Survival patients nephrectomy. Medical search. Frequent questions

According to the NWTSG protocol, the first step in the treatment of Wilms tumor is surgical staging followed by radical nephrectomy, if possible. (medscape.com)
Although end-stage kidney disease after unilateral radical nephrectomy is uncommon (0.25% in the NWTSG trial), preserving healthy kidney tissue may prevent this complication, especially in patients with an underlying intrinsic kidney disease (eg, WAGR [Wilms tumor, aniridia, genitourinary anomalies, and mental retardation] syndrome, Denys-Drash syndrome). (medscape.com)
For patients with localized disease, partial or radical nephrectomy is the standard of care for most, and surveillance or ablation can be considered in a subset of patients with stage I disease. (onclive.com)
When comparing partial nephrectomy, radical nephrectomy, ablative therapies, and active surveillance through a large registry, cancer-specific survival was comparable in all groups when adjusting for age and comorbidities. (urologytimes.com)
Radical nephrectomy resulted in significantly worse kidney function in patients with a small renal mass. (urologytimes.com)
Radical nephrectomy should be considered when there is increased oncologic potential. (urologytimes.com)
In a study, diabetes increased the odds of pathologic upgrading of renal cell carcinoma by 65% and 32%, among patients undergoing partial and radical nephrectomy, respectively. (renalandurologynews.com)
A radical nephrectomy removes the entire kidney that contains the cancer. (healthline.com)
The KEYNOTE-564 trial was designed to evaluate adjuvant immunotherapy following partial or radical nephrectomy (removal of the cancerous kidney) within 12 weeks prior to randomization. (dana-farber.org)
3 Patients were treated with neoadjuvant axitinib for up to 8 weeks prior to radical nephrectomy. (urologytimes.com)
Objectives: To determine whether preoperative laboratory values are independently associated with death from clinically confined clear cell renal cell carcinoma (RCC) after radical nephrectomy. (elsevierpure.com)
Methods: We identified 1707 patients with clinically confined (pNx/pN0, pM0), unilateral, sporadic clear cell RCC treated with radical nephrectomy between 1970 and 2002. (elsevierpure.com)
Retrospective studies suggest that partial nephrectomy (PN) provides improved survival compared to radical nephrectomy (RN), even when performed electively. (auanet.org)
2004) Nephron sparing surgery for appropriately selected renal cell carcinoma between 4 and 7 cm results in outcome similar to radical nephrectomy. (medscape.org)
1969) The results of radical nephrectomy for renal cell carcinoma. (medscape.org)
2000) Laparoscopic versus open radical nephrectomy: a 9-year experience. (medscape.org)
Partial nephrectomy, which is removal of only the cancer and a small border of normal tissue, is the standard treatment for the smallest cancers however patients will require a radical nephrectomy, or removal of the entire kidney for larger renal cell cancers. (yourcancercare.com)
Up to date, the culprit of treatment is surgical management with radical nephrectomy, lymph node dissection, thrombectomy and vascular reconstruction if necessary. (bvsalud.org)
6 Overall survival of patients with T1b tumors may also be better when compared to radical nephrectomy based on data from the National Cancer Database. (auanews.net)
Overall survival of patients with T1b tumors may also be better when compared to radical nephrectomy. (auanews.net)

1 The median overall survival was 18.4 months for patients treated with targeted therapy using sunitinib vs 13.9 months for those treated with nephrectomy followed by sunitinib-the current standard of care. (ascopost.com)
The Association Between Cytoreductive Nephrectomy and Overall Survival in Metastatic Renal Cell Carcinoma with Primary Tumor Size ≤4 cm. (urotoday.com)
Overall survival was worse in the active surveillance group, but this was likely attributable to older age and worse health status at baseline. (urologytimes.com)
Investigators believe their study is the first to demonstrate the adverse impact of LVI on overall survival in patients with surgically treated renal cell carcinoma. (renalandurologynews.com)
Relapse-free survival should not be used as a surrogate for overall survival in cancer trials testing adjuvant immunotherapy, according to researchers. (renalandurologynews.com)
Adding stereotactic body radiation therapy to immune checkpoint inhibitor therapy was safe but failed to improve progression-free and overall survival. (renalandurologynews.com)
And although there have been advancements in systemic treatment strategies for patients with advanced disease, the 5-year overall survival for patients with advanced disease is less than 50% in the modern era. (ascopost.com)
3 The study demonstrated an improvement in disease-free survival (6.2 months vs 4.0 months, hazard ratio [HR] = 0.74, 95% confidence interval [CI] = 0.55-0.99, P = .04) with adjuvant sunitinib over placebo, with no benefit in overall survival (HR = 0.92, 95% CI = 0.66-1.28) and increased toxicity. (ascopost.com)
5 Neither sunitinib nor sorafenib improved overall survival vs placebo in the overall population. (ascopost.com)
However, in clinical practice, utilization of sunitinib remains limited, given no appreciable benefit in overall survival and increased toxicity. (ascopost.com)
The trial is continuing to see if the adjuvant treatment increases overall survival. (dana-farber.org)
The estimated overall survival rate at 24 months was 96.6% with pembrolizumab and 93.5% with placebo. (dana-farber.org)
Overall survival, defined as the time from randomization to death due to any cause, is a secondary end point. (dana-farber.org)
The researchers are continuing to monitor the patients to determine if there is a difference in overall survival between the two arms of the trial, which Choueiri said may take additional follow up. (dana-farber.org)
Despite these promising outcomes, Stewart said the single-agent TKI approach used in NAXIVA is outdated and the trial had other shortcomings, such as being a single-arm trial with no overall survival end point. (urologytimes.com)
At a median follow-up of 23.5 months, the median overall survival and median disease-free survival had not yet been reached. (urologytimes.com)
Overall survival was calculated using the Kaplan-Meier method. (biomedcentral.com)
The overall survival was 58% at 1 year, 37% at 2 years and 12% at 5 years. (biomedcentral.com)
Variables and outcomes analyzed in each group included the percent of patients with metastatic disease at presentation, lymph node involvement, Eastern Cooperative Oncology Group score, response to immunotherapy, and median and overall survival using Kaplan-Meier curves. (nih.gov)
The median overall survival was not reached. (actionkidneycancer.org)
Overall, of the 249 patients with favorable risk, the median overall survival (OS) is 63.3 mo. (bmj.com)
SUMMARY: Patients with resected RCC should be counselled on their risk of recurrence and the potential option of adjuvant pembrolizumab, recognizing that overall survival data are not yet available. (bvsalud.org)
Variables associated with event free survival (EFS) rate, overall survival (OS) rate and cumulative recurrence rate were evaluated by Lasso regression analysis (including variables selection, model construction and hazard ratio calculating). (bvsalud.org)
The final analysis of the phase 3 LEAP-002 study did not demonstrate an overall survival (OS) benefit of the addition of pembrolizumab to first-line lenvatinib in patients with advanced hepatocellular carcinoma (HCC). (medicom-publishers.com)
A previous systematic review and meta-analysis of 14 studies comprising 3003 patients with incurable advanced gastric cancer revealed that palliative gastrectomy significantly improved overall survival [ 9 ]. (biomedcentral.com)
1 , 2 In one trial, a significant improvement in progression-free survival (PFS) was seen with sunitinib over interferon-alfa (11 vs 5 months), 1 with a borderline statistically significant benefit in overall survival despite robust crossover. (jnccn.org)

