Systemic administration topical. Medical search. Frequent questions

The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. (drugs.com)
Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. (drugs.com)
Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients. (drugs.com)
Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use, and the addition of occlusive dressings. (drugs.com)
It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk. (druglib.com)
Although no information exists on the use of oxymetazoline specifically during breastfeeding, very little should reach the infant through breastmilk because of the local administration and limited absorption into the maternal bloodstream. (nih.gov)
Dermal absorption is negligible and does not contribute significantly to systemic toxicity. (cdc.gov)

There is some evidence that corticosteroids can be absorbed after topical application and cause systemic effects. (medi-vet.com)
Topical corticosteroids can be absorbed from normal intact skin. (drugs.com)

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Triamcinolone acetonide is a potent synthetic corticosteroid providing rapid and prolonged symptomatic relief on topical administration. (medi-vet.com)
Anna Gregoire, MD, and a team of investigators determined the rates and types of psoriasis flares during or within 3 months after concluding systemic corticosteroid administration in adult patients with a known history of psoriasis. (hcplive.com)
The team assessed patients at least 18 years old with an established diagnosis of psoriasis and exposure to at least 1 systemic corticosteroid. (hcplive.com)
The electronic health record was used to identify systemic corticosteroid prescriptions. (hcplive.com)
Nearly 40% of patients indicated their flares began before receiving systemic corticosteroid prescriptions. (hcplive.com)
Among all patients, 55% had ARCI-LI and 45% had XLRI subtypes, and those with ARCI-LI had greater prior use of corticosteroid, emollient, and oral/topical retinoids. (medscape.com)

The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents. (drugs.com)
The effects of topical or oral steroids are usually shorter-lived, with peak levels of drug in the bloodstream usually dissipating within 24 to 48 hours. (liquidimageco.com)
However, researchers have detected the effects of oral steroids in horses' systemic circulation for up to 4 weeks after administration. (liquidimageco.com)
The most common treatment is the administration of oral steroids, especially prednisone . (wikidoc.org)
Mild cases sometimes respond to the application of topical steroids. (wikidoc.org)
The findings suggested systemic steroids may be much less likely to trigger severe flares than what was traditionally taught in dermatology . (hcplive.com)

UV-B-induced skin damage may be prevented by avoidance of intense sun exposure, as well as topical and systemic administration of antioxidants ( 11 ). (spandidos-publications.com)
The study, " Psoriasis Flares Following Systemic Glucocorticoid Exposure in Patients With a History of Psoriasis ," was published online in JAMA Dermatology . (hcplive.com)

Children may absorb proportionally larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity (See PRECAUTIONS-Pediatric use ). (drugs.com)
Ingestion of ethylene glycol leads to systemic toxicity beginning with CNS effects, followed by cardiopulmonary effects, and finally renal failure. (cdc.gov)

These results support ongoing investigation of TMB-001 as a promising alternative to systemic retinoids for participants with CI," Bunick concluded. (medscape.com)
He noted that while he is not privy to details of TMB-001's IPEG delivery system, "the way they have used polyethylene glycol to encapsulate the isotretinoin allows for greater barrier penetration and reduces a lot of the tolerability issues that are seen with other topical retinoids. (medscape.com)

OBJECTIVE To quantify plasma concentrations and determine adverse ocular, renal, or hepatic effects associated with repeated topical ophthalmic application of 0.1% diclofenac to healthy cats. (avma.org)
CONCLUSIONS AND CLINICAL RELEVANCE Topical ophthalmic administration of 0.1% diclofenac was well tolerated in healthy cats, with only mild signs of ocular irritation. (avma.org)
Systemic administration of PEA reduces IOP in patients with glaucoma and ocular hypertension. (arvojournals.org)
Project Summary/Abstract Ocular pharmaceuticals predominantly use the topical route of administration, which involves a number of benefits and limitations when compared to systemic drug routes. (sbir.gov)

