• metabolic
  • The rates of metabolic diseases, such as type 2 diabetes mellitus (T2DM), obesity, and cardiovascular disease (CVD), markedly increase with age. (frontiersin.org)
  • Oxidative stress and hyperglycemia in metabolic diseases lead to adverse neurophysiological phenomena, including neuronal loss, synaptic dysfunction, and improper insulin signaling, resulting in Parkinson's disease (PD). (frontiersin.org)
  • According to a recent survey, the prevalence of metabolic diseases increases by approximately 46.7% among people older than 60 years compared to younger individuals ( Sepúlveda and Murray, 2014 ). (frontiersin.org)
  • The dynamic interactions between the severity, overall duration, and repetitive frequency of IH and the level of maturity of the organs and systems at the time of IH will modify the ventilatory, metabolic, and cardiovascular responses to hypoxia and the adaptive (beneficial) or maladaptive (detrimental) consequences after exposure to IH. (frontiersin.org)
  • Lustig's research examines links between excess consumption of fructose-a component of sucrose (table sugar), honey, fruit and some vegetables-and the development of metabolic syndrome. (wikipedia.org)
  • Articles (2013) with R. Weiss, A. A. Bremer, "What is metabolic syndrome, and why are children getting it? (wikipedia.org)
  • doi:10.1111/nyas.12030 PMID 23356701 Epidemiology of metabolic syndrome Epidemiology of obesity Fed Up (documentary featuring Lustig, 2014) Metabolic disorder Vanessa C. Campos, Luc Tappy, International Journal of Obesity, March 2016: "A high intake of fructose-containing sugars is associated with body weight gain in large cohort studies, and fructose can certainly contribute to energy imbalance leading to obesity. (wikipedia.org)
  • cardiac
  • However, patterns in the traditional frequency domain (measured in Hz, or cycles per second) may capture different cardiac phenomena at different heart rates. (harvard.edu)
  • Both conditions lead to a decrease in cardiac output which is accompanied by an elevation of central venous pressure that reflects, in an imperfect fashion, the real status of intravascular volume in this scenario [ 5 ].Stasis in deep venous circulation puts the patient in an increased risk for thromboemolism. (intechopen.com)
  • Similarly, AKI after cardiac surgery occurs in over 10% of patients under normal circumstances and is associated with dramatic increases in mortality. (jove.com)
  • Cardiorenal syndrome (CRS) refers to multiple abnormalities characterized by a cluster of concurring symptoms related to cardiac and renal damage. (intechopen.com)
  • This intronless gene is deleted in AMME contiguous gene syndrome and is potentially involved in the cardiac and neurologic abnormalities found in the AMME contiguous gene syndrome. (wikipedia.org)
  • Heart failure characteristically involves increased catecholamine activity on the heart, which is responsible for a number of deleterious effects, including increased oxygen demand, propagation of inflammatory mediators, and abnormal cardiac tissue remodeling, all of which decrease the efficiency of cardiac contraction and contribute to the low ejection fraction. (wikipedia.org)
  • ventricular
  • Brugada syndrome is a relatively rare but lethal ventricular arrhythmia most commonly linked to voltage-gated sodium channel gene SCN5A mutations, but also associated with some Kv channel gene sequence variants. (wikipedia.org)
  • These two gene variants did not affect KCNQ1-KCNE1 currents when co-expressed in CHO cells, but produced larger currents than wild-type KCNE5 when coexpressed with Kv4.3-KChIP2, giving a possible mechanism for Brugada syndrome, i.e., increased ventricular Ito density. (wikipedia.org)
  • obesity
  • In conclusion, obesity in combination with presence of a parental history of diabetes may be particularly hazardous in men as these two factors were observed to synergistically increase the risk of developing type 2 diabetes in men. (jove.com)
  • disease
  • Vascular function is an important pathophysiological factor in cardiovascular disease, and is influenced by many factors, one of the principles being hypertension. (biomedsearch.com)
  • Patients with coronary heart disease frequently present with acute coronary syndromes (ACS), resulting in ≈1.14 million hospitalizations each year in the United States. (ahajournals.org)
