Suppresses von hippel lindau tumor suppressor protein. Medical search. Frequent questions

Mutations in ciliary protein genes can lead to dysfunctional or absent cilia and are the cause of a large group of heterogeneous diseases known as ciliopathies. (bvsalud.org)
There the SMAD proteins mediate the extent to which genes are activated and translated into proteins and other gene products. (goethe-university-frankfurt.de)
Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. (mc1-r.com)
Although epigenetically silenced, endogenous retroviral (ERV) genes become activated in tumors and function to ignite immune responses. (frontiersin.org)
This compound markedly decreased the hypoxia-induced accumulation of HIF-1α protein dose-dependently, whereas it did not affect the expressions of HIF-1β and topoisomerase-I (topo‑I). Furthermore, celastrol prevented hypoxia-induced expression of HIF-1 target genes for vascular endothelial growth factor (VEGF) and erythropoietin (EPO). (spandidos-publications.com)
By studying the patients and the genetic patterns of tumors collected from these patients, the researchers hypothesized that they could find genes responsible for kidney cancer. (nih.gov)
This study shows that genes regulating cell death can be hypoxically induced and are overexpressed in clinical tumors. (ox.ac.uk)
ADPKD is due to mutations in the genes PKD1 and PKD2, which encode polycystin proteins. (medscape.com)
TS is caused by mutations in the suppressor genes TSC1 and TSC2, which encode hamartin and tuberin, respectively. (medscape.com)

VHL syndrome is distinct from most other autosomal dominant conditions because there should be two gene mutations present in order for tumors to begin forming, leading the presentation of the syndrome. (bajaprogofficial.com)
When there are two mutations in the VHL gene, abnormal proteins are produced and the function of the gene is altered. (bajaprogofficial.com)
Moreover, aminooxyacetate, which inhibits the enzymatic activity of aminotransferases including GPT2, suppresses xenograft tumour growth of CRCs with mutations, but not with WT mutations as a cause of glutamine dependency in CRCs and suggest that targeting glutamine metabolism may be an effective approach to treat CRC patients harbouring mutations. (bibf1120.com)
Moreover, we show that aminooxyacetate (AOA), a compound that inhibits enzymatic activity of aminotransferases, suppresses xenograft tumour growth of CRCs with mutations, but not with wild-type (WT) mutations and that targeting glutamine metabolism may be an effective approach to treating CRC patients harbouring tumour mutations of this gene. (bibf1120.com)
We observed gain of functions in VHL mutations, thereby stabilizing HIF2α protein and reprograming HIF2α genome-wide target gene transcriptional programs. (biomedcentral.com)
For instance, it can be activated by oncogenic mutations of PTEN, VHL, the RAS/mitogen-activated protein kinase (MAPK) pathway and the phosphorylation of phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway. (spandidos-publications.com)
In August 2021, the U.S. Food and Drug Administration (FDA) approved belzutifan (Welireg), a new drug that has been shown in a clinical trial led by National Cancer Institute (NCI) researchers to shrink some tumors associated with VHL disease [1], which is caused by inherited mutations in the VHL tumor suppressor gene. (nih.gov)
They soon discovered that tumors from patients with sporadic clear cell kidney cancer also have mutations in this gene. (nih.gov)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

In fact, HIF-1α is a major factor for regulating tumor microenvironment (TME) for tumor cell survival and angiogenesis [6, 7]. (cd4inhibitors.com)
AXL significantly promotes tumour cell migration, invasion and metastasis, as well as angiogenesis. (cancerindex.org)
Caffeic acid inhibits VEGF, a growth factor which promotes angiogenesis to feed tumor cells. (turmeric.com)

Apoptosis regulatory proteins are delicately balanced. (bmj.com)
The key regulator of this process, hypoxia inducible factor 1 (HIF-1), can initiate apoptosis by inducing high concentrations of proapoptotic proteins, such as BNIP3, and can cause stabilisation of p53. (bmj.com)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a tumor-selective apoptosis inducer that is expressed in natural killer cells, whose cytotoxicity is activated by interferon (IFN). (oncotarget.com)
Bcl2/adenovirus EIB 19kD-interacting protein 3 (BNIP3) is a cell death factor that is a member of the Bcl-2 proapoptotic family recently shown to induce necrosis rather than apoptosis. (ox.ac.uk)

