When intracranial pressure is increased, the blood supply to RVLM neurons is compromised, and the local hypoxia and hypercapnia increase their discharge. (dailytechguides.com)
The increase in blood pressure is promoted by hypoxia and hypercapnia accompanying chronic bronchial obstruction, as well as the influence of vasoactive substances (serotonin, catecholamines and their predecessors). (artery-diseases-info.com)
Acidosis9
IV bicarbonate can lead to intracellular acidosis, hypercapnia, hypocalcemia, and a reduction in oxygen delivery via the Bohr effect. (medscape.com)
The animal responded well to the intermittent positive pressure ventilation and within 90 minutes of its commencement, the respiratory acidosis and hypercapnia had been resolved. (vin.com)
All patients were randomized to three groups receiving high V T [10 mL/kg of predicted body weight (PBW), the HVT group, n = 20], low V T (6 mL/kg PBW, the LVT group, n = 20), and low V T combined with a moderate hypercapnia and hypercapnic acidosis (6 mL/kg PBW, PaCO 2 45-60 mm Hg, the LVT + HC group, n = 20). (frontiersin.org)
The combination of low V T and permissive hypercapnia results in hypercapnic acidosis decreasing the lactate concentration but adding no additional benefits and warrants further investigations. (frontiersin.org)
3. Hypercapnia-induced respiratory and metabolic acidosis induced compensatory mechanisms, which have a regulatory effect on the acid-base balance, as well as on systemic oxygen supply. (fu-berlin.de)
4. The hypercapnia-induced mixed acidosis is inducing changes in the concentration of several plasma electrolytes, comparable to a HCl-induced metabolic acidosis (Ultsch et al. (fu-berlin.de)
To characterize the importance of carotid body SNOs in the regulation of ventilatory control and the ventilatory responses to hypoxia/hypercapnia/acidosis, in rats and in transgenic and normal mice. (grantome.com)
This project will provide insights into (1) the role of carotid body SNOs in ventilatory control of rats and mice, (2) mechanisms regulating the synthesis/storage of SNOs in PGCs in the carotid bodies, (3) the mechanisms regulating the exocytosis of SNOs during hypoxia, hypercapnia and acidosis, and (4) the signaling elements mediating the SNO responses. (grantome.com)
It is enhanced in the neonatal/fetal circulations, in periods of acidosis (either respiratory or metabolic), hypercapnia, hypoxia (hence the name), and even in iron deficiency. (rk.md)
Hypoxemia6
Intraoperative monitoring revealed severe systemic hypertension, hypercapnia and hypoxemia. (vin.com)
A protective lung ventilation strategy was also initiated to reverse the hypoxemia and hypercapnia. (vin.com)
When autoregulation is intact, cerebral vessels will vasodilate in response to hypercapnia or hypoxemia. (vin.com)
Question, does short-duration systemic hypoxemia cause HPV? (rk.md)
I just can't see the connection between systemic hypoxemia and blood vessel constriction due to lack of air in the alveoli. (rk.md)
The degree of hypoxemia, hypercapnia, inspiratory flow limitation and the number of arousal episodes are measured during the study. (thumbayuniversityhospital.com)
The goal of this study was to assess the effects of ventilation with low tidal volume (V T ) either alone or in a combination with moderate permissive hypercapnia in major pancreatoduodenal interventions. (frontiersin.org)
Beyond the lower V T , the subgroup of protectively ventilated patients with ARDS with permissive hypercapnia might have certain additional benefits. (frontiersin.org)
This "permissive hypercapnia" has been accepted progressively in critical care for adult, pediatric, and neonatal patients requiring mechanical ventilation. (mhmedical.com)
Conventionally, the protective effect of ventilator strategies incorporating permissive hypercapnia is solely secondary to lower tidal volume, with hypercapnia being permitted so as to achieve this goal. (mhmedical.com)
Hypocapnia2
As we discussed before, alveolar hypocapnia leads to systemic cell hypoxia, generation of free radicals, and immune system dysfunction. (normalbreathing.com)
7 Traditional approaches to CO 2 management in the operating room and for patients with acute respiratory failure generally focused on the deleterious effects of hypercapnia, traditionally targeting therefore normocapnia or even hypocapnia. (mhmedical.com)
Arterial1
The resultant rise in systemic arterial pressure tends to restore the blood flow to the medulla and over a considerable range, the blood pressure rise is proportional to the increase in intracranial pressure. (dailytechguides.com)
Severe4
On the other hand, the above-mentioned Canadian researchers stated the following: "Deliberate elevation of PaCO2 (therapeutic hypercapnia) protects against lung injury induced by lung reperfusion and severe lung stretch. (normalbreathing.com)
Risks might be higher in frail patients, especially if they have not previously been treated with either or both drugs, and in people with severe COPD and hypercapnia. (bmj.com)
Severe exacerbations requiring hospitalizations are commonly treated with bronchodilators, oxygen supplementation, systemic steroids, and antibiotics. (enclarapharmacia.com)
In COPD, long-term oxygen therapy improves survival in severe daytime hypoxaemia and noninvasive ventilation reduces the need for intubation after acute hypercapnic respiratory failure and improves survival in stable in chronic hypercapnia. (ersjournals.com)
