AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
VasoconstrictionHemodynamicsVasoconstrictor AgentsVascular ResistanceRegional Blood FlowPulmonary CirculationAnoxiaArteriolesPulmonary ArteryBlood PressureVasodilationEndothelin-1NorepinephrineShiveringForearmSkin TemperatureRenal CirculationPhenylephrineMesenteric ArteriesVasomotor SystemBody Temperature RegulationMuscle, Smooth, VascularReceptors, EndothelinAdrenergic alpha-1 Receptor AgonistsAdrenergic alpha-AgonistsVasodilator AgentsSympathetic Nervous SystemNitric OxideEndothelinsPerfusionReceptor, Endothelin AAdrenergic alpha-AntagonistsDogsArteriesAngiotensin IIDose-Response Relationship, DrugReceptor, Endothelin B15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidNG-Nitroarginine Methyl EsterReceptors, Adrenergic, alphaRats, Sprague-DawleyHeadache Disorders, PrimaryMethoxamineCoronary VesselsTyramineSplanchnic CirculationEndothelium, VascularViper VenomsHeart RatePrazosinMicrocirculationNitric Oxide SynthaseMeclofenamic AcidPeptides, CyclicPotassium ChlorideEnzyme InhibitorsAcetylcholineKidneyPhentolamineReceptors, Adrenergic, alpha-1Hypertension, PulmonaryOxygenRats, WistarLaser-Doppler Flowmetry
Vascular resistanceInhibition of hypoxic pulmonary vasocoRenal vasoconstrictionVasodilationIncrease in systemicHypertensionInflammationArterial pressureCapillaryCatecholamineHypotensionDecongestantsHaemodynamicsInflammatory responseAngiotensinToxicityProfoundStimulantsReductionPerfusionAcuteMechanismsCerebralHypoxiaVasodilatationEndothelinCardiac outputVasoconstrictorsEndothelialSevereCirculationRegulation of bloodSymptomsThrombosisOxygenFluid lossPatientsArteriesIncreasesAmbientInvestigateDecreaseTriggerSecondaryPromotesBlood pressureFactorsMechanismReducesHormoneEffectsTopical
Vascular resistance10
Inhibition of hypoxic pulmonary vasoco2
Renal vasoconstriction2
  • Background The pathogenetic mechanism of hepatorenal syndrome (HRS) is paradoxical renal vasoconstriction consequent upon systemic and splanchnic arterial vasodilatation. (bmj.com)
  • Uric acid may mediate aspects of the relationship between hypertension and kidney disease via renal vasoconstriction and systemic hypertension. (nih.gov)
Vasodilation3
Increase in systemic1
Hypertension3
  • Alpha1- and alpha2-adrenergic blocking agent that blocks circulating epinephrine and norepinephrine action, reducing hypertension and coronary vasoconstriction due to catecholamine effects on alpha-receptors. (medscape.com)
  • ACE inhibitors are also frequently used (typically in combination with other arterial dilators) to manage systemic hypertension in dogs and cats. (tonictreat.com)
  • This vasoconstriction creates an acute increase in hydrostatic pressure and severe hypertension in normovolemic patients. (vetbloom.com)
Inflammation4
  • Emerging data support systemic microvascular inflammation as an enduring aggravation factor ( Paulus and Tschope, 2013 ). (frontiersin.org)
  • Short-term exposure to ambient particulate matter is proposed to alter either systemic inflammation or coagulability or both. (cdc.gov)
  • Abstract: Dead and dying cells release purine nucleotides, which then engage nucleotide receptors on the surfaces of leukocytes and endothelial cells to trigger inflammation, coagulation, and vasoconstriction. (nih.gov)
  • Unfortunately, COPD and HFrEF frequently coexist not only because of their high individual prevalence but also due to common risk factors, including cigarette smoking, advanced age, oxidative stress and systemic inflammation [ 1 ]. (ersjournals.com)
Arterial pressure1
Capillary4
  • Systemic capillary leak syndrome (SCLS) is a rare and potentially fatal vascular disorder characterized by reversible bouts of hypotension and edema. (nih.gov)
  • Infusion of dobutamine should be started at a low rate (0.5 to 1.0 µg/kg/min) and titrated at intervals of a few minutes, guided by the patient's response, including systemic blood pressure, urine flow, frequency of ectopic activity, heart rate, and (whenever possible) measurements of cardiac output, central venous pressure, and/or pulmonary capillary wedge pressure. (pfizermedicalinformation.com)
  • Hypoxia worsens leading to a sympathetic capillary vasoconstriction. (vetbloom.com)
  • The increase in pulmonary intravascular volume coupled with the capillary vasoconstriction leads to an acute increase in hydrostatic pressure. (vetbloom.com)
Catecholamine1
  • The inciting event creates a massive catecholamine release, leading to systemic vasoconstriction. (vetbloom.com)
Hypotension2
