Synthesis drug stability. Medical search. Frequent questions

My teaching activities cover all aspects of organic chemistry from basic structure and bonding in organic molecules, to complex organic synthesis. (exeter.ac.uk)
The second major area of my group's research has involved studies into the use of structurally 'unusual' heterocycles as protected, reactive functional groups in organic synthesis. (exeter.ac.uk)
Cytoxic Manufacture and Complex Organic Synthesis. (almacgroup.com)

In this work, 28 GaMF1 analogs are synthesized to overcome those issues and improve both ATP synthesis and mycobacterial growth inhibition. (ntu.edu.sg)
In this work, 16 EGCG analogs are synthesized to understand the structure-activity relationship in which both catechin and gallate ester moieties are required for mycobacterial ATP synthesis inhibition. (ntu.edu.sg)
Additionally, catechol ester can improve the effectiveness of inhibiting ATP synthesis in catechin analogs. (ntu.edu.sg)
The structural motifs of a leading NCE candidate are then optimized for biological activities and safety by the synthesis of a series of analogs. (chromatographyonline.com)
In this study, in order to identify the reactive metabolite of NVP mainly responsible for CYP inhibition and liver injury, we synthesized five NVP analogs designed to avoid the proposed bioactivation pathway and evaluated their metabolic stabilities, CYP3A4 time-dependent inhibitory activities, and cytotoxicity. (unboundmedicine.com)

This dissertation describes the synthesis, characterization, and investigation of novel zwitterionic polymers containing phosphorylcholine (PC), sulfobetaine (SB), and functional choline phosphate (CP) zwitterions for use as surfactants, self-assembled nanomaterials, and therapeutics. (umass.edu)
Here, we describe the synthesis of a new heptamethine indocyanine dye (NIR-27) modified with a glycine at the end of each N-alkyl side chain, and its biological characterization for in vivo cancer-targeted NIR imaging. (dovepress.com)

their stability and ability to catalyse oxygen atom transfer (in particular the oxidation of sulfite) will be assessed and their suitability to bind in the active site pocket of the protein and restore activity will be tested. (europa.eu)
As you can imagine, any spelling error that stops the synthesis of this protein, you end up with a one-ended shock absorber and it can't work. (thenakedscientists.com)
The goal of this project is the synthesis of small molecule inhibitors of HCV that specifically target the NS2 protease and furthers our fundamental understanding of this important protein. (concordia.ca)
Usually, human proteins remain stable up to about 40°C. Higher temperatures are of course not found in the body, but the stability of C4BP has a completely different purpose: "As is the case with all components of the complement system, the C4b binding protein is present in blood plasma. (nanowerk.com)
Therefore, the protein needs a high stability in order to be able to withstand these forces. (nanowerk.com)
Practically used in drug development and protein engineering, this product comes with rigorous quality assurance. (procure-net.com)
An anticancer drug is coupled to an antibody that targets a specific tumor antigen (or protein ) that, ideally, is only found in or on tumor cells. (wikipedia.org)
It acts by binding to the 30S ribosomal subunit of the organism, thereby inhibiting protein synthesis. (medscape.com)
The eIF2B protein helps regulate overall protein production (synthesis) in the cell by interacting with another protein, eIF2. (medlineplus.gov)
The eIF2 protein is called an initiation factor because it is involved in starting (initiating) protein synthesis. (medlineplus.gov)
Proper regulation of protein synthesis is vital for ensuring that the correct levels of protein are available for the cell to cope with changing conditions. (medlineplus.gov)
Partial loss of eIF2B function makes it more difficult for the body's cells to regulate protein synthesis and deal with changing conditions and stress. (medlineplus.gov)

The use of radical-based methodology in the synthesis of highly substituted amines and amino acids. (exeter.ac.uk)

