• Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. (wikipedia.org)
  • An antibody ( Ab ), also known as an immunoglobulin ( Ig ), [1] is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses . (wikipedia.org)
  • The crystal structure of the human RIG-I helicase domain, a key player protein in the antiviral innate immune response, is reported. (iucr.org)
  • Compact globular protein domains of about 80 to 110 amino acids .They are characterized by two antiparallel beta sheets stabilized by HYDROPHOBIC INTERACTIONS and disulfide bonds between opposing strands. (online-medical-dictionary.org)
  • The encoded protein is extensively glycosylated and contains five Ig-like domains that share high homology with corresponding domains in ICAM-1 and ICAM-2. (sigmaaldrich.com)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing IG domain in the selected taxonomic class. (embl.de)
  • The proteins functional domains, this is the subject has had the same protein tein bands. (stonecottagegardens.com)
  • ICAM1 a type I membrane protein of the immunoglobulin superfamily. (affbiotech.com)
  • Violin plots show distribution of expression levels for Immunoglobulin domain-containing-like protein isoform 1 (SMED30002117) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
  • Expression of Immunoglobulin domain-containing-like protein isoform 1 (SMED30002117) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
  • Violin plots show distribution of expression levels for Immunoglobulin domain-containing-like protein isoform 1 (SMED30002117) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
  • Human ESAM is synthesized as a 390 amino acid (aa) protein composed of a 29 aa signal peptide, a 216 aa extracellular region, a putative 26 aa transmembrane segment, and a 119 aa cytoplasmic domain. (reliatech.de)
  • In the cytoplasmic domain, there is a docking site for the multifunctional adaptor protein MAGI1. (reliatech.de)
  • The protein encoded by this gene is a member of the immunoglobulin superfamily. (utsouthwestern.edu)
  • The protein contains two immunoglobulin domains and thirteen fibronectin type III domains. (utsouthwestern.edu)
  • This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet known. (utsouthwestern.edu)
  • Phosphorylated ITAM motifs on CD3 recruit and activate SH2 domain-containing protein tyrosine kinases (PTK) such as Zap70 to further mediate downstream signalling through tyrosine phosphorylation, leading to transcription factor activation including NF-κB and consequent T cell activation. (wikidoc.org)
  • Ig molecules are highly modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. (wikipedia.org)
  • We report now that NEPH1 belongs to a family of three closely related proteins that interact with the C-terminal domain of podocin. (nih.gov)
  • Such processes require membrane traffic to particular domains of the cell surface, in order to insert proteins at restricted regions of the membrane, to enlarge particular regions of the cell membrane, or to signal asymmetrically to neighboring cells. (sdbonline.org)
  • There are 417572 IG domains in 173507 proteins in SMART's nrdb database. (embl.de)
  • Taxonomic distribution of proteins containing IG domain. (embl.de)
  • The complete taxonomic breakdown of all proteins with IG domain is also avaliable . (embl.de)
  • They are a family of carbohydrate binding proteins within the immunoglobulin superfamily. (bdbiosciences.com)
  • Siglecs are integral membrane proteins with extracellular N-terminal, V-set Ig domains, followed by variable numbers of C2-set Ig domains. (bdbiosciences.com)
  • All Siglecs are single-pass type 1 integral membrane proteins containing extracellular domains with one (or two, in the case of Siglec-12) unique and homologous N-terminal V-set Ig domain, followed by variable numbers of C2-set Ig domains, ranging from 16 in sialoadhesin to 1 in CD33. (medchemexpress.com)
  • Antibodies (also known as immunoglobulins [1] ) are proteins that are found in blood or other bodily fluids of vertebrates , and are used by the immune system to identify and neutralize foreign objects, such as bacteria and viruses . (wikidoc.org)
  • Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. (utsouthwestern.edu)
  • Siglecs are cell surface receptors belonging to the immunoglobulin superfamily that recognize sugar antigens. (biolegend.com)
  • Siglecs (sialic acid-binding immunoglobulin-like lectins) are single-pass cell surface receptors that have inhibitory activities on immune cells. (mdpi.com)
