MRNA expressionTumor cellsProteinsClinicalOutcomeProliferationSquamousProgressionPathwaysReceptorEpithelial cellsGeneAntigenPrognosisSCLCDifferentiationInfiltrationHematological malignanciesProteinLigandReceptorsFragmentationCycleMetastasisExpressionLung cancerTumorsTherapyPatientsActivationDamageResultsTreatmentHumanAdditionNormalSpecificLossFactor
MRNA expression2
- Murine PD-1 mRNA expression has been shown to be correlated with activation-induced apoptosis in a mouse T-cell hybridoma cell line and murine thymocytes [ 13 ]. (biomedcentral.com)
- There was a close association of GADD45G mRNA expression and immune cells, including neutrophils, NK cells, CD8 T cells, and macrophages. (bvsalud.org)
Tumor cells5
- Moreover, increasing data have shown that peripheral T-cell tolerance is an essential property of the specific immune response to tumor cells. (biomedcentral.com)
- and or tumor cells infected with oncolytic viruses release PAMPs, which increases immune responses (217, 218). (azd1152.com)
- The results of phase I and II trials showed that the use of Newcastle virus-infected tumor cells reduced recurrence and increased OS in CRC patients (44, 219). (azd1152.com)
- A second concern is usually cytokine release syndrome due to the CAR-T cells activation following binding to antigens in both tumor cells and normal cells (226). (azd1152.com)
- Nestin stabilizes lamin A-C for maintaining nuclear integrity and protecting tumor cells from senescence. (cusabio.com)
Proteins4
- E3 ligases are also key players in cell cycle control, mediating the degradation of cyclins, as well as cyclin dependent kinase inhibitor proteins. (e3ligasesignal.com)
- These compounds generally penetrate cell membranes, act on specific target proteins in cells, regulate intracellular signaling pathways, and cause some changes in cell phenotype. (chemscene.com)
- Review: Evaluation of pancreatic cancer stem cells-related markers CD133, CD44, Oct4, and Nestin proteins in PANC-1 and SW1990 cells by western blotting. (cusabio.com)
- Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. (cusabio.com)
Clinical5
- Phase III clinical trials of Rova‑T for patients with small‑cell lung cancer and a phase III clinical trial of nirogacestat for patients with desmoid tumors are ongoing. (spandidos-publications.com)
- In the past decade, many clinical trials have been investigating anti-CTLA-4 as well as anti-programmed cell death protein 1 (PD-1) therapies in various solid tumors, including HCC. (stanford.edu)
- There are two clinical types of lung cancer: non-small cell lung carcinoma (NSCLC), which accounts for 85% of all cases, and small cell lung carcinoma (SCLC) [ 1 , 3 ]. (oncotarget.com)
- although it is derived from cells of the renal tubular epithelium, it has several histological subtypes which differ in their clinical outcome and biological features. (hindawi.com)
- The Cancer Genome Atlas (TCGA) LUAD data set was used to explore associations among B-cell infiltration, PD-L1 expression, clinical outcome, and gene landscape. (cancer-genetics.org)
Outcome2
- Based on their functional outcome, co-signaling molecules can be divided as co-stimulators and co-inhibitors, which positively and negatively control the priming, growth, differentiation and functional maturation of a T-cell response. (biomedcentral.com)
- Main Outcome(s) and Measure(s): The primary study outcome was to determine the prognostic value of p53 Abs from a large population of patients with solid tumors, as determined before data collection. (stanford.edu)
Proliferation6
- Such immune dysfunction may be due to a disorder in thymic output function (in particular in young patients), which results in a lower level of naive T-cells in the peripheral blood available for an immune response to the proliferation and abnormal expression of the T cell receptor (TCR) repertoire. (biomedcentral.com)
- Depletion of GPR171 with an anti-GPR171 antibody decreased proliferation of lung carcinoma cells and attenuated tumor progression in a mouse xenograft model. (oncotarget.com)
- An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
- 4.2 Adoptive T Cell Therapy Take action is a malignancy immunotherapy method in which T cells are collected from your tumor, lymph nodes, or peripheral blood of a patient and returned Vanin-1-IN-1 to the patients body after proliferation and selection of tumor-specific T cells. (azd1152.com)
- Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. (cusabio.com)