  • The long-term effects of alcohol consumption range from cardioprotective health benefits for low to moderate alcohol consumption in industrialized societies with higher rates of cardiovascular disease to severe detrimental effects in cases of chronic alcohol abuse. (wikipedia.org)
  • There are reports of ETS being used to achieve cerebral revascularization for people with moyamoya disease, and to treat headaches, hyperactive bronchial tubes, long QT syndrome, social phobia, anxiety, and other conditions. (wikipedia.org)
  • apnea
  • There are numerous reports indicating adverse effects of IH on development, behavior, academic achievement, and cognition in children with sleep apnea syndrome. (frontiersin.org)
  • In sleep clinics, obstructive sleep apnea syndrome or obstructive sleep apnea-hypopnea syndrome is normally diagnosed based on the frequent presence of apneas and/or hypopneas rather than differentiating between the two phenomena. (wikipedia.org)
  • enzyme
  • These protect them from the damaging effects of ice formation and falling rates of enzyme catalysis at low temperatures, and from enzyme denaturation and increased photorespiration at high temperatures. (wikipedia.org)
  • system
  • For the treatment of primary hypertension, meta-analyses of studies which mostly used atenolol have shown although beta blockers are more effective than placebo in preventing stroke and total cardiovascular events, they are not as effective as diuretics, medications inhibiting the renin-angiotensin system (e.g. (wikipedia.org)
  • gene
  • Pleiotropy is the phenomenon where one gene controls for more than one phenotypic trait in an organism. (wikipedia.org)
  • The theme of G.C. William's idea about antagonistic pleiotropy was that if a gene caused both increased reproduction in early life and aging in later life, then senescence would be adaptive in evolution. (wikipedia.org)
  • Patients with Laron syndrome possess one of three genotypes for the growth hormone receptor gene (GHR). (wikipedia.org)
  • In humans it is encoded by the PEMT gene within the Smith-Magenis syndrome region on chromosome 17. (wikipedia.org)
  • dependence
  • This is due to the effect of a phenomenon called reverse use dependence. (wikipedia.org)
  • This co-assembly induces a +140 mV shift in voltage dependence of activation (when co-expressed in CHO cells) which would inhibit KCNQ1 activity across the normal physiological voltage range in most tissues. (wikipedia.org)
  • sensitivity
  • As an added measure tongue photography is used to assess papillae density, with higher density often being associated with increased taste sensitivity. (jove.com)
  • A Ryr2 mutation may increase sensitivity to luminal calcium activation, therefore increasing calcium release from the SR under store-overload conditions and thus triggered arrhythmias. (wikipedia.org)
  • The mutation would compromise the stability of the Ryr2's closed state and increase its sensitivity to stimuli like luminal and cytosolic calcium. (wikipedia.org)
  • control
  • The paraventricular nucleus of the hypothalamus (PVN) plays a major role in central cardiovascular and volume control, and has been implicated in controlling sympathetic nerve activity (SNA) during volume expansion and in heart failure (HF). (biomedsearch.com)
  • There is anatomic and physiological evidence for a polyvagal control of the heart. (wikipedia.org)
  • clinical
  • Although clinical evidence suggests the importance of the gastrointestinal tract in the development of sepsis syndrome, bacterial translocation itself may not be the primary cause [ 8 ]. (hindawi.com)
  • This was also the first time the phenomenon was described as clinical syndrome. (wikipedia.org)
  • temperature
  • Purpose: The purpose of this study was to investigate the increases in intraosseous temperature generated by a modern ultrasonic device for bone surgery (UDBS) and the influences of working pressure and cooling irrigation on this temperature. (biomedsearch.com)
  • permeability
  • This pronounced loss of proteins is due to an increase in glomerular permeability that allows proteins to pass into the urine instead of being retained in the blood. (wikipedia.org)
  • humans
  • In recent years there has been an increase in research on the issue of how humans can survive and work in space for extended and possibly indefinite periods of time. (wikipedia.org)
  • effect