Cyclin-dependent kinase 5 (CDK5) affects the tumor microenvironment, which may influence the efficacy of TKI+IO. (e-crt.org)
Associate Professor Margaret Currie is interested in how the tumour microenvironment affects tumour growth, tumour cell metastasis and tumour response to therapy. (otago.ac.nz)
The local tumour microenvironment is the milieu within which the tumour develops, and includes tumour blood vessels, other cells types (e.g. immune cells, fibroblasts, adipocytes), soluble growth factors and signalling molecules. (otago.ac.nz)
All the various components of the tumour microenvironment can influence tumour growth and spread and, conversely, tumour cells can influence the local tumour microenvironment. (otago.ac.nz)
A further layer of complexity exists because the wider tumour microenvironment (i.e. the body within which the tumour develops) alters with age and health, and is affected by systemic changes in metabolism, hormones and immunity. (otago.ac.nz)
The Mackenzie Cancer Research Group has been investigating the contribution of stromal cells and the tumour microenvironment to human tumour biology since the inception of our research group in 1998. (otago.ac.nz)
Drivers (A and B). The metabolic derangements in cancer cells may arise either from the selection of cells that have adapted to the tumor microenvironment or from aberrant signaling due to oncogene activation. (pharmaceuticalintelligence.com)
The tumor microenvironment is spatially and temporally heterogeneous, containing regions of low oxygen and low pH (purple). (pharmaceuticalintelligence.com)
One compelling idea to explain the Warburg effect is that the altered metabolism of cancer cells confers a selective advantage for survival and proliferation in the unique tumor microenvironment. (pharmaceuticalintelligence.com)
Breakthroughs in anti-tumor immunity have led to unprecedented advances in immunotherapy, yet it is now clear that the tumor microenvironment (TME) restrains immunity. (elifesciences.org)
As T cell metabolism dictates effector function, it is now apparent that the effect of cancer cell metabolism on the tumor microenvironment (TME) may impair anti-tumor immunity, and these new hallmarks of cancer are therefore inextricably linked. (elifesciences.org)

A marked increase in IFN-induced DR4 protein expression after tocilizumab treatment was observed by immunohistochemical staining in the tumor from the mice xenograft model. (oncotarget.com)
In vivo studies further confirmed the inhibitory effect of celastrol on the expression of HIF-1α proteins, leading to a decreased growth of Hep3B cells in a xenograft tumor model. (spandidos-publications.com)
Xenograft tumor growth was slightly inhibited by si-Vav3/atelocollagen complex injection and combined use of si-Vav3/atelocollagen complex and docetaxel produced a greater effect than docetaxel alone. (biomedcentral.com)

Researchers at the Goethe University Frankfurt, Heidelberg University, the German Cancer Research Center (DKFZ), Heidelberg University Hospital and the University Hospital in Jena have now discovered how the von Hippel-Lindau tumour suppressor protein (pVHL) intervenes in this signalling pathway. (goethe-university-frankfurt.de)

1] In children, pheochromocytoma is more frequently associated with other familial syndromes, such as neurofibromatosis, von Hippel-Lindau disease, tuberous sclerosis, Sturge-Weber syndrome, and as a component of multiple endocrine neoplasia (MEN) syndromes (MEN 2A, MEN 2B). (medscape.com)

Many oncogenes and tumour suppressors impact glutamine metabolism4. (bibf1120.com)