Severe cases require administration of systemic immunosuppressive agents. (wikipedia.org)
Investigators noted the results did not support that patients with psoriasis who received or tapered off systemic corticosteroids had significant rates of severe psoriasis flares. (hcplive.com)
Consensus was reached on 12 statements, including that systemic corticosteroids should generally be avoided but can be used rarely for severe AD under certain circumstances, including a lack of other treatment options, as a bridge to other systemic therapies or phototherapy, during acute flares in need of immediate relief, in anticipation of a major life event or in the most severe cases. (medscape.com)
[ 1-8 ] While systemic CS can lead to rapid clearing of AD, their side-effect profile and the risk of severe rebound flares after discontinuation limit their use. (medscape.com)
Despite reasons for caution, systemic CS are still commonly used for patients with moderate-to-severe AD. (medscape.com)
In a recent clinical trial for adults with moderate-to-severe AD, which took place in North America and Europe, 36% of participants reported use of systemic CS in the year prior to the trial. (medscape.com)
[ 19 ] Baseline data from a German registry of moderate-to-severe AD revealed that 13% of participants had been on systemic CS in the 3 months prior to enrollment, [ 20 ] and in another German study, 10% of patients with AD had used systemic CS over 2 years. (medscape.com)
[ 21 ] In a survey of 61 U.K. consultant dermatologists, 42% listed systemic CS as their first-line systemic agent for adult moderate-to-severe AD. (medscape.com)
[ 22 ] In surveys of European and North American paediatric dermatologists, oral CS were the first-line systemic agents for severe paediatric AD for 31% and 5% of respondents, respectively. (medscape.com)

Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. (drugs.com)

Patients with recessive X-linked and autosomal recessive lamellar congenital ichthyosis (CI) achieved treatment success with a novel topical isotretinoin ointment known as TMB-001, results from a phase 2b study demonstrated. (medscape.com)

If more than one topical ophthalmic drug is being used, the drugs should be administered at least five minutes apart. (nih.gov)
SIMBRINZA ophthalmic suspension may be used concomitantly with other topical ophthalmic drug products to lower IOP. (nih.gov)
The onset of reduction in intraocular pressure following administration of Timolol Maleate Ophthalmic Solution can usually be detected within one-half hour after a single dose. (nih.gov)

1 Modes of topical fluoride delivery include toothpastes, gels, mouthrinses, and professionally applied fluoride therapies. (ada.org)
however, limited data have been obtained from controlled trials in SS to guide the treatment of systemic symptoms using therapies including antimalarials, glucocorticoids, immunosuppressive drugs and biologic agents. (nih.gov)

The topical treatment of mild to moderate atopic dermatitis in pediatric patients 3 months to 18 years of age. (globalrph.com)
Background Guidelines discourage the use of systemic corticosteroids for atopic dermatitis (AD), but their use remains widespread. (medscape.com)
In clinical practice guidelines and position statements concerning the management of atopic dermatitis (AD), the use of systemic corticosteroids (CS), including prednisone, hydrocortisone and celestone, is generally discouraged, with use limited to special circumstances ( Table 1 ). (medscape.com)

Therefore, the same types of adverse reactions that are attributable to sulfonamides may occur with topical administration of SIMBRINZA. (nih.gov)
The same adverse reactions found with systemic administration of beta-adrenergic blocking agents may occur with topical administration. (theodora.com)

Observe and exercise appropriate precautions for handling, preparation, administration, and disposal of hazardous drugs. (pdr.net)

Two otic preparations of topical fluoroquinolones, ofloxacin 0.3 percent (Floxin otic) and ciprofloxacin 0.2 percent with hydrocortisone 1.0 percent (Cipro HC otic), have been introduced. (aafp.org)
A recent, large study 4 of acute otitis externa treatment patterns among subspecialists and generalists revealed that a combination topical product containing polymyxin B, neomycin (an aminoglycoside) and 1 percent hydrocortisone (Cortisporin) is the most frequently prescribed treatment for this condition. (aafp.org)
Locoid Lipocream contains hydrocortisone butyrate, a non-fluorinated hydrocortisone ester [Pregn-4-ene-3, 20-dione, 11, 21-dihydroxy-17- [(1-oxobutyl) oxy (11β)-] for topical dermatologic use. (globalrph.com)

ACZONE (dapsone) Gel, 7.5%, contains dapsone, a sulfone, in an aqueous gel base for topical dermatologic use. (rxlist.com)

Since fluoroquinolone antibiotics were introduced for systemic use in the 1980s, their indications and use have increased rapidly. (aafp.org)
However, other forms of infection respond well to topical antibiotics. (aafp.org)

SAP and SGPT (ALT) enzyme elevations, polydipsia and polyuria, vomiting, and diarrhea (occasionally bloody) have been observed following parenteral or systemic use of synthetic corticosteroids in dogs. (medi-vet.com)

Introduction to Administration and Kinetics of Drugs See Nanomedicine for an overview of all the ways in which nanotechnology has improved drug delivery. (msdmanuals.com)

