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Drosophila ProteinsDrosophilaDrosophila melanogasterMolecular Sequence DataInsect ProteinsAmino Acid SequenceSequence Homology, Amino AcidBase SequenceLarvaMutationGene Expression Regulation, DevelopmentalEmbryo, NonmammalianGenes, InsectAnimals, Genetically ModifiedTranscription FactorsNuclear ProteinsCloning, MolecularSequence AlignmentPhenotypeDNA-Binding ProteinsWingProtein Structure, TertiaryDNA, ComplementarySignal TransductionRecombinant Fusion ProteinsMembrane ProteinsChromosome MappingProtein BindingDNANerve Tissue ProteinsPhotoreceptor Cells, InvertebrateRNA, MessengerInsect HormonesTranscription, GeneticZinc FingersProteinsPupaCarrier ProteinsGenome, InsectCell LineEyeCell NucleusMultigene FamilyBody PatterningEvolution, MolecularOogenesisGenes, LethalPhylogenyCrosses, GeneticMorphogenesisConserved SequenceHomeodomain ProteinsWnt1 ProteinIn Situ HybridizationEcdysoneDNA Transposable ElementsMushroom BodiesChromosomesNervous SystemBlastodermMetamorphosis, BiologicalSense OrgansRNA InterferenceReceptors, NotchSpecies SpecificityGenes, HomeoboxX ChromosomeAllelesBinding SitesChromosomes, InsectFat BodyRepressor ProteinsHemocytesModels, GeneticGene ExpressionModels, BiologicalModels, MolecularTransgenesSequence Homology, Nucleic AcidOptic Lobe, NonmammalianDNA PrimersCentral Nervous SystemBiological EvolutionArmadillo Domain ProteinsSalivary GlandsEye ProteinsSequence Analysis, DNAMalpighian TubulesNeuropeptidesMutagenesisEcdysteroneImaginal DiscsNeuronsCompound Eye, ArthropodCell PolarityGerm CellsCourtshipEye ColorFertilityOvary
MelanogasterImmunoglobulin superfamilyHomologKinaseReceptorsCadherin superfamilyRegulateKinasesEmbryogenesisExtracellularEncodesStructural ClassifiNeuromuscularPeptidesHistone ProteinsSignal TransductionMolecularLarvalFruitflyGenesSynapticEpithelialTumorTranslationalHighly conservedPolarityTranscriptionInteractionsGenomeSensoryRecognitionMembraneLeucine rich rPlay critical rolesTissuesSerinePathwayImmuneInteractionTyrosine phosphataseNeuronsSequencePathwaysChromatinSequencesFruitInnateCellDomain
Melanogaster5
Immunoglobulin superfamily5
  • Drosophila Dpr (21 paralogs) and DIP proteins (11 paralogs) are cell recognition molecules of the immunoglobulin superfamily (IgSF) that form a complex protein interaction network. (nih.gov)
  • By alternative splicing, Dscam encodes a vast number of cell-surface proteins of the immunoglobulin superfamily. (elsevierpure.com)
  • The protein encoded by this gene is a member of the immunoglobulin superfamily. (utsouthwestern.edu)
  • We identified a new ligand for the Drosophila Lar RPTP, the immunoglobulin superfamily CAM Sticks and Stones (Sns). (sciety.org)
  • Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila. (uchicago.edu)
Homolog3
  • Protein flightless-1 homolog is a protein that in humans is encoded by the FLII gene. (wikipedia.org)
  • This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. (epigentek.com)
  • This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. (nih.gov)
Kinase4
  • Serine/Threonine Kinases (STKs), cAMP-dependent protein kinase (PKA) subfamily, PRKX-like kinases, catalytic (c) subunit. (umbc.edu)
  • The PKA subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. (umbc.edu)
  • Members of this group include human PRKX (X chromosome-encoded protein kinase), Drosophila DC2, and similar proteins. (umbc.edu)
  • This protein belongs to the ROCO (ROC and COR domain) protein family and is made up of five characteristic functional domains: leucine-rich repeats (LRR domain), Rasp of complex proteins (ROC domain), C-terminal of Roc (COR domain), mitogen activated protein kinase kinase kinase (MAPKKK domain), and the WD40 domain. (biomedcentral.com)
Receptors5
  • Decipher misregulations of the TGFß/BMP pathway induced by HLA-B27 in immune and intestine cells, in Drosophila and Human, to identify peptides and receptors involved in HLA-B27 non-canonical effects. (anr.fr)
  • DAP-type PGN is sensed by two receptors, both members of the peptidoglycan recognition protein (PGRPs) family of receptors. (biomedcentral.com)
  • Receptor-like protein-tyrosine phosphatases (RPTPs) have cytoplasmic phosphatase domains and cell adhesion molecule (CAM)-like extracellular domains that interact with cell-surface ligands and/or co-receptors. (sciety.org)
  • Further, three significantly enriched ungapped motifs in the protein sequence of all 72 A. aegypti gustatory receptors were found. (bvsalud.org)
  • G protein-coupled receptors are the largest superfamily of cell surface receptors in the Metazoa and play critical roles in transducing extracellular signals into intracellular responses. (sdbonline.org)
Cadherin superfamily2
  • We show that two cadherin superfamily members, Fat and Dachsous, and the transmembrane/secreted protein Four-jointed play important roles in this process. (nih.gov)
