Polymorphism, GeneticPolymorphism, Single NucleotideGenetic Predisposition to DiseaseProtein ConformationDisease SusceptibilityGene FrequencyAllelesModels, MolecularGenotypeMolecular Sequence DataHaplotypesCase-Control StudiesPolymorphism, Single-Stranded ConformationalMicrobial Sensitivity TestsPolymerase Chain ReactionAmino Acid SequenceMutationLinkage DisequilibriumProtein BindingGenetic Association StudiesGenetic VariationBase SequenceBinding SitesAsian Continental Ancestry GroupProtein Structure, TertiaryProtein Structure, SecondaryCircular DichroismCrystallography, X-RayMolecular ConformationKineticsPhenotypeThermodynamicsAnti-Bacterial AgentsSequence Analysis, DNAAmino Acid SubstitutionGenetic MarkersSpectrometry, FluorescenceRisk FactorsHomozygoteDNAProtein FoldingGenetic LinkageChromosome MappingGenome-Wide Association StudyMagnetic Resonance SpectroscopyMolecular Dynamics SimulationNucleic Acid ConformationEuropean Continental Ancestry GroupChinaEscherichia coliLigandsDNA PrimersNuclear Magnetic Resonance, BiomolecularHeterozygotePromoter Regions, GeneticHydrogen-Ion ConcentrationProtein DenaturationStructure-Activity RelationshipTemperatureBacterial ProteinsDNA Mutational AnalysisMicrosatellite RepeatsModels, ChemicalSpecies SpecificityComputer SimulationMethylenetetrahydrofolate Reductase (NADPH2)ExonsOdds RatioAmplified Fragment Length Polymorphism AnalysisRecombinant ProteinsGlutathione TransferaseMutagenesis, Site-DirectedDrug Resistance, BacterialHydrogen BondingPoint MutationDrug Resistance, MicrobialProteinsGenetic LociProtein Structure, QuaternaryMutation, MissenseModels, GeneticPedigreeCattlePeptidesTryptophanTime FactorsJapanDimerizationPhylogenySolutionsAllosteric RegulationCatalytic DomainCell LineSequence AlignmentCarrier ProteinsIntronsPeptide FragmentsAntifungal AgentsCohort StudiesGenetics, Population