Following the failure of TKIs in the adjuvant setting, pembrolizumab (Keytruda) was studied in the phase 3 KEYNOTE-564 trial (NCT03142334), randomizing 994 patients 1:1 to 1 year of adjuvant immunotherapy vs placebo. (onclive.com)
The KEYNOTE-564 study is the first positive adjuvant immunotherapy trial in patients with resected renal cell carcinoma and presents an advancement in the care of these patients. (ascopost.com)
7 The study, which was reported in The New England Journal of Medicine by Choueiri et al and is summarized in this issue of The ASCO Post , is the first positive adjuvant immunotherapy trial in patients with resected renal cell carcinoma and represents an advancement in the care of these patients. (ascopost.com)
Researchers conducting this phase 3 trial in multiple sites around the country are examining the use of the immunotherapy Opdivo in patients with kidney cancer at two different points: before surgery, to possibly shrink the tumor, thereby reducing the amount of tissue to be removed during nephrectomy, and after surgery, to increase survival. (curetoday.com)
This phase 1 study was created to determine the highest dose of the investigational immunotherapy drug CDX-1140 that can be given safely to patients. (curetoday.com)
An immunotherapy drug given after surgery improved disease-free survival rates in patients with kidney cancer at high risk of relapse. (dana-farber.org)
This is the first positive study of adjuvant immunotherapy in patients with kidney cancer at high risk of relapse. (dana-farber.org)
Treatment with an immunotherapy drug following kidney cancer surgery, prolonged disease-free survival rates in patients at high risk for recurrence, according to an interim report of a phase 3 clinical trial of adjuvant immunotherapy in this patient population. (dana-farber.org)
ESMO 2023: Does stopping VEGFR TKI treatment and continuing immunotherapy influence the survival of patients on combination therapy? (actionkidneycancer.org)
These survival algorithms have been applied to assess outcomes in patients receiving T-cell checkpoint inhibitory immunotherapy and tyrosine kinase inhibitor therapy, but have not been applied extensively to patients receiving high dose interleukin-2 (HD IL-2) immunotherapy. (bmj.com)
Methods: Clinical data from patients diagnosed with metastatic NSCLC who received immunotherapy plus single-agent chemotherapy as a second- or later-line setting were retrospectively collected between March 2019 and January 2022. (bvsalud.org)
Overall, 44.1% of patients treated with lenvatinib plus pembrolizumab received subsequent systemic anti-cancer treatment (34.9% tyrosine kinase inhibitor, 14.4% immunotherapy, 3.5% chemotherapy). (medicom-publishers.com)
Of all patients treated with lenvatinib plus placebo, 52.1% received subsequent systemic therapy (40.1% tyrosine kinase inhibitor, 22.8% immunotherapy, 3.3% chemotherapy). (medicom-publishers.com)

His results demonstrated that by performing a liver mobilization, urological oncologists could avoid a thoracic incision in many patients Building on the techniques described for resecting large renal tumors, Ciancio adapted his liver mobilization technique to address retrohepatic or even suprahepatic inferior vena caval thrombus associated with renal tumors. (wikipedia.org)
Tumors involving other organs and the CNS (brain, spinal cord) are present in 25% of patients with VHL disease. (medscape.com)
Postchemotherapy excision of the tumor is indicated in patients with bilateral tumors, tumors that extended beyond the midline and have shrunk, and tumors with vascular extension. (medscape.com)
Large tumors that extend beyond the midline, have vascular extension, or both are relative contraindications, since some surgeons elect to obtain tissue via surgical excision, but this may expose patients to increased surgical risks. (medscape.com)
In patients with bilateral Wilms tumors, solitary kidney, or kidney insufficiency, partial nephrectomy is a reasonable consideration. (medscape.com)
Also new in the guideline: The guideline prioritizes partial nephrectomy in the management of cT1a renal masses and nephron-sparing approaches for patients with solitary kidneys, bilateral tumors, known familial RCC, pre-existing chronic kidney disease (CKD), or proteinuria. (urologytimes.com)
Currently, many patients who are diagnosed with primary tumors that originate inside the kidney are treated surgically. (scienceblog.com)
Preserving kidney function has been clearly demonstrated to maximize quality of life and length of life for patients with kidney tumors," Dr. Cadeddu said. (scienceblog.com)
Upper pole tumors with direct extension into the adrenal gland predict significantly worse survival than similarly staged tumors with fat invasion and they have a prognosis similar to that of stage pT4 disease. (nih.gov)
Background: The aim of the study was retrospective analysis of nephron-sparing surgery results of 53 patients, performed due to unilateral small kidney tumors in the period of 1988-1998. (medscimonit.com)
Young patients had lower stage tumors with a low Fuhrman grade, a lower rate of lymphovascular invasion than patients in the other age groups. (korea.ac.kr)
2004) Safety and efficacy of partial nephrectomy for all T1 tumors based on an international multicenter experience. (medscape.org)
2003) Comparative analysis of laparoscopic versus open partial nephrectomy for renal tumors in 200 patients. (medscape.org)
2007) Comparison of 1,800 laparoscopic and open partial nephrectomies for single renal tumors. (medscape.org)
Minimally invasive nephrectomy is performed routinely for adult renal tumors and for many benign pediatric conditions. (northwestern.edu)
The APSA Cancer Committee performed a systematic review to better understand the risks and benefits of MIS in pediatric patients with renal tumors. (northwestern.edu)
Survival data are similar between groups, but follow-up times were inconsistent and patient selection was clearly biased, with only small tumors being selected for MIS. (northwestern.edu)
Patients were included if they were determined to have (after nephrectomy) pathological stage T3 or higher tumors (or node positive tumors) or pathological T2 tumors with nuclear grade 4, or T2 tumors with sarcomatoid differentiation. (auanews.net)
Partial nephrectomy for T1b tumors is expected to be complex and must have good preoperative imaging to determine the location of the mass in relation to the hilar vessels. (auanews.net)