ACZONE ® (dapsone) Gel, 7.5%, is indicated for the topical treatment of acne vulgaris in patients 12 years of age and older. (rxlist.com)
Owing to the excellent efficacy of systemic administration of corticosteroids, most patients achieve remission even if they required second-line treatment. (hindawi.com)
Therefore, patients receiving a large dose of a potent topical steroid applied to a large surface area or under an occlusive dressing should be evaluated periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests. (drugs.com)
Because of a higher ratio of skin surface area to body mass, pediatric patients are at a greater risk than adults of HPA-axis suppression when they are treated with topical corticosteroids. (druglib.com)
Adverse effects including striae have been reported with inappropriate use of topical corticosteroids in pediatric patients. (druglib.com)
HPA axis suppression, Cushing's syndrome, and intracranial hypertension have been reported in pediatric patients receiving topical corticosteroids. (druglib.com)
For the treatment of cutaneous manifestations of CTCL in patients who are refractory to at least 1 prior systemic therapy. (pdr.net)
Strict avoidance of systemic corticosteroids among patients with psoriasis may be unnecessary. (hcplive.com)
Recent study findings indicate flares during or immediately following the administration of systemic corticosteroids are low in patients with a known history of psoriasis . (hcplive.com)
Patients were excluded if they were younger than 18 years old, had a diagnosis of psoriatic arthritis , and if they received only topical, intraarticular, or intrabursal corticosteroids. (hcplive.com)
Overall, 516 patients with established psoriasis who received systemic corticosteroids were manually validated. (hcplive.com)
Despite some patients experiencing psoriasis flares, the rates overall were low among patients receiving systemic corticosteroids for any reason. (hcplive.com)
Aggressive resuscitation, nutritional support, thorough surgical excision of infected wounds, early wound closure, grafting and the development of effective topical and systemic chemotherapy have largely improved morbidity and mortality rates of burn patients. (who.int)
La réanimation agressive, la prise en charge nutritionnelle, l'excision chirur- gicale complète des plaies infectées, la fermeture rapide des plaies, les greffes et la mise au point d'une chimiothérapie locale et systémique efficace ont permis d'améliorer grandement le taux de morbidité et de mortalité chez les patients brûlés. (who.int)

Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. (drugs.com)
To address the concern of inappropriate use and overuse of systemic CS for AD in clinical practice and to provide guidance for clinicians as to what circumstances may constitute appropriate use, a consensus process was initiated among the councillors and associates of the International Eczema Council (IEC). (medscape.com)

Aczone Gel 5% may interact with other topical medications, harsh or abrasive soaps, or cosmetics on the affected area. (rxlist.com)
Anti-infectives for systemic use (49.2 %) and alimentary tract and metabolism medications (18.2 %) were the most common classes involved with PEs. (springer.com)

The treatment of primary Sjögren's syndrome (SS) is based principally on the management of sicca features and systemic manifestations. (nih.gov)

Nonetheless, many other viral infections can affect the oral cavity in humans, either as localized or systemic infections. (medscape.com)

The occurrence of systemic reactions is rarely a problem with topical administration. (medi-vet.com)
The following additional local adverse reactions have been reported infrequently with topical corticosteroids but may occur more frequently with the use of occlusive dressings. (globalrph.com)

Aczone ( dapsone ) Gel, 5% is a sulfone drug indicated for the topical treatment of acne vulgaris . (rxlist.com)
For the treatment of otitis media with tympanic membrane perforation, topical fluoroquinolones are effective and safe. (aafp.org)
Recently, topical formulations for the eye and ear have appeared, expanding the options for the treatment of certain bacterial infections. (aafp.org)
1 The broad spectrum of fluoroquinolone activity ( Table 1 ) , especially activity against Staphylococcus aureus and Pseudomonas aeruginosa , has generated interest in the use of this class of agents for topical eye and ear treatment. (aafp.org)
Bacterial ear infections, such as necrotizing (malignant) otitis externa and otitis media in ears with intact tympanic membranes, require systemic treatment. (aafp.org)
5-Aminosalicylates or topical treatments are usually the first-line treatment, and corticosteroids are the second-line treatment. (hindawi.com)

Accordingly, the present invention provides novel JAK inhibitors which are both potent JAK inhibitors, and in particular TYK2/JAK1 inhibitors, but also display high clearance in human hepatocytes, thus affording significantly improved systemic clearance, and thereby reducing the risk of adverse side effects upon topical administration while retaining efficacy in the skin. (justia.com)