  • Sialic acid-binding Immunoglobulin-like lectins (Siglecs) are cell-surface I-type lectins that act as immunomodulatory sialic acid-binding receptors. (medchemexpress.com)
  • Siglecs belong to the Immunoglobulin (Ig) superfamily. (medchemexpress.com)
  • Ig-like domains are involved in a variety of functions, including cell-cell recognition, cell-surface receptors, muscle structure and the immune system. (wikipedia.org)
  • The terms antibody and immunoglobulin are often used interchangeably, [1] though the term 'antibody' is sometimes reserved for the secreted, soluble form, i.e. excluding B-cell receptors. (wikipedia.org)
  • Cell surface receptors containing an immunoglobin domain. (embl.de)
  • CNTFR encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. (novusbio.com)
  • Like many cell surface receptors/markers, CD4 is a member of the immunoglobulin superfamily . (wikidoc.org)
  • IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. (jax.org)
  • The α chain of haemoglobin (α) has been crystallized as a homodimer bound to a domain from the S. aureus haemoglobin receptor iron-regulated surface determinant H (IsdH). (iucr.org)
  • The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. (novusbio.com)
  • Nishimura M, Takanashi M, Okazaki H, Satake M, Nakajima K: Role of CD7 expressed in lung microvascular endothelial cells as Fc receptor for immunoglobulin M. Endothelium. (exbio.cz)
  • In the absence of SAP, interaction of CD48 on EBV-infected cells with 2B4 (a receptor belonging to the immunoglobulin superfamily that is found on natural killer [NK] cells as well as a small subset of T cells) on NK cells inhibits their ability to kill the EBV-infected cell. (medscape.com)
  • The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulphide bonds. (wikipedia.org)
  • C2-set domains are found primarily in the mammalian T-cell surface antigens CD2 (Cluster of Differentiation 2), CD4 and CD80, as well as in vascular (VCAM) and intercellular (ICAM) cell adhesion molecules. (wikipedia.org)
  • and CELL ADHESION MOLECULES which possess immunoglobulin domains . (online-medical-dictionary.org)
  • Among the superfamily of cell adhesion molecules, in this article, we mainly focus on Ig-Superfamily CADMs: the members of the Immunoglobulin superfamily of cell adhesion molecules, which play diverse roles in immune responses, neural development, and cell signaling. (pharmiweb.com)
  • also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules (1-3). (rndsystems.com)
  • CD2, CD48 and CD58 are structurally similar cell adhesion-molecules forming a subset of the immunoglobulin superfamily (IgSF). (ox.ac.uk)
  • Endothelial cell selective adhesion molecule (ESAM) is a 55 kDa type I transmembrane glycoprotein that belongs to the JAM family of immunoglobulin superfamily molecules. (reliatech.de)
  • CD4 interacts with the β 2 -domain of MHC class II molecules through its D 1 domain. (wikidoc.org)
  • A family of calcium-independent cell adhesion molecules of the immunoglobulin superfamily. (bvsalud.org)
  • C2-set domains, which are Ig-like domains resembling the antibody constant domain. (wikipedia.org)
  • Structurally an antibody is also partitioned into two antigen-binding fragments (Fab), containing one V L , V H , C L , and C H 1 domain each, as well as the crystallisable fragment (Fc), forming the trunk of the Y shape. (wikipedia.org)
  • 1) Antibody deficiency disorders are defects in immunoglobulin-producing B cells . (lu.se)
  • Antibody deficiencies are treated with intravenous immunoglobulin substitution therapy. (lu.se)
  • The immunoglobulin variable (IgV) domain of D 1 adopts an immunoglobulin-like β-sandwich fold with seven β-strands in 2 β-sheets, in a Greek key topology . (wikidoc.org)
  • Antibodies are glycoproteins belonging to the immunoglobulin superfamily . (wikipedia.org)
  • Ig-Superfamily CADMs are named after the presence of one or more Immunoglobulin-like domains in their extracellular region, which are characteristic structural motifs found in antibodies. (pharmiweb.com)
  • Structural studies have shown that these domains share a common core Greek-key beta-sandwich structure, with the types differing in the number of strands in the beta-sheets as well as in their sequence patterns. (wikipedia.org)
  • CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence. (wikipedia.org)
