• Inhibition of inositol monophosphatase may be key in the action of lithium in treating bipolar disorder, specifically manic depression. (wikipedia.org)
  • Other names in common use include: myo-inositol-1(or 4)-monophosphatase, inositol 1-phosphatase, L-myo-inositol-1-phosphate phosphatase, myo-inositol 1-phosphatase, inositol phosphatase, inositol monophosphate phosphatase, inositol-1(or 4)-monophosphatase, myo-inositol-1(or 4)-phosphate phosphohydrolase, myo-inositol monophosphatase, and myo-inositol-1-phosphatase. (wikipedia.org)
  • After all three magnesium ions have bound, the inositol monophosphatase can bind, the negatively charge phosphate group stabilized by the three positively charged magnesium ions. (wikipedia.org)
  • Inositol monophosphatase plays an important role in maintaining intracellular levels of myo-inositol, a molecule that forms the structural basis of several secondary messengers in eukaryotic cells. (wikipedia.org)
  • Inhibition of inositol monophosphatase may be crucial in the action of the metal ion lithium. (inhn.org)
  • Inositol was successfully biosynthesized after introducing two crucial enzymes: inositol-3-phosphate synthase (IPS) from Trypanosoma brucei , and inositol monophosphatase (IMP) from E. coli . (biomedcentral.com)
  • The enzyme Inositol phosphate-phosphatase (EC 3.1.3.25) is of the phosphodiesterase family of enzymes. (wikipedia.org)
  • The enzymes from animals and plants also have the activity of EC 2.7.1.159 , inositol-1,3,4-trisphosphate 5/6-kinase. (enzyme-database.org)
  • Nitric oxide synthase (NOS) and nicotinamide adenine dinucleotide phosphate-oxidase (NOX) enzymes play an important role in Dox-induced production of ROS [ 15 ]. (oncotarget.com)
  • Inositol phosphate-phosphatase are enzymes of the phosphodiesterase super-family which include phosphodiesterase V widely used in male erectile sexual disorders. (inhn.org)
  • Phytases are degrading enzymes that hydrolyze phytate (myo inositol hexa kis phosphate) to release a series of lower phosphate esters of myoinositol and orthophosphate. (setpublisher.com)
  • IMPase dephosphorylates the isomers of inositol monophosphate to produce inositol, mostly in the form of the stereoisomer, myo-inositol. (wikipedia.org)
  • Recombinant Escherichia coli strains have been constructed by metabolic engineering strategies to produce inositol, but with a low yield. (biomedcentral.com)
  • Research applying G-6-P to produce inositol via a two-step reaction has been extensive. (biomedcentral.com)
  • Somatic mutations of the TSH receptors and G α protein confer constitutive activation to the cyclic adenosine monophosphate (cAMP) cascade of the inositol phosphate pathways. (medscape.com)
  • SIL-CE-ESI-MS enables the accurate monitoring of InsPs and PP-InsPs arising from compartmentalized cellular synthesis pathways, by feeding cells with either [13C6]-myo-inositol or [13C6]-D-glucose. (biomed.news)
  • In doing so, we provide evidence for the existence of unknown inositol synthesis pathways in mammals, highlighting the potential of this method to dissect inositol phosphate metabolism and signalling. (biomed.news)
  • These binding sites appear to be conserved in other phosphodiesterases such as fructose 1,6-bisphosphatase (FBPase) and inositol polyphosphate 1-phosphatase. (wikipedia.org)
  • The phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible to the extent that the enzyme can act like an inositol polyphosphate phosphatase in the presence of ADP. (enzyme-database.org)
  • IMPase does this by dephosphorylating inositol monophosphate to produce inorganic phosphate and myo-inositol, the precursor to PIP2. (wikipedia.org)
  • Myo-inositol (inositol), an important compound in the pharmaceutics, cosmetics and food industries, is usually produced from phytate via a harsh set of chemical reactions. (biomedcentral.com)
  • Inositol triphosphate is also a second messenger which activates receptors on the endoplasmic reticulum to release calcium ion stores into the cytoplasm, creating a complex signaling system that can be involved in modulating fertilization, proliferation, contraction, cell metabolism, vesicle and fluid secretion, and information processing in neuronal cells. (wikipedia.org)
  • The catalyzed reaction: myo-inositol phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } myo-inositol + phosphate This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. (wikipedia.org)
  • Finally an activated water molecule acts a nucleophile and hydrolyzes the substrate, giving inositol and inorganic phosphate. (wikipedia.org)
  • It would be a step forward to carry out systematic studies in order to confirm the experiment that adding a micro-dose of lithium in the drinking water (e.g., 300 mcg per day) could have anti-aging, anti-violence and anti-suicidal effects. (inhn.org)
  • SPX-containing proteins have been known as key players in phosphate signaling and homeostasis. (biomedcentral.com)
