DerivativesSolid-phase pepPyrrolidines and piperidinesHeterocyclesTotal synthesisCharacterizationCompoundsPyrrolidineScaffold1990Alkaloids1993PyridinePrecursorPeptide SynthesisHighly substitutedInhibitorsMolecular FormulaAlkylChemistryReactionsAnaloguesIntermediatesInhibition1989SubstratesCatalystCyclizationSodiumSolventScaffoldsDeprotectionNitrileWidelyFmocSynthesizeAromaticProtocols
Derivatives8
- Piperidine and its derivatives are ubiquitous building blocks in pharmaceuticals and fine chemicals. (wikipedia.org)
- Two derivatives (3a and f) in this class of piperidines (3a-i) showed considerable inhibition against different sources of ACNE in vitro and reduced average number of mistakes done by wistar rats as compared to scopolamine treated group in vivo (rodent memory evaluation). (uni-mysore.ac.in)
- Nowadays, derivatives of ferrocene are considered to be modular building blocks in organic synthesis and are usually used to introduce a redox-responsive moiety into molecules. (degruyter.com)
- In this paper we studied the synthesis of ferrocenyl-4,5-dihydrooxazoles and their salts using the condensation of 2,3-diferrocenylcyclopropenone (multicomponent) and of 2,3-diferrocenylcyclopropenylium tetrafluorobarate with the derivatives of 1,2-aminoalcohols. (degruyter.com)
- Digressing from azaheterocycle methodologies, we developed a 10-step racemic total synthesis of collybolide, as well as an asymmetric formal synthesis of collybolide, to facilitate the potential creation of unnatural derivatives. (auburn.edu)
- A simple and efficient protocol has been developed for the synthesis of highly substituted Piperidines derivatives. (lupinepublishers.com)
- Gold(I)-Catalyzed Substitution-Controlled Syntheses of Spiro[indoline-3,3 ' -pyrrolidine] and Spiro[indoline-3,3 ' -piperidine] Derivatives. (bvsalud.org)
- Quantum Mechanical Prediction and Experimental Verification of Au(I)-Catalyzed Substitution-Controlled Syntheses of 1 H -Pyrido[4,3- b ]indole and Spiro[indoline-3,3'-pyridine] Derivatives. (bvsalud.org)
Solid-phase pep3
- Piperidine is also commonly used as a base for the deprotection of Fmoc-amino acids used in solid-phase peptide synthesis. (wikipedia.org)
- Brandt M, Gammeltoft S, Jensen KJ (2006) Microwave heating for solid-phase peptide synthesis: general evaluation and application to 15-mer phosphopeptides. (springer.com)
- It is an alternative for peptide synthesis on solid-phase peptide synthesis in the. (biosolve-chemicals.eu)
Pyrrolidines and piperidines2
- Here we present a combined experimental and computational study on the regio- and stereoselective C4 arylation of pyrrolidines and piperidines with C3 aminoquinoline amide directing groups. (imperial.ac.uk)
- Professor Gryko said: "We demonstrated that nature native cobalt complex - vitamin B12 - and light as the source of energy can facilitate the synthesis of complex and valuable organic compounds, including pyrrolidines and piperidines. (thieme.de)
Heterocycles2
- My present concentration is on the field of organocatalysis, envisioned multicomponent stereoselective synthesis of heterocycles via organocatalysis. (jnu.ac.in)
- Dihydropyridines are advantageous intermediates in the synthesis of such heterocycles, but previous methods to synthesize such compounds usually required specialized starting materials. (auburn.edu)
Total synthesis2
- Efficiency, selectivity, and generality are important for total synthesis of natural products , medicines and materials. (chemistry1science.com)
- Formal total synthesis of macarpine via a Au(I)-catalyzed 6- endo - dig cycloisomerization strategy. (bvsalud.org)
Characterization1
- Gharamaleki, J. , Akbari, F. , Karbalaei, A. , Ghiassi, K. and Olmstead, M. (2016) Synthesis, Characterization and Crystal Structure of a New Schiff Base Ligand from a Bis(Thiazoline) Template and Hydrolytic Cleavage of the Imine Bond Induced by a Co(II) Cation. (scirp.org)
Compounds5
- The Piperidines and its analogues represent one of the most prominent compound classes which are widely distributed in biologically active compounds, pharmaceuticals and natural products [1]. (lupinepublishers.com)
- Several compounds possessing Piperidines scaffold have been reported to exhibit a wide range of valuable bioactive properties including antihypertensive, neuro-protective, antiinflammatory, antibacterial, anti malarial and anticonvulsant activities [2]. (lupinepublishers.com)
- Synthesis and conformational analysis of a bridged anabasine and related compounds. (unthsc.edu)
- Dive into the research topics of 'Synthesis and conformational analysis of a bridged anabasine and related compounds. (unthsc.edu)
- Followed by synthesis, in vitro assay of these compounds was performed against Cryptococcus neoformans . (ukdiss.com)
