• axonal
  • The neuroprotective slow Wallerian degeneration ( Wld s ) mutation delays degeneration in axonal and synaptic compartments of neurons following a wide range of traumatic and disease-inducing stimuli, providing a powerful experimental tool with which to investigate modulation of neuronal vulnerability. (biomedcentral.com)
  • These data suggest a strong correlation between modified cell cycle pathways and altered vulnerability of axonal and synaptic compartments in postmitotic, terminally differentiated neurons. (biomedcentral.com)
  • We further explore the interdependence of axons and myelin to better understand how glial dysfunction might cause axonal damage and vice versa. (rupress.org)
  • cell
  • In this review, we propose that as a result of the tight cell biological interconnection of axons and myelin, damage to either can spread, which might convert a local inflammatory disease process early in MS into the global progressive disorder seen during later stages. (rupress.org)
  • In particular, we discuss the commonalities and differences in the way axons and glial cells degenerate to find out which mechanistic concepts can be transferred from one cell type to the other. (rupress.org)