Synthesis cholesterol. Medical search. Frequent questions

However, the therapeutic effects of cholesterol-lowering drugs on HCC are controversial, indicating that the relationship between cholesterol metabolism and HCC is more complex than anticipated. (nature.com)
Cellular metabolism, involving the synthesis and breakdown of complex organic molecules, requires harmonious coordination of the various enzymes, biochemical reactions, and so forth. (newworldencyclopedia.org)
Cholesterol-related disorders have been associated with sEH, which plays an important role in the metabolism of cholesterol precursors. (frontiersin.org)
Finally, this review focused on the metabolism of cholesterol and its association with AD. (frontiersin.org)
Cholesterol metabolism in the brain is independent of peripheral tissues due to the blood-brain barrier (BBB) that impairs the entrance of the protein-bound lipid into the central nervous system (CNS). (frontiersin.org)
Brain tissues contain large amounts of cholesterol, up to 25% of the body's cholesterol content ( Dietschy, 2009 ) whose metabolism and complex homeostasis regulation in the CNS remain unclear ( Zhang and Liu, 2015 ). (frontiersin.org)
Finally, we discuss cholesterol metabolism and its implication in AD. (frontiersin.org)
Proprotein convertase subtilisin/kexin type 9 (PCSK9)-antibodies are known to reduce LDL-c, and decrease the risk of cardiovascular events, but there is limited evidence regarding the interrelations between PCSK9 metabolism, cholesterol synthesis, and cholesterol absorption [1]. (pace-cme.org)
2009. The relationships of cholesterol metabolism and plasma plant sterols with the severity of coronary artery disease. (pace-cme.org)
2010. The associations of cholesterol metabolism and plasma plant sterols with all-cause and cardiovascular mortality. (pace-cme.org)
Concentrations of cholesterol and triglycerides are strongly correlated in the adipocyte, but little is known about mechanisms regulating cholesterol metabolism in fat cells. (jci.org)
While the physiological role of adipose tissue in cholesterol and oxLDL metabolism remains to be established, the induction of OLR1 is a potential means by which PPARγ ligands regulate lipid metabolism and insulin sensitivity in adipocytes. (jci.org)
The thyroid hormone regulates energy and fat metabolism and protein synthesis by regulating different enzymes that are involved in those processes. (cdc.gov)
Farese RV Jr, Herz J. Cholesterol metabolism and embryogenesis. (medscape.com)
Pathway enrichment analysis highlighted branch-chained and aromatic amino acid synthesis/metabolism, aminoacyl-tRNA biosynthesis, and sphingolipid metabolism. (lu.se)
Conclusion: Our data suggest a graded derangement of the circulating metabolite profile from lean to obese to MetS, in particular for metabolites involved in amino acid synthesis/metabolism and sphingolipid metabolism. (lu.se)
Cerebrotendinous xanthomatosis is a rare genetic metabolic disorder of cholesterol and bile acid metabolism that results in systemic and neurologic abnormalities. (medscape.com)
2. Some biological importance of the above disturbances seem evident if one considers the influence of nicotinic acid on the pathways of the lipid metabolism: Chronic exposure to CS2 results in changes of the lipid metabolism consisting of an increase of the cholesterol, phospholipids and triglycerides in blood. (cdc.gov)

Cholesterol is a tetracyclic alcohol and a type of sterol. (wikipedia.org)
The rates of sterol synthesis were estimated in vivo with 1-14C acetate, as previously validated. (bmj.com)
The rates of HDL uptake in the upper villus cells were similar along the length of the small intestine in both types of rat, but the rates of sterol synthesis varied up to eightfold. (bmj.com)
Plasma levels of the cholesterol precursor sterol squalene were only slightly increased (6%), suggesting enhanced conversion of squalene to lathosterol in this disorder. (ru.nl)
Plant sterols are structurally similar to cholesterol except for substitutions at the C24 position on the sterol side-chain. (medscape.com)
Cholesterol is a sterol, a type of lipid molecule composed of a complex structure of four fused hydrocarbon rings. (biochemden.com)
In this situation, the increases in sterol mass should be attributable solely to de novo sterol synthesis. (nih.gov)
Sterol synthesis was only modestly decreased (about 30%) when the cells were cultured in media prepared with whole calf serum. (nih.gov)
In spite of the capacity to furnish its sterol requirements by de novo synthesis, the lens epithelial cells readily degraded 125I-labeled bovine LDL, and LDL greatly decreased sterol synthesis when added to the media at low levels. (nih.gov)
Sterol synthesis was also reduced in the large intestine and stomach. (elsevierpure.com)
Whole body cholesterol synthesis, fractional cholesterol absorption, and fecal neutral and acidic sterol excretion were not consistently changed with Ro 48-8071 treatment. (elsevierpure.com)
LDL-cholesterol more than 152 mg/dl (15% f or sterol-enriched yogurt and 12% for tomato sauce at high adherence). (researchgate.net)
cialised sterol-enriched yogurt in term of absolute LDL-cholesterol change. (researchgate.net)
The primary enzymatic defect in cerebrotendinous xanthomatosis is in mitochondrial sterol 27-hydroxylase, a key enzyme in the complicated process of bile acid synthesis from cholesterol. (medscape.com)

