vascular, digestive, cardiopulmonary and renal. (scirp.org)
  • It is characterized by microcirculation abnormalities and scleroderma and/or visceral sclerosis. (scirp.org)
  • However, recent results published by the Canadian Scleroderma Research Group (CSRG) point out the importance of assessing oral health in patients with systemic sclerosis (SSc). (the-rheumatologist.org)
  • In systemic sclerosis sine scleroderma, patients have systemic sclerosis-related antibodies and visceral manifestations of the disease but no skin tightening. (msdmanuals.com)
  • Systemic sclerosis is also referred as scleroderma.Systemic Sclerosis is an chronic autoimmune disorder. (longdom.org)
  • Have you been diagnosed with either sine scleroderma (ssSSc) or limited cutaneous systemic sclerosis (lcSSc)? (beaconresearchstudy.com)
  • 2 Estimates show that more than half of patients with systemic sclerosis die as a direct result of their disease, most frequently caused by pulmonary fibrosis due to ILD, followed by pulmonary hypertension, and scleroderma renal crisis (SRC). (rheumatologyadvisor.com)
  • Sclerodactyly is often preceded by months or even years by Raynaud's phenomenon when it is part of systemic scleroderma. (wikipedia.org)
  • It is generally associated with systemic scleroderma and mixed connective tissue disease, and auto-immune disorders. (wikipedia.org)
  • Treatment of sclerodactyly is by physical therapy, phototherapy, surgery, topical corticosteroids or vitamin D analogues, and systemic immunosuppressive drugs when the condition is part of systemic scleroderma[citation needed]. (wikipedia.org)
  • Widespread scleroderma can occur with other autoimmune diseases, including systemic lupus erythematosus and polymyositis . (medlineplus.gov)
  • Systemic scleroderma, or sclerosis -- May affect large areas of skin and organs such as the heart, lungs, or kidneys. (medlineplus.gov)
  • Scleroderma 70 (Scl-70) is commonly used in the clinic for aiding systemic sclerosis (SSc) diagnosis due to its recognition as autoantibodies in the serum of SSc patients . (bvsalud.org)
  • Patients with both systemic sclerosis (SSc) and systemic lupus erythematosus (SLE) are more likely to be female, Black, and diagnosed with limited cutaneous SSc. (medscape.com)
  • Application to patients with multiple sclerosis and systemic lupus erythematosus. (bvsalud.org)
  • Systemic lupus erythematosus (SLE) is an autoimmune disease with many potential manifestations and complex classification criteria. (cdc.gov)
  • Revise to systemic lupus erythematosus (M32. (cdc.gov)
  • In one survey one quarter of patients with Raynaud phenomenon not fitting the 1980 American College of Rheumatology classification criteria were reclassified as having systemic sclerosis using the 2013 American College of Rheumatology/European League Against Rheumatism (EULAR) criteria. (medscape.com)
  • The new American College of Rheumatology/European League Against Rheumatism classification criteria will enable earlier diagnosis and, therefore, the use of newer treatment modalities for systemic sclerosis (SSc). (medscape.com)
  • Rheumatology: Current Research, Atherosclerosis: Open Access, Acta Rheumatologica, Multiple Sclerosis, Annals of the Rheumatic Diseases, International Journal of Rheumatic Diseases, Rheumatic Disease Clinics of North America, Clinics in Rheumatic Diseases, Clinical and Experimental Rheumatology. (longdom.org)
  • Drugs (eg, bleomycin, carbidopa, pentazocine, cocaine, penicillamine, vitamin K): A limited form of cutaneous systemic sclerosis has been described with paclitaxel in with the setting of breast cancer. (medscape.com)
  • The purpose of this study is to evaluate the effectiveness and safety of KD025 in patients with diffuse cutaneous systemic sclerosis. (mayo.edu)
  • CREST syndrome , also known as limited cutaneous systemic sclerosis , is an autoimmune condition, and its name is an acronym that stands for calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasias. (osmosis.org)
  • CREST syndrome , also known as the limited cutaneous form of systemic sclerosis is a multisystem connective tissue disorder. (osmosis.org)
  • We are currently enrolling individuals between 18 and 75 years of age who have been diagnosed with diffuse cutaneous systemic sclerosis (dcSSc). (beaconresearchstudy.com)
  • touchIMMUNOLOGY caught up with Dinesh Khanna (University of Michigan, Ann Arbor, MI, USA) to discuss the results of the NOVESA Phase 2a study of ziritaxestat in cutaneous systemic sclerosis (NCT03798366). (touchimmunology.com)
  • His abstract entitled ' A Phase 2a Randomized, Double-blind, Placebo-controlled Study of Ziritaxestat in Early Diffuse Cutaneous Systemic Sclerosis (NOVESA) ' was presented at the virtual ACR Convergence 2020, 5-9 November 2020. (touchimmunology.com)
  • Systemic sclerosis is categorized as either having a limited cutaneous or diffuse cutaneous presentation, defined in this SSc framework for therapy as "descriptors of skin thickness distribution only and provide crude sub-typing of an extremely complex disease. (rheumatologyadvisor.com)
  • Sclerodactyly is one component of the limited cutaneous form of systemic sclerosis (lcSSc), also known as CREST syndrome (CREST is an acronym that stands for calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia. (wikipedia.org)
