Suramin. Medical search. Frequent questions

Background/aim: Suramin is a potent angiogenesis inhibitor in rodents and attenuates placental development in rat pregnancy. (tubitak.gov.tr)
We investigated therapeutic repositioning of suramin to protect against cartilage damage, as suramin may interact with tissue inhibitor of metalloproteinase-3 (TIMP3). (univ-lorraine.fr)
Suramin is an inhibitor of purinergic signalling that has been used to treat African sleeping sickness since shortly after it was first synthesised in 1916. (dailymail.co.uk)
In their latest work, Naviaux again tested the effect of suramin, a well-known inhibitor of purinergic signaling that was first synthesized in 1916 and is used to treat trypanosomiasis or African sleeping sickness, a parasitic disease. (technologynetworks.com)

The mechanism of action for suramin is unclear, but it is thought that parasites are able to selectively uptake suramin via receptor-mediated endocytosis of drug that is bound to low-density lipoproteins and, to a lesser extent, other serum proteins. (wikipedia.org)

Pathological examination of kidneys showed an acute tubular injury after suramin injection. (tubitak.gov.tr)

Results: Increased blood pressures and proteinuria were detected in suramin-given pregnant rats. (tubitak.gov.tr)

Suramin is a medication used to treat African sleeping sickness and river blindness. (wikipedia.org)
Suramin is used for treatment of human sleeping sickness caused by trypanosomes. (wikipedia.org)
Objectives: Suramin is an old drug used for the treatment of African sleeping sickness. (univ-lorraine.fr)
Preliminary results show that the drug called suramin, which is already used to treat sleeping sickness in Africa, corrects autism-like symptoms in mice. (dailymail.co.uk)
As the only manufacturer of the treatments Nifurtimox and Suramin, recognized by the WHO as essential medicines, our initial focus has been on fighting the diseases these medicines treat like Chagas disease and African sleeping sickness (HAT). (bayer.com)
BUFFALO, N.Y. - Suramin, a 100-year old drug used to treat sleeping sickness, has been repurposed to fight oral mucositis and diabetic foot ulcers, according to University at Buffalo-supported research. (buffalo.edu)
Researchers treated a Fragile X genetic mouse model, one of the most commonly studied mouse models of ASD, with suramin, a drug long used for sleeping sickness. (superdoctors.com)

Naviaux noted that suramin is not a drug that can be used for more than a few months without a risk of toxicity in humans. (superdoctors.com)

Once inside parasites, suramin combines with proteins, especially trypanosomal glycolytic enzymes, to inhibit energy metabolism. (wikipedia.org)
Altogether, these data show that the resistance phenotype is dependent on the binding of suramin to VSGsur, establishing that the VSG proteins can possess functionality beyond their role in antigenic variation. (unibas.ch)

Suramin was assayed using high-performance liquid chromatography, vascular endothelial growth factor (VEGF) using ELISA (enzyme-linked immunosorbent assay), and urinary protein profile using surface-enhanced laser desorption ionisation mass spectroscopy (SELDI). (ox.ac.uk)
Methods: In vitro extracellular matrix (ECM) accumulation and turnover in the presence or absence of suramin were studied in the ATDC5 micromass model of chondrogenesis and in pellet cultures of human articular chondrocytes from osteoarthritis and control patients, by gene expression, protein analysis, colorimetric staining, immunoprecipitation, fluorimetric analysis and immunohistochemistry. (univ-lorraine.fr)

We administered Suramin intravesically to determine a concentration with low toxicity but with evidence of a pharmacodynamic effect, to recommend a dose level for phase II trials. (ox.ac.uk)
Intravesical Suramin shows lack of toxicity and low systemic absorption. (ox.ac.uk)
Pieters survived long enough to be the first patient to participate in an experimental trial for suramin , the first antiviral drug for AIDS, which was subsequently recalled for its severe toxicity. (wordandway.org)

Suramin has been a primary early-stage treatment for African trypanosomiasis for nearly 100 yr. (unibas.ch)
Adverse reactions to suramin treatment in patients with T. b. rhodesiense trypanosomiasis are frequent, but usually mild and reversible. (cdc.gov)

Suramin treatment resulted in increased glycosaminoglycans. (univ-lorraine.fr)
Translational validation in human chondrocytes confirmed increased TIMP3 function and reduced cartilage breakdown after suramin treatment. (univ-lorraine.fr)
Weekly treatment with suramin in the Fragile X genetic mouse model was started at nine weeks of age, roughly equivalent to 18 years in humans. (superdoctors.com)

Suramin is not extensively metabolized and about 80% is eliminated via the kidneys. (wikipedia.org)

The co-crystal structure of VSGsur with suramin reveals that the chemically symmetric drug binds within a large cavity in the VSG homodimer asymmetrically, primarily through contacts of its central benzene rings. (unibas.ch)

