• 28.7% of tumour cells) correlated with longer survival following metastasis (median 21.5 vs. 13.3 months, p = 0.05). (ox.ac.uk)
  • We studied mRNA/protein expression in radically resected (n = 130) and metastatic patients (n = 50). (nih.gov)
  • Thirty-three fresh-frozen HPV-16 positive OPSCC samples with known integration status were analyzed by mRNA expression profiling. (cancerindex.org)
  • Interestingly, MMP-1 expression levels above the median were associated with distal disease of the colon (p = 0.02). (ox.ac.uk)
  • Here, we demonstrate that the transcription factor E2F6, a member of the polycomb repressive complex 1.6 (PRC1.6), is critical to target and initiate epigenetic silencing at germline genes in early embryogenesis. (cnrs.fr)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • METHODS: MMP expression was determined immunohistochemically and apoptotic index (AI) was ascertained using the TUNEL assay. (ox.ac.uk)
  • RESULTS: Low levels of MT1-MMP, MMP-1 and AI were found to be favourable markers significantly associated with longer survival. (ox.ac.uk)
  • CONCLUSIONS: These findings reveal that MT1-MMP and MMP-1 expression levels and AI are useful prognostic indicators in advanced colorectal carcinoma and suggest that markers of MMP expression might be used in identifying patients who would benefit from new treatment modalities involving MMP inhibitors. (ox.ac.uk)
  • Our findings elucidate the mechanisms of epigenetic targeting of germline genes and provide a paradigm for how transient repression signals by DNA-binding factors in early embryonic cells are translated into long-term epigenetic silencing during mouse development. (cnrs.fr)
  • E2F6 cooperates with MGA to silence a subgroup of germline genes in mouse embryonic stem cells and in embryos, a function that critically depends on the E2F6 marked box domain. (cnrs.fr)
  • Low collagenase-1 (MMP-1) and MT1-MMP expression levels are favourable survival markers in advanced colorectal carcinoma. (ox.ac.uk)
  • Because we showed that integration neither affects the levels of viral genes, nor those of virally disrupted human genes, a genome-wide screen was performed to identify human genes which expression is influenced by viral integration and have clinical relevance. (cancerindex.org)
  • Gene expression analysis of larvae from BPA exposed F2 parents showed significant reduced expression of DNA methyltransferases such as dnmt1, dnmt3, and dnmt5. (oregonstate.edu)
  • MT1-MMP, MMP-1 and AI were all found to have significant independent effects on survival. (ox.ac.uk)
  • CYB5A silencing had opposite effects, restoring TRAF6 expression and wound healing. (nih.gov)
  • Three transcript variants encoding different isoforms have been found for this gene. (cancerindex.org)
  • therefore, we examined matrix metalloproteinases expression (MMP-1, MMP-13 and MT1-MMP) and apoptosis in tumours from 49 patients with advanced colorectal disease. (ox.ac.uk)
  • Differentially expressed genes significantly overlap with gene-expression changes observed in brains of Autism Spectrum Disorder (ASD) individuals. (bvsalud.org)
  • BACKGROUND: To identify differentially expressed genes (DEGs) between muscle and adipose in cattle, we analyzed the data from the RNA sequencing of three Angus×Qinchuan crossbred cattle. (bvsalud.org)
  • These findings suggest that Mbd2 is a novel epigenetic regulator of genes that are associated with ASD in humans. (bvsalud.org)
  • 0.05) decrease in cell survival across all challenge conditions along with an increase in DNA damage, determined by Comet analysis and H2AX phosphorylation, and apoptosis, determined by Annexin-V staining, relative to cells unexposed to hyperoxia or radiation. (nih.gov)
  • In isolated RT112 cells, pH(i) regulation is unaffected by CA9 expression. (ox.ac.uk)
  • This also refers to the transfer of genes into eukaryotic cells by viruses. (lookformedical.com)
  • The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. (lookformedical.com)
  • The aim of this in vitro study was to evaluate the effect of MLT on the viability, mRNA/protein expression and mineralization of pre-osteoblastic cells. (bvsalud.org)
  • The concentrations 5, 2.5, 1, 0.1 and 0.01 mM MLT were tested on pre-osteoblastic cells (MC3T3) compared to control (no MLT), evaluating proliferation and cell viability (C50), gene expression (RT-PCR) and secretion (ELISA) of COL-I and OPN at 24h, 48h and 72h, and the formation of mineral nodules (alizarin red and fast red) after 10 days of treatment. (bvsalud.org)
  • Cell survival, DNA damage, apoptosis, and indicators of oxidative stress were evaluated after 1 and 2 cycles of exposure. (nih.gov)
  • To better understand the roles of TGF-beta in bone metabolism, we investigated osteoclast survival in response TGF-beta and found that TGF-beta inhibited apoptosis. (ox.ac.uk)
  • Adenoviral-mediated TAK1 or MEK inhibition eliminated TGF-beta-mediated kinase pathway activation and constitutively active AKT expression overcame apoptosis induction following MEK inhibition. (ox.ac.uk)
  • Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes. (lookformedical.com)
  • After the DEGs were identified, we used STRING and Cytoscape to construct a protein-protein interaction (PPI) network, subsequently analyzing the major modules of key genes. (bvsalud.org)
  • The timing of activation coincided with SMAD activation and dominant negative SMAD expression did not inhibit NFkappaB activation, indicating that kinase pathway activation is independent of SMAD signaling. (ox.ac.uk)
  • Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription. (omeka.net)
  • To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. (lookformedical.com)
  • Notably, downregulated genes are significantly enriched for human ortholog ASD risk genes. (bvsalud.org)
  • The functional differences among this cell type are heavily influenced by multiprotein nuclear complexes that control their gene expression. (bvsalud.org)
  • We suggest that pH(i) coordination may favor survival and growth of a tumor. (ox.ac.uk)