  • The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. (nih.gov)
Regulate6
  • How interactions between these proteins regulate layer-specific synaptic circuitry is not known. (nih.gov)
  • The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulate a host of biological functions, including DNA replication, cell cycle progression, energy metabolism, and cell growth and differentiation. (rupress.org)
  • Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and control protein stability. (rupress.org)
  • The striking evolutive conservation of snoRNP functions, coupled with a highly divergent mechanism of telomere lenghthening, makes Drosophila a suitable system in which to assess the mechanisms by which pseudouridine synthases regulate stemness maintenance. (unina.it)
  • Signaling genes necessary for orchestrating these processes (like the JNK pathway ( Rios-Barrera & Riesgo-Escovar, 2013 )) regulate cytoskeletal proteins, like the FERM-domain proteins Coracle ( Fehon, Dawson & Artavanis-Tsakonas, 1994 ) and Yurt ( Hoover & Bryant, 2002 ). (peerj.com)
  • Dr. Benyajati is interested in studying the molecular mechanisms that regulate differential gene expression during development using the Drosophila alcohol dehydrogenase ( Adh ) gene as the model system. (rochester.edu)
Kinases4
  • Levels of cellular protein phosphorylation are modulated both by protein kinases and phosphatases. (rupress.org)
  • A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)
  • Catalytic domain of PRKX-like Protein Serine/Threonine Kinases. (umbc.edu)
  • Transition of the preRC to an active initiation complex is regulated by cyclin-dependent kinases and other signaling molecules, which promote further protein assembly and activate the mini chromosome maintenance helicase. (usc.edu)
Embryogenesis2
  • The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. (wikipedia.org)
  • Drosophila embryogenesis has proven to be an extremely powerful system for developmental gene discovery and characterization. (peerj.com)
Extracellular3
  • Of the four putative novel defence proteins (DFPs) annotated by PSI-BLAST three showed similarity to extracellular matrix proteins from vertebrates implicated in innate immunity, while the fourth was similar to, yet distinct from, the anti-microbial protein cecropin. (biomedcentral.com)
  • Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. (utsouthwestern.edu)
  • An extracellular interactome of immunoglobulin and LRR proteins reveals receptor-ligand networks. (uchicago.edu)
Encodes4
  • This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. (wikipedia.org)
  • This gene encodes a member of the G protein-coupled receptor superfamily. (epigentek.com)
  • LRRK2 encodes a large protein containing three catalytic and four protein-protein interaction domains. (biomedcentral.com)
  • LRRK2 is a large gene spanning a genomic region of 144 kb with 51 exons and encodes a multidomain protein consisting of 2527 amino acids. (biomedcentral.com)
Structural Classifi2
Neuromuscular3
Peptides1
  • In Drosophila , the humoral immune response is characterized by the rapid induction of a battery of antimicrobial peptides (AMPs). (biomedcentral.com)
Histone Proteins1
Signal Transduction1
  • Dr. Fuyu Tamanoi's research focuses on signal transduction involving the Ras-superfamily G-proteins, anti-cancer drugs and nanoparticle-based delivery of anticancer drugs. (uclahealth.org)
Molecular3
  • This involves both farnesylation (catalyzed by protein farnesyltransferase) and geranylgeranylation (catalyzed by protein geranylgeranyltransferase-I). Small molecular inhibitors of protein geranylgeranyltransferase-I were identified from a library of compounds generated by phosphine catalysis of allenoate compounds. (uclahealth.org)
  • Since Drosophila midgut has recently emerged as an ideal model for the study of the molecular mechanisms underlying somatic stem cell maintenance, it provides an useful system to evaluate the effects caused by loss of function of genes involved in this process. (unina.it)
  • The GTPase superfamily: conserved structure and molecular mechanism. (xenbase.org)
Larval1
  • I thus used the GAL4/UAS system to silence in vivo Nop60b/mfl, the Drosophila ortholog of DKC1, and investigate in detail the effects triggered by gene silencing on the formation of larval Adult Midgut Precursor (AMPs) cells. (unina.it)
Fruitfly1
  • Our previous work allowed us to identify that HLA-B27 misregulates the TGFß/BMP pathways in the Drosophila fruitfly. (anr.fr)
Genes4
  • Genetic analysis has uncovered that genes necessary for epithelial polarity code for cytoskeletal proteins and their regulators, like the par-3 protein Bazooka ( Kuchinke, Grawe & Knust, 1998 ) or the EGF and laminin domains-containing protein Crumbs ( Tepass, Theres & Knust, 1990 ). (peerj.com)
  • The present study has identified many potential immune-related genes in A. mylitta some of which are vertebrate homologues and others are hitherto unreported putative defence proteins. (biomedcentral.com)