Decongestants2
Haemodynamics4
  • Objective To assess the efficacy of MARS in improving systemic and renal haemodynamics in patients with cirrhosis with refractory ascites and type 1 HRS not responding to vasoconstrictor therapy. (bmj.com)
  • Results There were no significant changes in systemic haemodynamics and GFR following MARS treatments, despite a significant reduction in NO concentrations (111.5±18.8 μmol/l pre-MARS, to 65.1±8.2 μmol/l post-MARS, p=0.05). (bmj.com)
  • Conclusions In patients with cirrhosis, refractory ascites and type 1 HRS not responding to vasoconstrictor treatment, MARS is ineffective in improving systemic haemodynamics and renal function despite reduction in NO levels, suggesting that vasodilatation in advanced cirrhosis is not due to excess systemic vasodilators alone. (bmj.com)
  • In order to address these issues, we simultaneously assessed COx, systemic haemodynamics and gas exchange during progressive exercise in COPD patients presenting or not with HFrEF as a comorbidity. (ersjournals.com)
Inflammatory response4
  • Multiple organ dysfunction syndrome (MODS) is a systemic, dysfunctional inflammatory response that requires long intensive care unit (ICU) stay. (scirp.org)
  • Multiple organ dysfunction syndrome (MODS) is a systemic, dysfunctional inflammatory response that requires long intensive care unit (ICU) stay and has high mortality rate of 27% - 100% depending on the number of organs involved [1-3]. (scirp.org)
  • Patients with a heterogeneous trauma load and clinical picture are resuscitated into a similar state of systemic hyperinflammation, termed systemic inflammatory response syndrome (SIRS). (scirp.org)
  • It is a sequela to conditions that cause a profound systemic inflammatory response and results in pulmonary epithelial and endothelial damage and a subsequent increase in vascular permeability. (vetbloom.com)
Angiotensin1
Toxicity3
  • For this reason, the skin is often exposed to potentially hazardous agents, including chemicals, which may contribute to the onset of a spectrum of adverse health effects ranging from localized damage (e.g., irritant contact dermatitis and corrosion) to induction of immune-mediated responses (e.g., allergic contact dermatitis and pulmonary responses), or systemic toxicity (e.g., neurotoxicity and hepatoxicity). (cdc.gov)
  • To evaluate the knowledge of dentists about signs and symptoms that may be indicative of systemic toxicity associated with the use of local anesthetic solutions. (bvsalud.org)
  • Hence, among other factors, it is important for local anesthetics to show rapid onset of action, provide adequate duration of anesthesia, and be composed by substances (i.e. local anesthetics, vasoconstrictors) with minimal or no systemic toxicity 1-2 . (bvsalud.org)
Profound1
  • Patients with a primary pulmonary disease, such as pneumonia, or patients with a profound systemic disease, such as sepsis, are at increase risk for developing ARDS or ALI. (vetbloom.com)
Stimulants1
Reduction1
  • Changes in PaCO 2 alters CA: both hypo and hypercapnia can induce cerebral ischemia from the reduction of perfusion through vasoconstriction or vasodilatation, respectively, the latter also promoting higher ICP. (biomedcentral.com)
Perfusion1
  • Therefore, perfusion is tightly regulated by cerebral autoregulation (CA) to preserve cerebral blood flow facing variations in systemic pressure and metabolism. (biomedcentral.com)
Acute3
  • The antihistamine is effective for acute onset and reduces pruritus, while the decongestant reduces chemosis, eyelid edema, and redness via vasoconstriction. (uspharmacist.com)
  • Systemic arterial embolism is typically associated with an acute or peracute presentation, usually with rear limb paralysis/paresis. (vin.com)
  • Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are true critical care syndromes that arise secondary to a local or systemic insult. (vetbloom.com)
Mechanisms1
  • Multiple cardiac-related systemic comorbidities drive the molecular and hemodynamic mechanisms implicated in this disease. (frontiersin.org)
Cerebral3
  • It is conceivable that the presence of HFrEF would further deteriorate this scenario by adding components of dysfunctional cerebral autoregulation, lower cardiac output and hypocapnia-induced vasoconstriction [ 4 ]. (ersjournals.com)
  • 8. Hemorrhagic reversible cerebral vasoconstriction syndrome: A retrospective observational study. (nih.gov)
  • It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART , and dilates BRONCHI and cerebral vessels. (bvsalud.org)
