Suggests genetic predisposition to disease. Medical search. Frequent questions

Centers for Disease Control and Prevention. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)

Genetic factors might play a substantial role in the incidence of YEL-AVD. (cdc.gov)
Evidence indicates a higher incidence of AA among genetically related individuals, suggesting a genetic predisposition. (keratin.com)
Non-alcoholic fatty liver disease (NAFLD) has grown in incidence to become the most common chronic liver disease worldwide [1] and is projected to surpass alcoholic liver disease as the leading cause of liver transplantation in the United States by 2030 [2]. (termedia.pl)
Type 1 diabetes (T1D) and Hashimoto's thyroiditis (HT) are the two most common autoimmune endocrine diseases that have rising global incidence. (portlandpress.com)
The incidence is similar in both sexes, but the significant ethnic background and geographic differences point out the importance of environmental factors in the development of the disease. (pap.es)
RESULTS -The severity of insulitis in these transgenic mice is significantly decreased, disease onset is delayed, and the incidence of diabetes is markedly decreased compared with littermate controls. (diabetesjournals.org)
Epidermolysis bullosa acquisita (EBA) is a rare disease, with an incidence of 0.26 case per million population, which is 5% of all blistering diseases. (medscape.com)
The age-adjusted diseases who attended the outpatient oph- incidence of the disease is estimated to be thalmology or dermatology clinic in the 22.4 per 100 000 [16]. (who.int)
After taking informed consent from the erately rapid increase in the incidence of the women, a structured questionnaire was disease in recent years [16]. (who.int)

CONCLUSIONS--These findings suggest that CLDN in preterm children is not related to a genetic or familial predisposition towards asthma, COPD, or allergy. (bmj.com)
Among them, it has usually been suggested that a genetic factor or a familial predisposition may be of relevance to the development of disc herniation. (bmj.com)

The disease is believed to occur when there is susceptibility, or a lack of immune system resistance, to DPB-causing bacteria or viruses, caused by several genes that are found predominantly in individuals of East Asian descent. (wikipedia.org)
Several genes within this region of class I HLA are believed to be responsible for DPB, by allowing increased susceptibility to the disease. (wikipedia.org)
Published in the New England Journal of Medicine in 2015, we found a surprisingly high percentage of pediatric cancer patients carry germline mutations in known cancer predisposition genes. (stjude.org)
Furthermore, research has identified specific genes more common in AA patients, indicating a polygenic susceptibility to the disease. (keratin.com)
Studying genes in families with a propensity for certain diseases has led to many critical advances in medicine, including the discovery of statins in family members who suffered heart attacks at an early age. (sciencedaily.com)
Other candidate genes were presumed to be involved in the pathogenesis of disc diseases, such as glycosaminoglycans or different types of collagen, particularly type II collagen. (bmj.com)
Dr Allam noted a likely effect of genetic inheritance, pointing out that much of the human predisposition to atherosclerosis could be secondary to their genes. (eurekalert.org)
Other rheumatic diseases such as rheumatoid arthritis and ankylosing spondylitis occur more frequently in individuals with particular MHC genes. (papaa.org)
It is thought that there is a genetic predisposition to the development of psoriasis and psoriatic arthritis but exactly which genes are involved is unknown at present. (papaa.org)
Using transcriptome-wide association and colocalisation to infer the effect of gene expression on disease severity, we find evidence implicating multiple genes, including reduced expression of a membrane flippase (ATP11A), and increased mucin expression (MUC1), in critical disease. (cdc.gov)

Cystitis describes a broad range of diseases with diverse etiology and pathologic mechanisms but with similar clinical presentations. (medscape.com)
Vogt-Koyanagi-Harada syndrome is a multisystem disease of presumed autoimmune etiology that is characterized by chronic, bilateral, diffuse, granulomatous panuveitis with accompanying integumentary, neurologic, and auditory involvement. (aao.org)
The precise etiology and pathogenesis of VKH syndrome are unknown, but current clinical and experimental evidence suggests a cell-mediated autoimmune process driven by T lymphocytes directed against self-antigens associated with melanocytes of all organ systems in genetically susceptible individuals. (aao.org)
Currently, IPT is considered an autoimmune disease and its etiology is related to immunological mechanisms such as antibodies and antiplatelet immunoglobulin in the blood 16 . (bvsalud.org)
Paget’s is a disease of unknown etiology in which there is cellular remodeling and bone deformity from breakdown and disorganized new bone formation. (cdc.gov)