Chemical synthesis is an essential field of study that involves creating new compounds through various reactions and processes. (popherald.com)
This article explores the practical applications of chemical synthesis in different industries and research fields, highlighting its importance and impact on modern society. (popherald.com)
Chemical synthesis plays a vital role in creating new pharmaceuticals by synthesizing target compounds that exhibit desired biological activity. (popherald.com)
Chemical synthesis is used to produce the active ingredients of medications, ensuring their purity and effectiveness. (popherald.com)
Chemical synthesis enables the creation of libraries of diverse compounds, which are screened for potential therapeutic activity. (popherald.com)
Chemical synthesis assists in modifying drugs to optimize their chemical properties, such as solubility, stability, and target selectivity. (popherald.com)
Chemical synthesis enables the production of nanomaterials with tailored properties for use in electronics, energy storage, catalysis, and biomedical applications. (popherald.com)
Chemical synthesis is utilized to develop lubricants and coatings with enhanced wear resistance, friction reduction, and corrosion protection capabilities. (popherald.com)
Chemical synthesis is necessary for creating catalysts with specific compositions and structures, enabling efficient chemical reactions in industrial processes. (popherald.com)
Chemical synthesis helps create composite materials by combining different substances to achieve improved properties, such as strength, toughness, and heat resistance. (popherald.com)
Chemical synthesis is employed to develop chemicals that aid in the purification of water, including disinfectants, adsorbents, and coagulants, to address water pollution challenges. (popherald.com)
Chemical synthesis contributes to the production of catalysts and absorbents used in air purification systems, reducing harmful emissions from industrial processes and vehicles. (popherald.com)
Chemical synthesis is important in the development of materials and catalysts for energy conversion and storage technologies, such as fuel cells, batteries, and solar cells. (popherald.com)
Chemical synthesis plays a role in transforming waste materials into useful products through processes such as pyrolysis and gasification, reducing the environmental impact of waste disposal. (popherald.com)
Chemical synthesis aids in the creation of sensors and probes for the detection and monitoring of pollutants, facilitating environmental research and regulation. (popherald.com)
Chemical synthesis enables the development of effective pesticides and herbicides to protect crops from pests and weeds, ensuring higher agricultural yields. (popherald.com)
Chemical synthesis is used to produce fertilizers that provide essential nutrients to enhance plant growth and improve soil quality. (popherald.com)
Chemical synthesis aids in the creation of plant growth regulators that control the growth, development, and metabolism of crops, optimizing agricultural practices. (popherald.com)
Chemical synthesis contributes to the production of food additives, such as preservatives and flavor enhancers, ensuring food safety and enhancing the sensory experience. (popherald.com)
Chemical synthesis is used to create seed treatments that protect seeds from diseases, pests, and environmental stress, promoting successful germination and crop establishment. (popherald.com)
Chemical synthesis enables the generation of diverse libraries of compounds for use in drug discovery, materials science, and other research areas, facilitating innovative discoveries. (popherald.com)
Chemical synthesis is essential for creating small molecules that selectively bind to specific biological targets, aiding in the understanding of biological processes and disease mechanisms. (popherald.com)
Chemical synthesis is used to produce reference standards that serve as quality control tools, ensuring the accuracy and reliability of analytical measurements in research and industry. (popherald.com)
They are considered to be next-generation drugs due to two important factors: firstly, they act not only on proteins that have traditionally been targeted by conventional small-molecule or antibody base drugs, but also on functional RNA such as mRNA and miRNA, and secondly they can be manufactured by chemical synthesis, which means that they can be easily mass produced. (jascoinc.com)
For two service sectors, chemical synthesis and fill-finish, anticipated spending increased between the first and third quarters (see Figure 4). (biopharminternational.com)
During drug discovery, the medicinal chemist focuses on synthesizing new chemical entities (NCEs) that interact selectively with the molecular targets (such as receptors or enzymes), leading to potential disease mitigation (1). (chromatographyonline.com)
This plays an important role in the synthesis of a wide-range of chemical structures, including many drugs that are used to treat numerous diseases. (concordia.ca)
Prodrugs are derivatives of drug molecules that are pharmacologically inactive but require either chemical or enzymatic transformation to release the active drug in vivo in order to exert a pharmacological effect. (ijpsonline.com)
CSS - (Chemical Synthesis Services) - one of Europe's leading providers of chemistry and analytical services - announced at the recent AusBiotech Conference in Perth (20th-22nd November) that it plans to extend its global reach to the Australian Market. (almacgroup.com)
Additionally, DMSO is used in chemical synthesis, particularly in medicinal chemistry. (precedenceresearch.com)