5,6 Given the high recurrence rate after curative-intent therapy, perioperative therapy has been studied to improve upon patient outcomes. (onclive.com)
13 Inclusion criteria comprised patients with a clear-cell component and met criteria for a high risk of recurrence (pT2 with nuclear grade 4 or sarcomatoid differentiation, pT3+, pTanyN+, or M1 NED post completely resected metastatic disease within 1 year of nephrectomy). (onclive.com)
In patients with locoregional renal cell carcinoma (RCC) who were at high risk of tumor recurrence after nephrectomy, adjuvant sunitinib (Sutent) showed a 2-year advantage in median survival versus placebo. (urologytimes.com)
Historically, trials of adjuvant cytokine-based treatments have failed to demonstrate improvements in disease-free survival for patients at high risk of recurrence following definitive surgical resection. (ascopost.com)
The results of the S-TRAC trial contrasted with those of the large phase III ASSURE trial, which tested the efficacy of sunitinib vs sorafenib vs placebo in patients with renal cell carcinoma at high risk of recurrence. (ascopost.com)
The KEYNOTE-564 study was a phase III, double-blind, randomized, placebo-controlled trial testing the efficacy of pembrolizumab vs placebo as adjuvant therapy for patients with clear cell renal cell carcinoma at high risk of recurrence following definitive nephrectomy. (ascopost.com)
The trial enrolled a heterogeneous patient population regarding risk of recurrence, including patients with high-grade pT2 disease to those with metastatic disease who had undergone complete definitive resection of all metastatic disease and were without evidence of metastatic disease on radiographic imaging. (ascopost.com)
For inclusion in the trial, patients were required to have a clear-cell component of their tumor and be at intermediate-high or high risk of recurrence. (dana-farber.org)
The primary endpoint was disease-free survival, which is the time from randomization to the first documented local or distant renal-cell carcinoma recurrence or death due to any cause. (dana-farber.org)
The estimated percentage of patients who remained alive and recurrence-free at 24 months was 77.3% with pembrolizumab and 68.1% with placebo. (dana-farber.org)
Gender, location of metastases, time between diagnosis of renal cell carcinoma and treatment of metastatic disease, incidence of local recurrence, radiation and chemotherapy did not influence survival. (biomedcentral.com)
Perioperative variables collected were age and gender of the patient, type of surgery, complications, time period after first diagnosis of RCC and after onset of symptoms, metastatic pattern, location of metastases, incidence of pathologic fracture and local recurrence and time of survival. (biomedcentral.com)
2. Prospective 10-year survival time in our patients was 98%, including 92% of patients remaining without recurrence or metastases. (medscimonit.com)
There is a clear need for treatments to reduce the risk of RCC recurrence and thus improve survival. (bvsalud.org)
1999) Nephron sparing surgery for localized renal cell carcinoma: impact of tumor size on patient survival, tumor recurrence and TNM staging. (medscape.org)

According to the results of this retrospective study, patients who underwent CN and subsequently were treated with TT had better outcomes compared to patients treated with upfront TT. (muni.cz)
Nephrectomy has been the standard of care for metastatic renal cell carcinoma for 20 years, but now that targeted therapies have improved outcomes substantially, the question is whether all patients should have nephrectomy as well as targeted therapy. (ascopost.com)
Patient-reported outcomes in metastatic renal cell carcinoma trials using combinations versus sunitinib as first-line treatment. (urotoday.com)
Cytoreductive partial and radical nephrectomies provide equivalent oncologic outcomes in T1-2M1 renal cell carcinoma. (urotoday.com)
A retrospective study revealed no significant difference in 36-month progression-free survival and renal function outcomes in patients with small renal masses. (renalandurologynews.com)
The FDA granted Welireg a priority review after it showed promising outcomes for patients with pretreated advanced renal cell carcinoma. (curetoday.com)
In an article available online in the journal Cancer , Dr. Jeffrey Cadeddu, professor of urology and radiology at UT Southwestern Medical Center, reported the outcomes of more than 200 patients who were treated with radiofrequency ablation (RFA). (scienceblog.com)
Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St. (medscimonit.com)
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o. (medscimonit.com)
Given that the functional dividends of elective PN did not correlate with better survival, our study suggests that selection bias for procedure is the main factor impacting outcomes. (auanet.org)
Lane BR and Gill IS (2007) 5-Year outcomes of laparoscopic partial nephrectomy. (medscape.org)
2005) Exploring the learning curve, pathological outcomes and perioperative morbidity of laparoscopic partial nephrectomy performed for renal mass. (medscape.org)
For T1b renal masses, partial nephrectomy results in improved postoperative renal function with equivalent oncologic outcomes, though the complication rate and blood loss are expected to be greater. (auanews.net)
The robotic and open approach for partial nephrectomy is based on surgeon experience and can have equivalent oncologic outcomes. (auanews.net)
In the upcoming years, Dr. Jonasch predicted, the next wave of clinical trials will test the combination of novel immunotherapies with antiangiogenic agents in the hope of further improving patient outcomes. (jnccn.org)
NSCLC patients treated in California, as well as the influence of facility American College of Surgeons Commission on Cancer (CoC) accreditation on long-term outcomes. (cdc.gov)
however unlike volume, the relationship between CoC accreditation and patient outcomes has not been well studied. (cdc.gov)
The CoC is a conglomerate of over 50 organizations that focus on improving oncologic outcomes and quality of life for cancer patients [10-13]. (cdc.gov)

