• Salt Screens - Designed to screen for potentially suitable salts to improve physical properties, solubility, or stability of the drug substance. (catalent.com)
  • Co-crystal Screens - Designed to discover co-crystals composed of drug substance and pharmaceutically acceptable cocrystal formers, to improve properties of the drug substance by increasing solubility, improving stability etc. (catalent.com)
  • However, sometimes it is not feasible to prepare eye drops with pH 7.4 due to drug stability or solubility issues. (cehjournal.org)
  • The technologies are used to formulate biological therapeutic entities that could help address delivery issues associated with solubility, stability, and permeability. (drug-dev.com)
  • There were three delivery challenges facing the peptide: solubility, permeability, and GI stability. (drug-dev.com)
  • APIs are thus combined with the suitable excipients which are pharmacologically and therapeutically inactive but enhance its stability and activities. (openpr.com)
  • Excipients are the one which do not interfere with physical, chemical and pharmacological effects of the active ingredients but they assist in getting desired pharmacological effect from the dosage forms and helps in getting safe and effective dosage form suitable for administration to patients. (ashdin.com)
  • Natural excipients obtained from plants have diverse applications in drug delivery and they play different roles in dosage forms as binders, disintegrants, emulsifying agents and suspending agents. (ashdin.com)
  • Now a day's extensive studies are being conducted for finding the applicability of these natural excipients in the design of novel drug delivery systems [ 1 - 6 ]. (ashdin.com)
  • Presentations and publications on stable drug formulations will offer the opportunities for pediatric patients to receive the desired drugs and doses most effectively and safely. (nih.gov)
  • In this paper, we will review the new progress in the methods for preparing stable nanofluids and summarize the stability mechanisms. (hindawi.com)
  • Crystal Form Screens - Designed to discover polymorphs and solvates (including hydrates) and determine suitable developable forms and the most thermodynamically stable form. (catalent.com)
  • If the drug is not stable at high temperatures, eye drops in solution form can be sterilised by filtration through a 0.22 μm filter into a sterile final container. (cehjournal.org)
  • This investigation demonstrated the potential of the exceptionally stable RGO nanodispersion in nano drug delivery and electrochemical sensing applications. (nottingham.ac.uk)
  • The XCH-500SD single door medicine drug environmental stability testing chamber, using advanced high-quality components and manufacturing technology, stable and reliable performance, suitable for GMP certified users. (thchamber.com)
  • This 150L temperature and humidity test chamber, high quality stability chamber, using advanced high-quality components and manufacturing technology, stable and reliable performance, suitable for GMP certified users. (thchamber.com)
  • This 250L climatic test chamber, adopt temperature and humidity controlled, is a ideal stability test chamber, using advanced high-quality components and manufacturing technology, stable and reliable performance, suitable for GMP certified users. (thchamber.com)
  • Accelerated Approach high throughput API screening platform that will help accelerate your development and optimization of drug molecules. (catalent.com)
  • In previous work, our group has prepared micellar ethaselen formulation employing PLA-based copolymers and characterized its drug loading contents and stability (data not shown), which have demonstrated the compatibility between the core of micelles and the ethaselen molecules. (springer.com)
  • The similarity measurement of small molecules has been the focus of essentially every compound-based approach to design or identify novel drug candidates [ 1 ]. (biomedcentral.com)
  • It is demanding and necessary if information from multiple data sources can be integrated together to produce a comprehensive representation and assessment of similarity relationship between small molecules [ 2 ], thus expected to boost the results of virtual drug screening. (biomedcentral.com)
  • Nonetheless, small molecules will continue to represent the majority of prescribed drugs for the foreseeable future and thus are the major growth driver for the CDMO market. (drug-dev.com)
  • In some cases, the technologies have been used to deliver large molecules orally by enhancing GI stability and permeability. (drug-dev.com)
  • In the last decade, technology changes have enabled the process of drug discovery to evolve into a system where new lead molecules can be rapidly found against novel, and sometimes, difficult targets. (ddw-online.com)
  • Cell membranes are biologic barriers that selectively inhibit passage of drug molecules. (msdmanuals.com)
  • Develop processes suitable to ensure long-term stability of vialed drug product. (biospace.com)
