DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
Neoplasms, Multiple PrimarySyndromeNeoplasms, Second PrimaryAdenomatosis, PulmonarySkin NeoplasmsLi-Fraumeni SyndromeGerm-Line MutationPaget's Disease, MammaryMelanomaNeoplastic Syndromes, HereditaryLung NeoplasmsGastrointestinal NeoplasmsGenes, p16Soft Tissue NeoplasmsPedigreeDown SyndromeMetabolic Syndrome XGenes, p53DNA Mutational AnalysisOsteosarcomaBreast NeoplasmsRegistriesGenetic Predisposition to DiseaseMutationSarcomaColonic NeoplasmsRiskHead and Neck NeoplasmsPancreatic NeoplasmsIncidenceCarcinoma, Squamous CellPrognosisAdenocarcinomaNeoplasmsRisk FactorsRetrospective StudiesExonsNephrotic SyndromeNeoplasm StagingSjogren's SyndromeFollow-Up StudiesNeoplasms, Cystic, Mucinous, and SerousTime FactorsTumor Suppressor Protein p53Myelodysplastic SyndromesTurner SyndromeAbnormalities, MultipleCushing SyndromeKidney NeoplasmsAcute Coronary SyndromePolycystic Ovary SyndromeWilliams SyndromeMyeloproliferative Disorders
MyelodysplasticMyelomaTumorBenignTumorsLymphomaCarcinomaParaneoplastic SyndromesMalignanciesCancerMyelofibrosisMetastasesMyeloproliferative neoplasmMalignant neoplasmDiseasesFamilialMalignancyClinicalCystsLeukemiaEtiologySecondaryHemophagocytic syndromeBladderMeSHAdenocarcinomaHepaticMutationLymphomasSpinalColonPathogenesisDiagnosisVascular1987CutaneousImmunohistochemicalGermlineReportableFibrousCancersTissueOvaryCushing
Myelodysplastic4
  • Myelodysplastic syndromes (MDS) are uncommon in children and have a poor prognosis. (nature.com)
  • Myelodysplastic syndromes include a variety of diseases that affect the blood and bone marrow. (uillinois.edu)
  • 8. Which of the following genetic abnormalities is commonly associated with myelodysplastic syndromes (MDS)? (medicalbiochemist.com)
  • It is under development for the treatment of clonal cytopenia of undetermined significance (CCUS), hematologic malignancies including untreated or relapsed and refractory AML (in the EU), and myelodysplastic syndrome (MDS), relapsed/ refractory multiple myeloma, chronic myelomonocytic leukemia (CMML), myeloproliferative neoplasm solid tumors, hepatic impairment. (pharmaceutical-technology.com)
Myeloma6
  • Multiple myeloma is cancer that begins in the bone marrow and affects plasma cells. (uillinois.edu)
  • Leukemia, lymphoma and multiple myeloma, 1950-1987. (org.ua)
  • Leukemia, lymphoma, and multiple myeloma after pelvix radiotherapy for benign disease. (org.ua)
  • 5. Which of the following is a characteristic feature of multiple myeloma? (medicalbiochemist.com)
  • Diseases covered by the company's proprietary CAR technologies include B and T cell lymphoma and leukemia, myeloproliferative neoplasms, myeloid dysplastic syndrome (MDS), acute myeloid leukemia (AML), multiple myeloma (MM), non-hematological (non-blood) cancers and autoimmune disorders. (uoflnews.com)
  • They usually originate as carcinomas of the lungs, breasts, prostate, kidneys, or thyroid or are sarcomas or hematologic malignancies, such as multiple myeloma or lymphoma. (msdmanuals.com)
Tumor7
  • Surprisingly, germline variants in SAMD9 or SAMD9L were present in 17% of primary MDS patients, and these variants were routinely lost in the tumor cells by chromosomal deletions (e.g., monosomy 7) or copy number neutral loss of heterozygosity (CN-LOH). (nature.com)
  • In this study we perform tumor and normal whole exome sequencing (WES) on 32 pediatric primary MDS patients and targeted sequencing on another 14 cases through a single institution study focused on defining the genomic landscape of pediatric MDS. (nature.com)
  • The 2007 rules said a glioblastoma multiforme (GBM) following an astrocytic or glial tumor was a single primary. (registrypartners.com)
  • In the 2018 Solid Tumor Rules GBM subsequent to an astrocytic or glial tumor is a multiple primary. (registrypartners.com)
  • The highest RR observed was for CNS lymphoma following any first primary tumor in men (7.9, 5.5-11.0). (familialcancerdatabase.nl)