in the absence of a particular enzyme, the abnormal or unregulated synthesis of complex molecules might result. (newworldencyclopedia.org)
The first and rate-limiting step of cholesterol synthesis is the conversion of acetyl-CoA to mevalonate by the enzyme HMG-CoA reductase (HMGCR) . (biochemden.com)
Cholesterol synthesis starts in the cell's cytosol with the conversion of two molecules of acetyl-CoA into a four-carbon molecule called acetoacetyl-CoA, which is then converted into 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) by the enzyme HMG-CoA synthase . (biochemden.com)
The next step of cholesterol synthesis occurs in the endoplasmic reticulum (ER), where HMG-CoA is converted into mevalonate by the enzyme HMG-CoA reductase (HMGCR) . (biochemden.com)
The next step of cholesterol synthesis involves condensing six isoprene units (three IPP and three DMAPP) to form a 30-carbon molecule called squalene, which is catalyzed by the enzyme squalene synthase . (biochemden.com)
Given that brain cholesterol disturbances play a role in the onset of Alzheimer's disease (AD) as well as of other neurodegenerative diseases, understanding the functions of this enzyme could provide pivotal information on the pathophysiology of these conditions. (frontiersin.org)
The loss-of-function mutation seen in CHILD syndrome prevents the NSDHL enzyme from catalyzing a step in the cholesterol biosynthetic pathway. (medscape.com)
CHILD syndrome is caused by an X-linked dominant mutation in the NSDHL gene encoding for an enzyme in the cholesterol biosynthetic pathway. (medscape.com)
ACL is an enzyme upstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase in the cholesterol biosynthesis pathway. (medscape.com)

Mevalonate then undergoes a series of enzymatic reactions to form isoprenoids, precursors of cholesterol. (biochemden.com)

The role of abnormalities in the distal pathway of cholesterol synthesis in the Congenital Hemidysplasia with Ichthyosiform erythroderma and Limb Defects (CHILD) syndrome. (medscape.com)

In response to treatment with PCSK9-antibodies, circulating PCSK9 strongly increased in all groups, whereas total cholesterol, triglycerides, and LDL-c decreased in all groups. (pace-cme.org)
Low "good" HDL cholesterol and high triglycerides are also linked to increased risk ( 2 ). (healthline.com)
An analysis of 10 studies determined that substituting avocados for other fats was linked to lower total cholesterol, LDL and triglycerides ( 7 ). (healthline.com)
Studies have shown that fasting may not influence total cholesterol, LDL-C and HDL-C. 8 Recent recommendations advocate re-testing if LDL-C or triglycerides (TGs) are raised. (uk.com)
Excess abdominal fat is associated with higher total cholesterol, LDL and triglycerides and lower HDL cholesterol. (bvsalud.org)
There are 2 major types of lipids in the study comprising 1155 diabetic type 2 pa- blood: cholesterol and triglycerides. (who.int)

