Suppressor cell line tumor. Medical search. Frequent questions

Nowell, a tumor biologist in the pathology department at the University of Pennsylvania School of Medicine, was interested in the relationship between cancer and alterations in genes (although he had no proof there was one). (laskerfoundation.org)
Through a genome-wide search for such genes that were epigenetically controlled by the PI3K pathway in thyroid cancer cells, we found a wide range of genes with broad functions epigenetically targeted by the PI3K pathway. (oncotarget.com)
This task can be accomplished by replacing tumor suppressor genes that have been lost or mutated, selectively inserting genes that produce cytotoxic substances, or modifying the immune system to destroy the tumor cells. (medscape.com)
Activation of the Wnt pathway stabilizes beta-catenin, allowing it to move into the cell nucleus and control the expression of many different genes. (eurekalert.org)
A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. (nottingham.ac.uk)
Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. (nottingham.ac.uk)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
Inactivation of tumor suppressor genes is an essential stage in the development of human cancer but the extent of the involvement of epigenetic silencing and hypermethylation in this process remains unclear. (the-scientist.com)
In April 4 Nature, Ina Rhee and colleagues from Johns Hopkins University School of Medicine, show that two enzymes (DNMT1 and DNMT3b) cooperate to silence genes and maintain DNA methylation in human cancer cells.Rhee et al. (the-scientist.com)
These results "establish that methylation is essential for silencing tumor suppressor genes in human cancer cells. (the-scientist.com)
Results of mechanistic studies demonstrated that inhibiting KDM1 increased the expression of tumor suppressor p53 target genes through epigenetic modifications, according to Sareddy. (medindia.net)
Global CpG island hypermethylation, which induces epigenetic silencing of tumor suppressor genes, is also a unique feature of EBVaGC and is considered to be crucial for its carcinogenesis. (spandidos-publications.com)
Deletions of multiple GID subunits compromise cell proliferation, and this defect is accompanied by deregulation of critical cell cycle markers such as the retinoblastoma (Rb) tumor suppressor, phospho-Histone H3 and Cyclin A. We identify the negative regulator of pro-proliferative genes Hbp1 as a bonafide GID/CTLH proteolytic substrate. (elifesciences.org)
The Ras-assocation family (RASSF) of tumour suppressor genes (TSGs) contains 10 members that encode proteins containing Ras-assocation (RA) domains. (biomedcentral.com)
succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/paraganglioma tumors. (ed.ac.uk)
Several genes in the mammalian hedgehog signaling network are known oncogenes or tumor suppressor genes. (bcm.edu)
2003). More recently, array comparative genomic hybridization (CGH) analyses indicate that genomic loss at the Ptch1 locus was the fourth most commonly detected change among the tumor suppressor genes identified in the study, occurring in 19 percent of human breast cancers and 33 percent of breast cancer cell lines (Naylor et al. (bcm.edu)
Essentially, it used the cells' shape to predict which genes are turned "on" and "off," information that reveals a cell's identity. (stanford.edu)
Breast cancer susceptibility genes BRCA1 and BRCA2 are tumour suppressor genes the alleles of which have to be inactivated before tumour development occurs. (lu.se)
Hereditary breast cancers linked to germ-line mutations of BRCA1 and BRCA2 genes almost invariably show allelic imbalance (Al) at the respective loci. (lu.se)
Genetic predisposition, which might lead to either activation of oncogenes or inhibition of tumor suppressor genes, are risk factors of colon cancer development. (lu.se)
In conclusion, these findings provide important information for better understanding of the tumor microenvironment and the tumor suppressor genes in colon cancer and might help to identify new therapeutic targets for colon cancer patients. (lu.se)
In a second line, we use natural genetic variation to find genes that regulate hematopoietic stem and progenitor cells (HSPC) in humans. (lu.se)

We showed that overexpression of DKK3 can decrease cell invasion, proliferation, and colony forming ability of GBC cells. (amrita.edu)
At the same time, TET1 of glioma U251 cells was knocked down or overexpressed to observe its effect on glioma cell proliferation and invasion as well as autophagy level. (nih.gov)
When TET1 gene in glioma U251 cells was knocked down by CRISPR/Caspase-9 system, the proliferation and invasive ability of U251 increased remarkably. (nih.gov)
But when TET1 was overexpressed in U251 cells, the proliferation and invasion were impaired. (nih.gov)
Single-cell RNA-sequencing (scRNA-seq) analysis of thousands of DIPG tumor cells containing H3K27M mutations showed that most of these tumor cells resemble oligodendrocyte precursor cells (OPC-like)-a cell type that exhibits obviously enhanced proliferation and tumor-propagating potential compared with other cell subsets in tumor samples 9 . (nature.com)
and 3) the forced overexpression of CMTM5-v1 in cultured DU145 cells (a human prostate cancer cell line) reduces, while the forced higher expression of the CMTM5-v1 levels increases, their proliferation and migration. (wikipedia.org)
Demethylating the hypermethylated REC8 gene restored its expression in thyroid cancer cells in which the PI3K pathway was genetically over-activated and induced expression of REC8 protein inhibited the proliferation and colony formation of these cells. (oncotarget.com)
Beta-catenin is a central component of the Wnt signaling pathway that controls cell proliferation and differentiation. (eurekalert.org)
Promisingly, they have already uncovered at least four naturally occurring chemicals in the family known as the benzophenones that are effective at preventing the proliferation of cancer cells, including multi-drug resistant varieties. (naturalnews.com)
The inhibitory effect of MicroRNA-16-5p on the proliferation, invasion, cell cycle and apoptosis of glioma cells was evaluated by the cell proliferation, invasion and flow cytometry. (ijpsonline.com)
A hallmark of the disease is the proliferation of cells that have not completely matured. (genengnews.com)
SCARA5 overexpression significantly inhibited cell proliferation and induced apoptosis of CAL-27 and SCC-9 cells. (degruyter.com)
In conclusion, SCARA5 inhibited the proliferation and EMT and induced the apoptosis of OSCC cells through the inhibition of STAT3 and PI3K/AKT signaling pathways, thereby exerting a tumor suppressor effect. (degruyter.com)
EBVaGC is defined by monoclonal proliferation of carcinoma cells with latent EBV infection, as demonstrated by EBV-encoded small RNA (EBER) in situ hybridization. (spandidos-publications.com)
These abnormalities result in significant alterations in gene expression related to cell proliferation, apoptosis, migration and immune signaling pathways. (spandidos-publications.com)
Silence of miR-769-5p conspicuously suppresses glioma cell proliferation and fosters cell apoptosis [ 8 ]. (hindawi.com)
Tight control of the cell cycle in eukaryotic cells exists to control proliferation, differentiation or apoptosis. (benthamscience.com)
However, the underlying mechanisms involved in the induction of genomic instability, genotoxicity, mutations and consequent increased cell proliferation are still a matter of intense research. (benthamscience.com)
Many factors are involved in causing and permitting the unregulated proliferation of cells that occurs in cancer. (msdmanuals.com)
Загальні відомості про злоякісні новоутворення Cancer is an unregulated proliferation of cells. (msdmanuals.com)
Aspects of cell proliferation in oral epithelial dysplastic lesions. (bvsalud.org)