  • A series of monomethoxy poly(ethylene glycol)-poly(lactide) (mPEG-PLA) diblock copolymers were synthesized, and mPEG-PLA micelle was fabricated and used as a nanocarrier for solubilization and delivery of a promising anticancer drug ethaselen. (springer.com)
  • The excellent stability at physiological pH promotes its utilization of RGO dispersion as a carrier of Paclitaxel (Ptx) - an anticancer drug. (nottingham.ac.uk)
  • Biocompatibility results supported the use of the G-Au nanocomposite system for anticancer applications such as drug delivery, imaging, etc. (nottingham.ac.uk)
  • It is believed that, due to the unique mode of action, AMPs could overcome the problem of resistance to conventional antibiotics in multi-drug resistant bacteria and even to currently used anticancer drugs for the treatment of tumor cells. (unina.it)
  • Applicants should have relevant pharmaceutical sciences related experience with various aspects of drug product development. (biospace.com)
  • Any drug is composed of two components, the first one is the active pharmaceutical ingredient, which is the central ingredient of the drug and the second is an excipient. (openpr.com)
  • The increasing prevalence of chronic diseases is expected to increase the demand for drugs, in turn fueling the active pharmaceutical ingredients market in the near future. (openpr.com)
  • The increase in non-communicable disease is also expected to increase the demand for drug, lending growth for the active pharmaceutical ingredients market in the future. (openpr.com)
  • The Company is also exploiting the use of its stem cell lines as a drug discovery platform through its ReNcell product, which is marketed to pharmaceutical companies and academia for use as a drug discovery tool and for general research. (reneuron.com)
  • ReNeuron's stem cells also have the capability to form neural networks suitable for use in biosensors, currently being developed as a potential detection tool to combat bio-terrorism or as a drug screening tool in the pharmaceutical industry. (reneuron.com)
  • Dissolving the active pharmaceutical ingredient/ preservative (in powder form) in a suitable vehicle (either sterile water or a buffer solution). (cehjournal.org)
  • The demand for outsourcing pharmaceutical formulation development and manufacturing is on the rise for drug developers at all levels. (drug-dev.com)
  • In this annual Drug Development & Delivery magazine report, some of the key players in the CDMO market present case studies about how they are helping pharmaceutical and biopharma companies overcome a variety of formulation and manufacturing challenges. (drug-dev.com)
  • Pharmaceutical research has successfully incorporated a wealth of molecular modeling methods, within a variety of drug discovery programs, to study complex biological and chemical systems. (mdpi.com)
  • Currently, nearly all pharmaceutical companies follow common technology processes for discovering drugs. (ddw-online.com)
  • In a drive to improve productivity and to sustain market share, pharmaceutical and biotechnology firms have over the years invested billions of dollars in innovative technologies that are able to accelerate the drug discovery and development processes. (ddw-online.com)
  • Stability testing is one of the most important steps during the development of a pharmaceutical product. (pittcon.org)
  • The stability of a pharmaceutical product has been defined as the capability of a particular formulation in a specific packaging system to remain within its physical, chemical, microbiological, toxicological, protective and informational specifications. (pittcon.org)
  • Defining the stability of a pharmaceutical product is thus critical to ensuring patient safety and the desired clinical outcomes. (pittcon.org)
  • In addition, pharmaceutical companies are keen to get their product to market as quickly as possible so rapid effective technologies are needed for accurate characterization so approval is not delayed by unforeseen stability issues, for example by the presence of impurities from degradation. (pittcon.org)
  • The Regional Committee is invited to advise on the adoption of the attached draft guidelines on Stability Testing of Active Substances and Pharmaceutical Products in countries of the Eastern Mediterranean Region. (who.int)
  • These guidelines are intended to define the stability data package for active substances and pharmaceutical products that is sufficient for a registration application within countries of the World Health Organization's Eastern Mediterranean Region [1]. (who.int)
  • The purpose of stability testing is to provide evidence on how the quality of an active substance or pharmaceutical product varies with time under the influence of a variety of environmental factors such as temperature, humidity and light. (who.int)
  • For example, lack of efficacy of various formulations of tenofovir-based PrEP 17 in the VOICE trial were explained, in part, by undetectable drug levels in many participants 17 and imperfect adherence was also implicated for the lack of efficacy in the FEM-PrEP trial 18 . (nature.com)