  • 2] studied 135 Connecticut residents with multiple primary tumors and at least one CNS tumor. (familialcancerdatabase.nl)
  • Symptoms are often associated with the site of tumor origin and reflect the tumor obstructing organs involved in normal body function but may be less specific if related to carcinoid syndrome. (medifocus.com)
Benign4
  • Gardner syndrome is set apart as a subtype because, in addition to colonic polyps, there are also extra-colonic growths (both malignant and benign). (wikipedia.org)
  • A syringoma is a benign appendageal neoplasm that typically presents in adolescent females. (medicaljournals.se)
  • 6] Case reports have described AN associated with hematologic malignancies, including acute myeloid leukemia, and even benign gastrointestinal neoplasms. (medscape.com)
  • Experience in the SEER registries has shown that using the Supplemental List increases casefinding for benign brain and CNS, hematopoietic neoplasms, and other reportable diseases. (cancer.gov)
Tumors15
  • Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant disorder characterized by fibrofolliculomas, renal tumors, and pulmonary cysts with recurrent pneumothorax. (nih.gov)
  • Multiple granular cell tumors may seen in the context of LEOPARD syndrome, due to a mutation in the PTPN11 gene. (wikipedia.org)
  • These tumors, on occasion, may appear similar to neoplasms of renal (relating to the kidneys) origin or other soft tissue neoplasms. (wikipedia.org)
  • Gardner syndrome is an autosomal dominant form of polyposis characterized by the presence of multiple polyps in the colon together with tumors outside the colon. (wikipedia.org)
  • Gardner syndrome is also associated with familial adenomatous polyposis and may manifest as aggressive fibromatosis (desmoid tumors) of the retroperitoneum. (wikipedia.org)
  • Sebaceous gland tumors of the eyelids and conjunctiva in the Muir-Torre syndrome: A clinicopathologic study of five cases and literature review. (meduniver.com)
  • 3. Torre D. Multiple sebaceous tumors. (meduniver.com)
  • 6. Tillawi I, Katz R, Pellettiere V. Solitary tumors of meibomian gland origin and Torre s syndrome. (meduniver.com)
  • GBM is now being collected as a new primary so it is possible to analyze the frequency with which these tumors recur in a more aggressive form (GBM). (registrypartners.com)
  • 1] This article focuses on cutaneous paraneoplastic syndromes caused by solid tumors. (medscape.com)
  • 1] used SEER data to calculate relative risks (RR) of primary brain tumors following other tumors. (familialcancerdatabase.nl)
  • 3] studied the risk of primary cancer following brain tumors in patients from the Finnish cancer registry. (familialcancerdatabase.nl)
  • Over the years it became clear that carcinoid tumors can be quite aggressive, can metastasize, and can cause carcinoid syndrome . (medifocus.com)
  • Carcinoid syndrome describes a combination of symptoms that result from hormones or hormone-like substances, (e.g., serotonin, gastrin, ACTH) that are produced by some carcinoid tumors. (medifocus.com)
  • ARMC5 Alterations in Patients With Sporadic Neuroendocrine Tumors and Multiple Endocrine Neoplasia Type 1 (MEN1). (cdc.gov)
Lymphoma1
  • [ 1 ] ETP-ALL frequently has mutations in RUNX1 and/or ETV6 in addition to genes that are more commonly associated with myeloid neoplasms and are otherwise rare in T-cell lymphoblastic leukemia/lymphoma (such as FLT3 , IDH1/2 , TET2 , and DNMT3A mutations). (medscape.com)
Carcinoma4
  • Eyelid sebaceous carcinoma associated with Muir-Torre syndrome in two cases. (meduniver.com)
  • Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin-Goltz syndrome or basal cell nevus syndrome (BCNS), is characterized by a variety of neoplasms and skeletal anomalies with the universal finding being multiple basal cell carcinomas (BCCs). (plasticsurgerykey.com)
  • Prevalence of Parathyroid Carcinoma and Atypical Parathyroid Neoplasms in 153 Patients With Multiple Endocrine Neoplasia Type 1: Case Series and Literature Review. (cdc.gov)