Absolute rates of cholesterol synthesis were estimated for the cultured cells from incorporation of [3H]water. (nih.gov)

and the liver is the main organ for its synthesis. (nature.com)
An imbalance in cholesterol homeostasis can contribute to liver injury, which triggers HCC. (nature.com)
It is reported that hepatic accumulation of cholesterol drives liver injury and subsequent HCC [ 7 ]. (nature.com)
Cholesterol homeostasis requires collaboration between various organs, which ensures a balance between cholesterol absorption (in the intestine) and cholesterol synthesis and removal in the liver [ 14 ]. (nature.com)
The liver preferentially excretes plant sterols over cholesterol. (medscape.com)
In the liver, cholesterol and plant sterols may be transported to peripheral tissues by very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL), converted to bile acids, or transported out of the liver into the bile for excretion. (medscape.com)
In peripheral tissues, the ABC1 transporter (defective in Tangier disease) delivers cholesterol to high-density lipoprotein (HDL) for return to the liver. (medscape.com)
Congenital bile acid synthesis defect type 1 is a disorder characterized by cholestasis, a condition that impairs the production and release of a digestive fluid called bile from liver cells. (medlineplus.gov)
As a result, cholesterol and other fats build up in the liver and fat-soluble vitamins are not absorbed, which contribute to the signs and symptoms of congenital bile acid synthesis defect type 1. (medlineplus.gov)
Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease. (medlineplus.gov)
Cholesterol synthesis occurs mainly in the liver and other tissues, such as the intestine and adrenal glands. (biochemden.com)
This is articulated through the interplay of a constellation of genes that ultimately determines the net amount of chylomicron cholesterol delivered to the liver. (elsevierpure.com)
The liver stores of fat soluble vitamins (A, D, E, K). Cholesterol is synthesized in the liver. (histology-world.com)
Bempedoic acid is a first-in-class adenosine triphosphate-citrate lyase (ACL) inhibitor that lowers low-density lipoprotein cholesterol (LDL-C) by inhibiting cholesterol synthesis in the liver. (medscape.com)

[ 8 ] The exact pathogenesis by which this mutation causes the clinical findings in individuals with CHILD syndrome is still under investigation, but contributing factors likely include deficient cholesterol synthesis, buildup of toxic metabolites in the cholesterol biosynthesis pathway, and abnormal sonic hedgehog signaling. (medscape.com)

To reduce the risk of myocardial infarction, myocardial revascularization procedures, and cardiovascular mortality in adults with elevated low-density lipoprotein cholesterol (LDL-C) without clinically evident coronary heart disease (CHD). (nih.gov)

Unexpectedly, HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) and G6PD (glucose-6-phosphate dehydrogenase), the rate-limiting enzymes of cholesterol synthesis and the PPP, were identified as direct targets of microRNA-206. (nature.com)
For example, in familial hypercholesterolemia, enzymes do not receive the signals that typically inhibit cholesterol synthesis, so that excessive production of cholesterol occurs, leading to early coronary vascular disease and strokes in patients. (newworldencyclopedia.org)
This article will explain the step-by-step mechanism of cholesterol synthesis , its key enzymes and genes, and the feedback mechanisms that control its production and transport. (biochemden.com)

In addition to activation of cholesterol synthesis, enhancement of cholesterol absorption and impaired cholesterol removal also contributes to increased hepatic and serum cholesterol [ 14 ]. (nature.com)
In light of prior metabolic and genetic research, our purpose was to ascertain whether FCH cases had significant abnormalities of plasma markers of cholesterol synthesis and absorption as compared to unaffected kindred members. (ru.nl)
METHODS AND RESULTS: Plasma levels of squalene, desmosterol, and lathosterol (cholesterol synthesis markers) and campesterol, sitosterol, and cholestanol (cholesterol absorption markers) were measured by gas-liquid chromatography in 103 FCH patients and 240 normolipidemic relatives (NLR). (ru.nl)
We did not observe any apparent differences for the cholesterol absorption markers among FCH patients and NLR. (ru.nl)
In the present study, the impact of treatment with PCSK9-antibodies on cholesterol synthesis and absorption was assessed, in the context of an observational study. (pace-cme.org)
For this purpose, the circulating cholesterol precursor lathosterol was measured to estimate cholesterol synthesis, and the plant sterols campesterol and sitosterol were measured to estimate cholesterol absorption [2,3], in 245 patients aged ≥ 18 years, with hypercholesterolemia, who routinely received PCSK9-antibodies (alirocumab 75 or 150 mg sc. (pace-cme.org)
PCSK9-antibodies strongly reduce non-cholesterol sterols but they do not significantly affect the balance between cholesterol synthesis and absorption, independently of cholesterol-lowering pretreatment. (pace-cme.org)
Major advances in our insights into regulation of the cholesterol absorption pathway have been made using genetically manipulated mouse models and agents such as ezetimibe. (elsevierpure.com)
These plant compounds are structurally similar to cholesterol and help lower cholesterol by blocking its absorption in your intestines. (healthline.com)