Overall, 35% of patients (n = 7) had a response and 7 (41.2%) of 17 patients who underwent nephrectomy had less invasive surgery than originally planned. (urologytimes.com)
Of 1,087 patients who underwent nephrectomy 27 were identified with direct adrenal involvement and 187 were identified with perinephric fat or renal sinus involvement. (nih.gov)
METHODS BAP1 expression was assessed, using IHC, in 1479 patients who underwent nephrectomy to treat clinically localized ccRCC. (elsevierpure.com)

The role of cytoreductive nephrectomy (CN) in treatment of locally advanced or metastatic renal cell carcinoma (mRCC) in the era of targeted therapies (TT) is still not clearly defined. (muni.cz)
In a study, the Selection for Cytoreductive Nephrectomy (SCREEN) score demonstrated superiority in predicting first-year mortality among patients with metastatic kidney cancer compared with an IMDC model. (renalandurologynews.com)
Metastatic disease is treated in the appropriate situation (such as for a patient with a good performance status and a readily resectable primary tumor) with cytoreductive nephrectomy [ Figure 1 ] and then systemic therapy [ Figure 2 ]," stated Dr. Jonasch. (jnccn.org)

The panel that developed an updated AUA guideline on localized kidney cancer has recognized great variance in patient/oncologic/functional characteristics and recommends individual counseling on therapeutic choices rather than basing such decisions on index (healthy vs. unhealthy) patients. (urologytimes.com)
however cancer-specific survival is a key metric for all concerned with providing quality oncologic care. (cdc.gov)

Differential Prognostic Value of Extrarenal Involvement in Patients With Non-Metastatic Renal Cell Cancer. (urotoday.com)
In conclusion, young age at diagnosis was associated with favorable pathologic features, although it was not an independent prognostic factor for survival in patients with surgically-treated RCC. (korea.ac.kr)
Current study aimed to develop and validate prognostic nomograms for patients with metastatic gastric adenocarcinoma treated with palliative gastrectomy. (biomedcentral.com)
Renal carcinoma in patients undergoing nephrectomy: analysis of survival and prognostic factors. (broomeoncology.com)
Renal cell carcinoma: survival and prognostic factors. (broomeoncology.com)
Statistical analysis was used to determine prognostic factors for cancer-specific survival. (cdc.gov)

The study enrolled patients with metastatic clear cell renal cell carcinoma at the time of diagnosis. (ascopost.com)
In aggregate, all studies to date were negative, with the exception of the phase III S-TRAC study, which tested the adjuvant use of sunitinib in patients with locally advanced (pT3-4) or node-positive clear cell renal cell carcinoma. (ascopost.com)
Although the ASSURE trial enrolled a heterogeneous patient population, including those with either clear cell or variant histology renal cell carcinoma and either pT1b grade 3-4, pT2-T4, or node-positive disease, subset analyses in patients with clear cell renal cell carcinoma with pT3-4 or node-positive disease failed to demonstrate a benefit with adjuvant sunitinib. (ascopost.com)
This trial examined adjuvant pembrolizumab after nephrectomy in clear cell renal cell carcinoma. (auanews.net)

This phase 3 trial randomized patients to post-nephrectomy to 1 year of treatment with sunitinib vs placebo. (onclive.com)
The Kidney Cancer Risk Equation for predicting post-nephrectomy ESKD builds on the ubiquitous Kidney Failure Risk Equation and is easy to use, according to investigators. (renalandurologynews.com)

Five-year survival is dependent on stage at diagnosis: 93% for stage I, 72.5% for stage II/III, and 12% for stage IV metastatic disease. (onclive.com)
However, a proportion of patients will recur with incurable distant metastatic disease. (bvsalud.org)

Today, many laparoscopic nephrectomies are done with robotic assistance . (healthline.com)
All of our donors undergo laparoscopic donor nephrectomy which requires only a small incision and reduces postoperative pain and length of hospitalization (2-4 days on average). (downstate.edu)
1991) Laparoscopic nephrectomy. (medscape.org)
1993) Laparoscopic nephrectomy for renal neoplasms. (medscape.org)
2004) Laparoscopic partial nephrectomy: evaluation of long-term oncological outcome. (medscape.org)

While off-clamp and clamped robotic partial nephrectomy were equally safe, a relevant number of off-clamp partial nephrectomy cases were not feasible due to later bleeding. (urologytimes.com)
Disease free survival of 124 patients undergoing robotic partial nephrectomy. (biomedcentral.com)
Manage bleeding complications of robotic partial nephrectomy. (auanews.net)
Minimize positive margin rates of robotic partial nephrectomy. (auanews.net)

Stewart also mentioned the phase 3 PROSPER trial, which compared perioperative nivolumab with observation in patients with high-risk, localized RCC scheduled to undergo nephrectomy. (urologytimes.com)

Median survival for patients with pT3a disease and perinephric or renal sinus fat involvement was 36 months with a 36% 5-year cancer specific survival rate. (nih.gov)
Kaplan-Meier estimates showed that cancer-specific survival was significantly better in the young age group than in the other groups (log rank test, P = 0.008). (korea.ac.kr)
2004) Application of TNM, 2002 version, in localized renal cell carcinoma: is it able to predict different cancer-specific survival probability? (medscape.org)
The authors employed Kaplan-Meier and Cox regression models to associate BAP1 expression with cancer-specific survival. (elsevierpure.com)
Do Hospital Characteristics Influence Cancer-Specific Survival for Early Stage Lung Cancer? (cdc.gov)
We sought to evaluate the relationship of hospital volume for lobectomy on cancer-specific survival in NSCLC patients treated in California, as well as the influence of Committee on Cancer (CoC) accreditation. (cdc.gov)
Author Manuscript with longer cancer-specific survival for early-stage NSCLC, but that CoC accreditation is not. (cdc.gov)