  • Hereditary medullary thyroid carcinoma syndromes: experience from western India. (cdc.gov)
Paraneoplastic Syndromes1
  • Other paraneoplastic syndromes that commonly occur with AN include tripe palms and the sign of Leser-Trélat (which are discussed below). (medscape.com)
Malignancies6
  • Patients with malignancies or inflammatory conditions involving the gastrointestinal tract are at highest risk for development of secondary Budd-Chiari syndrome. (logicalimages.com)
  • Lynch syndrome is an autosomal-dominant disorder caused by defective DNA mismatch repair (MMR) genes and is associated with increased risk of malignancies in multiple organs. (oncotarget.com)
  • Lynch syndrome was confirmed in eight patients (4%), all of whom had synchronous/metachronous malignancies without noticeable familial histories. (oncotarget.com)
  • Small-intestinal adenocarcinomas were the first clinical manifestation in 37% (3/8) of Lynch syndrome patients, and second malignancies developed within 5 years in 63% (5/8). (oncotarget.com)
  • The primary focus is to treat and cure malignancies that have very poor prognoses and few available curative treatment options. (uoflnews.com)
  • Nervous system neoplasms and primary malignancies of other sites. (familialcancerdatabase.nl)
Cancer7
  • Its primary focus is on cancer, cardiovascular, immunology and fibrotic therapeutic projects. (pharmaceutical-technology.com)
  • Niraparib as maintenance therapy for treating recurrent or primary-advanced endometrial cancer after chemotherapy in combination with dostarlimab. (nihr.ac.uk)
  • Niraparib in combination with dostarlimab is in clinical development for patients with recurrent or primary-advanced endometrial cancer. (nihr.ac.uk)
  • iCell Gene Therapeutics is focused on developing CAR T and NK cells that target and destroy multiple types of cancer. (uoflnews.com)
  • New primary neoplasms of the central nervous system in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. (familialcancerdatabase.nl)
  • Malignant neoplasm, Cancer b. (cdc.gov)
  • For cancer, the diagnosis and primary therapy phase of all cancers, as well as colon and rectum cancer with stoma, larynx cancer with laryngectomy and breast cancer with mastectomy, were included (1). (who.int)
Myelofibrosis1
  • Common types of MPNs include chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). (medicalbiochemist.com)
Metastases1
  • The patient subsequently exhibited secondary symptoms (fever, night sweats), enlarged lymph nodes, renal metastases, and hemophagocytic syndrome, with clinical diagnosis stage IV of ENKL. (hindawi.com)
Myeloproliferative neoplasm1
  • For comparison, we similarly characterize 23 cases with overlapping features of MDS and myeloproliferative neoplasm (MDS/MPN), namely juvenile myelomonocytic leukemia (JMML), and 8 cases of AML with myelodysplasia-related changes (AML-MRC). (nature.com)
Malignant neoplasm1
  • Unspecified/other malignant neoplasm of skin of upper limb, incl. (cancer.gov)
Diseases2
  • Myeloproliferative neoplasms are a group of diseases of the bone marrow in which excess cells are produced. (uillinois.edu)
  • Extensive preparation was devoted to a review of the suitability of the structure of ICD, which was by definition a statistical classification of diseases and other health problems, to serve a wide variety of needs for mortality statistics, morbidity statistics, reimbursement, measuring quality of care, patients' safety, monitoring primary care and clinical recording. (who.int)
Familial5
  • Gardner's syndrome (also known as Gardner syndrome , familial polyposis of the colon , [1] or familial colorectal polyposis [2] ) is a subtype of familial adenomatous polyposis (FAP). (wikipedia.org)
  • To define the incidence and characteristics of Lynch syndrome-related small-intestinal adenocarcinomas, meticulous familial and clinical histories were obtained from 195 patients with small-intestinal adenocarcinoma, and MMR protein immunohistochemistry, microsatellite instability, MLH1 methylation, and germline mutational analyses were performed. (oncotarget.com)
