• Lysosome-associated membrane glycoproteins (LAMPs) are integral membrane proteins, specific to lysosomes, and whose exact biological function is not yet clear. (wikipedia.org)
  • Many surface membrane proteins are proteolytically released into a cell's secretome, where they can have additional functions in cell-cell-communication. (nih.gov)
  • Immunofluorescence-based confocal microscopy demonstrated that SUSPECS selectively labeled cell surface proteins. (nih.gov)
  • View our protocol for Staining Membrane-associated Proteins . (rndsystems.com)
  • The PEDV genome contains genes for the following proteins: pol1 (P1), spike (S) (180-220 kDa), envelope (E), membrane (M) (27-32 kDa), and nucleocapsid (N) (55-58 kDa) ( 2 ). (cdc.gov)
  • The serotype of influenza A virus is determined by the hemagglutinin (HA) and neuraminidase (NA) proteins present on its surface, and there are at least 18 subtypes of HA in influenza A. (scienceboard.net)
  • SARS-CoV-2 has various proteins on its surface including (M) membrane protein, (E) envelope small membrane protein and (S) spike glycoproteins. (springer.com)
  • M proteins insert into the membrane, where they interact with the spikes (2). (rkm.com.au)
  • Based on all the results, the increased resistance to trypsinization of C2C12, LF, HaCaT, and VSMC cells on amine PPs can be explained most probably by a non-specific cell adhesion such as electrostatic interaction between the cells and amine groups on the material surface, rather than by the receptor-mediated adhesion through serum-derived proteins adsorbed on the PPs. (nature.com)
  • The Mucin 1 (MUC1) gene encodes a membrane bound glycosylated phosphoprotein, belonging to the family of mucins which are heavily glycosylated proteins. (sigmaaldrich.com)
  • The purpose of this study was to identify membrane proteins of PMNs, and/or glomerular cells, as additional autoantigenic ANCA targets. (rupress.org)
  • Using these probes, evidence was provided that gp170/80-110 is identical with human lysosomal-associated membrane protein 2 (h-lamp-2), because both proteins were immunologically cross-reactive and screening of a cDNA expression library from human promyelocytic leukemia cells with anti-gp130 Ab yielded a clone derived from h-lamp-2. (rupress.org)
  • A recent study offers new modellings of one of the virus' a surface proteins, and its receptor, on human cells. (pasteur.fr)
  • Blood groups (antigens) are proteins, glycoproteins or glycolipids inherited surface markers on the red blood cell membranes, which determine the blood phenotypes of human beings. (academicjournals.org)
  • They utilize a panel of lectins (saccharide-binding proteins with distinct sugar specificities) immobilized onto a solid surface. (muni.cz)
  • The virus' surface proteins, hemagglutinin (HA) and neuraminidase (NA), were depicted in light and dark blue, respectively. (cdc.gov)
  • Here, we set up and evaluated the 'surface-spanning protein enrichment with click sugars' (SUSPECS) method for cell surface membrane glycoprotein biotinylation, enrichment and label-free quantitative mass spectrometry. (nih.gov)
  • Interestingly, protein changes at the cell surface only partly correlated with changes in the secretome. (nih.gov)
  • The protein encoded by this gene is an integral plasma membrane protein which promotes cell adhesion. (thermofisher.com)
  • December 7, 2020 -- A new universal influenza vaccine has been developed that targets the stalk portion of the influenza virus surface protein rather than the head portion. (scienceboard.net)
  • Interaction of the SARS-CoV-2 spike protein with angiotensin-converting enzyme 2 (ACE2) receptors on target the cell surface mediates SARS-CoV-2 entry into cells that is facilitated by transmembrane protease serine 2 (TMPRSS2) and lysosomal proteases. (springer.com)
  • Developed in 2007, the chemokine receptor antagonist blocks entry of certain specific strains of HIV, which attach to a particular protein on the immune cell's surface known as chemokine receptor 5 (CCR5). (hdkino.org)