The present paper analyses a large cohort of patients, and the results indicate that primary tumor removal should still be strongly considered in patients who are treated with targeted therapies. (muni.cz)
No patients had progression of their primary tumor. (urologytimes.com)
Finally, the cut-off value of the calculated total scores based on preoperative nomograms was set and validated by comparing survival with contemporary cases without primary tumor surgery. (biomedcentral.com)
28 showed no survival benefit with gastrectomy compared to no primary tumor surgery. (biomedcentral.com)
Some factors such as individual treatment strategy, according to the histology of the primary tumor, plan of treatment strategies carried out in a multidisciplinary manner, risk-benefit of radiotherapy, assessment of the degree of spinal instability, improvement in communication and referral between specialists in oncology showed an increase in the survival of these patients. (bvsalud.org)

Nephrectomy poses risks for complications such as blood loss, infection, pulmonary embolism, and heart problems and may delay necessary systemic treatment for weeks. (ascopost.com)
1995) Partial nephrectomy: technique, complications and pathological findings. (medscape.org)
Surgery is generally not a priority recommendation in such circumstances, except for patients with potentially life-threatening complications such as gastrointestinal bleeding, perforation, or obstruction. (biomedcentral.com)

The CN/TT cohort included patients having CN within 3 months from the mRCC diagnosis and subsequently being treated with TT, while the TT cohort included patients receiving TT upfront. (muni.cz)
CARMENA enrolled 450 patients from September 2009 to September 2017 to determine whether upfront nephrectomy is necessary before sunitinib treatment. (ascopost.com)
Upfront nephrectomy is still standard in appropriate patients. (jnccn.org)

In an evaluation of circulating "cell-free" tumor DNA (liquid biopsy) and known mutations found in RCC, researchers determined that 67% of their cohort had detectable DNA mutations versus 3% of control patients. (urologytimes.com)
For this cohort, PN associated with improved survival even though increased new baseline GFR failed to correlate. (auanet.org)
The aim of the present multi-institutional study was to evaluate the impact of age on clinicopathological features and survival in a large cohort of patients with RCC. (korea.ac.kr)
Baseline characteristics and renal function one year after nephrectomy in the donor cohort. (revistanefrologia.com)
CONCLUSIONS This study used a large patient cohort to demonstrate that BAP1 expression is an independent marker of prognosis in patients with low-risk (SSIGN≤ 3) ccRCC. (elsevierpure.com)

Material/Methods: The patients were followed-up according to EORTC directions for 20 to 143 months after the surgery. (medscimonit.com)
Methods Survival of 810 mRCC patients treated from 2006 to 2017 with high dose IL-2 (aldesleukin) and enrolled in the PROCLAIM SM registry data base was assessed utilizing the International Metastatic RCC Database Consortium (IMDC) risk criteria. (bmj.com)
Patients and methods: A study of nephrectomy only for the treatment of selected children with FH WT was undertaken. (feministlawprofessors.com)
PATIENTS AND METHODS: We herein describe in detail the first cases published of the above-mentioned renal malignancies associated with extensive inferior vena cava (IVC) thrombus, in which complex vascular reconstruction was performed. (bvsalud.org)
MATERIALS AND METHODS: In this retrospective chart review of patients with a diagnosis of mRCC, 167 patients received sunitinib during their treatment. (bvsalud.org)
The researchers carried out a descriptive study using bibliometric and scientometric methods and found that the combination of surgery with postoperative radiotherapy is effective and more efficient than these alone for the treatment of patients affected by metastatic neurological compression. (bvsalud.org)

The drug appears to have a 3-month longer median progression-free survival than temsirolimus (Torisel). (urologytimes.com)
Owing to the longer survival of patients with solitary bone metastasis, a number of authors recommend a surgical approach with curative intent and implant stabilization to prevent local disease progression [ 7 - 11 ]. (biomedcentral.com)
Short-term efficacy, progression-free survival (PFS), EV markers for response prediction, and adverse events were assessed. (bvsalud.org)
Results: Efficacy data were available for all 30 patients and included a partial response in 5 patients, stable disease in 18 patients, and disease progression in 7 patients. (bvsalud.org)
The dual primary endpoints were progression-free survival (PFS) and OS. (medicom-publishers.com)
At 24 months, 16.7% of participants treated with lenvatinib plus pembrolizumab were progression-free versus 9.3% of patients treated with lenvatinib plus placebo. (medicom-publishers.com)
Patients who achieve partial response or stable disease after completion of course 2 receive additional courses in the absence of disease progression or unacceptable toxicity. (knowcancer.com)
Patients who achieve complete response may receive additional courses, at the discretion of the protocol investigator, in the absence of disease progression or unacceptable toxicity. (knowcancer.com)
Patients with disease progression are allowed to stay on the study until any measurable lesion increases to over 100% of baseline measurement. (knowcancer.com)
Progression of renal artery stenosis in patients undergoing cardiac catheterization. (medscape.com)
BACKGROUND: Acid retention associated with reduced GFR exacerbates nephropathy progression in partial nephrectomy models of CKD and might be reflected in CKD patients with reduced eGFR by increased anion gap (AG). (cdc.gov)

Reporting on the KEYNOTE-564 trial results to date, Choueiri said the estimated disease-free survival at 24 months after surgery was 77.3% with pembrolizumab treatment versus 68.1% with placebo. (dana-farber.org)
Most patients in both arms had at least one adverse event, and 32.4% of patients in the pembrolizumab arm had a grade 3-5 adverse event versus 17.7% in the placebo arm. (dana-farber.org)
Excluding patients with new baseline GFR2, age, gender, and procedure (PN versus RN) were associated with NRCS (all p≤0.001) on multivariable analysis. (auanet.org)

Only one trial utilizing adjuvant pembrolizumab (Keynote-564) has shown a disease-free survival benefit in resected RCC. (bvsalud.org)

Unexplained kidney insufficiency may develop in elderly patients. (medscape.com)

In the modern era of targeted therapy, some patients with metastatic renal cell carcinoma may be able to forgo nephrectomy and be treated with sunitinib (Sutent) alone, according to results of the phase III CARMENA trial reported during the Plenary Session at the 2018 ASCO Annual Meeting. (ascopost.com)

This study investigated the feasibility of implementing a remote monitoring strategy for patients being treated with sunitinib for mRCC by examining the time trends of AEs. (bvsalud.org)

The remaining studies reported only on minimally invasive nephrectomy. (northwestern.edu)

The median survival has improved from 1 to 3 years with targeted therapy. (ascopost.com)
0.001), which was similar to median survival of those with stage pT4 disease (11 months). (nih.gov)
Unadjusted median survival time was 388, 542 and 1473 days for the ALS, no ALS and possible ALS groups, respectively. (cdc.gov)