Celiac disease is an autoimmune enteropathy induced by gluten intake in genetically susceptible individuals. (pediatriconcall.com)
Celiac disease (CD) is an autoimmune enteropathy induced by ingestion of gluten in genetically predisposed subjects. (pediatriconcall.com)
A total of 17,008 Alzheimer's cases and 37,154 controls were grouped to genetically determine increases in any risks that might be associated with Alzheimer's disease. (clinicaladvisor.com)
The authors also observed a link between genetically predicted higher levels of 25-hydroxyvitamin D and reduced risk of Alzheimer's disease (OR, 0.92) but found that increased coffee intake may increase Alzheimer's risks (OR, 1.26). (clinicaladvisor.com)

There are often data of family history of atopic diathesis, suggesting that there is a genetic predisposition in these patients. (pap.es)
Conclusion: Asthma risk depends on the interplay of genetic factors, gender, atopic predisposition, type of livestock, pesticide exposure, and magnitude and duration of exposure in the adult subject. (cdc.gov)

Epidermolysis bullosa acquisita (EBA) is an autoimmune disease, manifested by autoantibodies that target type VII collagen, the major protein of anchoring fibrils and the one that connects the epithelial basement membrane to the dermis. (medscape.com)
Conventional medicine often addresses autoimmune disease with powerful immune-suppressing medication rather than searching for the cause. (mindbodygreen.com)
7 - 9 A TMA is called "primary" when a genetic or acquired defect in a complement protein is identified (as in atypical hemolytic uremic syndrome [aHUS]) or "secondary" when occurring in the context of another disease process or factor such as infection, autoimmune disease, malignancy, or drugs. (jrheum.org)
Juvenile Myositis (JM) is a rare autoimmune disease that primarily affects children and adolescents, causing inflammation of the muscles and tissues. (myositissupportgroup.org)
Overall, while Juvenile Myositis poses significant challenges, early diagnosis, appropriate medical intervention, and ongoing supportive care can help improve outcomes and enhance the quality of life for those living with this rare autoimmune disease. (myositissupportgroup.org)
This autoimmune disease primarily affects children and adolescents, causing inflammation in their muscles. (myositissupportgroup.org)

Loss of immune tolerance to autoantigens associated with a specific organ results in the activation of organ-specific T and B cells that in turn cause organ-specific inflammation and the development of autoimmune diseases such as multiple sclerosis (MS) ( 5 ), rheumatoid arthritis (RA) ( 6 ), psoriasis ( 7 ), and type 1 diabetes (T1D) ( 8 ). (frontiersin.org)
The negative impact of sleep disorders on asthma, which is generally considered a chronic inflammatory disease, might be mediated by sleep-induced chronic inflammation," wrote the study researchers. (ajmc.com)
To make a diagnosis of inflammatory bowel disease, a doctor must first exclude other possible causes of inflammation. (msdmanuals.com)
Evidence suggests that inflammation in the skin and joints is in part directed and maintained by cells of the immune system called T lymphocytes. (papaa.org)
These results suggest that extensive colitis patients have a genetic predisposition to colorectal cancer and that longstanding inflammation is not of primary importance in the initiation/promotion of cancer in this disease. (bmj.com)
Recent findings show that encountered in the workplace include toluene diisocya- sensitized mice develop airway hyperreactivity and inflammation, nate (TDI), diphenyl-methane diisocyanate and hexam- reflective of human disease. (cdc.gov)