- This review presents the current knowledge on the role of Nestin in essential stem cell functions, including self-renewal/proliferation, differentiation and migration, in the context of the cytoskeleton. (cusabio.com)
Squamous4
- However, Notch signaling is inactivated in small‑cell lung cancer and squamous cell carcinomas. (spandidos-publications.com)
- To evaluate the expression of E-cadherin (E-cad) in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). (ijpmonline.org)
- Immunohistochemistry was used to detect E-cad expression in 20 cases each of normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma. (ijpmonline.org)
- We observed a significant decrease in E-cad expression from dysplasia to poorly differentiated squamous cell carcinoma suggesting that loss of expression of E-cad is closely related to carcinoma. (ijpmonline.org)
Progression2
- Moreover, T cell function becomes suppressed with disease progression. (biomedcentral.com)
- Therefore, we investigated the role of infiltrating B cells in LUAD progression and its correlation with PD-L1 expression. (cancer-genetics.org)
Pathways3
- The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
- It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
- Co-expressed genes of GADD45G were involved in several pathways including cell cycle, carbon metabolism, and peroxisome. (bvsalud.org)
Receptor4
- Small-molecule inhibitors, antagonistic monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), bispecific antibodies or biologics (bsAbs) and chimeric antigen receptor-modified T cells (CAR-Ts) targeting Notch signaling components have been developed as investigational anti-cancer drugs ( 10 - 12 ). (spandidos-publications.com)
- Notably, inhibition of GPR171 synergistically enhanced the tumoricidal activity of an epidermal growth factor receptor (EGFR) inhibitor in lung cancer cells. (oncotarget.com)
- EGFR (epidermal growth factor receptor), ALK (anaplastic lymphoma receptor tyrosine kinase), RET (ret proto-oncogene receptor tyrosine kinase), and BRAF (B-Raf proto-oncogene, serine/threonine kinase) are well-identified oncogenic driver mutations in lung cancer, and are targets for therapeutic application. (oncotarget.com)
- The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. (cancer-genetics.org)
Epithelial cells2
- The adaptation of cells to hypoxia appears to be mediated via hypoxia inducible factor-1α (HIF-1α) which is also said to be associated with malignant transformation of epithelial cells in various other carcinomas like prostate and cervical carcinoma. (ijpmonline.org)
- It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. (medchemexpress.cn)
Gene3
- The PD-1 gene is a CD28 family member that is a member of the immunoglobulin gene superfamily. (biomedcentral.com)
- Gene landscape and correlation between B-cell infiltration and programmed death ligand 1 expression in lung adenocarcinoma patients from The Cancer Genome Atlas data set. (cancer-genetics.org)
- The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. (medchemexpress.cn)
Antigen1
- Take action can be performed with unmanipulated cells or designed cells that express chimeric antigen receptors (CAR-T cells). (azd1152.com)
Prognosis1
- Molecular characterization and Biomarkers are becoming increasingly important in the management of HGG especially with respect to anaplastic glioma (AG) that have refined prognosis and increasingly are predictive with respect to treatment. (surgicalneurologyint.com)
SCLC1
- By contrast, somatic alterations in the genes encoding Notch signaling components drive various types of human cancer, such as breast cancer, small-cell lung cancer (SCLC) and T-cell acute lymphoblastic leukemia (T-ALL) ( 6 - 9 ). (spandidos-publications.com)
Differentiation1
- and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
Infiltration1
- However, associations between the expression of PD-L1 and infiltration of B cells (a major immunoregulatory cell) remain unknown. (cancer-genetics.org)
Hematological malignancies2
- The role of PD-1 and PD-L1 in T-cell immune suppression and the potential for immunotherapy via blocking PD-1 and PD-L1 in hematological malignancies are also reviewed. (biomedcentral.com)
- Notch signaling is aberrantly activated in breast cancer, non‑small‑cell lung cancer and hematological malignancies, such as T‑cell acute lymphoblastic leukemia and diffuse large B‑cell lymphoma. (spandidos-publications.com)
Protein2