Bile is used during digestion to absorb fats and fat-soluble vitamins, such as vitamins A, D, E, and K. People with congenital bile acid synthesis defect type 1 cannot produce (synthesize) bile acids, which are a component of bile that stimulate bile flow and help it absorb fats and fat-soluble vitamins. (medlineplus.gov)
The signs and symptoms of congenital bile acid synthesis defect type 1 often develop during the first weeks of life, but they can begin anytime from infancy into adulthood. (medlineplus.gov)
Excess fat in the feces (steatorrhea) is an additional feature of congenital bile acid synthesis defect type 1. (medlineplus.gov)
If left untreated, congenital bile acid synthesis defect type 1 often leads to cirrhosis and death in childhood. (medlineplus.gov)
however, it is the most common of all the congenital defects of bile acid synthesis. (medlineplus.gov)
Mutations in the HSD3B7 gene cause congenital bile acid synthesis defect type 1. (medlineplus.gov)
Bile acids are produced from cholesterol in a multi-step process. (medlineplus.gov)
Disorders of bile acid synthesis. (medlineplus.gov)
Cholesterol is essential to our cell membranes, hormones, and bile acids. (biochemden.com)
Cholesterol is a precursor molecule for synthesizing several essential compounds in the body, including steroid hormones, bile acids, and vitamin D. (biochemden.com)
If your anything like me and consume a lot of eggs and meat or if your just genetically predisposed to have high cholesterol, celery has the ability to reduce your cholesterol by way of bile acid secretion. (hubpages.com)
Studies have shown that bile acid synthesis controls cholesterol secretion. (hubpages.com)
Defective enzymatic function disrupts bile acid synthesis. (medscape.com)
this, in turn, disrupts feedback regulation on cholesterol 7-alpha-hydroxylase, which is the rate-limiting step in bile acid synthesis. (medscape.com)

fewer than 5% of plant sterols are absorbed compared with approximately 40% of cholesterol absorbed. (medscape.com)
The cholesterol precursor and plant sterols were measured before, and 4-8 weeks after the initiation of alirocumab or evolocumab treatment. (pace-cme.org)
Plant sterols are well known for their effects on blood cholesterol levels, however research into their potential role in mitigating cancer risk remains in its infancy. (mdpi.com)
As outlined in this review, the cholesterol modulating actions of plant sterols may overlap with their anti-cancer actions. (mdpi.com)

Trained in organic chemistry at University of Bergen (MSc 1983), including using computer-based expert system (SECS) and computational methods for strategies in organic synthesis. (ntnu.edu)

Patients with homozygous familial hypercholesterolaemia (HoFH) have markedly elevated low density lipoprotein (LDL) cholesterol levels that are refractory to standard doses of lipid-lowering drug therapy. (elsevierpure.com)

The analysis of several conditional mouse mutants targeting neuronal cholesterol synthesis at different ages has revealed a critical time window of neuronal cholesterol synthesis. (mpg.de)

Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway. (ru.nl)
OBJECTIVE: Familial combined hyperlipidemia (FCH) is a common familial lipid disorder characterized by increases in plasma total cholesterol, triglyceride, and apolipoprotein B-100 levels. (ru.nl)
A group of familial disorders characterized by elevated circulating cholesterol contained in either LOW-DENSITY LIPOPROTEINS alone or also in VERY-LOW-DENSITY LIPOPROTEINS (pre-beta lipoproteins). (bvsalud.org)

The metabolic defect in the affected patient causes hyperabsorption of sitosterol from the GI tract, decreased hepatic secretion of sitosterol with subsequent decreased elimination, and altered cholesterol synthesis. (medscape.com)
No significant differences were seen among the 4 pretreatment groups in the responses to PCSK9-antibodies of the lathosterol-, campesterol-, and sitosterol-to-cholesterol ratios and the campesterol- and sitosterol-to-lathosterol ratios. (pace-cme.org)