  • Despite the importance of SPX domain proteins in Pi signaling and nitrogen-dependent phosphate homeostasis, the functionality of all these proteins is still unclear. (biomedcentral.com)
  • The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)
  • Two general families of chaperones are reconized: Molecular chaperones, which bind and stabilize un- folded or partly folded proteins, thereby preventing these proteins from aggregating and being degraded Chaperonins, which directly facilitate the folding of proteins Molecular chaperones consist of Tradee and its homologs: Hsp70 in the cytosol and mitochondrial matrix, BiP in the en- doplasmic reticulum, and DnaK in bacteria. (forextrading-madeeasy.com)
  • In high P availability, inositol polyphosphates (PP-InsPs) bind to the basic surface of SPX domain proteins and facilitate their binding to PHR. (biomedcentral.com)
  • Despite these fluctuations, Lysine Surface Cluster (KSC), and the third residue of Phosphate Binding Sites (PBS) showed complete conservation in almost all of SPXs except few proteins in Selaginella moellendorffii and Papaver sumniferum, suggesting they might have different ligand preferences. (biomedcentral.com)
  • Additionally, SPX domain proteins were shown to be involved in nitrate-phosphate signaling crosstalk in rice where nitrate-dependent interaction with NRT1.1B caused ubiquitination and degradation of OsSPX4 and consequently translocation of OsPHR2 and OsNLP3 into nucleus to induce PSI genes and nitrate inducible genes, respectively [ 11 ]. (biomedcentral.com)
  • a series of engineered strains for inositol production was constructed by deleting the key genes pgi , pfkA and pykF . (biomedcentral.com)
  • One placebo-controlled study found that Inositol significantly reduced OCD symptoms in patients who took it. (wholisticresearch.com)
  • During the last 10 y, the more widespread use of screening has allowed clinicians to identify an earlier and more subtle presentation of PHPT: Hypercalcemia is mild (combined usually with normal or borderline-low serum phosphate) and symptoms are absent or subtle. (snmjournals.org)
  • As a traditional Chinese medicine, Rhizoma coptidis has excellent therapeutic effects on various diseases, but the underlying systematic molecular mechanisms are still far from being fully elucidated. (springer.com)
  • In addition, we hypothesized that there different phosphate sensing mechanisms might occur in S. moellendorffii and P. sumniferum . (biomedcentral.com)
  • Phytase successfully used as an animal feed additive to increase the bioavailability of phosphate from phytic acid in the grain-based diets of poultry and swine. (setpublisher.com)
  • Effects of soy protein and isoflavones on circulating hormone concentrations in pre‐ and post‐menopausal women: a systematic review and meta‐analysis. (tonzu.co.nz)
  • Such suitability, as mentioned in paragraphs 6(1) and 6(2), shall be demonstrated through a systematic review of the available data relating to the expected benefits and to safety considerations as well as, where necessary, appropriate studies, performed following generally accepted expert guidance on the design and conduct of such studies. (who.int)
  • In people who need hemodialysis due to kidney failure and have high levels of phosphate, taking niacinamide by mouth seems to help decrease phosphate levels. (medlineplus.gov)
  • The fBB 4 -R was coupled to phospholipase C with activation increasing [ 3 H]inositol phosphates and mobilizing Ca 2+ almost entirely from cellular sources. (acs.org)
  • Construction of metabolically engineered E. coli strains with high stoichiometric yield of inositol is desirable. (biomedcentral.com)
  • The analysis of myo-inositol phosphates (InsPs) and myo-inositol pyrophosphates (PP-InsPs) is a daunting challenge due to the large number of possible isomers, the absence of a chromophore, the high charge density, the low abundance, and the instability of the esters and anhydrides. (biomed.news)
  • The proper distribution of carbon flux between cell growth and inositol production is a major challenge for constructing an efficient inositol-synthesis pathway in bacteria. (biomedcentral.com)
  • The metabolically engineered E. coli strains represent a promising method for future inositol production. (biomedcentral.com)
  • Furthermore, inositol is an important intermediate used for the production of uronic acid and inositol derivatives. (biomedcentral.com)
  • In the present study, we designed an inositol-synthesis pathway from glucose with a theoretical stoichiometric yield of 1 mol inositol/mol glucose. (biomedcentral.com)
  • This study provides an essential reference to obtain a suitable distribution of carbon flux between glycolysis and inositol synthesis. (biomedcentral.com)
  • (3) However, it is important to note that not all Inositol supplements are created equal, and the amount of active ingredients can vary between brands or suppliers. (wholisticresearch.com)