Low ATP concentrations in hypoxic tumour cells disable the apoptotic cascade and induce cell death by necrosis. (bmj.com)
The VHL gene is a tumor suppressor gene located on chromosome 3 at 3p25-26 that is responsible for monitoring cell growth and division and preventing the cells from multiplying uncontrollably. (bajaprogofficial.com)
As a result of this, certain cells are able to divide more rapidly than usual and form tumors or cysts characteristic of VHL syndrome. (bajaprogofficial.com)
Tumour suppressors are proteins whose defects or reduced presence in multicellular organisms are associated with a high risk that cells will degenerate into tumour cells. (goethe-university-frankfurt.de)
Tumour cells are good at adapting to their environment inside the organism and to variations in oxygen availability. (goethe-university-frankfurt.de)
We investigated the effect of suppressor of cytokine signaling (SOCS) 3 on the expression of TRAIL receptors (DR4) and on TRAIL sensitivity in renal cell carcinoma (RCC) cells. (oncotarget.com)
This gene, often called a tumor suppressor gene, cannot protect cells from becoming cancerous when it isn't working properly. (choa.org)
We are culturing human fat cells (adipocytes) and tumour cells together, to find out how adipocytes alter tumour cell phenotype and response to therapy. (otago.ac.nz)
Solid tumors contain regions of hypoxia, a physiological stress that can activate cell death pathways and, thus, result in the selection of cells resistant to death signals and anticancer therapy. (ox.ac.uk)
Using cDNA arrays and serial analysis of gene expression, we found that hypoxia induces up-regulation of BNIP3 and its homologue, Nip3-like protein X. Analysis of human carcinoma cell lines showed that they are hypoxically regulated in many tumor types, as well as in endothelial cells and macrophages. (ox.ac.uk)
Regulation was hypoxia inducible factor-1-dependent, and hypoxia inducible factor-1 expression was suppressed by von Hippel-Lindau protein in normoxic cells. (ox.ac.uk)
These compounds generally penetrate cell membranes, act on specific target proteins in cells, regulate intracellular signaling pathways, and cause some changes in cell phenotype. (chemscene.com)
The distribution of NAT10 and its role in cell divi- sion raised the possibility that this protein play an important role in the proliferation of cancer cells [10]. (cd4inhibitors.com)
A benign tumor that arises from glandular epithelial cells. (amboss.com)
This review will discuss the metabolic changes that drive T cells into different stages of their development and how the TME imposes barriers to the metabolism and activity of tumor infiltrating lymphocytes. (elifesciences.org)
In contrast, ACT expands a patient's own T cells ex vivo to direct anti-tumor immunity when transfused back into the patient. (elifesciences.org)
We will then examine how tumor cells create a toxic milieu for T cells that enter the TME. (elifesciences.org)
Calebin-A induced death of malignant peripheral nerve sheath tumor cells by activation of histone acetyltransferase. (cancerindex.org)
Curcumin boosts levels of Nrf-2, a transcription factor protein that activates anticancer natural antioxidants , in cells that line kidney tubes. (turmeric.com)
The hypoxia-inducible elements (HIFs) will be the main transcriptional regulators of hypoxic version of tumor cells. (molecularcircuit.com)

VHL disease encompasses various types of tumors, including retinal or central nervous system hemangioblastoma (RH or CNSH), clear cell renal cell carcinoma (RCC), pheochromocytoma (PHE), multiple pancreatic cysts or tumors (PCT), epididymal or broad ligament cystadenomas and endolymphatic sac tumor. (biomedcentral.com)
The Warburg effect has since been demonstrated in different types of tumors and the concomitant increase in glucose uptake has been exploited clinically for the detection of tumors by fluorodeoxyglucose positron emission tomography (FDG-PET). (pharmaceuticalintelligence.com)

Markedly, we found that suppression of HIF-1α accumulation by celastrol correlated with strong dephosphorylation of mammalian target of rapamycin (mTOR) and its effectors, ribosomal protein S6 kinase (p70S6K) and eukaryotic initiation factor 4E (eIF4E) and extracellular signal-regulated kinase (ERK), pathways known to regulate HIF-1α expression at the translational level. (spandidos-publications.com)
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. (cancerindex.org)
Pyruvate dehydrogenase kinase 1 (PDK1) a HIF-1 focus on has been proven to suppress pyruvate admittance in to the TCA routine therefore reducing ROS era and cell loss of life (11). (molecularcircuit.com)
Aurora kinase C is a chromosomal passenger protein that interacts with aurora kinase B in the regulation of MITOSIS. (lookformedical.com)
An aurora kinase that is a component of the chromosomal passenger protein complex and is involved in the regulation of MITOSIS. (lookformedical.com)
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. (lookformedical.com)
The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters. (lookformedical.com)

