• proteins
  • The chimera recycled in parallel with synaptic vesicle proteins demonstrating that the nerve terminal efficiently sorts transmembrane proteins into different pathways. (rupress.org)
  • A family of phosphoproteins associated with synaptic vesicles and that interact with small G proteins such as rab to regulate neurotransmitter release and are phosphorylated by various kinases. (oup.com)
  • The identification of a number of highly conserved proteins that are important for membrane trafficking and fusion, combined with the development of new techniques for monitoring exocytosis have permitted models of the molecular events leading up to the calcium-dependent fusion of synaptic vesicles to be proposed. (rupress.org)
  • protein
  • Synaptic vesicles are concentrated in the distal axon, far from the site of protein synthesis. (rupress.org)
  • We have identified two distinct signal-dependent sorting steps that direct the synaptic vesicle protein synaptobrevin to its final destination. (rupress.org)
  • Following the mutation screening of genes known to cause amyotrophic lateral sclerosis (ALS) in index cases from 107 familial ALS (FALS) kindred, a point mutation was identified in vesicle-associated membrane protein-associated protein B (VAPB), or VAMP-associated protein B, causing an amino acid change from threonine to isoleucine at codon 46 (T46I) in one FALS case but not in 257 controls. (ed.ac.uk)
  • Drosophila VAMP-associated protein of 33 kDa A (DVAP-33A) is the structural homologue of hVAPB and regulates synaptic remodeling by affecting the size and number of boutons at neuromuscular junctions. (ed.ac.uk)
  • control
  • After control experiments verified that this combination of techniques is valid for the study of exocytosis in synaptic terminals, a comparison was made between the Ca 2+ dependence of the rate of exocytosis in synaptic terminals internally dialyzed with MgATP, MgATP-γ-S, or no added Mg 2+ or nucleotide. (rupress.org)
  • events
  • These events are paralleled by a prominent increase in evoked synaptic vesicle recycling that is blocked by the specific MAPK inhibitor 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one. (jneurosci.org)