  • This form of the disease is classified as diffuse cutaneous systemic sclerosis (dcSSc). (medlineplus.gov)
  • Cite this: Lupus May Overlap in Many Patients With Systemic Sclerosis - Medscape - Sep 15, 2023. (medscape.com)
  • In Systemic sclerosis patients suffer with the changes in texture and appearance of the skin due to excessive collagen production, which is a component of connective tissue. (selfgrowth.com)
  • A very important recent study advocates a baseline chest CT for all juvenile onset systemic sclerosis patients, which parallels adult organ screening recommendations. (scleroderma.org)
  • This investigation involved analyses of the potential for pulmonary hypertension (PH) and interstitial lung disease (ILD) to have an impact on patients living with systemic sclerosis. (ajmc.com)
  • For patients already living with systemic sclerosis, also having both pulmonary hypertension (SSc-PH) and interstitial lung disease (SSc-ILD) exacerbates their risk of all-cause mortality, and this risk only goes up with increasing severity of both comorbidities, reports a recent published study in Pulmonary Circulation . (ajmc.com)
  • Patients have acral sclerosis associated with vascular instability in addition to internal organ involvement. (skintherapyletter.com)
  • Objectives To identify the predictive clinical characteristics and establish a prediction model for the progression of mild interstitial lung disease (ILD) in patients with systemic sclerosis (SSc). (bmj.com)
  • To evaluate the clinico-serological profile and to assess diagnostic parameters of myopathy in patients with systemic sclerosis (SSc)-associated myopathy. (clinexprheumatol.org)
  • No one-size-fits-all approach exists for the care and treatment of patients with systemic sclerosis (SSc) and SSc with pulmonary involvement. (the-rheumatologist.org)
  • To measure the prevalence of different types of pulmonary hypertension (PH) and to identify patients with systemic sclerosis (SSc) at highest risk in a multicenter European sample, with a metaanalysis of relevant studies. (jrheum.org)
  • In generalized systemic sclerosis with diffuse skin involvement, patients have Raynaud syndrome and gastrointestinal (GI) complications. (msdmanuals.com)
  • Objectives: To standardize the cold stimulus-fingertip lacticemy test (CS-FTL) in normal individuals and to establish reference levels for discrimination of normal individuals and patients with systemic sclerosis (SSc).Methods: FTL was determined before (pre-CS) and 3, 8, and 13 min after cold stimulus (post-CS) in 94 normal controls according to gender and age. (unifesp.br)
  • The Functional Balance Status in Systemic Sclerosis Patients Using the Sensory Organization Test. (cu.edu.eg)
  • Dabbous, I. B. H., and A. O.., 'The Functional Balance Status in Systemic Sclerosis Patients Using the Sensory Organization Test. (cu.edu.eg)
  • Fatigue is a frequently reported disabling symptom for patients with systemic sclerosis (SSc). (acrabstracts.org)
  • Patients must have been diagnosed with ILD associated with systemic sclerosis during the study period to be considered candidates for the study. (rarediseaseadvisor.com)
  • Compared with patients with other rheumatic and pulmonary diseases, patients with systemic sclerosis often require significantly more health care resources, including physician and staff time, to monitor and manage multiple organ system disorders. (rheumatologyadvisor.com)
  • Mortality among patients with systemic sclerosis is increased by approximately 3 to 5 times. (rheumatologyadvisor.com)
  • Higher disability scores are a potential predictor of fracture risk among patients with systemic sclerosis, according to data published in Arthritis Care & Research. (nationalspinenetwork.org)
  • Body wide (systemic) treatments are most often used for this group of patients. (medlineplus.gov)
  • No therapies have been shown in blinded placebo-controlled trails to improve the overall course of systemic sclerosis. (skintherapyletter.com)
  • Nailfold irregularities reflecting the vasculature struggling against the pathologic progression of the disease appear early in the course of systemic sclerosis and are considered predictive of the disease. (rheumatologyadvisor.com)
  • There is broad consensus that air pollution contributes, at least in part, to the pathophysiology of systemic sclerosis, a disease characterized by autoimmune features and endothelial/fibroblast dysfunction. (rarediseaseadvisor.com)
  • Improved understanding of systemic sclerosis has allowed better management of the disease, including improved classification and more systematic assessment and follow-up. (nih.gov)
  • Systemic sclerosis varies in severity and progression, ranging from generalized skin thickening with rapidly progressive and often fatal visceral involvement (diffuse systemic sclerosis) to isolated skin involvement (often just the fingers and face) and slow progression (often several decades) before visceral disease develops. (msdmanuals.com)
  • Also see Juvenile Systemic Sclerosis for a pediatric focus. (medscape.com)
  • Ambartsumyan L, Zheng HB, Iyer RS, Soares J, Henstorf G, Stevens AM. Relationship between esophageal abnormalities on fluoroscopic esophagram and pulmonary function testing in juvenile systemic sclerosis . (scleroderma.org)