Taken together, our findings indicate that SS18-SSX-mediated attenuation of an EGR1-PTEN network regulates synovial sarcoma cell survival, and that HDAC inhibitor-mediated apoptosis operates at least in part through reactivation of this pathway. (nature.com)
Mutant K-RAS has been shown to have both tumor-promoting and -suppressing functions, and growing evidence suggests that the RASSF family of tumor suppressors can act as RAS apoptosis and senescence effectors. (cancerindex.org)
The over expression of MicroRNA-16-5p can inhibit the growth and invasion of the glioma cell line, promote the apoptosis and delay the cell cycle. (ijpsonline.com)
Ectopic expression of the gene in the cell lines resulted in cell growth inhibition and apoptosis in vitro and inhibition of tumor growth in vivo in nude mice. (uclahealth.org)
Differentiation and apoptosis have cell cycle withdraw in common, while cancer and degenerative processes both show altered control of the cell cycle. (benthamscience.com)
However, Ras proteins can also regulate apoptosis via several recently described effectors, namely the RASSF family of tumour suppressor proteins. (biomedcentral.com)
The resulting damage cannot be overcome by the antioxidant system to protect the cell from oxidative damage, leading to necrosis, apoptosis, or autophagy of the target cell and tissue ( 10 , 11 ). (spandidos-publications.com)
Previous work has shown that inhibition of LDHA in cancer cells leads to apoptosis. (suny.edu)
Accordingly, treatment of these cell lines with the FLCN-peptide results in apoptosis, suggesting a potential therapeutic intervention. (suny.edu)
43] Additionally, knockdown of slingshot 2 (SSH2) serine phosphatase was demonstrated to induce caspase 3/7 activation that can trigger apoptosis in human carcinoma cells with a FLCN mutation. (medscape.com)

E-cadherin has many other functions including acting as a tumor suppressor protein, which means it prevents cells from growing and dividing too rapidly or in an uncontrolled way. (medlineplus.gov)

We discovered that activation of BMP signaling promotes the exit of DIPG tumor cells from 'prolonged stem-cell-like' state to differentiation by epigenetically regulating CXXC5, which acts as a tumor suppressor and positive regulator of BMP signaling. (nature.com)
In this work, we made use of the inducible SDHD-ESR mouse, a conditional mutant in the SdhD gene, which encodes the small subunit of MCII, and that acts as a tumor suppressor gene in humans. (ed.ac.uk)
Gaur et al suggest FLCN acts as a tumor suppressor by negatively regulating rRNA synthesis. (medscape.com)

Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
Preclinical tests show that the inhibitor can change the microenvironment of a tumor by increasing populations of antitumor immune cells in the area. (genengnews.com)

Expression of the suppressor of cytokine signaling-1 (SOCS1) is inactivated in hematopoietic and solid cancers by promoter methylation, miRNA-mediated silencing, and mutations. (aacrjournals.org)
Thirteen FANCD2-monoubiquitinylation-positive FA cell lines excluded for genetic defects in the downstream pathway components and 300 familial BrCa patients negative for BRCA1/2 mutations were analyzed for genetic mutations. (lu.se)
The combination fueled a 10-fold increase in ALL mutations, including an alteration in the tumor suppressor gene TP53. (sciencecodex.com)
Working in two cell lines in the laboratory, Zhou and his colleagues replicated the thiopurine-induced TP53 mutations and chemotherapy resistance. (sciencecodex.com)
People with HDGC caused by CDH1 gene mutations are born with one mutated copy of the gene in each cell. (medlineplus.gov)
It is unclear why CDH1 gene mutations primarily occur in the stomach lining and these other tissues. (medlineplus.gov)
For example, loss-of-function mutations in Ptc1 , or gain-of-function mutations in Smo, Shh, Gli1 , and Gli2 , can each contribute to skin cancers, most notably basal cell carcinomas - the most common of all human cancers. (bcm.edu)
Germline mutations in FLCN predispose affected individuals to develop Birt-Hogg-Dubé syndrome, which is characterized by facial fibrofolliculomas, pulmonary cysts, spontaneous pneumothorax, and renal cell carcinoma. (suny.edu)
Mutations in p53, found in most cancers, lead to uncontrollable cell division. (medscape.com)

Exosomal release of beta-catenin and inhibition of Wnt signaling may explain why CD82 and CD9 suppress tumor metastasis. (eurekalert.org)
Researchers reveal a new way in which cells restrain beta-catenin and potentially suppress tumor metastasis: the protein can be ejected from cells in small vesicles called exosomes. (eurekalert.org)
CD82 and CD9 are both suppressors of metastasis whose expression is lost in several types of late stage tumor. (eurekalert.org)
CD82 may act as a metastasis suppressor by targeting beta-catenin for exosomal release and thereby reducing its availability as a Wnt signaling mediator," Caplan proposes. (eurekalert.org)
Srivatsan's studies further revealed that cathepsin L, a protein overexpressed in several tumors and linked to invasion and metastasis as the physiological target of cystatin E/M. (uclahealth.org)
Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)
Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)
Using cell culture, animal and patient studies, we investigated the biological role of microRNA-96 (miR-96) and microRNA-379 (miR-379) in prostate cancer bone metastasis. (lu.se)
In Paper II, we performed an in vivo anti-miRNA library screen, and identified miR-379 as a suppressor of prostate cancer bone metastasis. (lu.se)
Downregulation of miR-379 enhanced incidence of bone metastasis in mice, increased colony formation potential in osteoblast-conditioned media, and increased cell growth. (lu.se)