During the progression of colitis, genetic alterations associated with mucosal permeability [ e.g. those in extracellular matrix protein 1 ( ECM1 ), cadherin 1 ( CDH1 ), and hepatocyte nuclear factor 4 alpha ( HNF4A )] have been observed and considered to confer the risk of severe UC ( 11 , 12 ). (iiarjournals.org)
The most relevant articles summarising existing knowledge on RCC genomics, including tumour cell evolution and progression, were selected for this review. (springer.com)
Hypoxia is an important micro-environmental factor in promoting tumor progression. (spandidos-publications.com)
However, since 2009 Associate Professor Currie's interests have expanded to include the contribution to tumour progression made by tumour infiltrating immune cell populations, breast cancer stem cell-like populations, and obesity-related factors. (otago.ac.nz)
Therefore, inhibition of HIFs protein expression may be an attractive way to prevent tumor progression [6]. (cd4inhibitors.com)
The molecular biology underlying renal cell carcinoma (RCC) development and progression has been a key milestone in the management of this type of tumor. (cancerindex.org)
In melanoma, i have focused in acral lentiginous melanoma for which we described KIT mutation and protein expression status in a large series of cases and described TERT amplification in progression to metastasis. (mdanderson.org)

One universal problem experienced by solid tumors can be hypoxia which identifies air insufficiency. (molecularcircuit.com)

Curcumin inhibits growth of kidney tumors and cancer cell proliferation in lab and animal studies. (turmeric.com)
These observations led all of us to think about whether serine catabolism plays a part in tumor cell survival and proliferation also. (molecularcircuit.com)

Von Hippel-Lindau (VHL) disease is an autosomal dominant genetic neoplastic disorder caused by germline mutation or deletion of the VHL gene, characterized by the tendency to develop multisystem benign or malignant tumors. (biomedcentral.com)
The mutation increases the overall risk for affected children to develop cancer or a number of benign tumors, especially at younger ages. (choa.org)
DICER1 syndrome, also known as DICER1-pleuropulmonary blastoma familial tumor predisposition syndrome, is a condition in which an individual is born with genetic changes that predispose him or her to develop benign and malignant tumors during childhood, through adolescence and, rarely, as an adult. (choa.org)

Targeted protein degradation (TPD) is an emerging therapeutic strategy that would benefit from new chemical entities with which to recruit a wider variety of ubiquitin E3 ligases to target proteins for proteasomal degradation. (bvsalud.org)
This group of proteins ubiquitinates substrates in the body and marks them for degradation when they're not needed. (bajaprogofficial.com)
Further analysis revealed that celastrol inhibited HIF-1α protein synthesis, without affecting the expression level of HIF-1α mRNA or degradation of HIF-1α protein. (spandidos-publications.com)
The modified HIF-1α interacts with Von Hippel-Lindau (VHL), which is part of the E3 ubiquitin ligase complex targeting HIF-1α for 26S proteasomal degradation. (spandidos-publications.com)
5 4 Succinate functions as a competitive inhibitor for prolyl hydroxylase domain (PHD) proteins that are central to degradation of hypoxia-inducible factor (HIF)-1α subunit. (haematologica.org)
Hypoxia stabilises HIF-1α protein by relaxing its ubiquitin-proteasome degradation [ 12 ] and affects subcellular localisation, DNA binding capacity and transcriptional activation function of the HIF-1 complex. (biomedcentral.com)
In the middle section of HIF-1α lies a Pro-Ser-Thr oxygen-dependent degradation domain (ODDD, amino acids 401 to 603), which is responsible for the stability of the HIF-1α protein [ 12 ]. (biomedcentral.com)
Under normoxia the α subunits are hydroxylated on proline residues allowing recognition from the von-Hippel Lindau (VHL) tumor suppressor accompanied by proteosomal degradation. (molecularcircuit.com)

Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3. (mc1-r.com)
Further accumulation of genetic changes confers invasiveness or metastatic potential on the tumor ( 6 , 7 ), and to date, several indicators have been identified to predict outcomes ( 7 , 8 ). (iiarjournals.org)
Early identification affected individuals with asymptomatic VHL disease-associated tumors and mutation carriers via genetic recognition and rational medical interventions would improve patients' survival rates and quality of life. (biomedcentral.com)
The genetic changes that cause this syndrome are found in the DICER1 gene, a tumor suppressor gene. (choa.org)
There's exciting news for people with von Hippel-Lindau (VHL) disease , a rare genetic disorder that can lead to cancerous and non-cancerous tumors in multiple organs, including the brain, spinal cord, kidney, and pancreas. (nih.gov)
In this study, we demonstrated that Remodelin could not only inhibit the expression of HIF-1α or HIF-2α under hypoxic conditions but also suppress the constitutional expression of HIFs owing to genetic mutation. (cd4inhibitors.com)
Genetic conditions (e.g., von Hippel-Lindau disease). (turmeric.com)

In breast cancers HIF-1α splice variant levels were compared to clinicopathological parameters including tumour microvessel density and metastasis-free survival. (biomedcentral.com)
To evaluate the mechanisms underlying the role of AXL signalling in tumour metastasis, we screened a phage display library to generate a novel human monoclonal antibody, named DAXL-88, that recognizes both human and murine AXL. (cancerindex.org)
Curcumin suppresses microRNA that promote metastasis in kidney cancer cell lines. (turmeric.com)

The prognostic relevance of HIF-1α protein overexpression has been shown in breast cancer. (biomedcentral.com)
Aurora A overexpression in many malignant tumor types suggests that it may be directly involved in NEOPLASTIC CELL TRANSFORMATION. (lookformedical.com)

Von Hippel-Lindau (VHL) Syndrome is an inherited disorder that is caused by a mutation in the VHL gene, which leads to an increased risk of development of tumors in the central nervous system (CNS) and viscera. (bajaprogofficial.com)
This means that one copy of the mutation, which may be inherited from either parent, is able to increase the risk of developing the tumors and VHL syndrome. (bajaprogofficial.com)
What is Von Hippel-Lindau Syndrome? (bajaprogofficial.com)
Not all individuals with a diagnosis of DICER1 syndrome will develop tumors or cancer. (choa.org)

To study the potential role in this metabolic shift of von Hippel-Lindau (VHL), a protein component of a ubiquitin ligase complex, the authors generated nephron progenitor cell-specific VHL knockout mice. (lww.com)
a protein component of a ubiquitin ligase complex) and hypoxia-inducible factors (a family of transcription factors activated by hypoxia). (lww.com)

One of the key target proteins is hypoxia-inducible factor 2-alpha (HIF-2α), which plays a significant role in another protein complex referred to as HIF that affects the ability of an individual to adapt to atmospheric oxygen changes. (bajaprogofficial.com)

High ERV-K env total protein expression of all tumor subtypes significantly correlated with low tumor grading and a longer disease specific survival using multivariable analyses. (frontiersin.org)
This study supports ERV-K env as a single prognostic indicator for better survival of RCC, which we propose represents a new tumor antigen. (frontiersin.org)
Especially, this allows ATP and VEGF (vascular endothelial growth factor) to be synthesized in an oxygen-independent manner, thereby promoting angiogen- esis, cell survival and tumor growth [5]. (cd4inhibitors.com)
Curcumin reduces levels of proteins that promote cancer cell survival . (turmeric.com)

TCEB1 has been shown to interact with: TCEB2 and Von Hippel-Lindau tumor suppressor. (wikipedia.org)

Dr Xinlai Cheng and his colleagues at the Goethe University Frankfurt have discovered how a tumour suppressor known as pVHL influences signal transmission involving TGF-β. (goethe-university-frankfurt.de)
In the Journal of Cell Biology the scientists report the first evidence that pVHL degrades the SMAD3 protein. (goethe-university-frankfurt.de)
Stained liver tissue shows the complementary occurrence of pVHL and SMAD proteins: Where pVHL (green) is abundant, SMAD2/3 (red) is scarce, and vice versa. (goethe-university-frankfurt.de)
Germline heterozygous mutation of the VHL tumor suppressor gene, located on 3p25.3, encoding VHL tumor suppressor protein (pVHL), has been identified as the leading cause of VHL disease. (biomedcentral.com)
pVHL is best known as the substrate-binding subunit of an E3 ubiquitin ligase, which binds the transcription elongation factors C and B (elongin C/B) forms the VCB complex, then interacts with Cullin-2 (CUL2) and the RING finger protein RBX1 forming the VCB-CR complex(3). (biomedcentral.com)

Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. (wikipedia.org)
In this report, we describe a testis zinc finger protein (Tzfp) that binds to the upstream flanking sequence of the Aie1 gene. (lookformedical.com)

These often include hemangioblastomas, renal cell carcinoma (RCC) renal cysts and phaeochromocytoma, as well as tumors in the pancreas, epididymis uterus or endolymphatic sac in the inner ear. (bajaprogofficial.com)

William Kaelin, Jr. was in 1995 engaged in the study of the von Hippel-Lindau tumor suppressor gene, and after isolation of the first full-length clone of the gene showed that it could suppress tumor growth in VHL mutant tumorigenic cell lines. (nobelprize.org)
This occurs due to changes in the production of proteins in the body, which are involved in the regulation of cell growth and division. (bajaprogofficial.com)
The healthy gene itself may suppress the growth of tumors, resulting in uncontrolled cell growth when there is a mutation. (bajaprogofficial.com)
In particular, the proteins in the VCB-CUL2 complex change and affect the regulation of cell growth in the body. (bajaprogofficial.com)
Transforming Growth Factor beta (TGF-β) is a signalling protein whose dysregulation can cause developmental disorders and cancer. (goethe-university-frankfurt.de)
On growth factor stimulation, p85 is recruited to phosphorylated receptor protein kinases and adaptor proteins, thereby activating PI3K. (bibf1120.com)
We are also studying tumour samples from normal weight and obese breast cancer patients to better understand the role adipocytes play in promoting aggressive tumour growth and spread, and identify patients likely to benefit from additional treatment during cancer therapy. (otago.ac.nz)
And Peter Ratcliffe, University of Oxford, United Kingdom, discovered that HIF plays a role in blood vessel development and tumor growth. (nih.gov)
The expression of HIFs protein should be inhibited because it is great essential for tumor growth. (cd4inhibitors.com)
Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor growth and act as substrates for the hexosamine biosynthetic pathway (HBP). (biomedcentral.com)
It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). (cancerindex.org)
The effects of si-Vav3/atelocollagen complex alone or in combination with docetaxel were assessed on xenografts in nude mice by tumor growth delay. (biomedcentral.com)

Early diagnosis is important because the tumor may be fatal if undiagnosed, especially in pregnant women during delivery or in patients undergoing surgery for other disorders. (medscape.com)

These processes involve the hypoxia-inducible factor (HIF) transcription factor and one of its subunits, HIF-2α, that lead to tumor formation. (nih.gov)

Sixteen histological tumor subtypes exist and the most common are papillary, chromophobe and clear cell renal cell carcinoma (ccRCC) representing 85% of all RCC. (frontiersin.org)
Renal cell carcinoma (RCC) is the most common malignant kidney tumor and has a high incidence rate. (biomedcentral.com)
Nursing based on oxygen administration decreased the value of renal function indexes, serum inflammatory factors, and tumor markers in renal cell carcinoma patients. (biomedcentral.com)
Clear cell renal cell carcinoma (ccRCC) is the seventh most frequently diagnosed tumor in adults in Europe and represents approximately 2.5% of cancer deaths. (cancerindex.org)
Other types include renal pelvis carcinoma, which occurs where urine collects in the kidney, and Wilms tumor, which is typically found in very young children. (turmeric.com)

This inhibition reduces tumor vascularization, and leads to tumor shrinkage. (biomedcentral.com)

Development of new tumor-feeding blood vessels. (turmeric.com)

Inside the cell, the TGF-β receptors in their turn activate a protein called SMAD3, which then forms complexes with SMAD4 that translocate to the cell nucleus. (goethe-university-frankfurt.de)

The metabolic products of glutamine are utilized both to produce ATP and to synthesize macromolecules in the promotion of tumour growth4. (bibf1120.com)
A recent study showed that loss of tumour suppressor von hippel-lindau tumor suppressor (VHL) renders renal cell carcinomas sensitive to glutamine deprivation through hypoxia induced factor (HIF)-induced metabolic reprogramming10. (bibf1120.com)
Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nep. (lww.com)