  • People with certain types of arthritis, called inflammatory or systemic arthritis or autoimmune rheumatic disease, have a higher risk of getting flu-related complications, such as pneumonia. (cdc.gov)
  • Systemic sclerosis (SSc) is a heterogeneous autoimmune disease, characterised by vascular damage, inflammation and fibrosis of skin and various visceral organs. (bmj.com)
  • Systemic sclerosis is a rare chronic disease of unknown cause characterized by diffuse fibrosis and vascular abnormalities in the skin, joints, and internal organs (especially the esophagus, lower gastrointestinal tract, lungs, heart, and kidneys). (msdmanuals.com)
  • To investigate whether six microsatellite markers known to map closely to genes involved in fibrosis are associated with systemic sclerosis (SSc). (bath.ac.uk)
  • The recently described gadolinium-induced nephrogenic systemic fibrosis may mimic SSc as may other conditions which require a different treatment strategy. (medscape.com)
  • Systemic sclerosis (SSc) is a rare, complex, multiorgan autoimmune disease characterized by fibrosis of the skin and internal organs. (rheumatologyadvisor.com)
  • Clinical characteristics and outcomes in pulmonary manifestations of systemic sclerosis: Contribution from pulmonary hypertension and interstitial lung disease severity. (ajmc.com)
  • This increase in fatigue correlated with the extent of skin sclerosis, pulmonary hypertension and patient-reported digital ulcer and gastrointestinal involvement severity. (acrabstracts.org)
  • However, the burden of non-lethal complications associated with systemic sclerosis is substantial and is likely to become more of a challenge. (nih.gov)
  • When did you experience the onset of your first systemic sclerosis manifestation (other than Raynaud's phenomenon)? (beaconresearchstudy.com)
  • Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/433132/all/Ketanserin_for_Raynaud's_phenomenon_in_progressive_systemic_sclerosis. (unboundmedicine.com)
  • ACE-1334 is under development for the treatment of pulmonary disease with fibrotic component and systemic sclerosis and its associated interstitial lung disease. (globaldata.com)
  • Here, we review the clinical features of systemic sclerosis and describe the best practice approaches for its management. (nih.gov)
  • Systemic sclerosis is a multisystem disorder with vascular instability as a clinical hallmark. (skintherapyletter.com)
  • Finally, limited support is provided for an association between crystalline silica exposure and rheumatoid arthritis, systemic sclerosis, and systemic lupus erythematosis. (cdc.gov)
  • The activation of the immune system is of paramount importance in the pathogenesis of systemic sclerosis. (medscape.com)
  • Some data suggest that apoptosis and the generation of free radicals may be involved in the pathogenesis of systemic sclerosis. (medscape.com)
  • Systemic sclerosis is an autoimmunologic disease, but the pathogenesis is only partially understood. (medscape.com)
  • Although systemic sclerosis is uncommon, it has a high morbidity and mortality. (nih.gov)
  • Systemic sclerosis (SSc) is characterized by chronic inflammation and fibrosis. (unina.it)
  • Our goal for this specific study is simple-we want to improve the lives of people living with systemic sclerosis by developing an effective drug treatment. (23andme.com)
  • The ultimate goal of this research is to help develop an effective treatment for systemic sclerosis that can improve the lives of those living with the condition. (23andme.com)
  • What is the treatment for Systemic Sclerosis? (selfgrowth.com)
  • Ayurvedic Treatment of Systemic Sclerosis involves the balancing of vitiated doshas, which are responsible for all body ailments. (selfgrowth.com)
  • What are the unmet needs in the treatment of systemic sclerosis (SSc)? (touchimmunology.com)
  • Localized treatment won't halt systemic disease, but can restore function and cosmetic aspects of the affected digits. (wikipedia.org)
  • Systemic Sclerosis (SS) is characterized as an autoimmune disorder, in which the immune system mistakenly attacks their own body system. (selfgrowth.com)
  • When Sclerosis affects the Kidneys, people may increase blood pressure. (selfgrowth.com)
  • Systemic Sclerosis not only occurs in the skin but also in various organs like kidneys, liver, etc. leading to deregulation of body systems. (longdom.org)
  • One theory states that antigens from the human leukocyte antigen (HLA) histocompatability complex, including HLA-B8, HLA-DR5, HLA-DR3, HLA-DR52, and HLA-DQB2, are involved in systemic sclerosis. (medscape.com)
  • Conducting research using this data may help find better treatments for systemic sclerosis or similar conditions. (23andme.com)
  • Progressive systemic sclerosis predominantly affects women (3 to 8 women vs. 1 man). (scirp.org)
  • The objective of this presentation is to guide any practitioner towards diagnosis of renal crisis in the face of sudden multiple organ failure resulting from progressive systemic sclerosis. (scirp.org)
  • Progressive systemic sclerosis complicated with immune thrombocytopenia during D-penicillamine therapy. (lu.se)