  • Both the formulations were filled in suitable size of capsule as per dose of each drug. (selectbiosciences.com)
  • This review mainly highlights major issues of paediatric and geriatric drug therapy and provides the design of oral flexible formulations as an alternative formulation design for age appropriate formulation development. (ijpsonline.com)
  • Development of flexible formulations as an alternative to marketed different formulations of the same drug would reduce the cost of the formulation for patients particularly developing countries where accessibility to various types of formulations is less. (ijpsonline.com)
  • Properly designed and developed flexible formulations for new chemical entities and off-patent drugs are need of the hour to provide better treatment to varying age groups of paediatrics and geriatrics. (ijpsonline.com)
  • In terms of drug discovery and development, the role of nanotechnology currently lies in improving diagnostic methods, developing improved drug formulations and drug delivery systems for disease therapy. (ddw-online.com)
  • The regulatory requirements to validation of analytical procedures utilised for release and stability studies of drug substances and drug products are described in the ICH guideline Q2(R1). (gmp-compliance.org)
  • The weak acidic drugs (indomethacin, ibuprofen and naproxen) with amorphous polymeric carrier Eudragit E (EPO) were chosen as suitable combinations for study. (manufacturingchemist.com)
  • Specification of Drug Substances and Products. (researchandmarkets.com)
  • Therefore, stability testing is a routine procedure performed on drug substances and products at each stage of product development so the company can be certain that the quality of their products will endure throughout the time they are available for supply to patients. (pittcon.org)
  • Extemporaneous drug preparations are commonly practiced in hospital pharmacies across the globe. (ijpsonline.com)
  • Medicine Stability Testing Chamber apply to investigate the stability of drug substances and preparations, suitable for GMP and CGMP certified users. (thchamber.com)
  • The improved swelling time for crosslinked blends in aqueous medium supports the fact that the stability under physiological conditions of the blends is improved due to crosslinking with the metal ions. (amrita.edu)
  • Smart materials that can be triggered by external stimuli are seen with high potential for innovative treatments and improved drug delivery systems by regulatory agencies like the FDA and EMA. (researchgate.net)
  • Health Canada, the federal regulatory authority that evaluates the safety, efficacy, and quality of drugs available in Canada, recognises that with the expiration of patents for biologic drugs, manufacturers may be interested in pursuing subsequent entry versions of these biologic drugs. (canada.ca)
  • The objective of this document is to provide guidance to sponsors to enable them to satisfy the information and regulatory requirements under the Food and Drugs Act and Part C of the Food and Drug Regulations for the authorization of biosimilars in Canada. (canada.ca)
  • She also provides group and one-on-one training in drug development, regulatory affairs and project management topics. (researchandmarkets.com)
  • The importance of such information is highlighted by the fact that stability testing data are required for a new drug or formulation to receive regulatory approval. (pittcon.org)
  • The prepared complexes were characterized using differential scanning calorimetry, Fourier transform infrared spectroscopy, X-ray powder diffraction and both in vitro and ex vivo drug release studies. (ijpsonline.com)
  • In vitro and ex vivo studies showed that highest drug release occurred from inclusion complex prepared with hydroxypropyl-β-cyclodextrin with a ratio of 1:2.5. (ijpsonline.com)
  • In vitro ADME assays included skin penetration profiles, stability to proteases and liver microsomes, and plasma protein binding. (ku.dk)
  • The in vitro cytotoxicity analysis of the Ptx loaded RGO nanodispersion revealed the potential of the nanodispersion as a suitable drug carrier. (nottingham.ac.uk)
  • However, in the process of novel drug screening, the representation of a compound varies dramatically, which results in different similarity measurements. (biomedcentral.com)
  • In pediatric patients, the drug should be administered at a rate not exceeding 1-3 mg/kg/min or 50 mg per minute, whichever is slower. (globalrph.com)
  • The important technique to enhance the stability of nanoparticles in fluids is the use of surfactants. (hindawi.com)
  • In this method, the processes of drying, storage, transportation, and dispersion of nanoparticles are avoided, so the agglomeration of nanoparticles is minimized, and the stability of fluids is increased [ 5 ]. (hindawi.com)
  • These suggested that mPEG-PLA polymeric micelle nanoparticles had great potential as nanocarriers for effective solubilization of poorly soluble ethaselen and further reducing side effects and toxicities of the drug. (springer.com)