  • Human TIM-1 is synthesized as a 359 amino acid (aa) precursor that contains a 20 aa signal sequence, a 270 aa extracellular domain (ECD), a 21 aa transmembrane segment and a 48 aa cytoplasmic domain (4-6). (rndsystems.com)
  • We constructed a soluble chimeric molecule comprising the extracellular portion of rat CD48 and domains 3 and 4 of rat CD4 (sCD48-CD4) and used it to examine whether CD2 is a ligand for CD48 in rats. (ox.ac.uk)
  • The gene ICAM3 (intercellular adhesion molecule 3) encodes type I membrane glycoprotein that belongs to the immunoglobulin (ig) superfamily. (sigmaaldrich.com)
  • NEPH1, a member of the immunoglobulin superfamily, is structurally related to nephrin. (nih.gov)
  • These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. (nih.gov)
  • CD7 crosslinking induces a calcium flux in T lymphocytes, presumably as a result of cytoplasmic domain association with PI3-kinase. (exbio.cz)
  • Extracellular domain with 29aa N-terminal T7-His-TEV cleavage site tag (NP_002600). (abcam.com)
  • The extracellular domain of siglec-9 contains an IgV region, which binds sialic acid, followed by two IgC regions. (biolegend.com)
  • This structural conservation highlights the importance of the versatile domain composition of the RPF family. (iucr.org)
  • Structural plasticity in Ig superfamily domain 4 of ICAM-1 mediates cell surface dimerization. (harvard.edu)
  • Mouse CD226 (DNAM-1) is a 65 kd glycoprotein of a member of Ig super-family adhesion molecule containing 2 immunoglobulin-like domains. (biolegend.com)
  • It is a GPI-anchored cell adhesion molecule that is part of the immunoglobulin (Ig) domain-containing superfamily. (rndsystems.com)
  • Basal Cell Adhesion Molecule (BCAM) which is a product of alternate splicing of the Lutheran blood group molecule is a part of the immunoglobulin superfamily. (neuromics.com)
  • The ECD contains oneV-type Ig-like domain and a mucin region characterized by multiple PTTTTL motifs. (rndsystems.com)
  • The resulting close proximity between the TCR complex and CD4 (extracellular and intracellular) allows the tyrosine kinase Lck bound to the cytoplasmic tail of CD4 to tyrosine-phosphorylate the Immunoreceptor tyrosine activation motifs (ITAM) on the cytoplasmic domains of CD3 to amplify the signal generated by the TCR. (wikidoc.org)
  • Immunoglobulin Subunits" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • The NH2-terminal domain of rat CD2 binds rat CD48 with a low affinity and binding does not require glycosylation of CD2. (ox.ac.uk)
  • These results show that rat CD48 binds CD2 on its NH2-terminal IgSF domain with a low affinity and that binding is independent of glycosylation. (ox.ac.uk)
  • Several Ig-superfamily CADMs are crucial for immune cell interactions. (pharmiweb.com)
  • CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. (thermofisher.com)
  • There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). (wikipedia.org)
  • There are five types of heavy chains: alpha, delta, epsilon, gamma and mu, all consisting of a variable domain (VH) and three (in alpha, delta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). (wikipedia.org)
  • The structure of the catalytic domain of RpfC (Rv1884) closely resembles those of RpfB and RpfE. (iucr.org)
  • This graph shows the total number of publications written about "Immunoglobulin Subunits" by people in Harvard Catalyst Profiles by year, and whether "Immunoglobulin Subunits" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Immunoglobulin Subunits" by people in Profiles. (harvard.edu)
  • SwissProt sequences and OMIM curated human diseases associated with missense mutations within the IG domain. (embl.de)
  • Three major subtypes of Ig domains are recognized: variable (V), intermediate (I), and constant (C1 or C2). (online-medical-dictionary.org)
  • D 1 and D 3 resemble immunoglobulin variable (IgV) domains. (wikidoc.org)
  • It is a 110 kDa cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. (beckman.com)
  • Ig-superfamily CADMs are involved in mediating cell-to-cell adhesion, helping cells stick together and form tissues and organs. (pharmiweb.com)
  • The extracellular region contains one V-type and one C2-type Ig domain and is involved in hemophilic adhesion. (reliatech.de)
  • CD4 also functions to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases such as Lck. (stemcell.com)
  • CD106 contains 7 Ig-like C2-type (immunoglobulin-like) domains. (beckman.com)
  • D 2 and D 4 resemble immunoglobulin constant (IgC) domains. (wikidoc.org)