• Gene
  • The aim of this study was to compare the human sodium iodide symporter gene ( hNIS ) with the herpes simplex virus type 1 thymidine kinase gene ( HSV1-tk ) as the reporter gene in non-invasive imaging of cardiac transgene expression with positron emission tomography (PET). (springer.com)
  • It was previously reported that -pituitary tumour transforming gene- (PTTG) is overexpressed in thyroid tumours and downregulates the expression of the sodium iodide symporter (NIS) in FRTL-5 cells. (thyroidmanager.org)
  • concentration
  • Some anions like perchlorate, pertechnetate and thiocyanate, can affect iodide capture by competitive inhibition because they can use the symporter when their concentration in plasma is high, even though they have less affinity for NIS than iodide has. (wikipedia.org)
  • activity
  • NCC activity can be inhibited by thiazides, which is why this symporter is also known as the thiazide-sensitive Na+-Cl− cotransporter. (wikipedia.org)
  • Loading
  • I've offered the Halides Loading test too for years and now it seems it is a useful one for checking this Symporter issue too. (purehealthclinic.co.uk)
  • However, we do know that one of the main causes of a symporter issue is high halides, so do the Halides Loading test first and, if those are high, you have your answer. (purehealthclinic.co.uk)