- This approach was based on the assumption that the deregulation of a protein was causally linked to a disease state, and the pharmacological intervention through inhibition of the deregulated target was able to restore normal cell function. (biomedcentral.com)
- We found an increased expression of Nestin and GAP43 (growth associated protein 43) in treated cells. (cusabio.com)
Ligand2
- Moreover, it has been shown that the PD-1 ligand (PD-L1) is highly expressed in leukemia cells. (biomedcentral.com)
- NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are cell surface receptors that transduce juxtacrine signals of delta-like canonical Notch ligand (DLL)1, DLL3, DLL4, jagged canonical Notch ligand (JAG)1 and JAG2 from adjacent cells ( 1 - 3 ). (spandidos-publications.com)
Receptors1
- T-cell activation and dysfunction relies on direct and modulated receptors. (biomedcentral.com)
Fragmentation1
- for 12 hours) causes chromosomal fragmentation in HeLa cells. (medchemexpress.com)
Cycle2
- 24 hours) results in a large shift in cell-cycle populations from G1 and G2-M to S-phase with an accompanied induction of H2AX phosphorylation in U-2 OS cells [1] . (medchemexpress.com)
- Had an IC 50 of 37 nM and resulted in the G2-M population received DNA damage during S-phase but continued to progress through the cell cycle into an early mitosis. (medchemexpress.com)
Metastasis1
- Also, it is been detected in BC stem cells and newly-formed tumor vessels promoting invasion and metastasis. (cusabio.com)
Expression2
- In addition, the low cytotoxicity of T-cells may be related to the high expression level of inhibitory molecules including programmed death-1 (PD-1), LAG-3 and NKG2A in CD8+T cells [ 11 ]. (biomedcentral.com)
- Our previous studies have confirmed that GADD45G expression could be upregulated by 4-methoxydalbergione (4MOD) in liver cancer cells, but its potential pathological role in hepatocellular carcinoma (HCC) has not been fully understood. (bvsalud.org)
Lung cancer2
- Knockdown of GPR171 also inhibited migration and invasion of the lung cancer cell lines. (oncotarget.com)
- PD-L1 upregulation can impede infiltrating T-cell functions in lung adenocarcinoma (LUAD), a lung cancer subtype. (cancer-genetics.org)
Tumors1
- Recently, the treatment of newly diagnosed anaplastic glioma (AG) has changed, particularly in patients with 1p19q codeleted tumors. (surgicalneurologyint.com)
Therapy1
- Identification of TSAs is one of the current difficulties in CAR-T cell therapy (18). (azd1152.com)
Patients1
- In the context of mCRC, CAR-T cells as monotherapy or in combination with cytokines such as IL-12 had encouraging effects such as tumor reduction and long-term disease Vanin-1-IN-1 stability in some Vanin-1-IN-1 patients (222C225). (azd1152.com)
Activation1
- Melatonin disturbs SUMOylation-mediated crosstalk between c-Myc and nestin via MT1 activation and promotes the sensitivity of paclitaxel in brain cancer stem cells. (cusabio.com)
Damage1
- for 7 hours) results in DNA damage during S-phase in HeLa cells [1] . (medchemexpress.com)
Results1
- The use of tumor-specific unmanipulated cells has also yielded positive results in CRC. (azd1152.com)
Treatment1
- Approaches: Thirty-six subjects ended up randomized straight into Several groups-normal management class (D), diabetic person team (Deb), small-dose magnoline treatment team (M1) along with large-dose magnoline treatment method class (M2) (n=9 in every class). (e3ligasesignal.com)
Human1
- Renal cell carcinoma (RCC) accounts for approximately 3% of human malignancies, and its incidence appears to be increasing globally [ 1 ]. (hindawi.com)
Addition1
- In addition, PD-1/PD-L1 interactions contribute to functional T-cell impairment, which fails to elicit minimal residual disease and may be related to leukemia relapse. (biomedcentral.com)
Normal1
- In normal breast tissue, nestin is expressed in the basal/myoepithelial cells. (cusabio.com)
Specific1
- The mutation-specific CD8+ T cells were selected and returned to the patient, resulting in the removal of 85% of metastatic lesions (227). (azd1152.com)
Loss1
- Loss‑of‑function NOTCH1 mutations are early events during esophageal tumorigenesis, whereas gain‑of‑function NOTCH1 mutations are late events during T‑cell leukemogenesis and B‑cell lymphomagenesis. (spandidos-publications.com)
Factor1
- Notch signaling cascades crosstalk with fibroblast growth factor and WNT signaling cascades in the tumor microenvironment to maintain cancer stem cells and remodel the tumor microenvironment. (spandidos-publications.com)