  • Essential characteristics of SiO2's patented materials coating include thermal stability and integrity, chemical stability, a gas barrier, mechanical durability, no breakage, and precision molding. (businesswire.com)
  • With a thermal stability range of -196˚C to 121˚C and with a seal integrity down to -80˚C, the SiO2 vials and syringes provide the ideal primary container for therapies in any storage conditions. (businesswire.com)
  • Following intramuscular administration of prochlorperazine edisylate, the drug has an onset of action within ten to twenty minutes and a duration of action of three to four hours. (drugs.com)
  • Other parts of this strategy include thorough product characterization during development, upon which specifications are based and adherence to good manufacturing practices (GMP's), e.g., suitable facilities, a validated manufacturing process, validated test procedures, raw materials testing, in-process testing and stability testing. (researchandmarkets.com)
  • Specifications are chosen to confirm the quality of the drug substance and drug product rather than to establish full characterization and should focus on those characteristics found to be useful in ensuring the safety and efficacy of the drug substance and drug product. (researchandmarkets.com)
  • We are seeking a highly skilled and motivated Senior Research Associate / Engineer II in Drug Product Development, to work in a team developing Modernas sterile drug product processes and products that enable clinical and future commercial supply. (biospace.com)
  • This paper summarizes the recent progress on the study of nanofluids, such as the preparation methods, the evaluation methods for the stability of nanofluids, and the ways to enhance the stability for nanofluids, the stability mechanisms of nanofluids, and presents the broad range of current and future applications in various fields including energy and mechanical and biomedical fields. (hindawi.com)
  • The purpose of this paper will focuses on the new preparation methods and stability mechanisms, especially the new application trends for nanofluids in addition to the heat transfer properties of nanofluids. (hindawi.com)
  • Since 1991, Catalent's small molecule analytical team has developed and applied thousands of analytical methods to help customers progress their drug candidates. (catalent.com)
  • This guidance applies to biologic drugs that contain, as their active substances, well characterized proteins derived through modern biotechnological methods such as use of recombinant DNA and/or cell culture. (canada.ca)
  • Broadly used in modern drug design, molecular docking methods explore the ligand conformations adopted within the binding sites of macromolecular targets. (mdpi.com)
  • Details about drug properties, excipient selection and taste masking approaches were described. (ijpsonline.com)
  • Recent work by a team of researchers at Queen's University Belfast and University College London has demonstrated a recently developed strategy for the manufacture of a high drug loaded amorphous solid dispersion (HDASD) using a hot-melt extrusion (HME) based platform 1 . (manufacturingchemist.com)
  • Dr Tian said: 'The information we collected is particularly useful for the design of hot-melt extrusion processes, where a fully amorphous solid dispersion can be generated at conditions that are significantly lower than the melting point of the crystalline drug, and at much higher drug loadings. (manufacturingchemist.com)
  • 1. Tian, Y., E. Jacobs, D.S. Jones, C.P. McCoy, H. Wu, G.P. Andrews, The design and development of high drug loading amorphous solid dispersion for hot-melt extrusion platform, International Journal of Pharmaceutics (2020). (manufacturingchemist.com)
  • Both compounds were suitable for administration in an oil-in-water cream formulation (50% release in 8 h), and displayed no skin permeation, in the absence or presence of skin permeability modifiers. (ku.dk)
  • To comprehensively understand the relationship between the intrinsic features of chemical compounds and protein targets is an essential task to evaluate potential protein-binding function for virtual drug screening. (biomedcentral.com)
  • Then, a large-scale drug virtual screen was performed on 1267 compounds curated from Connectivity Map (CMap) dataset based on the fused similarity, which obtained a better ranking result compared to that of single-view. (biomedcentral.com)
  • The method of sterilisation depends on the stability of the drug at high temperature. (cehjournal.org)
  • Dr Tian said: "The solid-state properties of ball-milled samples and the dissolution/melting behaviours of crystalline drug in the polymeric matrix, as a function of temperature, were analysed using small angle/wide angle X-ray scattering. (manufacturingchemist.com)
  • The study was able to directly observe the temperature dependences of the X-ray scattering pattern for the crystalline drugs (IND, NPX and IBU) in the presence of a polymeric carrier. (manufacturingchemist.com)