Cox proportional hazards assessed factors associated with NRCS among patients with new baseline GFR ≥45ml/min/1.73m 2 . (auanet.org)
New baseline GFR after RCS was 80 ml/min/1.73m 2 for PN and 63 ml/min/1.73m 2 for RN (p2 (p=0.26) and only fell for patients with new baseline GFR below this level (p=0.001). (auanet.org)
For patients with GFR ≥60ml/min/1.73m 2 undergoing RCS, our data suggest priority for achieving new baseline GFR ≥45ml/min/1.73m 2 . (auanet.org)
Moreover, a recent study based on the Surveillance, Epidemiology, and End Results Program (SEER) data demonstrated a survival benefit for palliative gastrectomy in gastric cancer patients with stage IV disease after balancing baseline characteristics using propensity score matching analysis [ 10 ]. (biomedcentral.com)

Wilms tumor, treatment for which includes surgery (radical or partial nephrectomy), is the fifth most common pediatric malignancy and the most common type of renal tumor in children. (medscape.com)
Since 1947, Dana-Farber's sole focus has been to provide expert cancer care and groundbreaking treatments for adult and pediatric patients. (dana-farber.org)
This review demonstrates that lymph node harvest has been inadequate for MIS pediatric nephrectomy and there appears to be an increased risk for intraoperative spill. (northwestern.edu)

Nephrectomy may be more appropriate for low-volume disease, and initiating therapy with sunitinib alone may be more appropriate for high-volume disease as initial therapy. (ascopost.com)
The image below illustrates a hemangioblastoma of the retina as found in patients with VHL disease. (medscape.com)
[ 2 ] Diagnosed in 50% of patients with VHL disease, these hemangiomas are composed of endothelial cells and pericytes. (medscape.com)
The unexpected finding of a retinal or CNS hemangioblastoma or the diagnosis of a pheochromocytoma should prompt a search for other associated VHL disease features, as many of these patients may have the diagnostic criteria for VHL disease. (medscape.com)
If imaging studies demonstrate bilateral disease, nephrectomy is not performed, but biopsy specimens are obtained. (medscape.com)
3 Approximately two-thirds of patients are diagnosed with localized disease, and an additional third will progress after curative-intent surgery, including up to half of patients with high-risk disease. (onclive.com)
Results showed that disease-free survival (DFS) was significantly longer in patients who received pembrolizumab, with 24-month DFS rates at 77.3% with pembrolizumab vs 68.1% with placebo (HR, 0.68, P = .002). (onclive.com)
Important to note, approximately 90% of the patients enrolled in the trial had pT3 disease, 10% had sarcomatoid features, 6% had node-positive disease, and 6% had M1 no evidence of disease. (onclive.com)
Tumor enucleation can be considered specifically for patients with familial RCC, multifocal disease, or severe CKD, although more research is needed to conclude whether this is oncologically safe. (urologytimes.com)
Due to the asymptomatic and insidious nature, gastric cancer is rarely diagnosed in its early stage in China, and most patients have already advanced disease stage by the time of diagnosis and have poor prognoses [ 8 - 10 ]. (hindawi.com)
Although many patients who present with localized disease are cured with definitive surgery, some patients develop distant recurrent disease. (ascopost.com)
The development of adjuvant treatment options that not only delay but also prevent recurrent disease remains an unmet need in the treatment of patients with renal cell carcinoma. (ascopost.com)
Patients who were treated for nearly a year with pembrolizumab experienced a longer delay before the disease recurred, compared with those who got a placebo, said Toni K. Choueiri, MD , of Dana-Farber Cancer Institute , reporting on the KEYNOTE-564 clinical trial. (dana-farber.org)
The median disease-free survival was not reached in either the pembrolizumab or the placebo arm. (dana-farber.org)
Almost half (46%) of patients had a partial response (RECIST) and 13 patients had stable disease. (urologytimes.com)
Among patients with a partial response, 10 (83%) of 12 were disease-free at the study data cutoff. (urologytimes.com)
Factors influencing the choice of surgery included age, disease status, symptoms, morbidity of the patient, the location and extend of bone disease, existence of extraosseous metastases and the patient's wishes. (biomedcentral.com)
Results: The average observation time without any recurrences and metastases was 63.8 months, in 5.7% of patients local disease related recurrences and in 1.9% remote recurrences have been found. (medscimonit.com)
Renal Cancer Surgery for Patients without Preexisting Chronic Kidney Disease: Is there a Survival Benefit for Elective Partial Nephrectomy? (auanet.org)
Patients with ischemic renal vascular disease (RVD) present with one or more of the following clinical, historical, or diagnostic scenarios. (medscape.com)
Because of the strong association of RVD with generalized atherosclerosis, many patients with RVD will have evidence of cerebrovascular, cardiovascular, or peripheral vascular disease (eg, carotid bruits, history of transient ischemic attack or stroke). (medscape.com)
Atherosclerotic renovascular disease in United States patients aged 67 years or older: risk factors, revascularization, and prognosis. (medscape.com)
The adjuvant use of pembrolizumab clearly improved disease-free survival 5 and likely this will be FDA approved during the year ahead. (auanews.net)
In this study, we used a highly sensitive and specific immunohistochemistry (IHC) assay to test whether BAP1 expression is an independent marker of ccRCC-specific survival, particularly in patients with low-risk disease. (elsevierpure.com)
For example, for liver transplants, our average time to transplant is under 90 days for patients with a Model for End Stage Liver Disease (MELD) score greater than 15. (umc.edu)
The spine is the most frequent area of bone metastasis in patients with systemic neoplastic disease. (bvsalud.org)
Providing continuing information on changes over time in the extent of disease at diagnosis, trends in therapy, and associated changes in patient survival. (cdc.gov)

2 cm, active surveillance is an option for initial management, even in healthy patients. (urologytimes.com)
The development dataset comprised 1186 patients from the Surveillance, Epidemiology, and End Results Program who were diagnosed with metastatic gastric adenocarcinoma in 2004-2011, while the validation dataset included 407 patients diagnosed in 2012-2015. (biomedcentral.com)
Current recommendations suggest surveillance abdominal ultrasound examinations for the above patients, siblings of patients with familial Wilms and offspring of patients with bilateral Wilms. (pedsurglibrary.com)

