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  • Spinal
  • There are many causes of scoliosis, including spinal deformities, neuromuscular problems, and inherited diseases or conditions caused by the environment. (wikipedia.org)
  • gene
  • Unlike inherited disease-causing mutations, the gene variant that triggers Proteus occurs spontaneously in each affected individual during embryonic development. (genome.gov)
  • Only the cells that descend from the cell with the original AKT1 gene mutation display the hallmarks of the disease, leaving the individual with a mixture of normal and mutated cells. (genome.gov)
  • Proteus syndrome is caused by a mutation in a growth regulatory gene called AKT1 that occurs after fertilization of the embryo (somatic mutation). (medigoo.com)
  • It means that those who suffer from proteus syndrome have some cells with a normal copy of AKT1 gene and other cells with the abnormal gene. (medigoo.com)
  • An important gene associated with Cowden Syndrome 1 is PTEN (Phosphatase And Tensin Homolog), and among its related pathways/superpathways are VEGF Signaling Pathway and EGF/EGFR Signaling Pathway . (malacards.org)
  • Both of these disorders are inherited in a dominant fashion, which means that anyone who receives just one defective gene will have the disease. (encyclopedia.com)
  • tumors
  • Proteus syndrome may be complicated by kidney abnormalities, cystic lung disease, eye disorders such as crossed eyes, tumors, and cysts of the eyeballs. (medigoo.com)
  • Cowden syndrome is characterized by hamartomatous lesions affecting derivatives of ectodermal, mesodermal and endodermal layers, macrocephaly, facial trichilemmomas (benign tumors of the hair follicle infundibulum), acral keratoses, papillomatous papules, and elevated risk for development of several types of malignancy, particularly breast carcinoma in women and thyroid carcinoma in both men and women. (malacards.org)
  • The characteristic symptoms of NF-2 are due to tumors along the acoustic nerve that result in nerve dysfunction and the loss of hearing. (encyclopedia.com)
  • nevi
  • Keratinocytic nevi are frequent in this condition, occurring as velvety overgrowths of the skin, being found in at least half the people affected with Proteus syndrome. (news-medical.net)
  • Huntington's Disease
  • The total number of people affected by this condition is more than 2 million worldwide, which according to the Children's Tumor Foundation, makes it more common than cystic fibrosis, Duchenne muscular dystrophy, and Huntington's Disease, combined. (hubpages.com)
  • 7.NF is more prevalent than Cystic Fibrosis, hereditary Muscular Dystrophy, Huntington's Disease and Tay Sachs combined. (blogspot.com)
  • liver
  • As of 2007 the Infectious Disease Society of America (IDSA) and the American Thoracic Society recommended levofloxacin and other respiratory fluoroquinolines as first line treatment for community acquired pneumonia when co-morbidities such as heart, lung, or liver disease are present or when in-patient treatment is required. (wikipedia.org)
  • Infectious canine hepatitis is a sometimes fatal infectious disease of the liver. (wikipedia.org)
  • Symptoms include liver and kidney failure and vasculitis. (wikipedia.org)
  • infancy
  • The symptoms typically begin in early infancy and are progressive, often into general cognitive and/or functional disability. (wikipedia.org)
  • cause
  • Vitamin B12 deficiency can also cause symptoms of mania and psychosis. (wikipedia.org)
  • Canine herpesvirus is an infectious disease that is a common cause of death in puppies less than three weeks old. (wikipedia.org)
  • Pseudorabies is an infectious disease that primarily affects swine, but can also cause a fatal disease in dogs with signs similar to rabies. (wikipedia.org)
  • Canine minute virus is an infectious disease that can cause respiratory and gastrointestinal signs in young puppies. (wikipedia.org)
  • Brucellosis is a sexually transmitted bacterial disease that can cause uveitis, abortion, and orchitis in dogs. (wikipedia.org)
  • tumor
  • Symptoms depend on the size of the tumor, its location relative to the conduction system, and whether or not it obstructs blood flow. (wikipedia.org)
  • condition
  • For those who eventually encounter someone with the disease, and I'm pretty certain you will, I hope to dispel some myths about this condition. (hubpages.com)
  • There will be some pictures that will show you some images of NF patients, however I think it is important to stress that this condition has symptoms that are more than physical. (hubpages.com)
  • spine
  • Scheuermann's kyphosis is considered a form of juvenile osteochondrosis of the spine, and is more commonly called Scheuermann's disease. (wikipedia.org)
  • Megalencephaly
  • Megalencephaly, also known as macroencephaly , is related to megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 and megalencephaly-capillary malformation-polymicrogyria syndrome . (malacards.org)
  • Signs
  • One of the challenges in dealing with the signs of this disease is that there is high risk of an individual with acquiring Multiple Sclerosis. (ygoy.com)
  • Canine coronavirus is a gastrointestinal disease that is usually asymptomatic or with mild clinical signs. (wikipedia.org)
  • fatty
  • Reye's syndrome (RS) is named for Dr. Douglas Reye who along with Drs. G. Morgan and J. Baral described encephalopathy and fatty accumulation and degeneration in children in a 1963 Lancet article. (pediatriceducation.org)
  • affects
  • Blastomycosis* is a fungal disease caused by Blastomyces dermatitidis that affects both dogs and humans. (wikipedia.org)
  • Histoplasmosis* is a fungal disease caused by Histoplasma capsulatum that affects both dogs and humans. (wikipedia.org)
  • The disease in dogs usually affects the lungs and small intestine. (wikipedia.org)
  • Coccidioidomycosis* is a fungal disease caused by Coccidioides immitis or Coccidioides posadasii that affects a variety of species, including dogs. (wikipedia.org)
  • Sporotrichosis is a fungal disease caused by Sporothrix schenckii that affects both dogs and humans. (wikipedia.org)
  • acute
  • Other experimental trials for treating acute disseminated encephalomyelitis symptoms are under way. (ygoy.com)
  • patients
  • Some patients have a recognizable alteration of the facial outline - including down-slanting eyes, a low nasal bridge, a gaping mouth, and a long face - which is a marker for neurological involvement. (news-medical.net)
  • Most patients who undergo surgery to correct their kyphosis have Scheuermann's disease. (wikipedia.org)
  • Patients with NF-2 do not necessarily have the same characteristic skin symptoms that appear in NF-1. (encyclopedia.com)