  • Creates a temperature, humidity, light environment for drug stability evaluation. (thchamber.com)
  • There can be many reasons why a conventional upright bike is not suitable for your child. (hpvelotechnik.com)
  • In addition to its stem cell programmes, ReNeuron is also developing more conventional drugs targeting diseases of the nervous system. (reneuron.com)
  • Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. (drugs.com)
  • And now, even more pioneering technologies, such as nanotechnology, are set to streamline the drug discovery process further, through miniaturisation, automation, speed and reliability of assays by working at levels far smaller than conventional micro-arrays. (ddw-online.com)
  • Thermodynamic phase diagrams for three HDASD systems were constructed and used to guide the design of the hot-melt extrusion process and the processability and storage stability of HDASDs were further investigated using a range of conventional and advanced analytical techniques. (manufacturingchemist.com)
  • Suitable additives can significantly increase the stability of the drugs. (mytum.de)
  • Catalent continues to expand its biologics drug substance capabilities and capacity significantly with a fourth and fifth biomanufacturing train in Madison, WI, and the recent completion of a $14 million commercial packaging expansion, in Bloomington, IN. (drug-dev.com)
  • Sr. Research Associate, Drug Product Development job with Moderna, Inc. (biospace.com)
  • The primary role for this position will be to support drug product development activities including: image development, process development and scale-up, container development and conditions of use studies. (biospace.com)
  • Many drug development and drug formulation innovations can be limited due to variables associated with traditional glass vials and syringes. (businesswire.com)
  • The SiO2 vials and syringes eliminate these variables and allow drug development partners to bring their innovations to life. (businesswire.com)
  • However, development of such a system has previously proven difficult due to the limited residence of drugs in the gastrointestinal tract 39 . (nature.com)
  • Peggy J. Berry, MBA, RAC, is the President & CEO at Synergy Consulting where she provides consulting services to companies in all aspects of drug development. (researchandmarkets.com)
  • Rare diseases, fast-tracked drugs, and oncology treatments now account for much of pharma's development pipeline, so it is important that CDMOs provide specialized capabilities, technology, expertise, and experience relevant to these types of programs. (drug-dev.com)
  • By leveraging relevant experience and drug development knowledge, we can demonstrate strategies that maintain the integrity, quality, and timeliness of the development and manufacturing processes at the accelerated pace required of expedited programs," says Elliott Berger, Vice President and Chief Marketing Officer, Catalent. (drug-dev.com)
  • The International Conference on Harmonization (ICH) has long recognized the importance of stability testing in drug development and wants drugs to be made safer by having a well-defined stability profile. (pittcon.org)
  • 2. Benet, L. Z. The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development. (manufacturingchemist.com)
  • The Committee noted progress in the development of a solid-membrane assay suitable for use in the field which could detect the presence of orthopoxviruses or varicella virus in individuals presenting with symptoms consistent with smallpox infection. (who.int)
  • Most drugs are weak organic acids or bases, existing in un-ionized and ionized forms in an aqueous environment. (msdmanuals.com)
  • It establishes the set of criteria to which a drug substance or drug product should conform to be considered acceptable for its intended use. (researchandmarkets.com)
  • Conformance to specifications means that the drug substance and drug product, when tested according to the listed analytical procedures and meeting the listed acceptance criteria. (researchandmarkets.com)
  • Specifications are one part of a total control strategy for the drug substance and drug product designed to ensure product quality and consistency. (researchandmarkets.com)
  • Additionally, Catalent partnered with Arcturus Therapeutics to support the drug substance manufacture of its COVID-19 mRNA-based vaccine candidate. (drug-dev.com)
  • According to EU GMP Guide Part 1, Chapter 6, Quality Control (6.15) and US 21 CFR 211.194, analytical procedures must be suitable for their intended purpose. (gmp-compliance.org)
  • The need for such data will continue, because it is unlikely that all drugs approved for adults will also be labeled simultaneously for potential use in infants and children. (nih.gov)
  • The pharmacist should check the drug-specific data safety document (the drug safety data sheet) to get information about the toxicity of the drug. (cehjournal.org)
  • This 90-minute training will discuss the requirements of ICH for using testing and stability data to set specifications for drug substances and drug products including use of special stability studies. (researchandmarkets.com)
