• Lack of CD15, a cell-surface glycoprotein, leads to marked decrease in neutrophil motility. (mhmedical.com)
  • The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (wikidoc.org)
  • Sialyl LewisX (sLeX), also known as cluster of differentiation 15s (CD15s) or stage-specific embryonic antigen 1 (SSEA-1), is a tetrasaccharide carbohydrate which is usually attached to O-glycans on the surface of cells. (wikipedia.org)
  • CD15 (Lewis x), also known as stage specific embryonic antigen-1 (SSEA-1) is a trisacharide determinant (3-fucosyl-N-acetyllactosamine) expressed on several glycolipids, glycoproteins and proteoglycans of various cell types, e.g. granulocytes, mast cells, monocytes, macrophages, cells of gastric mucosa, nervous system or various tumour cells. (exbio.cz)
  • The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
  • The stage-specific embryonic antigen 4 (SSEA4) is brain. (lu.se)
  • Stage-Specific Embryonic Antigens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
  • This graph shows the total number of publications written about "Stage-Specific Embryonic Antigens" by people in UAMS Profiles by year, and whether "Stage-Specific Embryonic Antigens" was a major or minor topic of these publications. (uams.edu)
  • Below are the most recent publications written about "Stage-Specific Embryonic Antigens" by people in Profiles over the past ten years. (uams.edu)
  • The most common example of this type of fusion protein combines the hinge and Fc regions of an immunoglobulin (Ig) with domains of a cell-surface receptor that recognizes a specific ligand (Box 1). (coek.info)
  • Here, we demonstrate that NK cells (haNKs) engineered to express a PD-L1 chimeric antigen receptor (CAR) haNKs killed a panel of human and murine head and neck cancer cells at low effector-to-target ratios in a PD-L1-dependent fashion. (elifesciences.org)
  • Here, we describe the pre-clinical in vitro and in vivo study of irradiated haNK cells engineered to express a second-generation chimeric antigen receptor (CAR) targeting programmed death-ligand 1 (PD-L1). (elifesciences.org)
  • The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. (wikidoc.org)
  • A bivariate pseudocolor density plot showing the correlated expression of CD15 (or Ig Isotype control staining) versus side light-scatter signals (SSC-A) was derived from gated events with the forward and side light-scatter characteristics of intact human leucocytes. (bdbiosciences.com)
  • Clone HI98 has been described to specifically react with 3-fucosyl-N-acetyllactosamine (3-FAL), also called X-hapten, SSEA-1, CD15, or Lewis X. Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections 5 and formalin-fixed paraffin-embedded tissue sections. (biolegend.com)
  • ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
  • Efficacy was dependent on the number of CD8+ T cells able to recognize tumor antigens that infiltrated the malignant tissue. (unav.edu)
  • On gross examination, a 10.5 × 9.0 × 6.0 cm well-circumscribed tumor mass was found at the lower pole with necrosis on the cut surface. (biomedcentral.com)
  • T cell-based immunotherapy, such as immune checkpoint blockade or adoptive T cell transfer, is limited by the ability of T cells to detect major histocompatibility complex (MHC)-presented antigen by tumor cells. (elifesciences.org)
  • A membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically to CD30 ANTIGEN. (wakehealth.edu)
  • Small amounts R. africae antigens were demonstrated by immunohistochemical examination in 6 of 8 patients with ATBF. (cdc.gov)
  • Immunofluorescence assays, the reference diagnostic method, were carried out by using both R. conorii strain Seven (Malish, ATCC VR-613T) and R. africae strain ESF-5 as antigens ( 6 ). (cdc.gov)
  • CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
  • 2000). In *Correspondence to: Perrine Barraud, Department of Veterinary Medi- contrast, several cell surface markers have been used to cine, Neurosciences, Madingley Road, Cambridge CB3 OES, United enrich for NSCs in the rodent CNS. (lu.se)
  • The antigens are useful markers in the identification of EMBRYONIC STEM CELLS. (uams.edu)
  • Each clinicopathologic subtype can be further classified with respect to morphology, immunophenotype, and antigen markers. (medscape.com)
  • In mice, MDSC can be identified by species-specific cell surface markers (CD11b + Gr-1 + ) and may be further classified as monocytic (M-MDSC, Ly-6C hi ) or granulocytic (G-MDSC, Ly-6G + ) based on additional cell surface markers [ 6 ]. (iospress.com)
  • Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
  • Sialyl Lewis X is also one of the most important blood group antigens and is displayed on the terminus of glycolipids that are present on the cell surface. (wikipedia.org)
  • For sialyl-Lewisx to bind to E-selectin it can be part of either an N-linked or O-linked glycan attached to cell surface glycoproteins such as PSGL-1, CD43 or CD44. (wikipedia.org)
  • Defective synthesis of the sialyl Lewis X antigen results in immunodeficiency (leukocyte adhesion deficiency type 2). (wikipedia.org)
  • Reed-Sternberg cells display a characteristic pattern of Sialyl-Lewisx (CD15) positivity, with membranous staining combined with staining of the Golgi apparatus. (wikipedia.org)