Vitamins are part of the antioxidant system of human skin, and are detectable in different layers, so the topical application can be an alternative to maintain the functionality of the system. (intechopen.com)

Many civilizations used topical application of moldy bread, with many references to its beneficial effects arising from ancient Egypt, Nubia, China , Serbia , Greece, and Rome. (wikipedia.org)

Although systemic administration is safe and favors effects on different organs of the vestibular pathway, it remains to be seen whether topical (transtympanic) administration could be effective for pathologies of peripheral origin. (melatonina.it)

This experiment assesses whether test articles cause a reduction in inflammatory cytokine release in psoriasis compared with a control compound, for example, a ROR-ɣ inhibitor (systemic) or betamethasone (topical). (reprocell.com)
Bexarotene may induce metabolic enzymes and cause a reduction in the plasma concentrations of oral or other systemic hormonal contraceptives. (pdr.net)

Infrequently, signs and symptoms of steroid withdrawal may occur, requiring supplemental systemic corticosteroids. (drugs.com)

The present investigation aims to further characterize the potential skin photoprotective effects of a food supplementation and a topical administration of a melon concentrate alone or in combination. (mdpi.com)
Effects of a topical saffron ( Crocus sativus L ) gel on erectile dysfunction in diabetics: A randomized, parallel-group, double-blind, placebo-controlled trial. (naturalmedicinejournal.com)
To investigate the effects of a topical saffron gel on erectile dysfunction in diabetic men. (naturalmedicinejournal.com)
While topical saffron-containing creams and lotions have previously been studied for their direct therapeutic effects on the skin, 2 to my knowledge this is the first study investigating a systemic effect of topical saffron administration. (naturalmedicinejournal.com)

A topical formulation of 0.1% diclofenac was administered 4 times/d for 7 days to 4 cats, and artificial tear (control) solution was administered to the other 4 cats. (avma.org)
TMB-001 is a proprietary, novel, topical isotretinoin formulation to treat CI that is being developed by Timber Pharmaceuticals. (medscape.com)

If not treated, pemphigus is fatal, due to overwhelming systemic infection . (wikidoc.org)

If irritation develops, topical corticosteroids should be discontinued and appropriate therapy instituted. (drugs.com)
The choice for the use of topical vitamin E, compared to the oral is given by the safety as mild irritation and it has potential for multifunctional topical formulations. (intechopen.com)

Distribution- Rapidly distributed in the body after oral administration. (medicineindia.org)
JAK inhibitors known in the art often have properties which render them generally better suited for oral administration and less well suited for topical administration. (justia.com)

Drug administration is the giving of a drug by one of several means (routes). (msdmanuals.com)
There is currently no [Food and Drug Administration]-approved drug for CI. (medscape.com)

Nevertheless, caution should be exercised when topical corticosteroids are administered to a nursing woman. (druglib.com)

Self-applied topical fluorides include toothpastes, mouthrinses, and gels. (ada.org)
1 Modes of systemic fluoride delivery include water fluoridation or dietary fluoride supplements in the form of tablets, drops, or lozenges. (ada.org)

Some of the topical corticosteroids and their metabolites are also excreted into the bile. (drugs.com)

Evidence of the benefits and risks of systemic CS in AD is scarce. (medscape.com)

Topical fluorides strengthen teeth already present in the mouth, making them more decay resistant, while systemic fluorides are those that are ingested and become incorporated into forming tooth structures. (ada.org)
1, 3 Topical fluorides strengthen teeth already present in the mouth, making them more decay resistant. (ada.org)

Anatomy25

Organisms22

Diseases17

Chemicals and Drugs100

Analytical, Diagnostic and Therapeutic Techniques and Equipment64

Psychiatry and Psychology9

Phenomena and Processes35

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture3

Health Care8

Absorption7

Corticosteroids can be absorbed2

Lupus Erythematosus10

Corticosteroid6

Steroids6

Exposure2

Toxicity2

Retinoids2

Ocular4

Severe9

Systemically1

Ointment1

Ophthalmic3

Therapies2

Atopic dermatitis3

Occur with topical administration2

PRECAUTIONS1

Hydrocortisone3

Dermatologic1

Antibiotics2

Parenteral1

Drugs1

Patients14

Clinical2

Medications2

Manifestations1

Humans1

Reactions2

Treatment6

Efficacy1

Detectable1

Application1

Organs1

Reduction2

Symptoms1

Effects4

Formulation2

Infection1

Irritation2

Oral administration2

Drug2

Caution1

Include2

Metabolites1

Evidence1

Resistant2