Plasma MVA and 24-h urinary excretion of MVA, as markers of in vivo cholesterol synthesis, were elevated at baseline and decreased markedly with treatment. (elsevierpure.com)
One unresolved question is how a sustained pharmacological inhibition of intestinal cholesterol synthesis in vivo may affect cholesterol handling by the absorptive cells. (elsevierpure.com)
Here, we describe the synthesis of a new heptamethine indocyanine dye (NIR-27) modified with a glycine at the end of each N-alkyl side chain, and its biological characterization for in vivo cancer-targeted NIR imaging. (dovepress.com)

Chemical companies Merck & Co. and Monsanto saw commercial opportunities for steroid synthesis and not only funded Woodward but also provided him with large quantities of certain chemical intermediates from pilot plants. (wikipedia.org)

The action of hormones are transduced by regulating the synthesis of proteins (5% of proteins in the body are regulated by thyroid hormone). (cdc.gov)
Cholesterol is necessary for the synthesis of hormones, production of digestive acids, stabilization of cell membranes, and formation of myelin on nerve fibers. (medscape.com)
All adrenocortical hormones are steroid compounds derived from cholesterol (see the image below). (medscape.com)
Synthesis of adrenal cortical hormones. (medscape.com)

The conversion of cholestanol to cholesterol was already demonstrated by oxidation of the ketone, bromination to the bromoketone and elimination to the enone. (wikipedia.org)
[ 11 ] Deposition of cholestanol and cholesterol in the CNS (the brain and spinal cord), muscle (including the heart), blood vessels, eye, and tendon results in a degenerative process that worsens over time unless treated. (medscape.com)

Cholesterol synthesis and high density lipoprotein uptake are regulated independently in rat small intestinal epithelium. (bmj.com)
The rates of high density lipoprotein HDL uptake and cholesterol synthesis were compared in the normocholesterolaemic (SW) and genetically hypercholesterolaemic (RICO) rat intestine. (bmj.com)
When the mucosal epithelium was divided along the villus/crypt axis, HDL uptake increased two to threefold and cholesterol synthesis two to fivefold in the upper villus compared with the crypt cells in both SW and RICO rats. (bmj.com)
The high cholesterogenesis in the mucosal cells of the RICO rat is not related to a modified HDL cholesterol uptake. (bmj.com)
Thus, cholesterol synthesis and HDL uptake seem to be regulated independently in the rat small intestinal mucosa. (bmj.com)
Increased OLR1 expression, resulting either from TZD treatment or adenoviral gene delivery, significantly augments adipocyte cholesterol content and enhances fatty acid uptake. (jci.org)
It regulates the serum cholesterol level by influencing the level of cholesterol uptake into cells. (cdc.gov)

Hepatic cholesterol accumulation and hypercholesterolemia are implicated in hepatocellular carcinoma (HCC). (nature.com)
However, current studies described above only focused on hepatic and serum levels of cholesterol rather than cholesterol synthesis in HCC patients. (nature.com)
In contrast, hepatic cholesterol synthesis, while markedly suppressed initially, rebounded to higher than baseline rates within 7 days. (elsevierpure.com)

This reaction is the committed step of cholesterol synthesis and is regulated by feedback inhibition by cholesterol and its derivatives. (biochemden.com)
Increasing the dose of atorvastatin to 120 and 160 mg/day did not result in any further reduction in LDL cholesterol or urinary MVA excretion suggesting a plateau effect with no further inhibition of cholesterol synthesis at doses of atorvastatin greater than 80 mg/day. (elsevierpure.com)

Cholesterol-lowering drugs known as statins are at the forefront of the fight against heart disease. (sciencenews.org)

SB-12813 inhibited incorporation of tritiated water into cholesterol with an IC 50 of 1.2 μM but had no effect on fatty acid synthesis. (herts.ac.uk)
LRP1 Controls Intracellular Cholesterol Storage and Fatty Acid Synthesis through Modulation of Wnt Signaling. (igbmc.fr)
Avocados provide monounsaturated fatty acids and fiber, two heart-healthy and cholesterol-lowering nutrients. (healthline.com)
Because levels of transcription factor CCAAT/enhancer binding protein-β, peroxisome proliferator-activated receptor-γ, and lipoprotein lipase are also increased, lipid transport into cells and fatty acid synthesis within cells is increased ( 8 - 15 ). (cdc.gov)