These findings are consistent with REC8 being a novel major bona fide tumor suppressor gene and a robust epigenetic target of the PI3K pathway. (oncotarget.com)
This gene thus plays a role in both cell-cycle and epigenetic regulation. (cancerindex.org)
Such epigenetic marks are essential for cells to develop normally. (genengnews.com)
Furthermore, methylation-dependent silencing of SOX11 has been reported for B cell lymphomas and indicates that epigenetic drugs may be used to re-express this tumour suppressor, but information on SOX11 promoter methylation in EOC is still lacking. (lu.se)

Loss of DKK3 gene is associated with a possible tumor suppressor role in human cancers. (amrita.edu)
It has been reported that TET1 is a tumour suppressor in several cancers. (nih.gov)
Preliminary studies suggest that CMTM5-v1 (which cells commonly secrete to the extracellular spaces such as the blood) or an unspecified CMTM5 isoform has various functions including involvements in regulating the autoimmune system, the development of numerous types of cancers, and the cardiovascular system. (wikipedia.org)
These findings suggest that the CMTM5 gene may act as a tumor suppressor gene, i.e. a normal gene whose product(s) inhibit the development and/or progression of various cancers. (wikipedia.org)
The findings also support further studies to confirm and expand these relationships and determine if the expression of CMTM5 isoforms can be used as tumor markers for these cancers severities/prognoses and/or targets as for treating them. (wikipedia.org)
It focuses on how precision oncology has shaped advances in the impact of non-coding RNAs in epigenetics and cancer, immunotherapy and tumor biology, and the clinical significance of various therapies in a range of cancers. (biomedcentral.com)
For example, the model found that when tumor cells resembling neuron support cells, called astrocytes, clustered together abnormally, patients seemed to have more swift, aggressive cancers. (stanford.edu)
Background: The neural transcription factor SOX11 has been described as a prognostic marker in epithelial ovarian cancers (EOC), however its role in individual histological subtypes and tumour grade requires further clarification. (lu.se)

This gene is a candidate tumor suppressor gene. (wikipedia.org)

Targeted molecular therapy against EGFR has shown promise as an adjuvant therapy in preliminary studies in several solid tumors, including head and neck cancer. (medscape.com)
I think the future of oncology, in terms of treating solid tumors , will be these combination therapies," Dr. Hermann says. (genengnews.com)
Interestingly, evaluated cancer cell lines derived from solid tumors of the lung, breast, prostate, bladder, and colon also demonstrate dysregulation of LDHA activity and dissociation of FLCN-LDHA interaction. (suny.edu)
Researchers anticipate enrolling 130 participants with one of several solid tumors. (medscape.com)

Glioma was one of the most common malignant brain tumors. (ijpsonline.com)
Brain tumors are the abnormal growth of brain cells that may be benign or metastatic. (medindia.net)
Brain tumors account for about 2.4% of all the tumor diagnosesandare most challenging due to their critically delicate location. (medindia.net)
Gliomas, the deadliest form of primary central nervous system neoplasms, represent about 70 percent of brain tumors, according to Sareddy. (medindia.net)
Stanford Medicine scientists and colleagues create an algorithm that could help physicians better understand and target complicated brain tumors. (stanford.edu)

[ 1 ] Early stage head and neck squamous cell carcinoma (HNSCC) is treated relatively well with single-modality therapy (either surgery or radiation alone). (medscape.com)
Go to Imaging of Nasopharyngeal and Laryngeal Squamous Cell Carcinoma and Head and Neck Squamous Cell Carcinoma for complete information on these topics. (medscape.com)
Oral squamous cell carcinoma (OSCC) is a common tumor in the world. (degruyter.com)
However, analogous advanced treatments are not available for patients with lung squamous cell carcinoma (lung SCC). (oncotarget.com)
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and is divided into three subtypes according to pathogenesis: adenocarcinoma, squamous cell carcinoma and large cell carcinoma [ 2 ]. (oncotarget.com)
In contrast, there is a lack of effective therapeutic options to treat patients with lung squamous cell carcinoma (lung SCC) [ 3 ]. (oncotarget.com)
Low level of miR-381-3p constrains oral squamous cell carcinoma growth [ 10 ]. (hindawi.com)
To study oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma todetermine (1) the prevalence of p53 protein immunoreactivity, (2) number of p53 positive cells, and (3) the area of localization of p53 protein immunoreactivity. (bvsalud.org)
Two contiguous sections from 30 tissue specimens (10 each from oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma) were subjected to hematoxylin and eosin (H/E) staining for histopathological diagnosis and immunohistochemical (IHC) staining for demonstration of p53. (bvsalud.org)
Higher p53 positive cell counts were demonstrated in oral squamous cell carcinoma compared to hyperplastic and dysplastic tissues. (bvsalud.org)
However the quantitative analysis of p53 positive cells and their localization in oral epithelium is of importance as a marker for oral squamous cell carcinoma. (bvsalud.org)
Prognostic significance of p53 expression in oral squamous cell carcinoma without neck node metastases. (bvsalud.org)
early event of malignant transformation and has a predictive value for developing oral squamous cell carcinoma. (bvsalud.org)
preneoplastic oral lesion and oral squamous cell carcinoma. (bvsalud.org)
9. Iamaroon A, Khemaleelakul U, Pongsiriwet S, Pintong J. Co-expression of p53 and Ki67 and lack of EBV expression in oral squamous cell carcinoma. (bvsalud.org)
Expression of p53 in leukoplakia and squamous cell carcinoma of the oral mucosa: correlation with expression of Ki67. (bvsalud.org)

Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. (nottingham.ac.uk)
MicroRNA-16-5p was a tumor suppressor in the progression of glioma. (ijpsonline.com)
Molecular features of these tumors have expanded our vision of tumorigenesis and progression and provided abundant specifically targeted pathways [ 5 ]. (hindawi.com)
As an important member of the miRNA family, miR-381-3p also mediates tumor progression. (hindawi.com)
A multitude of pathways control cyclin-dependent kinase activities as the major event for cell cycle progression. (benthamscience.com)

We found that DKK3 expression levels were low in GBC patients and cell lines. (amrita.edu)
Treatment of GBC cell lines with demethylating agent 5-Aza- 2'-deoxycytidine enhances its expression, establishing impact of methylation on DKK3 expression. (amrita.edu)
We observed low expression of DKK3 in gallbladder adenocarcinoma tumors and highly invasive GBC cell lines. (amrita.edu)
Here, we reported that the expression of TET1 in glioma tissue was significantly lower than the corresponding non-tumour normal tissues, and the concentration of TET1 is negatively correlated with the glioma WHO classification. (nih.gov)
Following the down-expression of TET1, the level of autophagy in U251 cells decreased accordingly.However, when TET1 was overexpressed in U251 cells, the level of autophagy incraesed. (nih.gov)
Finally, restoration of EGR1 or PTEN expression is sufficient to induce synovial sarcoma cell death. (nature.com)
1996). Expression of Egr-1 correlates with the transformed phenotype and the type of viral latency in EBV genome positive lymphoid cell lines. (nature.com)
Expression was also detected in many epithelial tumor cell lines. (wikipedia.org)
The forced over expression of CMTM5-v1 in Huh7 human hepatic cells also inhibited the ability of these cells to grow in a mouse model of cancer. (wikipedia.org)
Long non-coding RNAs (lncRNAs) can exhibit cell-type and cancer-type specific expression profiles, making them highly attractive as therapeutic targets. (researchgate.net)
Our objective was to determine if CDK2AP1 mRNA expression levels were consistent with tumour-suppressive functions in breast cancer. (cancerindex.org)
There were no significant associations between CDK2AP1 expression and estrogen receptor status, tumour grade and tumour type. (cancerindex.org)
Caplan and colleagues blocked Wnt signaling in a metastatic cell line after restoring CD82 expression. (eurekalert.org)
and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
Compared with the normal tissues, the expression of MicroRNA-16-5precursor was low in glioma tissues, which was consistent with that in the Uppsala87 and Uppsala251 cell lines. (ijpsonline.com)
They silenced KDM1 expression with siRNA or inhibited it with pargyline or NCL-1 and found that reducing its expression or inhibiting it pharmacologically reduced glioma cell line growth in vitro. (medindia.net)
4SC-202 also appears to increase the expression of tumor-associated antigens and immunomodulatory molecules in cancer cell lines. (genengnews.com)
In this study, we found that the SCARA5 expression was lower in CAL-27 and SCC-9 cells than that in human normal oral epithelial keratinocytes. (degruyter.com)
In addition, SCARA5 repressed OSCC cell epithelial-mesenchymal transformation (EMT), evidenced by increased E-cadherin expression and reduced N-cadherin expression. (degruyter.com)
Expression levels of miR-145-5p and miR-145-3p were markedly reduced in cancer tissues, and ectopic expression of these miRNAs inhibited cancer cell aggressiveness, suggesting that both miR-145-3p as well as miR-145-5p acted as antitumor miRNAs. (oncotarget.com)
Finally, silencing of cathepsin L led to decreased cell growth and over expression promoted cell growth. (uclahealth.org)
Thus, his results clearly demonstrated that cystain E/M is a cervical cancer suppressor gene and controls cell growth through the inhibition of cathepsin L. His laboratory used lentiviral tetracycline inducible system for the exogenous expression of cystatin E/M and have shown growth suppression in xenograft tumor mice model pointing to suppressor function of cystatin E/M protein. (uclahealth.org)
Exogenous expression of PACS-1 into miRNA 34a or 449a transfected cervical cancer cell lines leads to reversal of the DNA damage response (DDR), p53 activation and cell death induced by the two miRNAs. (uclahealth.org)
Animal cells undergo fundamental shifts in gene expression when there are changes in the oxygen levels around them. (nobelprize.org)
These changes in gene expression alter cell metabolism, tissue re-modeling, and even organismal responses such as increases in heart rate and ventilation. (nobelprize.org)
Through the combined work of these three laureates it was thus demonstrated that the response by gene expression to changes in oxygen is directly coupled to oxygen levels in the animal cell, allowing immediate cellular responses to occur to oxygenation through the action of the HIF transcription factor. (nobelprize.org)
However, whether the efficacy of PDT depends on the expression level of p62 in colorectal cancer cell lines is not known. (spandidos-publications.com)
The present study aimed to examine the role of p62 expression levels in chlorin e6‑based PDT in colorectal cancer cells. (spandidos-publications.com)
I investigated the underlying mechanisms/signaling triggered by these tumor suppressors in colon cancer cells and whether the re-expression of these tumor suppressors could be an attractive therapeutic strategy for treatment of colon cancer patients. (lu.se)
In addition, I also found that the pro-inflammatory mediator LTC4 via CysLTR2 can induce the expression of 15-PGDH through the JNK pathway, which indicate that LTC4 via CysLTR2 has an anti-tumor effect. (lu.se)
Demethylation was successfully performed using 5'-Aza-2'deoxycytidine (5-Aza-dC) resulting in SOX11 mRNA and protein expression in a previously negative EOC cell line. (lu.se)
Six miRNAs had concordant expression in both tumors and breast cancer patient blood samples compared with the normal control samples. (cdc.gov)
Twelve miRNAs showed concordant expression in tumors vs. normal breast tissues and patient survival (n = 1093), with seven as potential tumor suppressors and five as potential oncomiRs. (cdc.gov)
This thesis focuses on microRNAs (miRNAs), which modulate gene expression in healthy and tumour cells. (lu.se)
The expression of p53 in epithelial hyperkeratosis was mainly localized to basal epithelial cells whereas in epithelial dysplasia, it was predominantly localized to spinous epithelial cells. (bvsalud.org)
Expression of cell cycle proteins in head and neck cancer correlates with tumour site rather than tobacco use. (bvsalud.org)