  • This domain occurred 395 times on human genes ( 899 proteins). (umbc.edu)
  • In most gram-positive bacteria, this operon consists of five genes dltXABCD but the involvement of the first ORF ( dltX ) encoding a small protein of unknown function, has never been investigated. (frontiersin.org)
Synaptic2
Epithelial1
  • also called myosin heavy chain 95F (Mhc95F), or 95F MHC), which is a motor protein necessary for the morphogenesis of epithelial tissues during Drosophila development. (nih.gov)
Tumor2
  • Drosophila immune deficiency (IMD) pathway is similar to the human tumor necrosis factor receptor (TNFR) signaling pathway and is preferentially activated by Gram-negative bacterial infection. (cnrs.fr)
  • Galectin-3 binding protein (Galectin-3BP), also known as MAC-2 binding protein (MAC-2BP or M2BP), and the 90 kDa tumor associated antigen (TAA90K or 90K), is a secreted glycoprotein of the scavenger receptor cysteine-rich (SRCR) superfamily (1, 2). (novusbio.com)
Translational1
  • We investigated combinatorial translational regulation by Drosophila Pumilio (Pum) and Nanos (Nos), which control development, fertility, and neuronal functions. (elifesciences.org)
Highly conserved3
  • The TWIST1 protein is highly conserved from Drosophila to humans, where it plays a key role during embryonic morphogenesis, mesoderm patterning and development. (biomedcentral.com)
  • These substitutions either create premature termination codons, which lead to truncated proteins, or substitute highly conserved residues in the bHLH region. (biomedcentral.com)
  • In addition, two highly conserved motifs inside the GR proteins were discovered that house a tyrosine (Y) and a cysteine (C) residue which may serve as targets for NO-mediated tyrosine nitration and S-nitrosylation, respectively. (bvsalud.org)
Polarity1
  • Planar polarity is evident in the coordinated orientation of ommatidia in the Drosophila eye. (nih.gov)
Transcription3
  • Originally discovered as a chief regulatory protein of glucose and lipid metabolism and cell differentiation, the peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor of the nuclear hormone receptor superfamily 8 . (nature.com)
  • TWIST1 is a transcription factor belonging to the basic helix-loop-helix (bHLH) superfamily. (biomedcentral.com)
  • Possible applications of the program include display of transcription factor binding sites in a genomic context or the visualisation of structural domain assignments in protein sequences and many more. (biomedcentral.com)
Interactions4
  • We demonstrate that heterophilic binding between Dpr6/10 and DIP-α and homophilic binding between DIP-α proteins promote interactions between processes in vivo. (nih.gov)
  • Knockin mutants disrupting the DIP/Dpr binding interface reveal a role for these proteins during normal development, while ectopic expression studies support an instructive role for interactions between DIPs and Dprs in circuit development. (nih.gov)
  • Current research goals are to investigate the mechanisms by which interactions of cis -regulatory sequences with sequence-specific trans-acting proteins in situ in chromatin effect the chromatin remodeling and the transcriptional regulation of Adh . (rochester.edu)
  • 1990 . Alternative DNA-protein interactions in variable-length internucleosomal regions associated with Drosophila Adh distal promoter expression. (rochester.edu)
Genome3
  • Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure. (cam.ac.uk)
  • The A. aegypti genome contains an array of gustatory receptor (GR) proteins that are related to the recognition of taste. (bvsalud.org)
  • Recently, the entire genome of this ectoparasitoid wasp was sequenced, enabling the identification of 79 venom proteins. (mdpi.com)
Sensory3
  • The Drosophila Extramacrochaetae protein antagonizes the proneural function of the Achaete and Scute proteins in the generation of the adult fly sensory organs. (biologists.com)
  • The function of the Drosophila extramacrochaetae ( emc ) gene has been characterized almost exclusively in relation to the pat-terning of the fly's sensory organs (chaetae and other types of sensilla). (biologists.com)
  • Here we demonstrate that dendrite self-avoidance in Drosophila da sensory neurons requires cell-recognition molecules encoded by the Dscam locus. (elsevierpure.com)
Recognition1
  • A short period of desiccation-elevated peptidoglycan recognition protein-LC ( PGRP-LC ) expression in MTs, increased antimicrobial peptide ( AMP ) gene induction, and protected animals from bacterial infection. (biomedcentral.com)
Membrane1
  • Tamanoi's laboratory has developed anti-cancer drugs against Ras proteins aimed at inhibiting their posttranslational modification and membrane association. (uclahealth.org)
Leucine rich r1
  • TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Res. (wikipedia.org)
