Mutations that occur within the immunodominant epitopes of hepatitis B surface antigen (HBsAg) allow mutant virus to propagate in the presence of a neutralizing immune response, while wild-type virus is reduced to undetectable levels. (cdc.gov)
An understanding of immunoassay reactivity with HBsAg mutants is key to establishing an appropriate testing algorithm for hepatitis B virus detection programs. (cdc.gov)
This article addresses recent information concerning the emergence of hepatitis B surface antigen (HBsAg) mutants, their impact on viral antigen presentation, latest prevalence data, and discussion of the issues associated with detection of mutants in healthcare settings. (cdc.gov)
The main antigen of the shell is HBsAg - the surface antigen of the virus. (lab24.pl)
HBsAg is the serologic hallmark of Hepatitis B Virus (HBV) infection that appears after acute inflammation. (yashraj.com)
For more than two decades, our flagship products of CRP, Cancer Antigens and HBsAg-Ad, HBsAg-Ay, NGAL, rSLO and rProlactin have routinely passed quality audits of leading global diagnostic manufacturers. (yashraj.com)
We evaluated hepatitis B floor antigen (HBsAg) kinetics after NAs discontinuation and through retreatment resulting from off-treatment scientific relapse amongst non-cirrhotic HBeAg-positive CHB sufferers. (jointsjournal.eu)
Therefore, HBsAg quantification (qHBsAg), HB corerelated antigen (HBcrAg) and HBV RNA among others, have been suggested as additional markers that could predict more precisely, patients with active infection who are likely to have long term complications [12]. (jscimedcentral.com)
There is a renewed interest in the quantitative HBsAg (qHBsAg) assay as a marker of hepatitis B viral activities in the last ten years [13]. (jscimedcentral.com)
Your doctor may recommend the HBsAg test if you have symptoms of acute hepatitis B, such as fatigue, fever, abdominal pain, dark urine, or yellowing of your skin or eyes ( jaundice ). (metropolisindia.com)
If the HBsAg test is positive, it means that you have a chronic hepatitis B infection and require treatment. (metropolisindia.com)
The HBsAg test is used to screen for hepatitis B infection and to help diagnose acute or chronic hepatitis B. This test can also be used to monitor people who are at risk for hepatitis B infection, such as people with HIV or those who have been exposed to the virus. (metropolisindia.com)
The HBsAg test is used to diagnose hepatitis B, determine if you are a carrier of the virus, and monitor the effectiveness of treatment for hepatitis B. (metropolisindia.com)
The HBsAg test is usually done as part of a panel of tests for hepatitis B. Other tests in this panel may include the hepatitis B core antibody (HBcAb) and the hepatitis B surface antibody (HBsAb). (metropolisindia.com)
Here we report a strategy for genetic transformation of lettuce plants (Lactuca sativa L.) using the surface antigen HBsAg of hepatitis B virus. (scielo.br)
HBsAg was the first viral antigen chosen to be produced in transgenic plants, firstly in tobacco [3] and subsequently in lupin callus and lettuce adapted to colder climates [4]. (scielo.br)
Thus, striking improvements in recombinant antigen were achieved by alternative polyadenylation signals and fusion proteins containing targeting signals designed to enhance integration or retention of HBsAg in the endoplasmic reticulum (ER) of plant cells [6]. (scielo.br)
Hepatitis B surface antigen (HBsAg) was employed as a model protein biomarker to demonstrate the analytical performance of the sensor in this study. (cdc.gov)
Recombinant antigens2
Established in 1999 as a research focused Biotech Company with ISO certifications ISO 13485:2016 and ISO 9001:2015, YBL manufactures a wide range of high pure biomarkers in the form of native and recombinant antigens that are used by the diagnostic industry as controls, calibrators and immunogens. (yashraj.com)
The obtainment of transgenic edible plants carrying recombinant antigens is a desired issue in search for economic alternatives viewing vaccine production. (scielo.br)
Infection20
There is a need for improved immunogenicity of hepatitis B virus (HBV) vaccines among young adults with risk of infection. (nih.gov)
To decide on the expediency of prescribing immunoglobulin to patients with viral hepatitis and a high risk of infection. (lab24.pl)
Among all the causes of the development of acute hepatitis and chronic viral infection, the hepatitis B virus is considered one of the most common in the world. (lab24.pl)