Vascular responses of aortic, renal, and uterine arteries in suramin-i" by SEBİLE GÜLER ÇEKİÇ, EDİP GÜVENÇ ÇEKİÇ et al. (tubitak.gov.tr)

Mice treated intra-articularly with suramin injections showed reduced cartilage damage compared with controls, with increased TIMP3 and decreased MMP and aggrecanase activity. (univ-lorraine.fr)

Conclusion: Suramin prevented loss of articular cartilage in a mouse model of cartilage damage. (univ-lorraine.fr)

NF449, a sulfated compound produced from the antiparasitic medication suramin, once was reported to inhibit infection by enterovirus A71 (EV-A71). (mindunwindart.com)

Suramin contains six aromatic systems - four benzene rings, sandwiched by a pair of naphthalene moieties - plus four amide functional groups (in addition to the urea) and six sulfonic acid groups. (wikipedia.org)
We aimed to produce preeclampsia-like syndrome by suramin administration in rats and to investigate the functional responses in aortic, renal, and uterine arteries. (tubitak.gov.tr)

Suramin is an antitrypanosomal agent with antineoplastic activity, but with serious systemic side effects. (ox.ac.uk)
Minimal systemic absorption of Suramin was found at the highest dose of 150 mg ml(-1). (ox.ac.uk)

To study suramin in vivo, the drug was injected intra-articularly in the papain model of joint damage. (univ-lorraine.fr)

Suramin is also effective in treating the first stages of both T. b. gambiense and T. b. rhodesiense but is recommended to be only used to treat the first stage of T. b. rhodesiense because of the risk of severe adverse reactions in patients co-infected with onchocerciasis, which can occur in T. b. gambiense -endemic areas. (cdc.gov)

Suramin does not distribute well into cerebral spinal fluid and its concentration in the tissues is equivalently lower than its concentration in the plasma. (wikipedia.org)

Structure-based, loss-of-contact mutations in VSGsur significantly decrease the affinity to suramin and lead to a loss of the resistance phenotype. (unibas.ch)

Results: In ATDC5 micromasses, suramin increased TIMP3 levels and decreased the activity of matrix metalloproteinases (MMPs) and aggrecanases. (univ-lorraine.fr)
In rare instances, suramin administration results in a hypersensitivity reaction, and, for this reason, a small test dose is usually given prior to the full first dose. (cdc.gov)

Suramin has been applied clinically to HIV/AIDS patients resulting in a significant number of fatal occurrences and as a result the application of this molecule was abandoned for this condition. (wikipedia.org)

The WHO has recommended that suramin not be used to treat onchocerciasis in individuals who are elderly or infirm or in patients with severe liver or renal disease. (medscape.com)
The teams will also test the efficacy and safety of two molecules (suramin and itraconazole) already used in other human diseases, to treat enteroviruses infections. (pasteur.fr)

Our early studies with Suramin to reduce the severity of oral mucositis have been promising. (buffalo.edu)

Suramin can also cause loss of appetite and irritability. (wikipedia.org)
Suramin uncommonly affects the eyes causing watery eyes, swelling around the eyes, photophobia, and changes or loss of vision. (wikipedia.org)

They found that suramin blocked the extracellular signaling pathway used by ATP and other mitokines in a mouse model of autism spectrum disorder (ASD), ending the cell danger response and related inflammation. (technologynetworks.com)

Here, we show that VSGsur binds tightly to suramin but other VSGs do not. (unibas.ch)

Suramin causes a fair number of side effects. (wikipedia.org)

however, the pharmacokinetics of suramin can vary substantially between individual patients. (wikipedia.org)

Suramin, the researchers discovered, is effective for wound healing and well-equipped to meet the needs of diabetic and cancer patient populations. (buffalo.edu)

In this study, we showed that preeclampsia-like syndrome occurred in suramin-given rats. (tubitak.gov.tr)

Phase I trial of intravesical Suramin in recurrent superficial transitional cell bladder carcinoma. (ox.ac.uk)

Suramin was made at least as early as 1916. (wikipedia.org)

In regions of the world where the disease is common suramin is provided for free by the World Health Organization (WHO). (wikipedia.org)

Ca(2+)-free medium or suramin abolished this change. (jneurosci.org)
This response was also blocked by Ca(2+)-free medium and by suramin. (jneurosci.org)

Inhibitor4

Mechanism of act1

Injection1

Proteinuria1

Sleeping sickness7

Naviaux1

Proteins2

Protein2

Toxicity3

Trypanosomiasis2

Treatment3

Kidneys1

Symmetric1

Vascular1

Mice1

Conclusion1

Medication1

Functional2

Systemic2

Drug1

Reactions1

Concentration1

Decrease1

Results2

AIDS1

Treat2

Reduce1

Loss2

Found1

Show1

Side effects1

Patients1

Effective1

Study1

Trial1

Early1

Disease1

Free2