Play critical roles1
  • The Ras-superfamily G-proteins play critical roles in cell growth and differentiation. (uclahealth.org)
Tissues1
  • If Extramacrochaetae par-ticipates in cell specification by dimerizing with basic-region-helix-loop-helix proteins, the variety of defects and tissues affected by the insufficiency of extramacrochaetae suggests that helix-loop-helix proteins are involved in many embryonic developmental processes. (biologists.com)
Serine2
  • STP, serine/threonine protein phosphatase. (rupress.org)
  • STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. (umbc.edu)
Pathway2
  • Genetic studies using fission yeast and Drosophila established that Rheb plays critical roles in both cell growth and cell cycle progression at the G1/S boundary and that this function of Rheb is mediated by its ability to activate the TOR/S6K signaling pathway. (uclahealth.org)
  • Thus, these results reveal that hunger induces reduction of responses to noxious heat through the Lk/Lkr signaling pathway in Drosophila. (sdbonline.org)
Immune3
  • Among the insects, only the dipterans ( Drosophila and various mosquito species) have been widely investigated for their immune responses towards diverse pathogens. (biomedcentral.com)
  • We also identified several unknown proteins, some of which could have probable immune-related functions based on the results of the ProDom analysis. (biomedcentral.com)
  • The Drosophila renal system is an important contributor to host defense and can modulate immune responses in an organ autonomous manner, responding to environmental changes such as desiccation. (biomedcentral.com)
Interaction2
  • These studies support an important role for the DIP/Dpr protein interaction network in regulating cell-type-specific connectivity patterns. (nih.gov)
  • Together with CLIP-190 (CAP-Gly domain-containing/cytoplasmic linker protein 190), Jar may coordinate the interaction between the actin and microtubule cytoskeleton. (nih.gov)
Tyrosine phosphatase1
  • use an assay in which alkaline phosphatase-tagged cell surface proteins are used to stain live embryos overexpressing other cell surface proteins to identify Sticks and stones (Sns) as a possible ligand for the Lar receptor protein tyrosine phosphatase. (sciety.org)
Neurons3
  • We employed conditional translating ribosome affinity purification (TRAP) followed by RNA sequencing (TRAP-seq) for transcriptome profiling of DA neurons in transgenic Drosophila lines expressing human PARIS wild type (WT) or mutant (C571A). (nature.com)
  • We also evidence that CIII neurons make use of atypical depolarizing chloride currents to encode cold, and that overexpression of ncc69 -a fly homologue of NKCC1 -results in phenotypes consistent with neuropathic sensitization, including behavioral sensitization and neuronal hyperexcitability, making Drosophila CIII neurons a candidate system for future studies of the basic mechanisms underlying neuropathic pain. (elifesciences.org)
  • The demonstration that the same class of somatosensory neurons can respond to innocuous versus noxious stimuli, depending upon which protein those neurons are activated, could shed light on disease states such as neuropathic pain when touch signals are confused as painful. (elifesciences.org)
Sequence2
  • Recombinant fusion protein containing a sequence corresponding to amino acids 370-600 of human ADGRA3 (NP_660333.2). (epigentek.com)
  • This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet known. (utsouthwestern.edu)
Pathways1
  • In Drosophila ovaries, piRNAs are produced via two distinct pathways: the primary processing and ping-pong cycle pathways. (elsevierpure.com)
Chromatin1
  • Experimental approaches are to characterize individual protein components of the multiprotein complex and to assemble individual chromatin complexes from purified components for structural and transcriptional analysis. (rochester.edu)
Sequences1
  • The versatility of BioSAVE extends to the display of annotation scores also in protein sequences. (biomedcentral.com)
Fruit1
  • The authors support the claims in the paper through the use of gene knockdown, behavioral experiments, neuroanatomy, and optogenetic activation in the Drosophila fruit fly. (elifesciences.org)
Innate1
  • Drosophila is a powerful model for the study of factors modulating innate immunity. (biomedcentral.com)
Cell2
  • This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. (nih.gov)
  • 2015). In my lab, we will explore the functions of cell surface proteins, including Dprs and DIPs, and their downstream signaling cascades in nervous system development. (uchicago.edu)
Domain2
  • The family level classification is conditional on the domain being a member of the specified superfamily. (cam.ac.uk)
  • Structure of the functional domain of the LRRK2 protein and the pathogenic mutations associated with PD. (biomedcentral.com)