  • The 4 subtypes of syringoma are classified according to their clinical features: localized, familial, Down's syndrome-associated and generalized (encompassing eruptive syringoma) (1-4). (medicaljournals.se)
  • Familial AN, drug-induced AN, AN occurring in hyperinsulinemic states (eg, diabetes, obesity), AN associated with polycystic ovary disease, and AN associated with a spectrum of autoimmune disease in women should be considered before AN is determined to represent a paraneoplastic syndrome. (medscape.com)
  • Pancreatic Neuroendocrine Neoplasm Associated with a Familial MAX Deletion. (cdc.gov)
Malignancy1
  • Budd-Chiari syndrome is hepatic venous outflow tract obstruction due to either primary vascular occlusion (thrombosis) or secondary occlusion from extrinsic compression (eg, malignancy). (logicalimages.com)
Clinical6
  • The clinical presentation of Budd-Chiari syndrome varies based on the acuity of vascular compromise. (logicalimages.com)
  • Herein we report a case with unilateral abducens nerve palsy as initial symptom in the primary sphenoidal sinus ENKL and investigated the clinical feature of the diagnosis and therapy. (hindawi.com)
  • Subsequently, she presented clinical a varicela deterioration and was taken to a hospital, where she was diagnosed with acute febrile syndrome, diarrhea with mild dehydration, and pharyngitis. (bvsalud.org)
  • Member States are also applying ICD-10 to morbidity statistics, resource allocation in primary care, measuring quality of care, patients' safety, billing for health insurance, clinical decision-making, clinical recording and research. (who.int)
  • Clinical Profile and Mutations Associated with Multiple Endocrine Neoplasia-Type1 (MEN1) and Their First-Degree Relatives at Risk of Developing MEN1: A Prospective Study. (cdc.gov)
  • Clinical features and signaling effects of RET D631Y variant multiple endocrine neoplasia type 2 (MEN2). (cdc.gov)
Cysts2
  • Multiple pulmonary cysts and pneumothorax are the key signs for diagnosing BHD syndrome. (nih.gov)
  • Later histopathological examination showed normal germinal follicles, multiple follicular cysts with normally developed theca interna and externa, and some follicles showing an attenuated layer of cells. (who.int)
Leukemia1
  • 1. Which of the following is NOT a primary characteristic feature of chronic myeloid leukemia (CML)? (medicalbiochemist.com)
Etiology1
  • Clinicians should be careful to exclude other etiologies of liver failure that can predispose patients to developing hepatic venous outflow tract obstruction that is either nonocclusive or not the primary etiology of the patient's liver failure. (logicalimages.com)
Secondary1
  • It can be present in two forms: primary or secondary. (bvsalud.org)
Hemophagocytic syndrome1
  • with hemophagocytic syndrome that evolved with multisystemic failure and died the following day. (bvsalud.org)
Bladder1
  • 1986. A retrospective study on malignant neoplasms of bladder, lung, and liver in Blackfoot disease endemic area in Taiwan. (cdc.gov)
MeSH2
  • Multiple Endocrine Neoplasia Type 2b" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • The primary endpoint was the annual rate of prophylactic parastomal mesh placement following rectal resection without sphincter preservation in Germany. (bvsalud.org)
Adenocarcinoma1
  • [8] There are many terms used to describe "APC-associated polyposis condition" including FAP, attenuated FAP, Gardner syndrome, Turcot syndrome, and gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). (wikipedia.org)
Hepatic2
  • Chronic Budd-Chiari syndrome can present with cirrhosis , which often results from months or years of outflow tract obstruction and subsequent ischemic hepatic injury. (logicalimages.com)
  • Budd-Chiari syndrome is readily diagnosed via abdominal ultrasound with Doppler flow demonstrating occlusive clot in the hepatic venous outflow tracts. (logicalimages.com)