Viral hepatitis B can occur both in the form of mild forms that last for several weeks, and in the form of a chronic infection with a long course. (lab24.pl)
There are several tests for the diagnosis of current or transferred viral hepatitis B. The determination of viral antigens and antibodies is performed to detect carriage, acute or chronic infection in the presence or absence of symptoms, in the monitoring of chronic infection. (lab24.pl)
It has two determinants Ad and Ay and helps in detection of Hepatitis infection or any other liver ailments. (yashraj.com)
Chronic hepatitis B infection is a public health problem with about 240 million people affected worldwide [1]. (jscimedcentral.com)
Major international and local guidelines suggested the use of serum HBV DNA quantification and serum alanine transferase (ALT) as markers to select patients with active chronic hepatitis B infection [7-10]. (jscimedcentral.com)
European Association for the Study of the Liver (EASL) and Asian Pacific Association for the study of the liver (APASL) guidelines recommended HBVDNA quantification greater than or equal to 2000IU/ml and raised serum alanine transaminase as criteria for active chronic hepatitis B infection which should be treated. (jscimedcentral.com)
The aim of this study was to describe the pattern of Hepatitis B surface antigen and DNA quantification among patients with e negative chronic hepatitis B virus infection attending two hospitals in south west Nigeria and determine if any, correlation between the two. (jscimedcentral.com)
Isolated elevations in serum glutamic pyruvic transaminase occurred equally in both groups and did not correlate with serologic evidence for hepatitis B infection. (johnshopkins.edu)
There are about 350 million hepatitis B virus (HBV) carriers in worldwide and these chronic carriers are responsible for one to five percent of infection spreading [1]. (scielo.br)
Hepatitis B infection is a worldwide healthcare problem, especially in developing areas. (medscape.com)
Patients with chronic hepatitis B infection can be immune tolerant or have an inactive chronic infection without any evidence of active disease, and they are also asymptomatic. (medscape.com)
Cirrhosis and liver cancer1
Chronic viral hepatitis B is associated with the development of cirrhosis and liver cancer. (lab24.pl)
Antibody3
Viral hepatitis and tests for the Australia (hepatitis-associated antigen and antibody. (who.int)
One Hundred and Twenty-One asymptomatic, treatment naïve, e negative chronic hepatitis B patients were recruited. (jscimedcentral.com)
Health workers included 2 physicians with chronic hepatitis, a chronic asymptomatic carrier nurse, a food handler with acute HB(s) Ag positive hepatitis and a physician who was HB(s) Ag positive for 25 days before the onset of acute hepatitis. (johnshopkins.edu)
Vaccine1
To demonstrate manufacturing equivalence of a 3-antigen (3A) HBV vaccine, evaluate noninferiority of seroprotection rate (SPR) of 3A-HBV vs single-antigen (1A) HBV after 2 and 3 vaccine doses, and compare safety and reactogenicity between 3A-HBV and 1A-HBV vaccines. (nih.gov)
Detection1
Laboratory techniques for the detection of hepatitis B surface antigen. (who.int)
These data do not demonstrate hepatitis B transmission from HB(2) Ag positive health workers to their patients. (johnshopkins.edu)
Virus12
Over the past decade, the importance of hepatitis B virus (HBV) mutants has made a transition from an academic phenomenon of unknown prevalence to a factor for consideration during disease diagnosis. (cdc.gov)
Title : Prevention of perinatal transmission of hepatitis B virus : prenatal screening of all pregnant women for hepatitis B surface antigen Corporate Authors(s) : National Center for Infectious Diseases (U.S.). Division of Viral Hepatitis. (cdc.gov)
According to approximate estimates, about 350 million people in the world are affected by the hepatitis B virus, and 620,000 die annually from its consequences. (lab24.pl)
The main symptoms of hepatitis: yellowness of the skin, fever, nausea, rapid fatigue, in tests - signs of impaired liver function and specific antigens of the hepatitis B virus. (lab24.pl)
The hepatitis B virus (HBV) vaccination schedule in Libya follows international recommendations (1st dose at birth, 2nd after 1 month and 3rd after 6 months). (hud.ac.uk)
Madour, A, Alkout, A & Vanin, S 2013, ' Première évaluation de la concentration sérique de l'antigène de surface du virus de l'hépatite b après la vaccination en Libye ', Eastern Mediterranean Health Journal , vol. 19, no. 12, pp. 990-994. (hud.ac.uk)