Clinical trials began testing the impact of single substances in supplement form, especially beta-carotene and vitamin E, as weapons against chronic diseases. (harvard.edu)
The numerous clinical, pathologic, and genetic similarities between SO and VKH syndrome suggest that they share a similar immunopathogenesis, albeit with different triggering events and modes of sensitization. (aao.org)
The clinical features of VKH syndrome also vary depending on the stage of the disease. (aao.org)
The authors examined the impact of this program on 55 clinical markers and the effect of genetic predisposition on these clinical changes. (cdc.gov)
They suggested that "a program combining multi-omic data with lifestyle coaching produces clinically meaningful improvements, and that genetic predisposition impacts clinical responses to lifestyle change. (cdc.gov)
Pruritus and recurrences are the clinical hallmark of the disease. (pap.es)
With the recent completion of the canine and feline genome sequences, the unique traits of breeds, many hereditary disorders and genetic predispositions to disease have been characterized from the clinical signs to the gene defect. (vin.com)
Today, many hereditary diseases are well characterized from clinical signs to the gene defect, precise diagnostic tools have been developed to detect affecteds but also carriers, specific treatments can be offered for a few, and genetic counseling with breeder clients can improve the health of small animals in future generations. (vin.com)
Because of the increased awareness of breeders, pet owners, and veterinarians of genetic defects and the improved diagnostic abilities in clinical practice, the number of reported hereditary diseases in small animals is rapidly growing. (vin.com)
Recent exciting advances in our current knowledge of the completed dog and feline genome sequences offer the opportunity to clinicians to use these emerging tools in clinical practice and have a positive impact on the health of dogs as well as cats and in particular the diagnosis, management, and control of hereditary diseases. (vin.com)
The genotype refers to the animal's genetic makeup, reflected by its DNA sequence, whereas the phenotype relates to the clinical manifestation of specific gene(s) and environment, or both. (vin.com)
Levels of a protein called neurofilament light chain (NfL) in the blood can identify those who might have neurodegenerative diseases such as Down's syndrome dementia, motor neuron disease (ALS) and frontotemporal dementia, when clinical symptoms are not definitive. (kcl.ac.uk)
Neurofilament light chain is a promising biomarker that could speed diagnosis of neurodegenerative diseases and shorten clinical trials. (kcl.ac.uk)
The clinical presentation is similar to that of multiple myeloma except that (1) organomegaly is common in Waldenström macroglobulinemia and is uncommon in multiple myeloma and (2) lytic bony disease and renal disease are uncommon in Waldenström macroglobulinemia but are common in multiple myeloma. (medscape.com)
The transfer of lymphocytes or ethylene di-isocyanate (HDI), which are used in a serum from sensitized mice can cause clinical disease in naive variety of industries including polyurethane foam mice. (cdc.gov)
Recent progress using animal models has been instrumental in clinical data have highlighted several important differ- furthering current understanding of the involvement of the ences, such as a low prevalence of specific IgE immune system in disease pathogenesis. (cdc.gov)

The interplay between genetic predisposition, immune response, and environmental triggers is crucial in the manifestation of AA. (keratin.com)
Accumulating evidence points towards the interplay between the disruption of gut microbial homeostasis (dysbiosis) and the breakdown of host immune tolerance at the onset of both diseases. (portlandpress.com)
A recent longitudinal study using data from the U.K. Biobank explores the interplay between plant-based diets and genetic predisposition in affecting the risk of non-alcoholic fatty liver disease (NAFLD). (news-medical.net)

The findings suggest that genetics play a stronger role in heart disease than previously thought, he said. (livescience.com)
To follow up, the team would like to compare the genetic makeup of other mummies with the state of their arteries, to tease out just how much of a role genetics play in heart disease, Zink said. (livescience.com)
For other people, genetics may not be involved, rather, the environment may play a very strong role, perhaps with several environmental triggers combining together to active the onset of disease. (keratin.com)
Researchers have produced a comprehensive picture of insulin signalling in mice and suggest that it is shaped by entangled effects of genetics and diet. (news-medical.net)

Some evidence suggests a genetic predisposition to the disease. (medscape.com)
A wealth of anecdotal evidence suggests that trauma can stimulate the immune system and precipitate AA with case reports published in the medical literature stretching back to the 1880s. (keratin.com)
Less data were available from developing countries, but the evidence suggests that IBD is emerging as a global disease. (medscape.com)
Recent evidence strongly suggests that the intestinal microbiota plays a role in accelerating or preventing disease progression depending on the compositional and functional profile of the gut bacterial communities. (portlandpress.com)
In this Perspective article, we review the theory and evidence for a disease model of complement-mediated TMA and important implications for treatment. (nature.com)
Evidence suggest that a patient's genetic predisposition together with environmental factors, such as exposure to pathogens that exhibit molecular mimicry, disturb immune tolerance ( 4 ). (frontiersin.org)
Some evidence suggests that a genetic predisposition to absorbing too much iron may also be involved. (medlineplus.gov)
The cause of inflammatory bowel disease is not known, but evidence suggests that normal intestinal bacteria inappropriately trigger an immune reaction in people with a genetic predisposition. (msdmanuals.com)
There are three main pieces of evidence which suggest the immune system is involved in psoriasis. (papaa.org)
Events underlying malignant transformation are poorly characterised in ovarian cancer, but accumulating evidence suggests that a majority of ovarian cancers arise in the Fallopian tube epithelium. (lu.se)

Although the disease more commonly affects some of the more darkly pigmented ethnic groups-including people of Asian, Hispanic, Native American, and Middle Eastern ancestry-and is uncommon among whites, VKH syndrome is also rare among sub-Saharan Africans, suggesting that additional factors, other than skin pigmentation, are important in its pathogenesis. (aao.org)
Although a cause hasnt been determined, the disease strikes certain breeds, such as Maine Coons and Ragdolls, more commonly, suggesting a genetic predisposition. (catwatchnewsletter.com)
Sex (geldings more commonly) and age (1-6 years) predilection have been proposed but recent studies suggest that there is no significant breed, sex or age predisposition. (arabianlines.com)