Pyrrolidine2
- Synthetic approaches to morphine and hasubanan alkaloids involving novel reactions for the formation of their dihydrobenzofuran, piperidine and pyrrolidine ring, respectively, are described. (nyu.edu)
- Three new µ-oxalato dinuclear copper(II) complexes [L(H 2 O)CuOxCu(H 2 O)L](ClO 4 ) 2 [L = 4-(2-aminoethyl)morpholine (aem), (1), 1-(2-aminoethyl)piperidine (ampp), (2) and 1-(2-aminoethyl)pyrrolidine (ampy), (3)] have been synthesized and characterized by X-ray single crystal analysis (1), IR, thermal analysis and magnetic measurements. (hw.ac.uk)
Scaffold1
- Next, we applied our methodology to the synthesis of the indoloquinolizine structural scaffold, a motif found in many polycyclic indole alkaloids. (auburn.edu)
19901
- Lacombe JM, Andriamanampisoa F, Pavia AA (1990) Solid-phase synthesis of peptides containing phosphoserine using phosphate tert. (springer.com)
Alkaloids4
- Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. (wikipedia.org)
- The piperidine structural motif is present in numerous natural alkaloids. (wikipedia.org)
- we present a unified strategy for a one-pot, catalytic enantioselective synthesis of 8 alkaloids and an anticancer antipode using readily available amides and alkynes. (chemistry1science.com)
- Synthesis of pyrrole and carbazole alkaloids. (novapublishers.com)
19931
- Ottinger EA, Shekels LL, Bernlohr DA, Barany G (1993) Synthesis of phosphotyrosine-containing peptides and their use as substrates for protein tyrosine phosphatases. (springer.com)
Pyridine4
- Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst: C5H5N + 3 H2 → C5H10NH Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol. (wikipedia.org)
- The mixture was stirred at -60 C for 30 min and a solution of 4- (3-chlorobenzyl)piperidine (200 mg, 0.96 mmol) and pyridine (253 mg, 3.2 mmol) in dichloromethane (5 mL) was added at -60 C. The resulting mixture was stirred at 25 C for 16 h. (ambeed.com)
- Dihydropyridines can be converted to the corresponding tetrahydropyridines and piperidines through functionalization reactions, or they can be rearomatized to form the corresponding pyridine. (auburn.edu)
- Pyridine is produced either by isolation from natural sources such as coal, or through chemical synthesis (HSDB 1989). (cdc.gov)
Precursor2
- Piperidine is listed as a Table II precursor under the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances due to its use (peaking in the 1970s) in the clandestine manufacture of phencyclidine. (wikipedia.org)
- BMK Glycidic Acid (sodium salt) New Bmk Powder cas 5449-12-7 is an analytical reference standard categorized as a precursor in the synthesis of phenylacetone. (medicalintermediate.com)
Peptide Synthesis9
- The formation of 3-(1-piperidinyl)alanyl-containing peptides via phosphoryl β -elimination was identified from the application of Fmoc-Ser(PO 3 Bzl,H)-OH in peptide synthesis as shown by RP-HPLC, ES-MS and 31 P-NMR analysis. (springer.com)
- In: Pennington MW, Dunn BN (eds) Peptide synthesis protocols. (springer.com)
- Deprotection/cleavage reagents such as TFA (Trifluoroacetic acid) or piperidine, as well as other solvents, Biosolve proposes a complete line of solvents for peptide synthesis . (biosolve-chemicals.eu)
- They are available for both research and large-scale peptide synthesis. (biosolve-chemicals.eu)
- High purity (>99.8%) N,N-Dimethylformamide for peptide synthesis filtered through 0.4µm and ï¬ lled under inert gas. (biosolve-chemicals.eu)
- Peptide synthesis grade N-Methyl-2-pyrrolidone with low water content (max. (biosolve-chemicals.eu)
- For better shelf life, Peptide synthesis grade N-Methyl-2-pyrrolidone is filtered through 0.4µm and bottled. (biosolve-chemicals.eu)
- Piperidine for peptide synthesis is filtered through 0.2µm and bottled under inert gas. (biosolve-chemicals.eu)
- Piperidine is used in peptide synthesis as a base in DMF for a mild deprotection in the Fmoc method. (biosolve-chemicals.eu)
Highly substituted4
- Especially, highly substituted Piperidines have been recognized as an important class of therapeutic agents in the treatment of cancer metastasis, influenza, Parkinson's disease, viral infections including AIDS and diabetes [4]. (lupinepublishers.com)
- So far, to the best of our knowledge, there is no report available on the use of camphor sulfonic acid as an organ catalyst for the synthesis of highly substituted Piperidines. (lupinepublishers.com)
- The pot atom step economic (PASE) synthesis of highly substituted Piperidines from relatively simple starting materials has been reported in the literature. (lupinepublishers.com)
- Synthesis of highly substituted Piperidines involves three component reactions of two equivalents of aldehydes, two equivalents of anilines and one equivalent Β-ketoesters. (lupinepublishers.com)
