• dysfunction
  • The main problem is the distinction between cholesterol embolism and vasculitis (inflammation of the small blood vessels), which may cause very similar symptoms - especially the skin findings and the kidney dysfunction. (wikipedia.org)
  • Other causes that may lead to similar symptoms include ischemic renal failure (kidney dysfunction due to an interrupted blood supply), a group of diseases known as thrombotic microangiopathies and endocarditis (infection of the heart valves with small clumps of infected tissue embolizing through the body). (wikipedia.org)
  • Adult males with an adrenomyeloneuropathy presentation typically present initially with muscle stiffness, paraparesis and sexual dysfunction. (wikipedia.org)
  • HDLS commonly manifests with neuropsychiatric symptoms, progressing to dementia, and after a few years shows motor dysfunction. (wikipedia.org)
  • POLD exhibits noninflammatory demyelination of axons with initial symptoms of euphoria, apathy, headache, and executive dysfunction. (wikipedia.org)
  • gene
  • The syndrome is thought to be inherited as an autosomal recessive genetic trait, meaning that in order to manifest symptoms, a person must inherit a gene for Abdallat-Davis-Farrage syndrome from both parents. (wikipedia.org)
  • acute
  • Acute disseminated encephalomyelitis (ADEM) is considered a monophasic acute demyelinating disorder of the central nervous system (CNS) characterized by diffuse neurologic signs and symptoms coupled with evidence of multifocal lesions of demyelination on neuroimaging. (aappublications.org)
  • mild
  • Although initially the symptoms are usually mild, they worsen rapidly over the course of hours to days, with the average time to maximum severity being about four and a half days. (wikipedia.org)
  • Administration of high doses of biotin in the early progression of the disorder eliminates pathological symptoms while delayed treatment results in residual paraparesis, mild mental retardation, or dystonia. (wikipedia.org)
  • include
  • Initial symptoms in boys affected with the childhood cerebral form of ALD include emotional instability, hyperactivity and disruptive behavior at school. (wikipedia.org)
  • multiple sclerosis
  • ADEM's symptoms resemble the symptoms of multiple sclerosis (MS), so the disease itself is sorted into the classification of the multiple sclerosis borderline diseases. (wikipedia.org)
  • The natural course of multiple sclerosis is extremely variable with symptoms that may appear, disappear, reappear, or gradually worsen over time. (bmj.com)
  • Commonly
  • As an X-linked disorder, ALD presents most commonly in males, however approximately 50% of heterozygote females show some symptoms later in life. (wikipedia.org)
  • With symptoms of personality changes, behavioral changes, dementia, depression, and epilepsy, HDLS has been commonly misdiagnosed for a number of other diseases. (wikipedia.org)
  • infection
  • Symptoms usually begin 1-3 weeks after infection. (wikipedia.org)
  • HTLV testing may be performed when a person has symptoms or findings that suggest that they have a condition associated with an HTLV-I or HTLV-II infection, especially when the person also has identified risk factors. (labcorp.com)
  • Initially diagnosed with an inner ear infection, the patient's symptoms did not improve and he was evaluated further. (neurology.org)
  • aphasia
  • The acronym "MASA" describes the four major symptoms - Mental retardation, Aphasia, Shuffling gait, and Adducted thumbs. (wikipedia.org)
  • syndrome
  • As the second reported case of such symptoms, it suggested that these symptoms were part of one entity, named "Primrose syndrome" In 1996, Lindor et al. (wikipedia.org)
  • Increased amounts of protein in the urine may cause edema (swelling) of the skin (a combination of symptoms known as nephrotic syndrome). (wikipedia.org)
  • The mortality rate is approximately 20%, with 50% of individuals living with anterior cord syndrome having very little or no changes in symptoms. (wikipedia.org)
  • This syndrome has severe symptoms in males, while females are carriers because only one X-chromosome is affected. (wikipedia.org)
  • Male descendants who inherit the affected chromosome will express the symptoms of the syndrome, but females who do will be carriers. (wikipedia.org)
  • irregular
  • Kidney involvement leads to the symptoms of renal failure, which are non-specific but usually cause nausea, reduced appetite (anorexia), raised blood pressure (hypertension), and occasionally the various symptoms of electrolyte disturbance such as an irregular heartbeat. (wikipedia.org)
  • citation needed] Albinism (hair) Irregular decreased skin pigmentation Excessive freckling Insensitivity to pain Paraparesis/quadraparesis Abdallat, A. (wikipedia.org)
  • disease
  • Treatment generally aims to control the specific symptoms, as there is no standard treatment available.Interferon alpha may be beneficial over short periods, and some aspects of the disease may be improved with interferon beta. (malacards.org)
  • Other symptoms usually occur, different in each case, but it is unknown whether or not these symptoms are caused by the same disease. (wikipedia.org)
  • gait
  • Furthermore, among the core symptoms of HSP are also included abnormal gait and difficulty in walking, decreased vibratory sense at the ankles, and paresthesia. (wikipedia.org)
  • patients
  • Because the onset of Dominant optic atrophy is insidious, symptoms are often not noticed by the patients in its early stages and are picked up by chance in routine school eye screenings. (wikipedia.org)
  • Motor
  • A brain MRI showed that her basal ganglia had partially calcified, which may have contributed to her paraparesis and motor tics. (wikipedia.org)