Mediators of TMA syndromes overlap with those released in cytokine storm, suggesting close connections between ineffective immune responses to SARS-CoV-2, severe pneumonia and life-threatening microangiopathy. (nature.com)
While initial descriptions and a response to corticosteroids led to a label of a "cytokine storm" ( 7 ) in severe disease cases, recent reports suggest that the abnormalities in host response may be more complex and nuanced ( 8 ). (medrxiv.org)

The clinic helps children and families who may have inherited genetic mutations that leave them at higher-than-normal risk of cancer. (stjude.org)
Genetic diseases are caused by chromosomal alterations or gene mutations. (vin.com)
Disease-causing mutations are heritable changes in the sequence of genomic DNA that alter the expression, structure, and function of the coded protein. (vin.com)
These molecular genetic changes include point mutations, deletions, and insertions in the DNA sequence that result in a missense or nonsense sequence with an altered codon sequence. (vin.com)

Observational studies suggest associations between extremes of sleep duration and myocardial infarction (MI), but the causal contribution of sleep to MI and its potential to mitigate genetic predisposition to coronary disease is unclear. (nih.gov)
He similarly raised the possibility that an inflammatory response to the frequent parasitic infections common to ancient Egyptians might predispose to coronary disease - in much the same way that immunocompromised HIV cases seem also predisposed to early coronary disease. (eurekalert.org)

Celiac disease is known to be associated with autoimmune diseases. (pediatriconcall.com)
This review aims to provide an assessment of the nature and extent of complement involvement in TMA associated with autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, and scleroderma renal crisis. (jrheum.org)
10 This review aims to provide an assessment of the nature and extent of complement involvement in the underlying pathophysiology of TMA associated with autoimmune diseases that will help to stratify patients for targeted therapy. (jrheum.org)

Induction of an active model of autoimmunity against type VII collagen in a hairless mouse strain (SKH1) revealed that regulatory T cells, which have been identified for their ability to inhibit the development of autoimmune diseases, do not inhibit the development of autoantibodies against the self-protein mouse-type VII collagen. (medscape.com)

10 This distinction is not absolute because genetic defects in complement proteins have been identified in secondary TMA. (jrheum.org)

however, it is believed to involve both genetic predisposition and environmental triggers. (myositissupportgroup.org)

Eosinophilic cystitis, a rare condition, can be associated with allergic and autoimmune diseases such as lupus, parasitic infection, and systemic peripheral eosinophilia, such as in idiopathic hypereosinophilic syndrome . (medscape.com)
HIV infection has been suggested as a potential trigger and there are several case reports of patients with HIV developing alopecia areata. (keratin.com)
Helicobacter pylori Infection Helicobacter pylori is a common gastric pathogen that causes gastritis, peptic ulcer disease, gastric adenocarcinoma, and low-grade gastric lymphoma. (msdmanuals.com)
This study shows that a booster injection of mRNA-1273 more than 6 months after completing the primary two-dose series is safe and elicited nAb titers that were statistically significantly higher than the peak titers detected after the primary vaccination series, suggesting that a booster dose of mRNA-1273 might result in increased vaccine effectiveness against infection and disease caused by SARS-CoV-2. (cdc.gov)
Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which enters human host cells via angiotensin-converting enzyme 2 (ACE2). (cdc.gov)
COVID-19 ranges from asymptomatic infection to severe disease, including respiratory failure and death, and has led to more than 5 million deaths worldwide since December 20195. (cdc.gov)
Host genetic factors have also been shown to modulate the risk of infection and disease severity9,10,11,12. (cdc.gov)
Although some MIS-C patients have typical manifestations, others appear to have substantial overlap with acute severe COVID-19 infection in other -- and other hyper inflammatory conditions such as Kawasaki disease and toxic shock syndrome. (cdc.gov)

Because this was an observational study and was not designed to assess causation, it is unclear whether a genetic predisposition to ADHD increases risk for Alzheimer's or just makes individuals more susceptible to damage caused by the disease. (medscape.com)
Our findings suggest that participants with higher genetic risk for ADHD may be more susceptible to the cognitive impairment associated with amyloid deposition," he added. (medscape.com)
Even those who lead a healthy lifestyle could be susceptible to flare-ups due to a genetic predisposition for the condition. (express.co.uk)