This first installment provides a comprehensive and updated overview of stability studies and testing of small molecule drugs, current regulatory requirements, and industry practices for forced degradation, as well as possible approaches for reduced testing and data evaluation to expedite stability study timelines. (chromatographyonline.com)

Tobias Bauer developed polymers - chains of molecules - and nanoparticles for better drug delivery. (universiteitleiden.nl)
Oligonucleotide therapeutics are mainly based on artificial oligonucleotides that are chemically modified DNA or RNA, which improves their structural stability in the human body and affinity to their target molecules 1 ). (jascoinc.com)
The evaluation of their interaction characteristics with target molecules and use as drugs, optimization of their number of the bases and sequence are critical. (jascoinc.com)
Various synthetic methods have shown for these drug molecules. (eurekaselect.com)
In this area, we have developed a methodology for the incorporation of protected isocyanates into organic molecules and this chemistry is being applied to the synthesis of a diverse set of biologically important, nitrogen-containing heterocycles. (exeter.ac.uk)
We can use the oligomerisation domain as a framework, in order to decorate it with drug molecules. (nanowerk.com)
Providing services for all stages of drug development for small (including highly potent) molecules and peptides. (almacgroup.com)
ADCs are complex molecules composed of an antibody linked to a biologically active cytotoxic (anticancer) payload or drug. (wikipedia.org)

The conformational restriction has led to the enhancement in target selectivity and in vivo stability of the nucleoside-based drug candidates. (beilstein-journals.org)

Polymer conjugation significantly improved the solution stability of TMZ, and the antitumor activity of polyMPC-TMZ prodrugs was demonstrated in TMZ-sensitive (U87MG) and TMZ-resistant (T98G) glioblastoma cell lines. (umass.edu)

Recently, EGCG was discovered to have promising enzymatic activity at the nanomolar level to inhibit Mycobacterium ATP synthesis by interfering with Mycobacterium FoF1-ATP synthase at the ε subunit. (ntu.edu.sg)
These prodrugs subsequently undergo enzymatic or non-enzymatic cleavage to release the active drug moiety (figure 1) [ 12 , 13 ]. (ijpsonline.com)

Medically reviewed by Drugs.com on Aug 21, 2023. (drugs.com)

Acetylation enhances the solubility and stability of certain amino acids. (swansonvitamins.com)

We have prepared derivatives of erythromycin B as putative paediatric prodrugs, taking advantage of the much improved acid stability of erythromycin B relative to erythromycin A. Thus, erythromycin B enol ether ethyl succinate is very poorly soluble in water, and its hydrolysis is undetectable in conditions resembling the medicine bottle. (nih.gov)

How can I modify the shape of the nanoparticles, how to modify their stability or scale up their synthesis? (universiteitleiden.nl)

These compounds serve as valuable starting points for drug discovery programs. (popherald.com)
Natural products continue to be an abundant source of lead compounds for drug discovery and development. (figshare.com)
The synthesis of TAN-2483B is therefore desirable from a drug discovery perspective. (figshare.com)
The present review is expected to be useful for scientists working in the field of drug discovery and development. (ijpsonline.com)
Dalton Pharma Services is a leading North American cGMP pharmaceutical organization providing integrated drug discovery, development, and manufacturing services. (dalton.com)
Our integrated services (drug discovery, formulation and process development, custom synthesis, cGMP sterile fill/finish of liquids and powders, cGMP API manufacturing and/or dosage form manufacturing, and Accelerated Stability Testing) all at one location helps us to be adaptable, flexible and cost-effective. (dalton.com)
CSS will provide radiolabelling services for the development of compounds from drug discovery to launch of API. (almacgroup.com)
CSS is an affiliated company of Almac Sciences which provides pharmaceutical services across drug discovery, manufacture of API, clinical trials and drug product manufacture. (almacgroup.com)