These methylation changes, the studies suggest, regulate the function of immunologically active blood cells (and, perhaps, blood platelets) and thereby the development, maintenance, and/or worsening of the cited autoimmune diseases. (wikipedia.org)
Further analyses of EOC cell lines showed that SOX11 mRNA and protein were expressed in two of five cell lines, correlating with promoter methylation status. (lu.se)

Researchers have begun to home in on these proteins, looking for drugs that inhibit their actions in the cell. (genengnews.com)
Cellular proteostasis involves the coordinated and compensatory action of pathways that control biogenesis, folding, trafficking and breakdown of proteins allowing the cell to adapt to physiological or pathological environmental changes. (elifesciences.org)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Mass spectrometry-based proteomics now enables genome-scale measurements of proteomes from diverse cells, tissues, and organisms. (biorxiv.org)
E-cadherin helps neighboring cells stick to one another (cell adhesion) to form organized tissues. (medlineplus.gov)
A lack of E-cadherin also impairs cell adhesion, increasing the likelihood that cancer cells will not come together to form a tumor but will invade the stomach wall and metastasize as small clusters of cancer cells into nearby tissues. (medlineplus.gov)
The analysis of the Hif1α pathway in SDHD-ESR tissues and in two newly derived cell lines after complete SdhD loss -a requirement for hereditary paraganglioma type-1 tumor formation in humans- partially recapitulated the "pseudo-hypoxic" response and rendered inconsistent results. (ed.ac.uk)
The immune system is comprised of highly specialized q The findings and conclusions in this report are those of the authors and cells, tissues, and organs that give the human body the do not necessarily represent the views of the Agency for Toxic Substances and Disease Registry. (cdc.gov)

Overexpression of p62 is likely related to tumorigenesis and has been observed in many types of tumors ( 13 , 21 - 23 ), such as chemotherapy-resistant epithelial cell carcinoma ( 24 ). (spandidos-publications.com)
The spatial transcriptomics data allows us to look at these types of tumors in a way that was not possible previously," Gevaert said. (stanford.edu)

It has been hypothesized that inactivation of the RASSF1A tumor suppressor facilitates K-RAS-mediated transformation by uncoupling it from apoptotic pathways such as the Hippo pathway. (cancerindex.org)
With the increased understanding of molecular mechanisms and basic pathways in the pathogenesis of squamous cell cancer of the head and neck , these pathways may be modified, and rational approaches in cancer therapy at the molecular level may be created. (medscape.com)
It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
Induction of miR-21-PDCD4 signaling by tungsten carbide-cobalt nanoparticle s in JB6 cells involves ROS-mediated MAPK pathways. (cdc.gov)
for example, in 1858 Louis Pasteur was the first to show that there is a complex balance of oxygen use in animal cells, and that cells use multiple pathways to accomplish energy con-version (Pasteur, 1858). (nobelprize.org)
p62 is a multifunctional protein that mediates cell signaling pathways, autophagy and tumorigenesis, and participates in important regulation processes at the intersection between autophagy and cancer. (spandidos-publications.com)

Multi-omics biomarkers of response to the discovered drugs were identified using human breast cancer cell lines. (cdc.gov)

Recent studies demonstrated that the tumor suppressor gene programmed cell death 4 (PDCD4) and its upstream regulator miR-21 have been considered as oncogenes for novel cancer prevention or anticancer therapies. (cdc.gov)

Specifically, clinical data revealed that many DIPG tumors have exploited the capacity of CHRDL1 to hijack BMP ligands. (nature.com)
although it is derived from cells of the renal tubular epithelium, it has several histological subtypes which differ in their clinical outcome and biological features. (hindawi.com)
Preclinical studies also suggest INCB059872 could help combat small-cell lung cancer and Ewing Sarcoma, and clinical trials are currently underway to test the drug's efficacy in patients with sickle-cell disease, as well as its safety in patients with advanced malignancies. (genengnews.com)
Using the inducible and HPV 16 E6 or E7 or E6 and E7 gene transformed human epidermal keratinocyte system the laboratory has shown non-cell autonomous growth inhibition of the tumor cell lines pointing to the utility of developing this suppressor protein for clinical studies. (uclahealth.org)
The aim of my thesis was to evaluate the clinical significance of the tumor suppressors 15-PGDH and WNT5A in colon cancer patients. (lu.se)
Understanding how HSPCs are regulated is of central importance for several areas in clinical hematology, including stem cell transplantation and the treatment of leukemias. (lu.se)

Autophagy contributes to the prolonged survival of tumor cells, whereas defects in autophagy play a critical role in tumorigenesis ( 15 , 16 ). (spandidos-publications.com)
In recent studies, renal and pulmonary tumors in Birt-Hogg-Dubé syndrome appear to follow the two-hit tumorigenesis theory relating to the interaction of folliculin with the FLCN-interacting protein 1 (FNIP1) and FLCN-interacting protein 2 (FNIP2). (medscape.com)
Pradella et al suggest that FLCN may not always follow a classic two-hit model of tumorigenesis and may alternatively be a noncanonical tumor suppressor gene. (medscape.com)

This suggests that autophagy is a form of adaptation of the nutritional environment of rapidly growing tumor cells in response to hypoxia. (spandidos-publications.com)

We recently demonstrated that the Survival Associated Mitochondrial Melanoma Specific Oncogenic Non-coding RNA (SAMMSON) is essential for UM cell survi. (researchgate.net)
The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)