Hypertension3
This stimulates systemic hypertension in an attempt to improve cerebral blood flow. (vin.com)
In COPD, chronic hypoxaemia appears to contribute to mortality and has been associated with complications such as systemic inflammation and pulmonary hypertension [ 16 ]. (ersjournals.com)
Prolonged obstruction could lead to pulmonary or systemic hypertension, cardiac arrhythmias, congestive cardiac failure and other heart conditions like myocardial infarction etc. (thumbayuniversityhospital.com)
Hypoxaemia1
Mechanical ventilation is frequently applied to protect the airway from the risk of aspiration and to prevent both hypoxaemia and hypercapnia, which are two major systemic factors of secondary brain injury. (itij.com)
Cardiac1
There is a progressive decrease in sympathetic activity, blood pressure (BP), stroke volume, heart rate, cardiac output, and systemic vascular resistance, during deeper NREM sleep stages [ 4 ]. (hindawi.com)
Ventilatory1
Ventilatory failure is a rise in PaCO2 (hypercapnia) that occurs when the respiratory load can no longer be supported by the strength or activity of the system. (msdmanuals.com)
Hypoventilation2
Here we review the anesthetic considerations for this population and the potential complications associated with late-stage DMD which include multi-systemic deterioration characterized by dysphagia, aspiration, arrhythmias, hypercapnia, hypoventilation, and failure to thrive (3). (fsahq.org)
Current "protective" ventilator strategies mandate lower tidal volumes (V T ), and generally necessitate hypoventilation and tolerance of hypercapnia. (mhmedical.com)
Vascular resistance2
Desflurane induces a dose dependent reduction in blood pressure due to reduced systemic vascular resistance. (wikipedia.org)
The main factor in increasing systemic blood pressure is central and regional hemodynamic disorders: an increase in peripheral vascular resistance, a decrease in pulse blood supply to the brain, and hemodynamic disturbances in the pulmonary circulation. (artery-diseases-info.com)
ARDS2
The potential for mechanical ventilation to contribute to lung and systemic organ injury and to worsen outcome in patients with the acute respiratory distress syndrome (ARDS) is clear. (mhmedical.com)
The demonstration that mechanical ventilation may cause systemic organ dysfunction in animal models could explain in part the high rate of multiorgan failure in ARDS. (mhmedical.com)
Vasodilatory2
Hypercapnia (transient breath holds), known to alter venous calibre in cortex, induced transient increases in white matter BOLD that disrupted the oscillation indicative of a vasodilatory/contractile mechanism. (biorxiv.org)
Both untreated and laser-treated arteries were smaller than the control diameter at 30 days (80% and 82%, respectively), but in each group the vasodilatory response to hypercapnia was preserved. (elsevierpure.com)
Alveolar1
Hypercapnia occurs when alveolar ventilation either falls or fails to rise adequately in response to increased carbon dioxide production. (msdmanuals.com)
Lungs1
I mean, regardless of systemic SpO2, my lungs are being ventilated. (rk.md)
Inflammation2
Systemic inflammation: theoretical and methodological approaches to description of general pathological process model. (mysciencework.com)
Systemic inflammation (SI) as a general pathological process is considered as a development of cellular stress in response to systemic action of damage factors. (mysciencework.com)
Oxygen supplementation for hypoxia with concomitant hypercapnia has been a matter of relative uncertainty for many decades. (enclarapharmacia.com)
Several researchers have assessed the consequences of oxygen supplementation in hypoxic AECOPD and, interestingly, hypercapnia was observed in all of these studies. (enclarapharmacia.com)
Cerebral1
These findings indicate that 1-μsec laser pulses are well tolerated by systemic and cerebral arteries in two different animal models, and suggest that the 480-nm pulsed-dye laser may have an application for the treatment or prophylaxis of cerebral vasospasm. (elsevierpure.com)
Circulation1
8 , 15 - 17 Intrapulmonary mediators and pathogens, such as prostaglandins, 18 cytokines, 19 endotoxins, 20 and bacteria, 21 have been demonstrated to access the systemic circulation following high-stretch mechanical ventilation. (mhmedical.com)
Mechanisms1
Based on the available data, three potential mechanisms were responsible for the development of hypercapnia. (enclarapharmacia.com)
Consequences1
Disruption of dystrophin has systemic, progressive life-threatening consequences. (fsahq.org)
A decline in pulse pressure without any change in mean pressure decreases the rate of baroreceptor discharge and provokes a rise in systemic blood pressure and tachycardia. (dailytechguides.com)
Local1
There is a growing body of literature describing the incidence, causes, treatment, and outcomes of common causes of PPCA (eg, malignant hyperthermia, massive trauma, and local anesthetic systemic toxicity) and the need for a better awareness of these topics within the anesthesiology community at large. (medscape.com)
Lower1
22 In current practice, hypercapnia is tolerated as the lesser of two evils so as to realize the benefits of lower tidal volumes. (mhmedical.com)
Effect1
Studied the role of VEGF, HSP-70 and S-100B in potentiating hypercapnia neuroprotective effect of hypoxia. (mysciencework.com)