Malformation syndromes caused by disorders of cholesterol synthesis. (medscape.com)

The source of the cholesterol required for the growth and division of these cells was studied by using cultures of bovine lens epithelial cells. (nih.gov)
We calculated that an average of 0.79 atoms of 3H of [3H]water were incorporated by these cells into cholesterol per carbon atom of cholesterol. (nih.gov)
It regulates the receptor for cholesterol, takes it out of the blood stream and puts it into the cells. (cdc.gov)
They work by blocking the synthesis of cholesterol inside cells. (sciencenews.org)
This, in turn, causes cells to produce more of a compound known as low-density-lipoprotein receptor, or LDLr, which plucks dangerous cholesterol from the bloodstream. (sciencenews.org)
As a result, cells are unable to produce cholesterol and there is a buildup of toxin byproducts of the cholesterol synthesis pathway. (medscape.com)

[ 10 ] Endogenous cholesterol production is essential for human development before and after birth. (medscape.com)

Reduction in the synthesis of anti-inflammatory isoprenylated proteins may account for the clinical syndrome. (msdmanuals.com)

b) otherwise, when there was no increase in the synthesis of nucleotides, the elevated excretion would result in a depletion of the systemic levels of the nucleotides if the exposure to CS2 had persisted for a sufficiently long time. (cdc.gov)

Cholesterol interacts with other lipids , such as phospholipids, to form lipid bilayers essential for cell membranes ' function. (biochemden.com)
Finally, it was verified that both the practice of recreational physical activities and regular and systematized physical exercises seem to benefit the lipid profile, specifically the HDL cholesterol of people with DS. (bvsalud.org)

The small intestine plays a fundamentally important role in regulating whole body cholesterol balance and plasma lipoprotein composition. (elsevierpure.com)
50%) of cholesterol synthesis in the whole small intestine. (elsevierpure.com)

Blocking the PPP prevented cholesterol synthesis and thereby HCC in c-Myc mice, while ablating glycolysis did not affect cholesterol synthesis and failed to prevent c-Myc-induced HCC. (nature.com)

Therefore, understanding the complex process of cholesterol synthesis and regulation in our body is crucial for maintaining our health. (biochemden.com)
It is a rate-limiting step of cholesterol synthesis and is also subject to feedback regulation by cholesterol and its derivatives. (biochemden.com)
The mRNA expression for multiple genes involved in intestinal cholesterol regulation including NPC1L1 was mostly unchanged although there was a marked rise in the mRNA level for the PXR target genes CYP3A11 and CES2A. (elsevierpure.com)

Cholesterol Synthesis: How Our Body Makes it and Regulates? (biochemden.com)

Total cholesterol, LDL-c, and triglyceride levels were highest in the group without pretreatment and lowest in the ezetimibe plus statin group. (pace-cme.org)
However, in animals and adults in the United States, serum cholesterol and triglyceride levels were paradoxically reduced, despite the obesity ( 1 - 4 ). (cdc.gov)

In addition, cholesterol plays a critical role in maintaining cell membranes' structural integrity and fluidity. (biochemden.com)

CONCLUSIONS: Our data indicate that both men and women with FCH have alterations in the cholesterol synthesis pathway, resulting in 51% higher levels of lathosterol (and additionally desmosterol in women). (ru.nl)

Cholesterol synthesis is a complex process involving a series of enzymatic reactions and regulatory steps in various cell organelles. (biochemden.com)
Rates were estimated on the assumption that 0.81 atoms of 3H of [3H]water were incorporated into cholesterol per carbon atom of cholesterol, a situation where all of the NADPH would be generated by oxidative enzymatic processes. (nih.gov)

The conversion of cholestenone into cholesterol by the method of Dauben and Eastham (1950) consisted of reduction of the enol acetate (lithium aluminium hydride) and fractionation with digitonin for the isolation of the correct isomer. (wikipedia.org)
Reduction in LDL cholesterol in the five receptor negative patients was similar to that achieved in the 30 patients with residual LDL receptor activity. (elsevierpure.com)

Trastorno familiar que se caracteriza por incremento de la concentración del colesterol transportado por las lipoproteínas de baja densidad (LDL) y por déficit de un receptor en la superficie celular que regula la degradación de las LDL y la síntesis del colesterol. (bvsalud.org)