5 Institute for Cancer Genetics and Dept of Pathology and Cell Biology, Columbia University, New York, USA. (nih.gov)
1998). p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. (nature.com)
Molecular and functional profiling of cancer cell lines is subject to laboratory-specific experimental practices and data analysis protocols. (ntnu.no)
The current challenge therefore is how to make an integrated use of the omics profiles of cancer cell lines for reliable biological discoveries. (ntnu.no)
We demonstrated the power of the integrative analyses by identifying a novel driver gene, ECHDC1, with tumor suppressive role validated both in breast cancer cells and patient tumors. (ntnu.no)
The multi-modal meta-analysis approach also identified synthetic lethal partners of cancer drivers, including a co-dependency of PTEN deficient endometrial cancer cells on RNA helicases. (ntnu.no)
Metformin (MTF) has been reported to target NLK (Nemo-like kinase) to inhibit non-small lung cancer cells. (cancerindex.org)
At a time when the idea that cancer had a genetic basis was widely disbelieved, Nowell's results provided the first clear evidence that a particular genetic defect in a single chromosome can lead to a population or clone of identical cells that accumulate in numbers to form a deadly malignancy. (laskerfoundation.org)
The tiny Philadelphia chromosome became a clear and consistent marker of CML, a cancer of the myeloid or bone marrow cells, with broad implications for diagnosis and prognosis of disease. (laskerfoundation.org)
Similar findings for an unspecified CMTM5 isoform are reported in ovarian cancer, hepatocellular carcinoma, pancreatic cancer, non-small-cell lung carcinoma, renal cell carcinoma, and breast cancer. (wikipedia.org)
Follicular cell-derived thyroid cancer is a common endocrine malignancy, which histologically consists of papillary thyroid cancer (PTC), follicular thyroid cancer (FTC) and anaplastic thyroid cancer (ATC) [ 1 - 3 ]. (oncotarget.com)
The goal of specific molecular targets in cancer therapy is to create a "magic bullet" that selectively kills cancer cells. (medscape.com)
As our understanding of the molecular biology of HNSCC continues to develop, we can target the specific components of cancer cells that are not found in normal cells. (medscape.com)
Ideal targets should be both specific to cancer cells and commonly found in cancer cells. (medscape.com)
Various techniques have been developed for targeting cancer cells: gene therapy, monoclonal antibodies (MAbs), antibody toxin conjugates, small-molecule inhibitors, antisense molecules, and tumor vaccines. (medscape.com)
The goal of gene therapy is to introduce new genetic material into cancer cells that selectively kills them without causing toxicity to the surrounding cells. (medscape.com)
Due to the heterogeneous nature of tumors, molecular profiling is crucial to our understanding of how genomics plays a role in the cause or development of an individual cancer. (biomedcentral.com)
Such tumor profiles can subsequently be applied to exclusively tailor cancer therapies to directly target a causative mutation for a malignancy, ultimately achieving a personalized and precise approach to cancer treatment. (biomedcentral.com)
In their research, Efferth and Kuete are testing the African plants against a cancer cell line that uses three separate drug-resistance strategies. (naturalnews.com)
The first, known as transporter-mediated resistance, occurs when a substance called P-glycoprotein causes drugs to be prematurely flushed out of cancer cells. (naturalnews.com)
The second, tumor-suppressor-gene-mediated resistance, results from a mutation to protein p53 that makes cancer cells enormously aggressive and resistant. (naturalnews.com)
Uncovering key kinases in tumor growth and invasion is crucial for improving targeted therapies in advanced-stage colorectal cancer. (medindia.net)
Together, the one-two punch could spur the body's own immune system to attack cancer cells. (genengnews.com)
Together, the drugs appear to prevent cancer cells from evading detection. (genengnews.com)
In this form, known as diffuse gastric cancer, there is no solid tumor. (medlineplus.gov)
however, because this type of cancer is hidden underneath the stomach lining, it is usually not diagnosed until the cancer has become widely invasive. (medlineplus.gov)
It is well known that miR-145-5p (the guide strand) functions as a tumor suppressor in several types of cancer. (oncotarget.com)
However, the impact of miR-145-3p (the passenger strand) on cancer cells is still ambiguous. (oncotarget.com)
Researchers have now identified a tumor suppressor gene, cystatin E/M, which may be involved in the control of cervical cancer development. (uclahealth.org)
The researchers have previously used microsatellite analysis of cervical cancer cell lines and primary tumors to localize a tumor suppressor gene to a 300kb interval of chromosome 11q13. (uclahealth.org)
Researchers have now obtained evidence confirming cystatin E/M as the cervical cancer suppressor gene. (uclahealth.org)
Liposome encapsulated curcumin-difluorinated (CDF) inhibits the growth of cisplatin resistant head and neck cancer stem cells. (uclahealth.org)
This gene encodes the cyclin-dependent kinase inhibitor p21(WAF1/Cip1), a factor implicated in cell cycle, senescence, and cancer. (ed.ac.uk)
Photodynamic therapy (PDT) is a treatment that involves photosensitizing agents and light to kill cancer cells. (spandidos-publications.com)
To study the effect of p62 on cancer cell death, we used PDT to treat a stable cell line overexpressing p62. (spandidos-publications.com)
Overexpression of p62 may contribute to colorectal cancer cell death. (spandidos-publications.com)
To treat patients with colorectal cancer, an approach that selectively targets cancer cells without damaging normal cells and which minimizes the risk of perforating the intestinal barrier is needed ( 2 ). (spandidos-publications.com)
PDT is considered as a complementary therapy aimed at preventing tumor recurrence after surgical resection of colorectal cancer ( 3 ), making it a suitable approach for continuous removal of small fractions of tumors ( 4 ). (spandidos-publications.com)
PDT has been reported to be effective for treating aggressive colon cancer showing a high level of the vascular endothelial growth factor, which promotes tumor growth through angiogenesis ( 5 ). (spandidos-publications.com)
PDT uses a modality-based photosensitizer, which selectively affects cancer cells, using excitation and light-absorption in the presence of oxygen to produce a high concentration of reactive oxygen species (ROS), such as singlet oxygen and other free radicals ( 7 - 9 ). (spandidos-publications.com)
Recently, small cell lung cancer was shown to be dependent on activated hedgehog signaling. (bcm.edu)
Even after glioblastoma patients undergo surgery, radiation and chemotherapy, some cancer cells almost always remain. (stanford.edu)
While the images often reveal the shape and location of cancer cells, they don't paint a complete picture of the tumor. (stanford.edu)
From these detailed pictures, the model learned which cell types, cell-cell interactions and profiles were linked to more favorable (or unfavorable) cancer outcomes. (stanford.edu)
Interestingly immune cells as mast cells and inflammatory mediators as LTC4 play an important role in colon cancer. (lu.se)
I found that presence of mast cells in colon cancer tissue was associated with better prognosis of colon cancer patients, and the presence of mast cells in polyps/tumors in a colitis-associated colon cancer mouse model was also beneficial. (lu.se)
I found that the tumor suppressor gene 15-PGDH is down-regulated in colon cancer patients as well as in colon cancer cell lines. (lu.se)
My results show that treatment of colon cancer cells with Foxy-5, a WNT5A mimicking peptide, leads to up-regulation of 15-PGDH through JNK/AP-1 pathway. (lu.se)
Cancer cells, particularly those arising from the bone marrow or lymphatic system, may have a short generation time, and there usually are a smaller percentage of cells in G0 (resting phase). (msdmanuals.com)
A subpopulation of cells within a cancer has the properties of stem cells. (msdmanuals.com)
A cancer may release cells into the circulation at a very early stage of development. (msdmanuals.com)
Circulating cancer cells are present in many patients with advanced cancer and even in some with localized disease. (msdmanuals.com)
The Nilsson lab focuses on how inborn genetic variation influences blood cell formation and blood cancer risk in humans. (lu.se)
In Paper IV, we compared the biological functions of unedited and edited miR-379 in prostate cancer cells. (lu.se)
Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)

