• PVNS
  • Plexxikon, a member of the Daiichi Sankyo Group, announced today promising, proof-of-concept Phase 1 extension clinical data with PLX3397 in pigmented villonodular synovitis (PVNS), a type of rare, often locally aggressive, musculoskeletal neoplasm that arises from the soft tissues of joints and tendons. (orphan-drugs.org)
  • Dr. Tap will be presenting this abstract in an oral presentation, "A pilot study of PLX3397, a selective colony-stimulating factor 1 receptor (CSF1R) kinase inhibitor, in pigmented villonodular synovitis (PVNS)," at the American Society of Clinical Oncology (ASCO) 50th Annual Meeting, at 9:00 AM CT on June 1, 2014, in Chicago. (orphan-drugs.org)
  • This study, designed as a proof of concept study of MCS110 in pigmented villonodular synovitis, will assess the clinical response to MCS110 treatment in Pigmented Villonodular Synovitis (PVNS) and Giant cell tumor of the tendon sheath (GCTTS) patients after multiple intravenous doses of MCS110 using magnetic resonance imaging to assess tumor volume, and to evaluate pharmacokinetics/pharmacodynamics, safety and tolerability in this population. (clinicaltrials.gov)
  • Pigmented villonodular synovitis (PVNS) is a joint disease characterized by inflammation and overgrowth of the joint lining. (wikipedia.org)