Prodrug concept is justified because it enables the active drug to overcome the barrier that would impede it from reaching the site of action to exert the required pharmacological activity. (ijpsonline.com)

In the first part of the project, I carried out the synthesis of the 9-residue peptide P9Nal(SS) which contains unnatural amino acids. (unina.it)
Recently, GaMF1 was reported to exhibit good inhibition in ATP synthesis of Mtb by binding at a unique and crucial peptide loop in the γ-subunit of Mycobacterium FoF1-ATP synthase. (ntu.edu.sg)

Here we describe an oral dosage form composed of distinct drug-polymer matrices which achieved week-long systemic drug levels of the antiretrovirals dolutegravir, rilpivirine and cabotegravir in a pig. (nature.com)
Facile, reproducible, and modular chemistries were utilized for incorporating zwitterions into a range of polymer backbones, and strategies were developed for overcoming difficult challenges encountered in zwitterionic polymer synthesis, especially related to the varying solubility of zwitterions, hydrophobic polymers, and functional comonomers. (umass.edu)
The impact of drug loading, polymer architecture, and adjuvant co-delivery on the cytotoxicity of polyMPC-TMZ conjugates was investigated. (umass.edu)

Through the copolymerization of PC- and CP-methacrylate monomers, functional mimics of conventional Pluronic structures became amenable to crosslinking and the successful synthesis of nanomaterials and robust gels. (umass.edu)
Nanomaterials have demonstrated a wide range of applications and recently, novel biomedical studies are devoted to improving the functionality and effectivity of traditional and unmodified systems, either drug carriers and common scaffolds for tissue engineering or advanced hydrogels for wound healing purposes. (researchgate.net)

Water-Insoluble Drug Formulation, Second Edition. (wikipedia.org)
The prodrug approach using various carriers has evolved as a significant tool in surmounting different obstacles in relation to drug formulation and targeting. (ijpsonline.com)
With a significant pharmaceutical presence, DMSO plays a pivotal role in drug formulation and research, aligning with the region's healthcare advancements. (precedenceresearch.com)
The pharmaceutical sector's continuous growth and the essential role of DMSO in drug formulation and delivery drive market demand. (precedenceresearch.com)

Binds to one or more PBPs, which, in turn, inhibit cell wall synthesis and result in bactericidal activity. (medscape.com)

The Live Online Training is designed for all persons involved in the compilation of pharmaceutical dossiers for marketing authorisations especially for Drug Master Files who want to become familiar with the different DMF procedures. (gmp-compliance.org)
An expiration date is required by regional laws to ensure the safety, efficacy, and quality of the drug products, and that these criteria are maintained throughout the labeled shelf life of the pharmaceutical product. (chromatographyonline.com)
Nevertheless, stability programs and their practices can vary widely, particularly between large and small pharmaceutical companies, often due to the depth of knowledge and available resources. (chromatographyonline.com)
The stability profile, a critical quality attribute (CQA) of a pharmaceutical entity, is based primarily on the physicochemical properties of the drug substance (DS) and drug product (DP). (chromatographyonline.com)
In most pharmaceutical companies, the nomination of an NCE to the status of a drug development candidate triggers the formation of a multidisciplinary technical development team. (chromatographyonline.com)
Fmoc-Ser(Bzl)-OH is a top-quality pharmaceutical product intended for proficient synthesis. (procure-net.com)
Fmoc-Ser(Bzl)-OH is a superior pharmaceutical product with optimal efficacy in synthesis. (procure-net.com)
Fmoc-Ser(Bzl)-OH is designed for industrial pharmaceutical synthesis and should be handled by professionals. (procure-net.com)
It plays a pivotal role in the pharmaceutical sector, facilitating drug delivery and acting as a cryoprotectant. (precedenceresearch.com)
Relevant of mutagenicity and clastogenici- angiosarcomas of the liver, which carcinogens discussed in this chap- ty, including the induction of sister are rare tumours, were identified in ter do not include pharmaceutical chromatid exchange (SCE), chro- humans, rats, and mice exposed to drugs classified in Group 1, which mosomal aberrations (CA), and mi- vinyl chloride. (who.int)