Cholesterol synthesis in cultured human peripheral lymphocytes. (bvsalud.org)

Taken together, neurons can function and mature in the absence of cholesterol synthesis provided sufficient external supply. (mpg.de)
Individuals from 3 population-based samples (EpiHealth, n=2342, SCAPIS-Uppsala, n=4985, and SCAPIS-Malmö, n=3978) were divided into groups according to their body mass index (BMI) and presence/absence of MetS (National Cholesterol Education Program [NCEP]/consensus criteria). (lu.se)

[ 1 , 2 ] The original report detailed 2 sisters who presented with extensive tendon xanthomas but normal plasma cholesterol levels. (medscape.com)
With treatment, cholesterol levels can normalize, and xanthomas can completely regress. (medscape.com)
A clue to sitosterolemia diagnosis in a patient with highly elevated plasma cholesterol level is parents with normal cholesterol levels. (medscape.com)
Phytosterols have been shown to reduce serum and plasma total cholesterol and LDL levels in healthy individuals. (medscape.com)
However, high cholesterol levels in the blood can increase the risk of heart disease and stroke. (biochemden.com)
Having high cholesterol levels - especially "bad" LDL - is linked to an increased risk of heart disease ( 1 ). (healthline.com)
There is currently no consensus on managing the risk of raised cholesterol levels for this patient group. (uk.com)
Subjects with hyperhomocysteinaemia had significantly elevated total cholesterol, LDL cholesterol, apolipoprotein A and apolipoprotein B and lower vitamin B levels compared with subjects with 12 normohomocysteinaemia. (who.int)
Hcy levels correlated with total cholesterol ( r = 0.09), apolipoprotein A ( r = 0.012), and B ( r = 0.013) levels and total/HDL cholesterol ratio ( r = -0.085). (who.int)

Cholesterol total synthesis in chemistry describes the total synthesis of the complex biomolecule cholesterol and is considered a great scientific achievement. (wikipedia.org)
Eating oats may lower total cholesterol by 5% and "bad" LDL cholesterol by 7% ( 18 ). (healthline.com)
Atherosclerosis accounts for up to 80% of cholesterol (LDL-C) and the total choles- deaths in diabetic patients due to coronary terol/HDL-C ratio (TC/HDL-C) [ 1 ]. (who.int)

It binds on the DNA, exerting an effect on DNA to regulate the synthesis of proteins regulated by DNA. (cdc.gov)

Surprisingly, all developmental defects can be rescued in vitro by cholesterol supplementation. (mpg.de)

The hydrophilic hydroxyl group enables cholesterol to form hydrogen bonds with water molecules. (biochemden.com)

Dyslipidaemia obesity and insulin changes highly acceler- encompasses changes in HDL-cholesterol ate the progression to atherosclerosis [ 2 ]. (who.int)

Conversion to the desired trans isomer 5 was accomplished by synthesis of the sodium enolate salt 4 (benzene, sodium hydride) followed by acidification. (wikipedia.org)
Cholesterol is a hydrophobic molecule that is insoluble in water and nonpolar solvents, such as ether, chloroform, and benzene. (biochemden.com)

Anatomy19

Organisms12

Diseases19

Chemicals and Drugs137

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Psychiatry and Psychology1

Phenomena and Processes48

Disciplines and Occupations1

Technology, Industry, Agriculture8

Information Science3

Health Care3

Metabolism18

Sterol14

Enzyme9

Precursors1

Pathway of Cholesterol Synthesis1

Triglycerides6

Rates of cholesterol synthesis1

Liver14

Biosynthesis pathway1

Lipoprotein cholesterol1

Enzymes3

Absorption9

Bile14

Sterols4

Organic Synthesis1

Elevated low density lip1

Neuronal1

Familial3

Sitosterol2

Vivo3

Steroid synthesis1

Hormones4

Cholestanol2

Uptake7

Hepatic3

Inhibition2

STATINS1

Fatty4

Disorders1

Cells6

Endogenous1

Anti-inflammatory1

Excretion1

Lipid2

Intestine2

Affect cholesterol1

Regulation3

Regulates1

Triglyceride levels2

Cell membranes1

Lathosterol1

Enzymatic2

Reduction2

Receptor1

Peripheral1

Absence2

Levels9

Total3

Proteins1

Vitro1

Molecules1

Insulin1

Benzene2