Targeted molecular therapy, like therapy with monoclonal antibodies, gene therapy, and other therapies, has limited or nonexistent side effects on normal cells of the body, unlike present modalities such as surgery, chemotherapy, and radiotherapy. (medscape.com)
This may include oncomir (oncogenic miRNA) inhibition, or tumor suppressor-miRNA replacement therapies [ 6 , 9 ]. (hindawi.com)
In the future, it may be possible to monitor bone marrow during treatment as a way to detect these mutational signatures early enough to help identify at-risk patients who may be candidates for emerging therapies like CAR-T cells," Zhang said. (sciencecodex.com)
That helps to eradicate the cells that are at the root of the leukemia, something conventional therapies can't do, Dr. Lee says. (genengnews.com)
Cell culture systems contribute to identifying molecular mechanisms for HBV and HDV propagation, finding drug targets for antiviral therapies, and testing antiviral agents. (cdc.gov)

Rapid blood and lymphatic spread and breast tumor emboli are the main features ofIBC 4 . (bvsalud.org)

This protein is found within the membrane that surrounds epithelial cells, which are the cells that line the surfaces and cavities of the body. (medlineplus.gov)
p53 positivity was looked for in each IHC stained slide and the number of positive cells amongst 1,000 epithelial cells were recorded. (bvsalud.org)

2004). Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma. (nature.com)
miR-381-3p overexpression remarkably represses malignant behaviors of papillary thyroid carcinoma cells [ 9 ]. (hindawi.com)
Malignancies involving mesothelial cells that normally line the body cavities, including the pleura (see the images below), peritoneum, pericardium, and testis, are known as malignant mesothelioma. (medscape.com)

Thirteen FANCD2-monoubiquitinylation-positive FA cell lines excluded for genetic defects in. (lu.se)
Mutational signatures reflect the history of genetic changes in cells. (sciencecodex.com)
But Stanford Medicine scientists and their colleagues recently developed an artificial intelligence model that assesses stained images of glioblastoma tissue to predict the aggressiveness of a patient's tumor, determine the genetic makeup of the tumor cells and evaluate whether substantial cancerous cells remain after surgery. (stanford.edu)
It reveals the location and genetic makeup of dozens of cell types, using specific molecules to identify genetic material in tumor tissue. (stanford.edu)
Their model showed that tumor cells with genetic traces of oxygen deprivation are often located in the center of a patient's tumor. (stanford.edu)
In a first line of research, we study genetic predisposition for multiple myeloma (MM). Studies going back to the 1920s support familial aggregation of MM. Recently, we and others discovered sequence variants influencing MM risk, including common variants at 24 loci and rare, high-penetrant variants in the tumor suppressor gene DIS3. (lu.se)
A Gradual Transition Toward Anaplasia in Wilms Tumor Through Tolerance to Genetic Damage. (lu.se)

These studies have demonstrated that overexpression of PACS-1 could serve as a diagnostic marker of tumor development and downregulation of PACS-1 through CRISPR/CAS9 system as a therapeutic model for the treatment of chemo-radiation resistant human tumors. (uclahealth.org)
Furthermore, overexpression of SOX11 in EOC cell lines confirmed the growth regulatory role of SOX11. (lu.se)

Thus, targeting the prolonged stem-cell-like state of DIPG cells to differentiation has been proposed as a potential strategy for DIPG treatment. (nature.com)
Mouse studies have suggested that Acvr1 G328V cooperates with Hist1h3b K27M and Pik3ca H1047R to generate high-grade diffuse gliomas, specifically by arresting the differentiation of oligodendroglial lineage cells 16 . (nature.com)
This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. (cancerindex.org)
Research has shown that lysine-specific histone demethylase 1 (LSD1) plays an essential role in the self-renewal of these "leukemic stem cells," Incyte principal investigator Sang Hyun Lee, Ph.D., tells GEN . Building on this finding, Dr. Lee and colleagues developed an LSD1 inhibitor called INCB059872, which spurs myeloid cell differentiation. (genengnews.com)
Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)

Previously we and others had demonstrated that several RASSF members, namely RASSF1A , RASSF2 , RASSF4 and RASSF5A are frequently epigenetically inactivated by promoter region CpG island hypermethylation in a broad range of solid tumour types [ 2 , 3 ]. (biomedcentral.com)