Though several studies have been carried out on various prodrugs, surprisingly very few reviews on different carriers, which can be used for prodrug synthesis were published to date. (ijpsonline.com)
Prodrugs have better delivery properties that surpass the parent drug molecule [ 1 ]. (ijpsonline.com)
Around 10 % of marketed medicines can be categorized as prodrugs currently, and also that during 2008, 33 % of approved small molecular weight drugs were prodrugs [ 5 - 7 ]. (ijpsonline.com)
Carrier-linked prodrugs are for drugs with major drawbacks, which are linked to a nontoxic carrier or promoiety through covalent linkage to change or get rid of their undesirable physicochemical properties. (ijpsonline.com)

Additionally, these biological materials from drug carriers require complex syntheses and are relatively expensive 12 , which create great obstacles for effective clinical application. (nature.com)
2 , 3 The heart of NIR imaging lies in the development of fulfilling fluorochromes, which must have a high molar absorption coefficient for intense fluorescence, good biocompatibility with low toxicity, and sufficient stability and water solubility in the complex biological environment. (dovepress.com)

Documentation of the drug substance quality is an integral part of any marketing authorisation application. (gmp-compliance.org)
The specifications also control the mutagenic 9-propenyladenine, which is a synthesis related substance, at 5 ppm. (who.int)
Delivering comprehensive solutions to support drug substance (API) and drug product development programs. (almacgroup.com)

In the past, "final determination" (for drugs approved under section 505) was interpreted to require publication of a final Federal Register notice under the Drug Efficacy Study Implementation (DESI) program. (fda.gov)
For example, lack of efficacy of various formulations of tenofovir-based PrEP 17 in the VOICE trial were explained, in part, by undetectable drug levels in many participants 17 and imperfect adherence was also implicated for the lack of efficacy in the FEM-PrEP trial 18 . (nature.com)
However, clinical researchers continually find that the involvement of drug carriers may lead to poor biocompatibility and biodegradability, low loading efficacy, and potential side effects. (nature.com)
12 , 13 Despite the fact that the conjugation strategies described above demonstrate some efficacy, the specificity for drug delivery, the potency of cancer therapeutics, and the potential for clinic application still remain unsatisfactory. (dovepress.com)
Peak serum levels correspond to efficacy of the drug. (medscape.com)

A program developed at Rice University details stable forms of collagen proteins for synthesis in the lab. (analytica-world.com)
Several molecular mechanisms with antifungal agents have been reported for C. albicans where insertions, deletions, and point mutations in genes codifying target proteins are frequently related to the antifungal drug resistance. (intechopen.com)

It is believed that, due to the unique mode of action, AMPs could overcome the problem of resistance to conventional antibiotics in multi-drug resistant bacteria and even to currently used anticancer drugs for the treatment of tumor cells. (unina.it)

Nevertheless, the water solubility and in vivo stability of GaMF1 are potentially problematic. (ntu.edu.sg)

Recent studies have focused on asymmetric synthesis of structurally complex amino acids, using what has proved to be a very versatile radical-based methodology and also the use of structurally unusual heterocycles for masking the reactivity of synthetically valuable functional groups. (exeter.ac.uk)
NMR spectroscopy or X-ray crystallography, but important width measurements at a single resonance frequency (or questions remain concerning the energetics, stability, and magnetic field strength), making it difficult to separate dynamics of this structurally diverse nucleic acid class. (lu.se)

Interestingly, sterile compounds and stability, storage, and testing experienced a drop in second-quarter projected spending, though projected budget allocation stayed consistent from the first quarter to the third (see Figure 6). (biopharminternational.com)