  • Benharroch D, Dima E, Levy A, Ohana-Malka O, Ariad S, Prinsloo I, Mejirovsky E, Sacks M, Gopas J: Differential expression of sialyl and non-sialyl-CD15 antigens on Hodgkin-Reed-Sternberg cells: significance in Hodgkin's disease. (exbio.cz)
  • Natural killer (NK) cell-based immunotherapy may overcome genetic mechanisms of resistance to T cell-based immunotherapy through antigen- and MHC-independent recognition of malignant cells. (elifesciences.org)
  • A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. (wakehealth.edu)
  • The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. (wakehealth.edu)
  • The protein has no known natural ligand [4] and its function is to enable optimal B-cell immune response, specifically against T-independent antigens. (wikidoc.org)
  • Antibody FMC7 ( F linder M edical C entre) appears to recognise a conformational variant of CD20 [10] [11] also known as the FMC7 antigen. (wikidoc.org)
  • This gene encodes a B-lymphocyte surface molecule that plays a role in the development and differentiation of B-cells into plasma cells . (wikidoc.org)
  • During inflammation, binding of selectins to cell-surface glycoconjugates mediates rolling adhesion of leukocytes on vascular surfaces. (ashpublications.org)
  • B-lymphocyte antigen CD20 or CD20 is an activated- glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase ( CD45 R+, CD117 +) and progressively increasing in concentration until maturity. (wikidoc.org)
  • Cell-surface molecules that exhibit lineage-restricted patterns of expression during EMBRYONIC DEVELOPMENT. (uams.edu)
  • Lack of H antigen, a precursor to ABO antigen, leads to Bombay blood type (hh). (mhmedical.com)
  • CD34 is expressed on early precursor cells of myeloid and B-cell lineages, and CD15 is expressed on immature monocytic lineage cells and highly expressed on granulocytic lineage cells.31 As diseased muscle contains many myeloid cells such as neutrophils, monocytes, and macrophages, a more specific marker for mesenchymal cells with adipogenic potential is AAF-CMK required for detailed characterization of these cells in human diseased muscle. (phytid.org)
  • Multiparameter flow cytometric analysis of CD15 expression on human peripheral blood leucocyte populations. (bdbiosciences.com)
  • However, it has been difficult to obtain human mAbs, especially those directed at human antigens, for at least two reasons. (coek.info)
  • A current research in contrast the activating impact that oxLDL and HSP60 have on T cells via DCs and irrespective of whether these two antigens depend upon each other for activation.112 DCs have been handled with human serum albumin (HSA) conjugated with malo. (dhfrinhibitor.com)
  • CD15 has been implicated in adhesion, as well as chemotaxis, phagocytosis, and bactericidal activity. (biolegend.com)
  • CD15 is present on almost all Reed-Sternberg cells, including their rare mononuclear variants, and, as such, can be used in immunohistochemistry to identify the presence of such cells in biopsies. (wikipedia.org)
  • Cells with high surface expression of Le(x) antigen exhibit strong self-aggregation, based on calcium-dependent Le(x)-Le(x) interaction. (exbio.cz)
  • This procedure is initiated by endothelial cells subjected to strain which express surface HSP60 triggering an antiHSP60 immune response prior established by prior publicity to bacterial HSP60.104 As a result, comprehending the recognition mechanisms of HSP60 while in the entire body, throughout infection or new vaccination approaches with foreign HSP60 can tremendously influence the end result of some inflammatory mechanisms of atherosclerosis. (dhfrinhibitor.com)
  • When cells from the subventricular zone are cultured in a way that allows the cells to freely float around (rather than growing on a surface), a few percent form spherical colonies called neurospheres. (elifesciences.org)
  • T cells are recruited to the vessel wall after initial exposure to the antigen. (medscape.com)
  • CD15 expression has been extensively used to confirm diagnosis of Hodgkin´s disease. (exbio.cz)
  • SSEA4, and CD15 expression is sustained in the ex- pone et al. (lu.se)
  • The cell surface phenotype of PDGFRand CD56 expression. (phytid.org)
  • Additionally, induced co -expression of luciferase, EGFP, and the melanosomal antigen gp100 facilitates studies on the underlying immunological mechanisms. (unav.edu)
  • CD3 subunits gamma, delta and epsilon are required for proper assembly, trafficking and surface expression of the TCR complex. (thermofisher.com)
  • VC 2006 Wiley-Liss, Inc. a glycolipid antigen with globo-series carbohydrate core structures (Kannagi et al. (lu.se)
  • Below are the most recent publications written about "Antigens, CD47" by people in Profiles. (rush.edu)
  • Immunohistochemical detection of rickettsial antigens may be useful in diagnosing ATBF. (cdc.gov)
  • Silver nanoparticles for the detection of cell surface antigens in mass cytometry. (smarttubeinc.com)
  • In 1972 a numerical system for the antigens in this blood group was introduced. (wikidoc.org)
  • Glycophorin A and glycophorin B carry the blood group MN and Ss antigens respectively. (wikidoc.org)
  • [1] The following year a new but related antigen was discovered in a Mrs Yus for whom an antigen in this system is also named. (wikidoc.org)
  • The antigen is named after one of the patients - a Mrs Gerbich. (wikidoc.org)