  • The genomics and proteomics revolution has delivered massive amounts of data about life's molecular components, giving the drug discovery industry more qualified targets and leads than ever before. (ddw-online.com)
  • The guidelines seek to exemplify the core stability data package required for registration. (who.int)
  • The Committee also reviewed preliminary data on a diagnostic assay based on protein-array technology, and agreed that additional studies will be needed to evaluate its robustness, stability, sensitivity and specificity. (who.int)
  • Stability of serum obtained with tubes containing separating gel: 48 hours at 2-8°C (note the data provided by the tube manufacturer). (cdc.gov)
  • Many naturally available polymers were being investigated for their applications in the design of sustained drug delivery systems. (ashdin.com)
  • The natural polymers which were characterized in the present research work have showed good flow properties and suitable physico chemical properties like low moisture content which enables low chance of microbial growth, high swelling index indicates high swellability and goodwater retention capacity there by enhanced permeation of drug for longer periods of time. (ashdin.com)
  • Many existing ASD polymers only work well at relatively low drug loadings, and, as a result, many ASDs consist of 90% polymer and 10% drug by weight. (manufacturingchemist.com)
  • In addition, they possess broad chemical stability, provide low protein and drug binding, and offer excellent heat resistance. (biovision.com)
  • This guidance document applies to all biologic drug submissions where the sponsor seeks authorization for sale based on demonstrated similarity to a previously approved biologic drug and relies, in part, on prior information regarding that biologic drug in order to present a reduced clinical and non-clinical package as part of the submission. (canada.ca)
  • Develop protocols to evaluate the compatibility of the drug product with processing materials, container closure components, and sterilization processes. (biospace.com)
  • Our study presented an efficient, extendable and quantitative computational model for integration of different compound representations, and expected to provide new clues to improve the virtual drug screening from various pharmacological properties. (biomedcentral.com)
  • SiO2's patented materials science is a combination of a plastic container with a microscopic, thin, undetectable to the naked eye, pure glass coating for biological drugs and vaccines. (businesswire.com)
  • The SiO2 vials solve significant challenges in the commercialization of vaccines and biological drugs, which presently cannot be solved by glass or plastic vials," Fredrickson said. (businesswire.com)
  • They have been applied in a wide range of biological systems ranging from drug delivery to tissue engineering. (springer.com)
  • BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. (biovision.com)
  • Here we describe an oral dosage form composed of distinct drug-polymer matrices which achieved week-long systemic drug levels of the antiretrovirals dolutegravir, rilpivirine and cabotegravir in a pig. (nature.com)
  • Others (Lyophilizers, fiber optic dissolution, stability chambers etc. (catalent.com)
  • The combined formulation was then studied for drug release in multimedia and biorelevant media dissolution. (selectbiosciences.com)
  • Conduct studies to support scale-up of drug product manufacturing (e.g. freeze/thaw, mixing, filling, filtration, transport etc). (biospace.com)
  • Nanomaterials have demonstrated a wide range of applications and recently, novel biomedical studies are devoted to improving the functionality and effectivity of traditional and unmodified systems, either drug carriers and common scaffolds for tissue engineering or advanced hydrogels for wound healing purposes. (researchgate.net)
  • accelerated stability & special stability studies. (researchandmarkets.com)
  • The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. (drugs.com)
  • In stress stability studies, zidovudine was sensitive to UV light. (who.int)
  • O Consultation on Regional Guidelines on Stability Studies of Medicines and Biologicals, held in Jeddah in February 2006. (who.int)
  • The term biosimilar biologic drug, hereafter referred to as biosimilar, is used by Health Canada to describe subsequent entry versions of a Canadian approved innovator biologic with demonstrated similarity to a reference biologic drug. (canada.ca)
  • however, careful consideration should be given to expression system differences that may present challenges to demonstrating similarity to the reference biologic drug. (canada.ca)
  • Filter sterilisation is not suitable for use with eye drops in suspension form, as the 0.22 μm filter will remove the finely dispersed drug particles and make the eye drops ineffective. (cehjournal.org)
  • Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. (globalrph.com)