  • The RNA is covered in an envelope known as capsid which has two glycoproteins (a kind of protein molecule that incorporates a sugar molecule), gp120 and gp41, embedded in its surface. (hdkino.org)
  • In many epithelia, this protein is attached to the apical surface by a transmembrane domain. (sigmaaldrich.com)
  • A novel class of autoantigens of anti-neutrophil cytoplasmic antibodies in necrotizing and crescentic glomerulonephritis: the lysosomal membrane glycoprotein h-lamp-2 in neutrophil granulocytes and a related membrane protein in glomerular endothelial cells. (rupress.org)
  • When membrane protein fractions were prepared from PMNs and isolated human glomeruli, and immunoblotted with ANCA sera of NCGN patients, two bands with apparent molecular masses of 170 and 80-110 kD (gp170/80-110) were labeled in PMNs, and a 130-kD glycoprotein (gp130) in glomeruli. (rupress.org)
  • The fusion (F) protein of parainfluenza virus 5 (PIV5) is a membrane-bound, homotrimeric glycoprotein located on the surface of PIV5 viral envelopes. (researchgate.net)
  • The DX12 monoclonal antibody specifically binds to human CD161 which is also known as Natural killer cell surface protein P1A (NKR-P1A). (bdbiosciences.com)
  • The article shows how the virus interacts with a receptor on human cells, the EphA2 receptor, via a surface protein complex made of glycoproteins H and L (gH/gL). (pasteur.fr)
  • The neuraminidase (NA) gene encodes the other surface protein of the virus. (cdc.gov)
  • Type I membrane protein. (lu.se)
  • [ 1 ] This protein, also known as polymorphic epithelial mucin or epithelial membrane antigen, has a large extracellular region, a transmembrane sequence, and a cytosolic domain. (medscape.com)
  • Rather, it suggests that one or more receptors localized to the ER membrane may mediate the selective transport of membrane glycoproteins out of the ER to the Golgi apparatus. (johnshopkins.edu)
  • Its biological activities are shared by IL-6-family of cytokines such as leukemia inhibitory factor and oncostatin M. IL-6 exerts its biological activities through interaction with specific receptors expressed on the surface of target cells. (sbhsciences.com)
  • Binding of gp120 to target cell receptors induces a conformational change in gp41, which then mediates the fusion of viral and cellular membranes. (proteopedia.org)
  • Analysis of this HA gene shows that it is closely related to avian A(H5) viruses in HA clade 2.3.4.4b and lacked amino acid changes that improve recognition of mammalian receptors or fusion of the viral membrane with the host endosomal membranes. (cdc.gov)
  • VWF binds to receptors on the platelet surface membrane (glycoprotein Ib/IX). (msdmanuals.com)
  • Platelet receptors for ADP include the P2Y12 receptor, which sends signals to suppress adenylate cyclase, decreases cyclic adenosine monophosphate (cAMP) levels, and promotes activation of the glycoprotein IIb/IIIa receptor (assembled on the activated platelet surface membrane from glycoproteins IIb and IIIa). (msdmanuals.com)
  • Monoclonal antibodies against a glycoprotein presumably involved in adhesion of aggregating Dictyostelium discoideum cells have been used for labeling of the antigen at the cell surface. (uni-regensburg.de)
  • The antigen is distributed over the whole surface of the cells, apparently in form of small clusters. (uni-regensburg.de)
  • The objective of this study is to design a new class of liposomes that can target tumor vasculature via Prostate-Specific Membrane Antigen (PSMA) and rapidly and extensively release therapeutic agents intracellularly by using the pH-sensitive peptide GALA conjugated to lipid moieties to destabilize the integrity of intracellular endosomes and achieve better tumor killing outcomes. (aiche.org)
  • Both prostate-specific membrane antigen (PSMA) PET/CT and ferumoxtran-10 nanoparticle-enhanced MRI (nano-MRI) are imaging modalities with high potential to identify LN metastases in PCa patients. (snmjournals.org)
  • Q89797_9HIV1 ] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity). (proteopedia.org)
  • Cancer antigen 27-29 (or CA 27-29) is an epitope of a large transmembrane mucin glycoprotein named MUC1 that is expressed on the cell surfaces of most glandular epithelia. (medscape.com)