In this comprehensive overview of stability studies and testing, we summarize current regulatory requirements, share industry practices for forced degradation, and explain approaches for reduced testing and data evaluation to expedite stability study timelines. (chromatographyonline.com)

Their discoveries have facilitated biochemical synthesis of the molecule. (nanowerk.com)

This installment is the first of a series of three white papers on stability studies and testing of pharmaceuticals, as well as the development and validation of stability-indicating high performance liquid chromatography (HPLC) methods. (chromatographyonline.com)
Introduction (S)-(-)-2-Methyl-2-propanesulfinamide is widely used in the synthesis of novel pharmaceuticals and serves as an important chiral source for amine-based drugs. (guidechem.com)

In this review different types of carriers, which can be used for prodrug synthesis are summarized. (ijpsonline.com)
The objective of this review is to provide the researchers with a compilation of which carriers would be suitable for prodrug synthesis and what would be their benefits. (ijpsonline.com)
Self-assembling natural drug hydrogels formed without structural modification and able to act as carriers are of interest for biomedical applications. (nature.com)

In 2001 Pfizer / Wyeth 's drug Gemtuzumab ozogamicin (trade name: Mylotarg) was approved based on a study with a surrogate endpoint , through the accelerated approval process . (wikipedia.org)
On May 10, 2021, the Food and Drug Administration (FDA) issued an Emergency Use Authorization (EUA) for Pfizer-BioNTech COVID-19 vaccine in persons aged 12-15 years for prevention of COVID-19. (cdc.gov)

Despite the advances in the therapies available to treat HCV, a major concern is the emergence of drug-resistant variants of the virus. (concordia.ca)

As with penicillins, inhibits third and final stage of bacterial cell wall synthesis by preferentially binding to specific PBPs located inside the bacterial cell wall. (medscape.com)

In a development that could lead to better drug design and new treatments for disease, Rice University researchers have made a major step toward synthesizing custom collagen. (analytica-world.com)
However, development of such a system has previously proven difficult due to the limited residence of drugs in the gastrointestinal tract 39 . (nature.com)
The NIAID's focus on product development makes the kinds of studies that resulted in these licensures available to companies and/or academic investigators who are developing drugs for a radiation indication. (nih.gov)
Right analytics at right time" plays significant role in drug product development cycle and is expected to strengthen by implementation of analytical quality by design (AQbD). (ijpsonline.com)
synthetic development of any drugs. (eurekaselect.com)
DMSO's role in drug development and biopharmaceutical applications remains pivotal. (precedenceresearch.com)

With its superior grade purity, Fmoc-Ser(Bzl)-OH guarantees robust and reliable synthesis results each time. (procure-net.com)

As such, P4-3-CMO could have both improved absorption and increased metabolic stability relative to progesterone. (wikipedia.org)

Several analytical techniques are available for analysis of both the drugs individually as well as in combination with other drugs [ 10 - 15 ]. (ijpsonline.com)

The desired NCEs need to be reasonably stable to be viable drug candidates, which are scaled up for clinical trials using simple formulations. (chromatographyonline.com)

In those GLP studies, both growth factor-based drugs improved survival when administered 24 hours after radiation exposure. (nih.gov)
Most companies have established standard operating procedures (SOPs) to supplement regulatory guidelines to provide more specific details, to ensure that stability studies are appropriate for their specific product types. (chromatographyonline.com)
Table I summarizes the characteristics of stability studies and testing. (chromatographyonline.com)
In an unusual departure from the radiolabelling service provided by others, CSS will also offer GMP synthesis of Carbon-14 labelled API for clinical studies. (almacgroup.com)

Removal of a purification step enabled the more expedient two-step synthesis of a diol intermediate. (figshare.com)

In addition alternative metals will be investigated with respect to possible benefits regarding stability and activity. (europa.eu)

ABSTRACT: The structural stability of guanine quadruplexes depends critically on an unusual configuration of dehydrated Na+ or K+ ions, closely spaced along the central axis of the quadruplex. (lu.se)

