• oxidation
  • Offering a multitude of benefits over your everyday toner, the hydrating formula contains a very high, stabilised concentration of yeast-derived Superoxide Dismutase, an anti-inflammatory compound that effectively fights cellular oxidation that can cause drastic DNA damage and result in premature signs of ageing. (hqhair.com)
  • The iron sulfur cluster is highly sensitive to oxidation by superoxide. (wikipedia.org)
  • free radicals
  • His discovery of the superoxide dismutase reaction essentially started the field of oxygen free radicals in biology and medicine, and that influence is shown by his election as president of the American Society of Biological Chemists (for 1982-83), the Oxygen Society (1987-1990), and the Society for Free Radical Research (1992-94), as well as award of the Science & Humanity Prize at the 2000 Oxygen Club World Congress. (wikipedia.org)
  • radical
  • As the first and initiating oxygen free radical in the ROS chain, superoxide (O 2 − ) consumption of NO is one of the most important mechanisms of endothelial dysfunction. (ahajournals.org)
  • peroxynitrite
  • Preclinical evidence indicates that levels of endothelial NO depend on various factors, which include the activity and coupling of eNOS, which determine whether NO or superoxide and peroxynitrite (ONOO − ) are the predominant products. (ahajournals.org)
  • Antioxidants
  • He holds an Honorary Doctorate from the University of Buenos Aires and has served as Honorary President of the International Society of Antioxidants in Nutrition and Health (ISANH) and as Chairman of the Third International Conference on Superoxide Dismutases at the Institut Pasteur. (wikipedia.org)
  • vivo
  • Although both complexes are effective porphyrin-based superoxide dismutases, MnTBAP [Mn(III)tetrakis (4-benzoic acid) porphyrin] was shown to better protect the cells from oxidative damages compared to ZnTBAP ((Zinc (III) tetrakis (4-benzoic acid)porphyrin chloride)) in vivo. (wikipedia.org)
  • electron
  • Mn-1 + O− 2 + 2H+ → Mn + H2O2 Net: Mn + 2O− 2 + 2H+ → Mn + O2 + H2O2 The metal complex must be electron deficient in nature, allowing it to accept electrons from the superoxide. (wikipedia.org)
  • H2O2
  • reduction of superoxide) The general form, applicable to all the different metal-coordinated forms of SOD, can be written as follows: M(n+1)+-SOD + O2− → Mn+-SOD + O2 Mn+-SOD + O2− + 2H+ → M(n+1)+-SOD + H2O2. (wikipedia.org)
  • The 3 substrates of this enzyme are reduced rubredoxin, superoxide, and H+, whereas its two products are rubredoxin and H2O2. (wikipedia.org)
  • whereas
  • In oxidative states, reduction in tetrahydrobiopterin results in uncoupling of eNOS, 5 resulting in production of superoxide by the eNOS monomer whereas the dimer, in the presence of abundant tetrahydrobiopterin, produces mainly NO. This delicate balance could exert a critical role in the ability of blood vessels to maintain normal homeostasis and remain dilated. (ahajournals.org)
  • structures
  • The 3D structures of the homologous Mn and Fe superoxide dismutases have the same arrangement of alpha-helices, and their active sites contain the same type and arrangement of amino acid side-chains. (wikipedia.org)
  • known
  • This review summarizes what is known about superoxide dismutases in pancreatic cancer and the most current treatment strategies to be advanced from this knowledge. (mdpi.com)