  • CD molecules are leucocyte antigens on cell surfaces. (wikipedia.org)
  • Using pulse-chase radiolabeling, the kinetics of appearance of the class I histocompatibility antigens, H-2K(k) and H-2D(k), at the cell surface were compared and found to be remarkably different. (johnshopkins.edu)
  • The rates of surface appearance for the two antigens closely resemble the rates at which their Asn-linked oligosaccharides mature from endoglucosaminidase H (endo-H)-sensitive to endo H-resistant forms, a process that occurs in the Golgi apparatus. (johnshopkins.edu)
  • Williams, DB, Swiedler, SJ & Hart, GW 1985, ' Intracellular transport of membrane glycoproteins: Two closely related histocompatibility antigens differ in their rates of transit to the cell surface ', Journal of Cell Biology , vol. 101, no. 3, pp. 725-734. (johnshopkins.edu)
  • 10 The presence of ABO antigens on RBC surfaces requires that careful blood-typing must be carried out prior to transfusion to avoid adverse and sometimes fatal hemolytic transfusion reactions. (cap.org)
  • Glycoprotein antigens on the extracellular surface of the RBC membrane determine an individual's blood group. (cap.org)
  • gp41, the transmembrane subunit, mediates fusion of viral and cellular membranes [ 3 ]. (plos.org)
  • The newest drugs attack the virus at the stage when it binds to the T-cell and prevent it from penetrating the cell membrane. (hdkino.org)
  • The latest ART drug to be approved by FDA in 2018, the post-attachment inhibitor prevents the viral envelope fusion with the cell membrane after it binds to the cell. (hdkino.org)
  • The SARS-CoV-2 spike binds to a receptor on the surface of the host cells' membrane-the angiotensin-converting enzyme 2 (ACE2). (chemistryviews.org)
  • PCSK9 binds to the LDL receptor and hinders its recycling to the cell surface, decreasing the LDL receptor density available for removal of LDL from the circulation. (fatsoflife.com)
  • The trimeric soluble or membrane CD154 binds to the monomeric CD40 and induces its oligomerization as well as its homodimerization. (umontreal.ca)
  • Fibrinogen binds to the glycoprotein IIb/IIIa complexes of adjacent platelets, connecting them into aggregates. (msdmanuals.com)
  • Griffithsin's antiviral activity stems from its ability to bind terminal mannoses present in high-mannose oligosaccharides and crosslink these glycans on the surface of the viral envelope glycoproteins. (mdpi.com)
  • The HIV-1 envelope (Env) glycoproteins are produced as a 160 kDa polyprotein that is subsequently processed to yield virion-associated, trimeric complexes of non-covalently associated gp120-gp41 heterodimers [ 1 , 2 ]. (plos.org)
  • This seems to be true not only of the core, which is probably icosahedral (3), but also it seems of the overlying membrane (viral envelope) which seems to hug the contours of the core reasonably closely. (rkm.com.au)
  • The envelope glycoprotein of HIV-1 consists of the surface subunit gp120 and the transmembrane subunit gp41. (proteopedia.org)
  • The mutant envelope glycoprotein expressed in 293T cells and incorporated within pseudotyped virions displayed only a moderate reduction in syncytium-inducing capacity and virus infectivity, respectively. (proteopedia.org)
  • Combinations of face envelope with T-shaped spikes measuring 7-10 key words such as Lassa fever and West Africa were nm and built with glycoprotein. (folkhalsomyndigheten.se)
  • Platelet Glycoprotein GPIIb-IIIa Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Platelet Glycoprotein GPIIb-IIIa Complex" by people in Harvard Catalyst Profiles by year, and whether "Platelet Glycoprotein GPIIb-IIIa Complex" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Platelet Glycoprotein GPIIb-IIIa Complex" by people in Profiles. (harvard.edu)
  • Exploratory Use of Glycoprotein IIb/IIIa Inhibition in Prevention of Blalock-Taussig Shunt Thrombosis. (harvard.edu)
  • The 80 kilodalton glycoprotein typical of aggregation competent cells has been purified by affinity chromatography on a monoclonal antibody column. (uni-regensburg.de)
  • Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. (harvard.edu)
  • CD161 is a 80 kDa disulfide-linked homodimer, type II membrane glycoprotein. (bdbiosciences.com)
  • A lipid membrane encapsulates the icosahedral nucleocapsid. (medscape.com)
  • Two outwardly projecting glycoproteins, E1 and E2, are inserted in the lipid membrane surrounding the nucleocapsid. (medscape.com)
  • This shows that the glycan exists in an extended configuration along the plane of the membrane and spans an area of 600 Å 2 , which is similar to the cross-sectional area of a monomeric N-terminal VSG domain. (dundee.ac.uk)
  • SUSPECS is based on click chemistry-mediated labeling of glycoproteins, is compatible with labeling of living cells and can be combined with secretome analyses in the same experiment. (nih.gov)
  • This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. (antibodies-online.com)
  • Membrane glycoproteins found in high concentrations on iron-utilizing cells. (umassmed.edu)
  • By contrast, gp130 was localized in the surface membranes of endothelial cells of human glomerular and renal interstitial capillaries, rather than in lysosomes, as found for h-lamp-2. (rupress.org)
  • These spikes help the virus to enter host cells by fusing the virus with cell membranes. (chemistryviews.org)
  • Interestingly, the in silico results strongly supported the hypothesis of a direct recognition between Lf and the spike S glycoprotein, which can thus hinder viral entry into the cells. (frontiersin.org)
  • Interestingly, the association of IL-6 with the soluble form of IL-6R alpha is capable of eliciting a biological response in cells that express only the membrane gp130. (sbhsciences.com)
  • This receptor is found within the membranes of cells facing the circulation, and promotes the endocytotic internalization and uptake of LDL lipid cargo into tissues. (fatsoflife.com)
  • They can be used for glycan profiling of various samples, including purified glycoproteins, cell/tissue lysates, membrane vesicles, complex biological samples, or entire cells. (muni.cz)
  • It is a type I transmembrane glycoprotein, expressed on the surface of hematopoietic and non-hematopoietic cells. (umontreal.ca)
  • The hemagglutinin (HA) gene codes for one of the two surface glycoproteins and is central to species specificity because it is responsible for virus attachment and fusion with host cells. (cdc.gov)
  • Liposomes were prepared by hydrating a thin lipid film with the desired aqueous phase buffer, incubating at 55° Celsius for 2 hours, and extruding the resultant suspension through 100 nm -pore polycarbonate membranes to generate unilamellar vesicles. (aiche.org)
  • Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling. (wikidoc.org)
  • Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. (bvsalud.org)
  • Muc1 is a type I transmembrane glycoprotein with a unique extracellular domain containing 20 amino acid variable number tandem repeat (VNTR) domain. (sigmaaldrich.com)
  • This glycoprotein possesses antimicrobial activity due to its capability to chelate two ferric ions per molecule, as well as to interact with bacterial and viral anionic surface components. (frontiersin.org)
  • PSSD can directly interact with virus particles to inhibit the adsorption of virus to the cell surface. (bvsalud.org)
  • PSSD may also interact with virus surface glycoproteins to block virus-induced membrane fusion. (bvsalud.org)
  • Coagulation factors interact on platelet and endothelial cell surfaces to produce thrombin , which converts fibrinogen to fibrin. (msdmanuals.com)
  • Pharmacological BACE1-inhibition selectively remodeled the neuronal surface glycoproteome, resulting in up to 7-fold increased abundance of the BACE1 substrates APP, APLP1, SEZ6, SEZ6L, CNTN2, and CHL1, whereas other substrates were not or only mildly affected. (nih.gov)
  • PSMA is a cell surface glycoprotein receptor present on tumor vascular endothelium of many types of cancer [6, 7]. (aiche.org)