Mutation1
  • Gardner syndrome is caused by mutation in the adenomatous polyposis coli (APC gene), located in chromosome 5q21 (band q21 on chromosome 5). (wikipedia.org)
Lymphomas1
  • Lymphoblastic leukemias/lymphomas are neoplasms of precursor T cells and B cells or lymphoblasts. (medscape.com)
Spinal1
  • Intradural extramedullary spinal neoplasms: Radiologic-pathologic correlation. (msdmanuals.com)
Colon3
  • Gardner syndrome can be identified based on oral findings, including multiple impacted and supernumerary teeth , multiple jaw osteomas that give a "cotton-wool" appearance to the jaws, as well as multiple odontomas , congenital hypertrophy of the retinal pigment epithelium (CHRPE), in addition to multiple adenomatous polyps of the colon. (wikipedia.org)
  • Multiple primary carcinomata of the colon duodenum and larynx associated with keratoacanthoma of the face. (meduniver.com)
  • CRC is a neoplasm that develops in the colon or rectum. (mindmeister.com)
Pathogenesis1
  • A Parathyroid-Gut Axis: Hypercalcemia and the Pathogenesis of Gastrinoma in Multiple Endocrine Neoplasia 1. (cdc.gov)
Diagnosis2
  • Diagnosis of Cushing syndrome. (medscape.com)
  • A meticulous patient history taking, MMR protein immunolabeling, and germline MMR gene mutational analysis are important for the diagnosis of Lynch syndrome-related small-intestinal adenocarcinomas. (oncotarget.com)
Vascular1
  • The common causes of unilateral abducens nerve palsy are neoplasm and vascular disease in middle-aged people [ 1 ]. (hindawi.com)
19871
  • 1987. Acute arsenic intoxication presenting as Guillain Barré like syndrome. (cdc.gov)
Cutaneous1
Immunohistochemical1
Germline4
  • Here, we describe the somatic and germline changes of pediatric MDS using whole exome sequencing, targeted amplicon sequencing, and/or RNA-sequencing of 46 pediatric primary MDS patients. (nature.com)
  • Despite this progress, no study to date has performed comprehensive sequencing on a pediatric MDS cohort to fully understand somatic and germline variation in this neoplasm. (nature.com)
  • We show that Ras/MAPK pathway mutations are common in pediatric primary MDS (45%) while mutations in RNA splicing genes are rare (2%), and that germline SAMD9/SAMD9L mutations are present in 17% of primary MDS patients. (nature.com)
  • Germline RET Leu56Met Variant Is Likely Not Causative of Multiple Endocrine Neoplasia Type 2. (cdc.gov)
Reportable1
  • Neurofibromatosis NOS, Neurofibromatosis 1 (NF1), Neurofibromatosis 2 (NF2), and schwannomatosis are genetic syndromes and not reportable neoplasms. (registrypartners.com)
Fibrous2
  • Histological examination of a biopsy specimen from a papule on the right forearm (Fig. 1B) revealed multiple small ducts embedded in fibrous stroma. (medicaljournals.se)
  • The specimen reveals multiple small ducts embedded in fibrous stroma. (medicaljournals.se)
Cancers1
Tissue2
  • Head computed tomography (CT) and magnetic resonance imaging (MRI) scans revealed soft-tissue density neoplasms that occupied the sphenoidal sinus and further invaded to destroy the clivus. (hindawi.com)
  • Computed tomography (CT) scanning revealed soft-tissue density neoplasms filling the sphenoidal sinus (Figure 1 ). (hindawi.com)
Ovary1
  • This can be easily mistaken for neoplasm, in which case the appropriate treatment will be removal of the whole ovary. (who.int)
Cushing3
  • Cushing syndrome (CS) takes its name from Harvey Cushing, who, in 1912, was one of the first physicians to report a patient affected with excessive glucocorticoid. (medscape.com)
  • [ 1 ] More than 99% of cases of Cushing syndrome are due to administration of excessive amounts of glucocorticoid. (medscape.com)
  • Although distinguishing endogenous from exogenous Cushing syndrome is usually straightforward, the investigation and differentiation of Cushing syndrome from other causes of hypercortisolism require a sound understanding of the physiology of the hypothalamic-pituitary-adrenal (HPA) axis. (medscape.com)