Irradiated Ce6 produced singlet oxygen which rapidly induces tumor cell death. (spandidos-publications.com)

but the molecular mechanisms underlying how cells adapt to variations in oxygen supply were unknown until the prize-winning work described here. (nobelprize.org)
These results strongly circumscribe the possible mechanisms of PINK1 action in the mitochondrial life cycle and also raise the possibility that mitochondrial turnover events that occur in cultured embryonic axons might be restricted to the cell body in vivo, in the intact nervous system. (sdbonline.org)
This new and unprecedented evidence for a link between SdhD dysfunction and p21(WAF1/Cip1) will open new avenues for the study of the mechanisms that cause tumors in Sdh mutants. (ed.ac.uk)

The third, oncogene-mediated resistance, occurs when the epidermal growth factor receptor (EGFR) signals cancerous tumors to accelerate their growth, overwhelming the capacity of drugs to kill them. (naturalnews.com)

Inactivating immune system checkpoints such as PD-1 and treating cells with 4SC-202 can inhibit tumor growth. (genengnews.com)

Folliculin (FLCN) is tumor suppressor protein whose function remains a topic of debate. (suny.edu)
They also demonstrated a Birt-Hogg-Dubé syndrome tumor-suppressor protein, folliculin. (medscape.com)
42] Another study by Nahorski et al demonstrated tumor suppression by the interaction of p0071 (plakophilin-4, a potential novel folliculin-interacting protein) and the regulation of RhoA. (medscape.com)

William Kaelin, Jr. was in 1995 engaged in the study of the von Hippel-Lindau tumor suppressor gene, and after isolation of the first full-length clone of the gene showed that it could suppress tumor growth in VHL mutant tumorigenic cell lines. (nobelprize.org)

Renal cell carcinoma (RCC) incidence has increased over the past two decades. (hindawi.com)
Renal cell carcinoma (RCC) accounts for approximately 3% of human malignancies, and its incidence appears to be increasing globally [ 1 ]. (hindawi.com)
Multiple or bilateral renal carcinomas, commonly chromophobe renal carcinoma and renal oncocytomas, and rarely, clear cell renal carcinomas have been reported in association with this syndrome. (medscape.com)
In summary, Birt-Hogg-Dubé syndrome is an autosomal dominant disorder clinically manifested by fibrofolliculomas, renal cell carcinoma, lung cysts, and spontaneous pneumothorax. (medscape.com)

Doctors and scientists also struggle with prognosis, as it can be difficult to parse which cancerous cells are driving each patient's glioblastoma. (stanford.edu)

The study appears online on September 13 in the Journal of Cell Biology ( www.jcb.org ). (eurekalert.org)
Founded in 1955, The Journal of Cell Biology (JCB) is published by The Rockefeller University Press. (eurekalert.org)

EBV was the first virus to be associated with human malignancy, which was discovered from a Burkitt's lymphoma cell line in 1964 ( 1 ). (spandidos-publications.com)

In this work, we confirmed that overexpressed miR-381-3p repressed biological functions of glioma cells. (hindawi.com)
miR-381-3p-mimic, oe-ANTXR1, and corresponding negative controls (NCs) (NC-mimic and oe-NC) were ordered from GeneChem (Shanghai, China) and transfected into glioma cells U87 at 50 nM using Lipofectamine 2000 (Invitrogen, Carlsbad, USA). (hindawi.com)

Furthermore, bafilomycin A1 (Baf-A1) but not 3-methyladenine (3-MA) could decrease the autophagy level of TET1 -/- U251 cells as the wild-type controls. (nih.gov)
It suggests that the tumour suppressor effect of TET1 seems to be mediated by regulating the level of autophagy, and the regulation of TET1 on autophagy is at an early stage. (nih.gov)
A recent study showed that the hypoxic environment produced by PDT can induce autophagy in tumor cells ( 17 ). (spandidos-publications.com)

Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells. (nature.com)
BRCA1 and BRCA2 are believed to take part in a common pathway in maintenance of genomic integrity in cells. (lu.se)

Frequency of myeloid suppressor cells (MDSC). (who.int)

Further, treatment of FLCN-deficient cells with this FLCN-derived peptide is sufficient to suppress glycolysis. (suny.edu)
Taken together, inhibition of LDHA by the tumor suppressor FLCN provides a mechanistic explanation for the endogenous regulation of glycolysis. (suny.edu)
44] Possik et al demonstrated FLCN is an AMPK-binding partner and considered to act as a negative regulator of AMPK, therefore serving as a tumor suppressor. (medscape.com)
This was demonstrated by the somatic PTEN deletion in parotid tumors in addition to the germline loss of FLCN, thereby following a model of compound heterozygosity, instead of the classic two-hit mutation. (medscape.com)

In human lung tumors, combined activation of K-RAS and inactivation of RASSF1A is closely associated with the development of the most aggressive and worst prognosis tumors. (cancerindex.org)

Nowell collaborated with the late David Hungerford who, he says, "knew more about chromosomes than I did," and together they made the startling observation that individuals suffering from chronic myelogenous leukemia (CML) had an abnormally small chromosome in the tumor cells. (laskerfoundation.org)
I came to realize that there were many questions about chromosome changes in patients that would be rewarding to study," noted Rowley, and for the next decade she labored over the microscope looking at chromosomes in leukemic cells. (laskerfoundation.org)

Anatomy28

Organisms12

Diseases44

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Phenomena and Processes60

Disciplines and Occupations1

Information Science3

Genes23

Proliferation21

Apoptosis10

Functions including acting as a1

Acts as a tumor suppressor3

Microenvironment2

Mutations9

Metastasis10

Epigenetic4

Cancers8

Candidate tumor supp1

Solid tumors4

Brain tumors5

Squamous Cell Carc16

Progression5

Expression36

Methylation2

Proteins2

Tissues6

Types of tumors2

Pathways6

Biomarkers1

Oncogenes1

Clinical6

Tumorigenesis3

Rapidly growi1

Survival2

Cancer55

Therapies5

Breast tumor1

Epithelial2

Malignant3

Genetic7

Overexpression2

Differentiation6

Epigenetically1

Induces1

Mechanisms3

Epidermal growth f1

Inhibit1

Folliculin3

Suppress tumor1

Renal4

Cancerous1

Biology2

Malignancy1

Glioma cells2

Autophagy3

Pathway2

Myeloid1

FLCN4

Inactivation1

Chromosome2