Drugs with low aqueous solubility are not absorbed well in the intestines because their dissolution in water is limited. (wikipedia.org)

138. One comment urged that the changes in the regulation on drug master files should apply only to information added to the master file after the date of publication of the final rule. (fda.gov)
FDA believes that a uniform effective date for changes in the regulation on drug master files is necessary. (fda.gov)
Introduction: Bisphosphonates (BP) are effective drugs in the prevention and treatment of various bone pathologies, acting in the regulation of osteoclast function through different mechanisms. (bvsalud.org)

So if the gene is not working in a cell, like in a skin cell or a liver cell, the drug won't do anything. (thenakedscientists.com)

In June 2010, after evidence accumulated showing no evidence of benefit and significant toxicity, the U.S. Food and Drug Administration (FDA) forced the company to withdraw it. (wikipedia.org)

The ability to synthesize custom collagen could lead to better drug design and treatment of disease. (analytica-world.com)
Our approach is to design a drug that acts as a genetic white-out, or a correcting fluid for the gene message. (thenakedscientists.com)

In vitro stability in human serum at 37°C was analyzed using radio-thin layer chromatography and radio-high-performance liquid chromatography. (snmjournals.org)
In vitro stability in human serum was at least 95% after 4 h of incubation. (snmjournals.org)
Subsequently, rhein hydrogels alleviate neuroinflammation with a long-lasting effect and little cytotoxicity compared to the equivalent free-drug in vitro. (nature.com)

A lack of knowledge about natural drug gels limits there current application. (nature.com)

The pro-drug has increased oral bioavailability compared to tenofovir. (who.int)

Antibody-drug conjugates or ADCs are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer. (wikipedia.org)

This process involves designing, optimizing, and synthesizing the drug candidates. (popherald.com)

Fluid-Dynamic Drag is a compilation of a vast amount of theoretical and experimental information about aerodynamic drag. (kitplanes.com)

Aspirin (ASP, Figure 1a ), is one of the most widely used drugs for analgesia, inflammation and antipyresis. (ijpsonline.com)

These approvals have paved the way for use of these already-stockpiled drugs, without the need for an Emergency Use Authorization (EUA), and has elevated their use to an expected standard of care in a mass casualty, radiation public health emergency. (nih.gov)

Research on therapeutic drug targets and vaccines for these viruses is limited because biosafety level 4 containment is required for handling them. (cdc.gov)

So it is working, but we have to make it work a little more efficiently, and that's why we're improving delivery or increasing the potency of the drug. (thenakedscientists.com)
The prodrug approach is rapidly becoming a crucial part in the stratagem of delivery of drugs. (ijpsonline.com)
Smart materials that can be triggered by external stimuli are seen with high potential for innovative treatments and improved drug delivery systems by regulatory agencies like the FDA and EMA. (researchgate.net)

Organic synthesis3

Analogs5

Characterization2

Protein12

Amines1

Chemical30

Small-molecule1

Molecules8

Selectivity1

Antitumor activity1

Enzymatic2

20231

Solubility and stability1

Derivatives1

Nanoparticles1

Discovery8

Pharmacological1

Peptide2

Polymer3

Nanomaterials2

Formulation4

Inhibit1

Pharmaceutical10

Prodrugs4

Biological2

Substance3

Efficacy5

Proteins2

Anticancer1

Water solubility1

Structurally2

Sterile1

Evaluation1

Molecule1

Pharmaceuticals2

Carriers3

Pfizer2

Emergence of drug-resistant1

Bacterial1

Development6

Purity1

Metabolic1

Analytical1

Stable1

Studies4

Purification1

Metals1

Abstract1

Aqueous1

Regulation3

Liver1

Toxicity1

Design2

Vitro3

Gels1

Bioavailability1

Biopharmaceutical1

Candidates1

Compilation1

Widely1

Emergency Use Authorization1

Vaccines1

Delivery3