CONCLUSIONS: The role of remote monitoring for mRCC patients on sunitinib remains relevant now with new waves of the Covid-19 pandemic, triggered by novel variants. (bvsalud.org)

Antiangiogenic therapies remain the standard of care in the front-line setting for renal cell carcinoma, although vascular endothelial growth factor (VEGF) blockade is not sufficient, and many patients do not respond to such treatment. (jnccn.org)
Because approximately 20% of patients exhibiting primary resistance to these anti-VEGF therapies, new therapies are needed. (jnccn.org)

Predicting Limited Survival Following Inguinal Lymph Node Dissection in Penile Cancer: Should We Revisit the Goals of Care? (moffitt.org)

For example, the NeoAvAx trial explored the combination of the PD-L1 inhibitor avelumab (Bavencio) and axitinib (Inlyta) in patients with high-risk, non-metastatic clear-cell RCC. (urologytimes.com)
In the open-label, single-arm phase 2 trial, neoadjuvant avelumab/axitinib induced a partial response in 12 (30%) of 40 patients. (urologytimes.com)

The fact that cancer survival rates were comparable to surgical interventions is very encouraging. (scienceblog.com)
We therefore explored factors potentially affecting the survival of patients after surgical treatment. (biomedcentral.com)
The aim of this study was to identify clinical, pathological and surgical factors that are associated with better survival of patients after surgical treatment of skeletal metastases from RCC. (biomedcentral.com)
The surgical treatment for bone metastases varied in each patient. (biomedcentral.com)
2002) Does the size of the surgical margin in partial nephrectomy for renal cell cancer really matter? (medscape.org)
Patients with early stage renal cell cancer are curable with surgical removal of the cancer. (yourcancercare.com)

2005) Elective nephron sparing surgery should become standard treatment for small unilateral renal cell carcinoma: long-term survival data of 216 patients. (medscape.org)
Herr HW (1999) Partial nephrectomy for unilateral renal carcinoma and a normal contralateral kidney: 10-year followup. (medscape.org)
Although flash pulmonary edema has been reported in patients with unilateral renal stenosis, it occurs more commonly in patients with bilateral renal stenosis. (medscape.com)

The study population consisted of 730 patients with synchronous mRCC. (muni.cz)
Distinct Predictive Immunogenomic Profiles of Response to Immune Checkpoint Inhibitors and IL2: A Real-world Evidence Study of Patients with Advanced Renal Cancer. (urotoday.com)
In a study of ultrasound and laboratory findings in Wilms tumor survivors with a solitary kidney, signs of kidney damage were seen in 22 of 53 patients (41.5%) on ultrasonography. (medscape.com)
The first checkpoint inhibitor approved for renal cell carcinoma was nivolumab in 2015, based on the results of the phase III CheckMate 025 study testing the efficacy of nivolumab vs everolimus in patients having received prior VEGF-targeting therapy. (ascopost.com)
This study is also enrolling patients with non-small cell lung, triple-negative breast, colorectal, head and neck cancer and bladder cancers. (curetoday.com)
The double-blind, phase 3 study, carried out at multiple sites internationally, enrolled 994 patients who were randomized to pembrolizumab once every three weeks for about a year, or a placebo. (dana-farber.org)
Our study represents a single-center, retrospective evaluation of 3,133 patients (1997-2008) with preoperative GFR ≥60ml/min/1.73m 2 managed with PN or RN, with PN performed in 1,732 (55%) cases. (auanet.org)
KOrean Renal Cell Carcinoma (KORCC) Group 2016, ' Impact of young age at diagnosis on survival in patients with surgically treated renal cell carcinoma: A multicenter study ', Journal of Korean medical science , vol. 31, no. 12, pp. 1976-1982. (korea.ac.kr)
PROJECTED ACCRUAL: A total of 20-31 patients will be accrued for this study within 12-18 months. (knowcancer.com)
A clinical-pathologic study in normotensive and hypertensive patients. (medscape.com)
The study was carried out to exhaust the scientific literature regarding surgery associated with radiotherapy in patients suffering from metastatic spinal cord compression and to assist in the decision of oncology physicians and professionals in choosing the best treatment for the patient. (bvsalud.org)
Crude prevalence and cumulative survival from index date to the date of death, disenrollment or end of the study were calculated. (cdc.gov)

In some cases, a patient's condition may worsen during treatment delay, and the patient may be unable to tolerate systemic treatment. (ascopost.com)
The trial randomised 794 patients with advanced HCC, Child-Pugh class A, and without prior systemic treatment 1:1 to lenvatinib plus pembrolizumab or lenvatinib plus placebo. (medicom-publishers.com)

Axitinib (Inlyta) appears to be well tolerated and effective for the treatment of patients with metastatic RCC who were unsuitable for nephrectomy. (urologytimes.com)
He started with a single-arm, single institution phase 2 trial of neoadjuvant axitinib (Inlyta), an oral TKI, in patients with locally advanced, nonmetastatic clear cell RCC. (urologytimes.com)

In the surgery arm, sunitinib was initiated 3 to 6 weeks after nephrectomy. (ascopost.com)
A partial nephrectomy is surgery that removes the area of the kidney that contains the cancer. (healthline.com)
The standard treatment is usually a partial nephrectomy, where the surgeon removes the tumor and some surrounding tissue via open or laparascopic surgery," said Dr. Cadeddu. (scienceblog.com)
With surgery, there is a 5 percent to 10 percent risk of bleeding and an associated need for transfusion, as well as an increased chance of readmission for the patient. (scienceblog.com)
Surgery is the primary treatment of skeletal metastases from renal cell carcinoma, because radiation and chemotherapy frequently are not effecting the survival. (biomedcentral.com)
As radiation and chemotherapy are ineffective in most patients, surgery is a better option to achieve local tumor control and increase the survival. (biomedcentral.com)
Results: At last follow-up, 1009 patients had died, including 425 who died from RCC at a median of 3.0 years after surgery (range, 0 to 26 years). (elsevierpure.com)
1989) Conservative surgery for renal cell carcinoma: a single-center experience with 100 patients. (medscape.org)
104 patients had MIS, with 47 patients having open surgery. (northwestern.edu)
Surgery provides a curative opportunity for a number of patients and is considered the foundation of multimodal management of gastric cancer. (biomedcentral.com)
This makes recovery after surgery even more convenient for our patients. (umc.edu)