Hypoxia1
  • Obstructive sleep apnea (OSA) is characterized by intermittent airway obstruction and systemic hypoxia during sleep, which can contribute to an increase in reactive oxygen species, vascular remodeling, vasoconstriction and ultimately cardiovascular disease. (nih.gov)
Vasodilatation1
  • Molecular adsorbent recirculating system (MARS) is a specialised form of dialysis that clears albumin-bound substances, including vasodilators, and therefore can potentially reduce systemic vasodilatation in cirrhosis. (bmj.com)
Endothelin1
Cardiac output1
  • The measurement of a diastolic P pa / P pcw gradient (DPG) combined with systemic blood pressure and cardiac output allows for a step-by-step differential diagnosis between pulmonary vascular disease, high output or high left-heart filling pressure state, and sepsis. (ersjournals.com)
Vasoconstrictors1
Endothelial1
  • Although vasoconstriction mediated by ET-1 through ETA activation on vascular smooth muscle cells has been well characterized, the expression/function of ETA in endothelial cells (ECs) has not been described. (nih.gov)
Severe5
Circulation1
Regulation of blood1
Symptoms2
  • Systemic use may only partially relieve allergic symptoms. (uspharmacist.com)
  • Symptomatology, when present, is quite variable reflecting systemic involvement, including symptoms of lower respiratory tract infection ( e.g. cough, fever and dyspnoea), neurological impairment, cutaneous manifestations, or gastro-intestinal issues especially in the elderly [ 2 ]. (ersjournals.com)
Thrombosis1
  • In patients with systemic lupus erythematosus (commonly referred to as lupus), stroke and venous thrombosis are relentlessly driven by oxidative stress and prothrombotic autoantibodies. (nih.gov)
Oxygen3
  • Impaired systemic oxygen delivery, particularly during exertion, is the key pathophysiological feature shared by chronic obstructive pulmonary disease (COPD) and heart failure with reduced left ventricular ejection fraction (HFrEF). (ersjournals.com)
  • The goal of vasoconstriction is to prioritize oxygen and nutrient supply to the most important organs - the vital organs. (biologydictionary.net)
  • 9]. Moreover, infusion of cell-free oxyhemoglobin (oxyHb) and heme-based oxygen carriers produces pulmonary vasoconstriction in numerous species including pigs, dog, sheep and h. (squalene-epoxidase.com)
Fluid loss1
Patients2
  • We routinely use systemic administration as first-line treatment for patients with PAH. (aarc.org)
  • 7. Intracerebral Hemorrhage Outcomes in Patients with Systemic Cancer. (nih.gov)
Arteries1
  • Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, in particular the large arteries and small arterioles. (wikipedia.org)
Increases1
Ambient1
Investigate1
  • To investigate a potential contribution of systemic physiology to recently reported BOLD fMRI signals in white matter, we compared photo-plethysmography (PPG) and whole-brain fMRI signals recorded simultaneously during long resting-state scans from an overnight sleep study. (nih.gov)
Decrease1
  • HYPOXIC pulmonary vasoconstriction (HPV) is a homeostatic mechanism whereby a decrease in alveolar P O 2 leads to constriction of adjacent arterioles and a subsequent diversion of blood flow to better oxygenated regions of the lung. (silverchair.com)
Trigger1
Secondary1
  • approx 28% change), consistent with bronchoconstriction and vasoconstriction secondary to the anaphylactic or anaphylactoid contrast reaction. (avma.org)
Promotes1
Blood pressure2
Factors1
Mechanism1
  • The mechanism that leads to vasoconstriction results from the increased concentration of calcium (Ca2+ ions) within vascular smooth muscle cells. (wikipedia.org)
Reduces1
Hormone1
  • Insulin is most commonly recognized for its role in glucose disposal, but it is a hormone with systemic effects. (omegafields.com)
Effects3
  • This document provides the scientific rationale and framework for the assignment of multiple hazard-specific skin notations (SK) that clearly distinguish between the systemic effects, direct (localized) effects, and immune- mediated responses caused by skin contact with chemicals. (cdc.gov)
  • Systemic therapy may not achieve the desired goal, be optimal for patient compliance, and produce undesired side effects. (aarc.org)
  • The flow-dependent nature of the response should be considered when assessing the effects of physiologic or pharmacologic interventions on the magnitude of hypoxic pulmonary vasoconstriction. (silverchair.com)
Topical1