• Baran
  • Treatment of the cyclopenenone intermediate with selenium dioxide under anhydrous conditions rapidly gave access to the highly oxygenated product bearing three oxidations in a single step In their recent synthesis of ingenol, Baran and co-workers chose selenium dioxide mediated allylic oxidation to access the correct oxidation state as a single diastereomer at the C-3 position. (wikipedia.org)
  • Samarium
  • He is particularly interested in reactions of lithiated alkoxyallenes, the use of samarium diiodide in synthesis and cycloadditions of nitroso alkenes. (wikipedia.org)
  • novel
  • Aqueous extract of the pericarp of Sapindus trifoliatus fruits: a novel 'green' catalyst for the aldimine synthesis. (biomedsearch.com)
  • The synthesis of sambutoxin reported by David Williams uses a novel Saegusa-Ito oxidation involving an unprotected enol moiety. (wikipedia.org)
  • A variation of the Zincke reaction has been applied in the synthesis of novel indoles: with cyanogen bromide mediated pyridine activation (König method). (wikipedia.org)
  • Enantioselective
  • The synthesis of 1 commenced (Scheme 1) with a highly enantioselective conjugate addition of an allyl silane to cyclohexenone to deliver 7 in 80% isolated yield (99% ee). (sciencemag.org)
  • Synthetic
  • Synthetic (+)-strychnine is also known. (wikipedia.org)
  • The other reason that they were able to get so many structures has to be that this synthesis actually produced 80mg of the synthetic natural product, which by the standards of the field is like scooping flour out of a fifty-pound sack. (sciencemag.org)
  • His research interests include the development of new synthetic methods, the investigation of reaction mechanisms and the synthesis of natural products. (wikipedia.org)
  • substituents
  • The Fukuyama Indole synthesis can generate a range of different substituents at the 2,3 position that were previously unattainable without a protecting group on the nitrogen in the ring. (wikipedia.org)
  • Indoles
  • The Fukuyama indole synthesis is a versatile tin mediated chemical reaction that results in the formation of 2,3-disubstituted indoles. (wikipedia.org)
  • doses
  • In high doses, strychnine is very toxic to humans and many other animals (LD50 = 16 mg/kg in humans, 1-2 mg/kg orally in rats and mice), and poisoning by inhalation, swallowing, or absorption through eyes or mouth can be fatal. (wikipedia.org)
  • In toxic doses, strychnine causes characteristic tetanic convulsions (opisthotonus, risus sardonicus). (thefreedictionary.com)
  • Vanderwal
  • The Vanderwal group has also reported the synthesis of 4-stannyldienals from Zincke aldehydes by addition of tributylstannyl anion and quenching with acetyl chloride. (wikipedia.org)
  • catalytic
  • The catalytic efficiency in organic synthesis of the aqueous extract of the pericarp of Sapindus trifoliatus fruits was evaluated. (biomedsearch.com)
  • The original conditions, though technically catalytic, still require 50 mol% of palladium(II) actetate, raising the cost to prohibitively high levels for large scale syntheses. (wikipedia.org)
  • natural products
  • He is considered by many to be the preeminent organic chemist of the twentieth century, having made many key contributions to the subject, especially in the synthesis of complex natural products and the determination of their molecular structure. (wikipedia.org)
  • In natural products synthesis, though, you have little choice: every single step is like juggling blown-glass sculptures on a tightrope. (sciencemag.org)
  • reagents
  • Each step of a synthesis involves a chemical reaction, and reagents and conditions for each of these reactions must be designed to give an adequate yield of pure product, with as little work as possible. (wikipedia.org)
  • spinal cord
  • The effect of strychnine derives from the ability to facilitate the transmission of excitation in the interneuronal synapses of the spinal cord, primarily in the region of the internuncial neurons, which act as inhibitory cells. (thefreedictionary.com)
  • oxidation
  • Reisman and co-workers leveraged selenium-dioxide mediated oxidation en route to their recent synthesis of the diterpenoid ryanodol. (wikipedia.org)
  • Despite this shortcoming, the Saegusa oxidation has been used in a number of syntheses as a mild, late-stage method for introduction of functionality in complex molecules. (wikipedia.org)
  • The wide applicability of the Saegusa-Ito oxidation is exemplified by its use in several classic syntheses of complex molecules. (wikipedia.org)
  • chemical reaction
  • The Stille reaction, or the Migita-Kosugi-Stille coupling, is a chemical reaction widely used in organic synthesis which involves the coupling of an organotin compound (also known as organostannanes) with a variety of organic electrophiles via palladium-catalyzed coupling reaction. (wikipedia.org)
  • complex
  • The assessed task will involve writing an essay about the analysis of a complex synthesis (which will not be one of the seven highlighted earlier). (slideplayer.com)
  • derivative
  • The synthesis of ring II was accomplished with an Fischer indole synthesis using phenylhydrazine 1 and acetophenone derivative acetoveratrone 2 (catalyst polyphosphoric acid) to give the 2-veratrylindole 3. (wikipedia.org)
  • Aldehydes
  • The use of cyanogen bromide for pyridine activation was independently reported by W. König: The synthesis and utility of Zincke aldehydes has been reviewed. (wikipedia.org)
  • group
  • The veratryl group not only blocks the 2-position for further electrophilic substitution but will also become part of the strychnine skeleton. (wikipedia.org)
  • Yong Qiang Tu's synthesis of the Alzheimer's disease medication galantamine likewise used this reaction in the presence of an acid-sensitive acetal group. (wikipedia.org)
  • Removed using hydrogenolysis Single electron process with Na/NH3 or Li/NH3 Benzyl protecting groups can be removed using a wide range of oxidizing agents including: CrO3/acetic acid at ambient temperature Ozone N-Bromosuccinimide (NBS) N-Iodosuccinimide (NIS) Trimethylsilyl iodide (Me3SiI) in dichloromethane at ambient temperature (selectivity can be achieved under specific conditions) p-Methoxybenzyl (PMB) is used as a protecting group for alcohols in organic synthesis. (wikipedia.org)
  • The group of Marazano recently found an alternative synthesis by condensation onto a variety of glutaconaldehyde derivatives using TFA. (wikipedia.org)
  • yields
  • This method suffers from long reaction times and often produces significantly lower yields than the stoichiometric equivalent as showcased in the synthesis of platyphillide by Nishida. (wikipedia.org)
  • This reaction is a one-pot synthesis and results in yields ranging from 50% to 98% depending on the substituent. (wikipedia.org)