Frequently, mesenchymal and hematopoietic progenitors are associated with the action of parathyroid hormone-related protein (PTHrP), a well-known regulator of tumour-associated bone destruction [ 1 ], as well as with the hypercalcemia seen in many types of cancer [ 2 ]. (aging-us.com)

The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (bvsalud.org)

Under well-oxygenated conditions, HIFs rapidly degraded by hydroxylation and bound to the von Hippel-Lindau (VHL) protein, while the hydroxylation of HIFs was inhibited and resulted in its highly expression in hypoxic conditions [3, 4]. (cd4inhibitors.com)

Curcumin inhibits COX inflammatory proteins . (turmeric.com)

Renal function indexes, serum inflammatory factors, and tumor markers were evaluated. (biomedcentral.com)
The treatment for renal parenchymal tumors has changed over time, and this trend continues today as a result of technological progress made with clinical research and improved diagnostic and therapeutic tools. (biomedcentral.com)

Usually, extra-adrenal tumors (extra-adrenal pheochromocytomas or paragangliomas) are located in the abdomen along the sympathetic chain and constitute about 10% of sporadic cases. (medscape.com)

Initially, their research focused on tumour blood vessel development and anti-angiogenic therapies. (otago.ac.nz)

The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. (wikipedia.org)
This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. (avivasysbio.com)
As the early tumor expands, it outgrows the diffusion limits of its local blood supply, leading to hypoxia and stabilization of the hypoxia-inducible transcription factor, HIF. (pharmaceuticalintelligence.com)

My research interests comprise cutaneous tumors with emphasis in lymphomas and melanoma. (mdanderson.org)
In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)

In this investigation a human RCC tissue microarray (TMA) (n=374) predominantly consisting of the most common histological tumor subtypes was hybridized with an ERV-K env antibody and correlated with patient clinical data. (frontiersin.org)

HIF-1 is a heterodimeric protein composed of two HIF-1α and HIF-1β/aryl hydrocarbon receptor nuclear translocator (ARNT) subunits [ 5 ]. (biomedcentral.com)

CircRNAs have essential functions as microRNA sponges, RNA-binding protein- and transcriptional regulators, and protein translation templates. (biomedcentral.com)

Clinical trials of belzutifan, including several supported by NCI, demonstrated potent anti-cancer activity in VHL-associated kidney cancer, as well as other VHL-associated tumors, leading to the aforementioned recent FDA approval. (nih.gov)
Eugenol reduces the incidence of kidney tumors caused by a carcinogenic toxin . (turmeric.com)

HIF-1α protein is composed of 826 amino acids [ 5 ]. (biomedcentral.com)

Elongin C is a protein that in humans is encoded by the ELOC gene. (wikipedia.org)
Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C". Science. (wikipedia.org)

A novel human anti-AXL monoclonal antibody attenuates tumour cell migration. (cancerindex.org)

The coiled-coil domain is a structural motif found in proteins that are involved in a diverse array of biological functions such as the regulation of gene expression, cell division, membrane fusion and drug extrusion and delivery. (antikoerper-online.de)
TMA results showed the highest amount of ERV-K env protein expression and the strongest significant membrane expression in ccRCC versus other RCC subtypes. (frontiersin.org)

Anatomy7

Diseases8

Chemicals and Drugs42

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes30

Humanities1

Information Science3

Genes9

Mutations9

Angiogenesis3

Apoptosis4

Microenvironment11

Xenograft3

Signalling pathway1

Tuberous sclerosis1

Oncogenes1

Cells20

Types of tumors2

Kinase7

Progression7

Solid tumors1

Proliferation2

Benign3

Degradation8

Genetic7

Metastasis3

Overexpression2

Syndrome4

Ubiquitin ligase complex2

Target proteins1

Survival4

TCEB21

PVHL5

Binds2

Endolymphatic sac1

Growth12

Diagnosis1

Hypoxia-induci1

Carcinoma5

Inhibition1

Blood vessels1

Receptors1

Metabolic3

Regulator1

Pathways1

Hypoxic conditions1

Inhibits1

Renal2

Sporadic1

Anti-angiogenic1

Transcription3

Cutaneous2

Histological1

Heterodimeric protein1

Transcriptional regulators1

Kidney2

Amino acids1

Elongin2

Monoclonal1

Expression2