• PtdIns5P
  • A major role for PIKfyve in synthesis of cellular PtdIns5P is suggested by data for reduced PtdIns5P mass levels upon heterologous overexpression of the enzymatically inactive PIKfyve point-mutant (PIKfyveK1831E) and PIKfyve silencing by small interfering RNAs. (wikipedia.org)
  • PIP5KI
  • Both Type I and Type II phosphatidylinositol-4-phosphate 5-kinase (PIP5KI) are further classified as PIP5Kα, PIP5Kβ and PIP5Kγ on the basis of their basic differences in primary structure and the variation in the expression level in different compartment of cells, indicating that individual PIP5KI isoform has non identical function . (wikipedia.org)
  • mannose
  • GlcNAc, Gal) are built onto a phosphatidylinositol (PI) molecule embedded in the membrane using sugars donated from sugar nucleotides and dolichol-P-mannose outside and inside the ER, respectively. (wikipedia.org)
  • hydrolysis
  • In 1975 he moved to Harvard University for a postdoctoral fellowship under Guido Guidotti, where he discovered that an impurity in commercial preparations of ATP, vanadate, acts as a transition state analog for phosphate hydrolysis. (wikipedia.org)
  • novo
  • The long-chain bases, sometimes simply known as sphingoid bases, are the first non-transient products of de novo sphingolipid synthesis in both yeast and mammals. (wikipedia.org)
  • De novo sphingolipid synthesis begins with formation of 3-keto-dihydrosphingosine by serine palmitoyltransferase. (wikipedia.org)
  • Chemotherapeutic agents such as daunorubicin and etoposide enhance the de novo synthesis of ceramide in studies done on mammalian cells. (wikipedia.org)
  • phospholipids
  • In vertebrates, peroxisomes harbor the enzymatic pathways for synthesis of specialized ether phospholipids vital for integrity of the central nervous system [ 10 ]. (hindawi.com)
  • Laboratory
  • In 1972 he was appointed as a demonstrator to the University of Cambridge where he stayed for 32 years, ultimately as Professor of Organic and Polymer Chemistry, and Director of the Melville Laboratory for Polymer Synthesis where he oversaw the founding and initial decade of the Melville Laboratory. (wikipedia.org)
  • Holmes
  • citation needed] As a postdoctoral researcher, Holmes worked on the total synthesis of Vitamin B12 with Albert Eschenmoser. (wikipedia.org)