This test can be used to screen for the virus that causes hepatitis B or to determine if you are actively infected with the virus. (metropolisindia.com)
It can also help to determine if someone who has already been infected with hepatitis B has developed immunity to the virus. (metropolisindia.com)
The hepatitis B virus (HBV) is commonly transmitted via body fluids such as blood, semen, and vaginal secretions. (medscape.com)
The pathogenesis and clinical manifestations of hepatitis B are due to the interaction of the virus and the host immune system, which lead to liver injury and, potentially, cirrhosis and hepatocellular carcinoma. (medscape.com)
Introduction: Antibodies to Hepatitis B surface Antigen (Anti-HBs) levels are measured as markers for immune response to vaccination and in decision making for post-exposure prophylaxis against Hepatitis-B. Several immunoassay formats are used to measure Anti-HBs, thus carrying the possibility of variation in measured levels between different assays. (manipal.edu)
Testing is typically ordered when someone is experiencing symptoms, especially if they have other types of autoimmune disorders or have already tested negative for viral hepatitis. (requestatest.com)
Patients with chronic active hepatitis, especially during the replicative state, may have symptoms similar to those of acute hepatitis. (medscape.com)
Immunity1
To determine transferred viral hepatitis B and the development of post-infectious immunity. (lab24.pl)
Icteric hepatitis is associated with a prodromal period, during which a serum sickness-like syndrome can occur. (medscape.com)
Assess1
To assess the hepatitis risk to patients exposed to HB(s) AG positive health care workers, 228 contacts were followed prospectively, for 6 to 9 mth. (johnshopkins.edu)
Immune3
Hepatitis B viral mutants can emerge in patients as a result of selection pressure from either immune response or treatment options. (cdc.gov)
The foremost histocompatibility complicated (MHC) class II characterised by monocytes CD14+ expression of human leukocyte antigen receptors (HLA-DR), is important for the synapse between innate and adaptive immune response in infectious illness. (jointsjournal.eu)
Autoimmune Hepatitis is a disorder in which the body's own immune system mistakenly targets cells in the liver. (requestatest.com)
The types of antibodies a person has can aid in making a diagnosis and well as differentiating between the 2 types of autoimmune hepatitis. (requestatest.com)
Concentration1
Geometric mean concentration (GMC) of serum hepatitis B surface antibodies (anti-HBs) and proportion of participants achieving seroprotection. (nih.gov)
Patients3
This study aimed to describe the pattern of quantitative hepatitis B surface antigen and DNA quantification among patients with e negative chronic hepatitis B. (jscimedcentral.com)
The physical examination findings in hepatitis B disease vary from minimal to impressive (in patients with hepatic decompensation), according to the stage of disease. (medscape.com)
This test includes 3 tests which can help to determine if a person has Autoimmune Hepatitis . (requestatest.com)
Annually1
Hepatitis B is a public health problem, responsible for about 6000 deaths annually. (jscimedcentral.com)
Data2
If there is data on transferred hepatitis of unknown etiology. (lab24.pl)
There is however paucity of data on the pattern of quantitative hepatitis B surface antigenaemia and its correlation with the viral loadin sub-Sahara Africa. (jscimedcentral.com)
Risk2
Health care workers positive for hepatitis B surface antigen: Are their contacts at risk? (johnshopkins.edu)
Dive into the research topics of 'Health care workers positive for hepatitis B surface antigen: Are their contacts at risk? (johnshopkins.edu)
Treatment1
Every 3-6 months during control of chronic viral hepatitis B and its treatment. (lab24.pl)
Levels1
Serum levels of hepatitis B surface antigen were determined in 277 randomly selected children aged 1-12 years. (hud.ac.uk)
High1
Our Antigens are purified as high pure and part pure and customized using our in-house developed methodology. (yashraj.com)
Delivery1
Our procurement teams have created a pan India network to access bio-medical fluid in order to ensure timely delivery of quality antigens to our clients with added benefits of consistency, customization and quality. (yashraj.com)
International1
Proposed international reference preparation for hepatitis B surface antigen / by Morag Ferguson, Valerie Seagroatt and G. C. Schild. (who.int)