Parkin, 2007 ) to define 2-center metal-ligand interactions of organometallic compounds as ML l X x Z z , where the ligand atoms are classified as L, X, and Z ligands ( Figure 1A ). (frontiersin.org)
Shown2
In esoteric targets, such as highly strained hydrocarbons like spiropentadiene, shown here, the rings can be identical. (wikipedia.org)
The 11-carbon bicyclic structure shown above, spiro[5.5]undecane, is also a fully carbocyclic spiro compound. (wikipedia.org)
Present3
319f.846f Spiro compounds are present throughout the natural world, some cases of which have been exploited to provide tool compounds for biomedical study and to serve as scaffolds for the design of therapeutic agents with novel shapes. (wikipedia.org)
citation needed] As well, the spiro motif is present in various practical compound types (such as dyes), as well as in a wide variety of oligo- and polymeric materials designs, for the unique shapes and properties the spiro center imparts, e.g., in the design of electronically active materials in particular. (wikipedia.org)
citation needed] Bicyclic ring structures in organic chemistry that have two fully carbocyclic (all carbon) rings connected through just one atom are present both in natural products, as well as in esoteric targets of chemical synthesis. (wikipedia.org)
Chemical synthesis3
citation needed] In both cases, the presence of the spiro center, often with four distinct groups attached, and with its unique aspects of chirality, adds unique challenges to the chemical synthesis of each compound type. (wikipedia.org)
citation needed] Bicyclic ring structures in organic chemistry that have two fully carbocyclic (all carbon) rings connected through just one atom are present both in natural products, as well as in esoteric targets of chemical synthesis. (wikipedia.org)
The project is an extension of the SECS Simulation and Evaluation of Chemical Synthesis program, and is proposing to collaborate with the Stanford SUMEX resource. (nih.gov)
Practical2
citation needed] As well, the spiro motif is present in various practical compound types (such as dyes), as well as in a wide variety of oligo- and polymeric materials designs, for the unique shapes and properties the spiro center imparts, e.g., in the design of electronically active materials in particular. (wikipedia.org)
The objectives of this researkn are to develop the logical and heuristic principles of biomolecular synthesis and incorporate this information into @ practical computer program to assist investigators in designing organic syntheses of complex biomolecules. (nih.gov)