At 30 months, an estimated 95.7% of patients who received pembrolizumab were alive compared with 91.4% in the group that received placebo. (onclive.com)
The phase III data supporting the use of the oral agent pazopanib were reported by Steinberg et al, 3 which compared pazopanib with placebo in treatment-naïve or cytokine-pretreated patients with advanced RCC. (jnccn.org)

Despite these mixed results with sunitinib, in 2017, the U.S. Food and Drug Administration (FDA) granted approval for adjuvant sunitinib in patients with renal cell carcinoma. (ascopost.com)
Supporting phase III data behind the use of sunitinib in patients with metastatic RCC come from Motzer et al. (jnccn.org)

The introduction of adjuvant radiotherapy raised the survival rate to 50% overall. (medscape.com)
Phase 2 Trial of Stereotactic Ablative Radiotherapy for Patients with Primary Renal Cancer. (urotoday.com)

Simple Summary: The treatment of metastatic renal cell carcinoma is traditionally initiated with the removal of the diseased kidney with the tumor in many patients. (muni.cz)
At the time that approval for adjuvant sunitinib was granted, single-agent immune checkpoint inhibitors had demonstrated efficacy for patients with metastatic renal cell carcinoma and had entered the treatment armamentarium. (ascopost.com)
As the treatment landscape continues to grow for kidney cancer, patients and their caregivers should be aware of the various clinical trials currently being conducted - particularly those they can possibly join. (curetoday.com)
In kidney cancer, treatment sometimes involves nephrectomy, which is the removal of part or all of the kidney. (curetoday.com)
Results Among the 810 patients, 721 were treatment-naïve (89%) and 59% were intermediate risk. (bmj.com)
All patients received CCLG-ALL 2018 regimen and clinical data for treatment efficacy evaluating was collected. (bvsalud.org)
All patients received CCLG-ALL 2018 regimen treatment. (bvsalud.org)
The predictive value of extracellular vesicle (EV) membrane proteins was explored in patients who underwent this treatment. (bvsalud.org)
Our survival nomograms for patients with metastatic gastric adenocarcinoma undergoing palliative gastrectomy can assist surgeons in treatment decision-making and prognostication. (biomedcentral.com)
One type creates a new, individualized treatment for each patient by removing some of the person's immune cells, altering them genetically to kill cancer, and then infusing them back into the bloodstream the other uses precision medications to enhance the immune systems response to the cancer. (yourcancercare.com)
These findings are important for cancer treatment planning and help professionals to seek greater survival. (bvsalud.org)
Results highlight the need for effective ALS treatment options and resources for patients with ALS who will likely face limited therapeutic choices and care options at the end of life. (cdc.gov)

Patients with kidney cancer who have metastasis when the cancer is first diagnosed account for about 20% of all kidney cancers worldwide. (ascopost.com)
This trial will specifically look at the different doses of laser light to be used in therapy for patients with persistent kidney and ureter cancers. (curetoday.com)

Patients in the investigational arm received pembrolizumab 200 mg every 3 weeks for up to 17 cycles. (onclive.com)
Safety was consistent with the known profile of pembrolizumab and grade 3 or higher adverse events were seen in 32.4% of patients who received pembrolizumab compared with 17.7% in the control arm. (onclive.com)
In addition, lenvantinib + pembrolizumab is now FDA approved, again with a clear survival improvement relative to sunitinib. (auanews.net)

We retrospectively reviewed a consecutive series of 101 patients surgically treated for osseous metastases from RCC between 1980 and 2005. (biomedcentral.com)
Results-- 7,587 patients were treated surgically. (cdc.gov)

A phase I trial was conducted to evaluate the feasibility, safety, and efficacy of a dendritic cell-based vaccination in patients with metastatic renal cell carcinoma (RCC). (aacrjournals.org)
OBJECTIVES: I. Determine the efficacy and toxicity of SU5416 combined with interferon alfa-2b in patients with unresectable or metastatic renal cell carcinoma. (knowcancer.com)

Sunitinib alone is noninferior to nephrectomy followed by sunitinib in some intermediate- and poor-risk patients with metastatic renal cell carcinoma. (ascopost.com)
Prevalence of germline mutations in cancer susceptibility genes in Chinese patients with renal cell carcinoma. (urotoday.com)
Of the 208 patients who underwent the RFA procedure, 160 were diagnosed with renal cell carcinoma, a type of kidney cancer that is slow-growing but malignant and able to spread easily to other organs. (scienceblog.com)
We retrospectively reviewed 101 patients operatively treated for skeletal metastases of renal cell carcinoma between 1980 and 2005. (biomedcentral.com)
4 This agent either alone or plus nivolumab has clear activity in advanced papillary renal cell patients. (auanews.net)

Both pre- and postoperative nomograms for predicting 1- or 2-year survival probabilities were constructed using the development dataset. (biomedcentral.com)

Anatomy8

Organisms1

Diseases26

Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Psychiatry and Psychology1

Phenomena and Processes6

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science2

Named Groups2

Health Care15

Radical Nephrectomy20

Overall survival26

Immunotherapy13

Tumors19

Recurrence15

Outcomes18

Underwent nephrectomy3

Cytoreductive3

Oncologic2

Prognostic6

Clear cell renal4

Post-nephrectomy2

Metastatic disease2

Laparoscopic5

Robotic4

Undergo1

Cancer-specific survival7

Primary tumor5

Complications3

Upfront3

Cohort5

Methods6

Progression11

Versus3

Adjuvant pembrolizumab1

Kidney insufficiency1

Sutent1

Treated with sunitinib1

Minimally1

Median survival3

Baseline4

Pediatric3

Disease27

Surveillance3

Conclusions1

Therapies2

Lymph1

Avelumab2

Surgical6

Unilateral renal3

Study12

Systemic2

Axitinib2

Surgery11

Placebo2

Sunitinib in patients2

Radiotherapy2

Treatment12

Cancers2

Pembrolizumab3

Surgically2

Efficacy2

Renal cell5

Postoperative1