  • Our results indicate that these peptoid-based drugs may be suitable as antimicrobials for local treatment of canine superficial pyoderma and that they can overcome the inherent limitations of stability encountered in peptides. (ku.dk)
  • Therefore, when a weak acid is given orally, most of the drug in the stomach is un-ionized, favoring diffusion through the gastric mucosa. (msdmanuals.com)
  • If the potency of a life-preserving drug is reduced, the condition being treated will not be controlled and may lead to the death of a patient. (pittcon.org)
  • Using this cell line, we have identified emetine as a specific inhibitor of HIF-2α protein stability and transcriptional activity. (aspetjournals.org)
  • The product is still suitable for use. (globalrph.com)
  • The equipment used in ADC manufacturing must protect employees from exposure to cytotoxins and prevent microbial contamination of the process intermediates and drug product during the conjugation process," Rohrer says. (biopharminternational.com)
  • In addition, the packaging may lose integrity over time, which may reduce the stability of the product it contains or even contaminate it. (pittcon.org)
  • Tardive dyskinesia, a syndrome consisting of potentially irreversible, involuntary, dyskinetic movements may develop in patients treated with antipsychotic drugs.Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to rely upon prevalence estimates to predict, at the inception of antipsychotic drug treatment, which patients are likely to develop the syndrome. (drugs.com)
  • Patient non-compliance due to poor taste and swallowing problems are major issues in paediatric and geriatric drug therapy. (ijpsonline.com)
  • Long-term genotypic stability is an essential pre-requisite for transplantation into the brain, meaning that this confirmation is an important step forward for the Company's cell therapy ambitions. (reneuron.com)
  • Ad26.ZEBOV/MVA-BN-Filo can maintain stability at 2°-8°C ( 10 ). (cdc.gov)
  • To maintain your employment as a TSO you must demonstrate readiness for duty on a regular basis with no impairment of drugs, alcohol, or sleep deprivation. (criminaljusticeonlineblog.com)
  • 4,5 A suitable buffer can be used to control and maintain the pH of the eye drops during storage, such as citrate or acetate buffer. (cehjournal.org)
  • Increased risk of hypotension if ability to maintain blood pressure has been compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (eg, phenothiazines or general anesthetics). (medscape.com)
  • With a gas barrier, SiO2 vials have gas permeation properties like glass and therefore provide the shelf life and stability required by many therapies. (businesswire.com)
  • This article will focus on the principal trends and the implications on drug discovery. (ddw-online.com)
  • The drug discovery industry has become such a competitive market that it continually faces a challenge to find better drug discovery technologies. (ddw-online.com)
  • The introduction of microarrays and lab-on-a-chip (LOC) technologies have already revolutionised the drug discovery process. (ddw-online.com)
  • Applications include flow cytometry, confocal microscopy and drug discovery. (photonics.com)
  • Osseous stability depends on the degree of flexion of the elbow. (medscape.com)
  • SiO2's syringes are precision molded and up to 15 times more dimensionally consistent than glass, enabling error-free operation with autoinjectors and other drug delivery devices. (businesswire.com)
  • Nanomaterials in combination with biomolecules are used in drug delivery, imaging and sensing applications by targeting the overexpressed cancer proteins such as folate receptors (FR), to control the disease from progressing to advanced levels. (nottingham.ac.uk)
  • Because they use proprietary optically pumped semiconductor laser (OPSL) technology, the Sapphire 588 LP lasers offer good performance and reliability, making them suitable for OEM and stand-alone applications. (photonics.com)
  • The results indicated a good reliability and validity of the questionnaire, making him suitable as a screening tool for epidemiological purposes. (bvsalud.org)
  • Certain drugs such as combination therapies, have numerous active ingredients, which treat different symptoms or act in different ways. (openpr.com)
  • Stability testing is thus a complex process as the effects of a variety of factors that may influence stability must be assessed. (pittcon.org)
  • In this way, potential stability issues can be predicted and tests for the associated impurities implemented into the production process. (pittcon.org)
  • [ 3 ] In maximal flexion, the coronoid process engages in the coronoid notch and accounts for stability. (medscape.com)
  • Each solid-state form of an API has unique physicochemical properties, which can have a profound impact on a finished product's bioavailability, stability, and manufacturability. (catalent.com)
  • The onset of resistance is mainly due to the massive and out-of-control use of these drugs in our community. (unina.it)