  • Mutations in the CT have been shown to affect the conformation of gp120 ectodomain [ 16 - 18 ], and more recently, Durham et al suggested that the CT regulates the conformation of Env at the cell surface and control epitope exposure through T cell virological synapses [ 19 ]. (plos.org)
  • PCSK9 is a secreted glycoprotein that regulates the membrane expression of the LDL receptor. (fatsoflife.com)
  • abstract = "The average solution conformation of the glycosylphosphatidylinositol (GPI) membrane anchor of Trypanosoma brucei variant surface glycoprotein (VSG) has been determined by using a combination of two-dimensional 1H-1H NMR methods together with molecular orbital calculations and restrained molecular dynamics simulations. (dundee.ac.uk)
  • Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. (wikidoc.org)
  • Its expression, restricted to the Langerhans cell lineage, is demonstrated at both the surface membrane and in the cytoplasm. (beckman.com)
  • Mature human LAMP1 is a 389 amino acid (aa) type I transmembrane glycoprotein. (rndsystems.com)
  • Both intracytoplasmic and surface membrane staining is observed. (beckman.com)
  • This illustration depicted a 3D computer-generated rendering of a whole influenza (flu) virus with a light grey surface membrane, set against a white background. (cdc.gov)
  • IL-6 Receptor (IL-6R, gp80) is 80 kDa alpha subunit, transmembrane glycoprotein that is 449 aa long. (sbhsciences.com)
  • Our results demonstrate that the proper folding of the gp41 core underlies the membrane fusion properties of the gp120-gp41 complex. (proteopedia.org)
  • Human TROP-2, also known as Tumor Associated Calcium Signal Transducer 2 (TACSTD2), GA733-1, gp50 and T16, is a type I cell surface glycoprotein that is highly expressed on human carcinomas. (rndsystems.com)
  • E2 appears to be primarily responsible for attachment of the viruses to cell surfaces. (medscape.com)
  • The medical application of materials mentioned above could benefit from plasma processing of material surfaces. (nature.com)
  • Plasma technology for surface modifications has many advantages compared to morphological and chemical treatments, such as low toxicity, short time of production, substrate independence and, if required, a negligible degradation of the original material. (nature.com)
  • High-Resolution Description of the Hantavirus Surface Glycoprotein Lattice and Its Membrane Fusion Control Mechanism. (cienciavida.org)
  • Le CD40, membre de la famille des récepteurs de TNFs (TNFRs), est une glycoprotéine transmembranaire de type I, exprimée à la surface des cellules hématopoïétiques et non hématopoïétiques. (umontreal.ca)
  • the S surface glycoprotein harbors the specific host cell receptor binding sites ( 3 ). (cdc.gov)
  • PBMCs are divided into various functional subtypes with respect to the specific cytokine expression profiles, surface markers, and the transcription factors. (frontiersin.org)
  • A particle according to claim 1 or 2, wherein the heterologous polypeptide has specific binding affinity for a cognate receptor on die surface of an eukaryotic cell, binding to which does not allow infection of the cell by the viral particle. (sumobrain.com)
  • A particle according to claim 1 or 2, wherein the heterologous polypeptide has no specific binding affinity for a eukaryotic cell surface component. (sumobrain.com)
  • The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. (nih.gov)
  • Cloning and expression of a new pregnancy-specific beta 1-glycoprotein member. (nih.gov)
  • Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants. (nih.gov)
  • The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed. (nih.gov)
  • Gene organization of the pregnancy-specific glycoprotein region on human chromosome 19: assembly and analysis of a 700-kb cosmid contig spanning the region. (nih.gov)
  • Structural and functional analysis of the HIV gp41 core containing an Ile573 to Thr substitution: implications for membrane fusion. (proteopedia.org)
  • Liu J, Shu W, Fagan MB, Nunberg JH, Lu M. Structural and functional analysis of the HIV gp41 core containing an Ile573 to Thr substitution: implications for membrane fusion. (proteopedia.org)
  • Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)