  • Under normal physiological conditions, RYR2 mutation has no discernable effect on calcium induced-calcium release from the sarcoplasmic reticulum (SR). Ryr2 is normally activated by increased cytosolic calcium, but under stressful conditions such as increased beta adrenergic activation, RYR2 is activated by luminal calcium in association with increased SR calcium loading. (wikipedia.org)
  • Cocaine-induced platelet activation and thrombus formation is another deleterious effect, caused by alpha-adrenergic- and adenosine diphosphate-mediated increase in platelet aggregation. (wikipedia.org)
  • Tobacco has the same effect of increasing the craving for alcohol. (wikipedia.org)
  • organ failure
  • The purpose of this paper is, therefore, to discuss bacterial translocation, including its definition and role in causing sepsis syndrome and organ failure in critically ill children. (hindawi.com)
  • A sustained increase of IAP over 20 mmHg associated with a new organ failure is recognized as the Abdominal Compartment Syndrome (ACS). (intechopen.com)
  • Hypertension
  • Sustained elevation of IAP is associated with multiple physiologic alterations (Intra-abdominal Hypertension) and may be life threatening when exceeds certain levels (Abdominal Compartment Syndrome). (intechopen.com)
  • According to the consensus document by the World Society of the Abdominal Compartment Syndrome (WSACS), updated on 2013, Intra-abdominal Hypertension is defined by a persistent or repeated elevation of IAP over 12 mmHg [ 3 ]. (intechopen.com)
  • commonly
  • Actual urinary complaints such as haematuria or oliguria are uncommon, though these are seen commonly in nephritic syndrome. (wikipedia.org)
  • changes
  • however, physiological changes caused by cocaine withdrawal include vivid and unpleasant dreams, insomnia or hypersomnia, anger, increased appetite and psychomotor retardation or agitation. (wikipedia.org)
  • present
  • It may also be used to treat bromhidrosis, although this usually responds to non-surgical treatments, and sometimes people with olfactory reference syndrome present to surgeons requesting sympathectomy. (wikipedia.org)
  • However
  • However, a number of physiological and technical issues can affect the accuracy of the results and appropriate guidelines for the technique have been published. (jove.com)
  • effects
  • At normal doses, caffeine has variable effects on learning and memory, but it generally improves reaction time, wakefulness, concentration, and motor coordination. (wikipedia.org)
  • time
  • Moderate doses of caffeine (around 5 mg/kg) can improve sprint performance, cycling and running time trial performance, endurance (i.e., it delays the onset of muscle fatigue and central fatigue), and cycling power output. (wikipedia.org)
  • Class Ia drugs increase the time one action potential lasts in the heart. (wikipedia.org)
  • studies
  • Our results suggest that beatquency and machine learning provide valuable tools in physiological studies of HRV. (harvard.edu)
  • In one of these studies, 99 individuals with Laron syndrome (a rare form of dwarfism) were monitored alongside their non-dwarf kin for a period of ten years. (wikipedia.org)
  • patients
  • A simple, validated protocol consisting of a battery of tests is available to identify elderly patients with frailty syndrome. (jove.com)
  • We wish to stimulate a comprehensive understanding of such a complex physiological phenomenon as intermittent hypoxia, which may be accompanied by other confounding factors (e.g., hypercapnia, polycythemia), in order to prevent or reduce its harmful consequences, while maximizing its potential utility as an effective therapeutic tool in pediatric patients. (frontiersin.org)
  • headaches
  • This disruptive pattern of breathing generates disruptive sleep patterns, the consequences of which being that those individuals may exhibit increased fatigability, lethargy, decreased ability to concentrate, increased irritability, and morning headaches. (wikipedia.org)
  • density
  • Furthermore, PC made via PEMT plays a wide range of physiological roles, utilized in choline synthesis, hepatocyte membrane structure, bile secretion, and very-low-density lipoprotein (VLDL) secretion. (wikipedia.org)
  • cause
  • Cocaine overdose may result in hyperthermia as stimulation and increased muscular activity cause greater heat production. (wikipedia.org)