Inhibitors1
- 3) ergosterol synthesis inhibitors (azoles) and (4) glucan synthesis inhibitors (echinocandins) [7]. (ukdiss.com)
Molecular Formula1
- Piperidine is an organic compound with the molecular formula (CH2)5NH. (wikipedia.org)
Alkyl1
- In the present study, we have docked cis-2,6-dimethyl piperidine sulfonamides (3a-i) on ACNE enzyme and synthesized by nucleophilic substitution reaction between cis-2,6-dimethyl piperidine and alkyl/aryl sulfonyl chlorides in the presence of triethylamine. (uni-mysore.ac.in)
Chemistry1
- Little information concerning the synthesis and chemistry of ferrocenyl-4,5-dihydrooxazoles is available. (degruyter.com)
Reactions1
- Also, camphor sulfonic acid (CSA) is achieving enormous significance in organic synthesis, as this catalyst is used in the synthesis of chromans, ligands, and pseudo glycosides, as an auxiliary and in some polymerization reactions [8]. (lupinepublishers.com)
Analogues1
- Also, some of Piperidines analogues possess enzyme inhibitory activity against farnesyl transferees and dihydroorotate dehydrogenase [3]. (lupinepublishers.com)
Intermediates1
- We investigated the use of boronic acid nucleophiles with rhodium catalysis to create 1,6-dihydropyridines for use as strategic intermediates in natural product synthesis. (auburn.edu)
Inhibition1
- These piperidine sulfonamides were subjected to in vitro AChE enzyme inhibition studies and in vivo antiamnesic study to reverse scopolamine induced memory loss in rats. (uni-mysore.ac.in)
19892
- Bernatowicz M, Daniels S, Koster H (1989) A comparison of acid labile linkage agents for the synthesis of C-terminal amides. (springer.com)
- Otvos L Jr, Elekes I, Lee VM (1989) Solid-phase synthesis of phosphopeptides. (springer.com)
Substrates1
- Enamines derived from piperidine are substrates in the Stork enamine alkylation reaction. (wikipedia.org)
Catalyst2
- Nano-Fe3O4 attached to Crosslinked sulfonated polyacrylamide (Cross-PAA-SO3H) as high performance catalyst for the synthesis of thiazoles under ultrasonic irradiations by: Hossein Shahbazi-Alavi, et al. (uitm.edu.my)
- Synthesis of propargylamines catalyzed by nano-colloidal silica-tethered polyhedral oligomeric silsesquioxanes with eight branches of 3-aminopropyltriethoxysilane as an efficient catalyst by: Safaei-Ghomi Javad, et al. (uitm.edu.my)
Cyclization1
- Collective Syntheses of 8-Oxoprotoberberines via Sequential In(OTf) 3 -Catalyzed Cyclization and Pd(OAc) 2 -Catalyzed Heck Coupling. (bvsalud.org)
Sodium1
- 4 Sodium hydroxide 5 (40%) or piperidine 6 may also be used as catalysts. (orgsyn.org)
Solvent1
- 13C NMR: (CDCl3, ppm) 47, 27.2, 25.2[citation needed] 1H NMR: (CDCl3, ppm) 2.79, 2.19, 1.51[citation needed] Piperidine is used as a solvent and as a base. (wikipedia.org)
Scaffolds1
- One of the main challenges of synthetic chemists lies in the development and implementation of efficient methodologies for the synthesis of biologically significant scaffolds. (lupinepublishers.com)
Deprotection1
- The application of the alternative N α -deprotection protocol using 50% cyclohexylamine/DCM (v/v) is therefore recommended for deprotection of the Fmoc group from the Fmoc-Ser(PO 3 Bzl,H) residue, with particular benefit anticipated for the synthesis of multiphosphoseryl peptides. (springer.com)
Nitrile1
- This is the synthesis of the 3-substituted nitrile by the Gould-Jacobs reaction from the aniline and a ethyl (ethoxymethylene)cyanoacetate (both of which are reasonably priced too! (sciencemadness.org)
Widely2
- Piperidine is widely used to convert ketones to enamines. (wikipedia.org)
- Donazepil is a widely prescribed ACNE inhibitor which displays a piperidine ring in its structure. (uni-mysore.ac.in)
Fmoc2
- Attard TJ, O'Brien-Simpson N, Reynolds EC (2007) Synthesis of phosphopeptides in the Fmoc mode. (springer.com)
- Perich JW, Ede NJ, Eagle S, Bray AM (1999) Synthesis of phosphopeptides by the Multipin method: evaluation of coupling methods for the incorporation of Fmoc-Tyr(PO3Bzl, H)-OH, Fmoc-Ser(PO3Bzl, H)-OH and Fmoc-Thr(PO3Bzl, H)-OH. (springer.com)
Synthesize1
- Boehm in 1943 reported the first multi component reaction between an amine, aldehydes and 1,3-dicarbonyl to synthesize functionalized piperidines [14]. (lupinepublishers.com)
Aromatic1
- An efficient pseudo six-component synthesis of bis-spiropiperidinesis presented by one-pot condensation of formaldehyde, aromatic amine and dimedone or N,N-dimethyl-barbituric acid using CeO2/CuO@N-GQDs@NH2 nanocomposite at room temperature. (uitm.edu.my)
Protocols1
- Absences of transition metals make these protocols attractive for the synthesis of pharmaceutical products [6]. (lupinepublishers.com)