They tapped the Alzheimer's Disease Neuroimaging Initiative (ADNI), a longitudinal multicenter study, to identify 212 adults aged 55-90 years who had no cognitive impairment and who had not been clinically diagnosed with ADHD. (medscape.com)
The study examined 3138 samples from King's College London, Lund University and Alzheimer's Disease Neuroimaging Initiative, including people with no cognitive impairment, people with neurodegenerative disorders, people with Down syndrome and people with depression. (kcl.ac.uk)

Waterfowl may develop tumors in areas that are poorly feathered, suggesting an association with exposure to sunlight. (ivis.org)

The next wave of truly transformative therapeutics should aspire to provide a cure by selectively suppressing pathogenic autoantigen-specific immune responses while leaving the rest of the immune system intact to control infectious diseases and malignancies. (frontiersin.org)
However, many of the characteristic breed traits and common and rare genetic diseases seen in veterinary practice and disease predispositions, now recognized to have a heritable basis, have taken on an increasingly important role in veterinary medicine as many infectious diseases, nutritional deficiencies, and intoxications have been controlled. (vin.com)
Emerging Infectious Diseases is a publication of the U.S. Government. (cdc.gov)

More than 2,500 patients have been evaluated by clinic staff and close to 500 families with an underlying cancer predisposition have been identified. (stjude.org)
By comparing the complete genomes from cancerous and normal cells for about 800 patients, we have successfully pinpointed the genetic factors behind some of the toughest pediatric cancers. (stjude.org)
Their previous studies found that up to 10% of patients with EAC or Barrett's esophagus -- a precursor to EAC -- have a family member with the disease, suggesting a potential genetic predisposition. (sciencedaily.com)
Reports of widespread thromboses and disseminated intravascular coagulation (DIC) in patients with coronavirus disease 19 (COVID-19) have been rapidly increasing in number. (nature.com)
One picture is coming into better focus, however, which suggests that an immune-triggered, complement-mediated thrombotic microangiopathy (TMA) is surprisingly common in patients with coronavirus disease 19 (COVID-19). (nature.com)
A genetic predisposition for the development of the disease is further supported by the strong association with HLA-DR4 among Japanese patients and with HLA-DR1 or HLA-DR4 among Hispanic patients from southern California. (aao.org)
and in patients with other chronic rheumatologic diseases. (msdmanuals.com)
To understand the physiopathology, it is necessary to take into account genetic abnormalities, dermal barrier impairment, immune system disturbances and the increased susceptibility of DA patients to suffer from microbial infections. (pap.es)
Its frequency is raised and estimated to be about 1:40 among patients suffering from celiac disease. (pediatriconcall.com)
All patients were 15 years of age or more at onset of disease and were followed for a minimum of 17 years and a maximum of 38 years. (bmj.com)
Examination of the data by interval from onset to cancer and by actual age at development of cancer suggests that patients who develop colorectal cancer will do so in a distribution around 50 years of age independent of duration of disease in adult onset ulcerative colitis (greater than 15 years at onset of disease). (bmj.com)
It considers severe to healthy patients, or on the contrary it considers not serious deficiency to patients with AATD-related disease and finally one must take into account the psychological considerations of the patients. (archbronconeumol.org)
Lung cancer and obstructive pulmonary disease share multiple etiological factors, such as cigarette smoking, occupational inhalation hazards, and air pollution, and 50-70% of lung cancer patients present with co-existing COPD or airflow obstruction 6 . (nature.com)
In one study, approximately 20% of 181 serial Waldenström macroglobulinemia patients presenting to a tertiary referral had a first-degree relative with either Waldenström macroglobulinemia or another B-cell lymphoproliferative disease. (medscape.com)

This is an important limitation, and we would like to highlight that more work is needed to link clinically confirmed ADHD symptoms and the development of Alzheimer's disease dementia," Laffe said. (medscape.com)
Ten years previously, his brother died of a clinically similar disease without a confirmed diagnosis 9 days after YF vaccination. (cdc.gov)

Past research has revealed that Ötzi likely suffered from joint pain, Lyme disease and tooth decay, and computed tomography (CT) scanning revealed calcium buildups, a sign of atherosclerosis, in his arteries. (livescience.com)
Initially, the atherosclerosis was a bit of a surprise, because much research has linked heart disease to the couch-potato lifestyle and calorie-rich foods of the modern world, Zink said. (livescience.com)
But in recent research, as scientists conducted CT scans on mummies from the Aleutian Islands to ancient Egypt, they realized that heart disease and atherosclerosis were prevalent throughout antiquity , in people who had dramatically different diets and lifestyles, he said. (livescience.com)
We think of atherosclerosis as a disease of modern lifestyle, but it's clear that it also existed 3500 years ago. (eurekalert.org)
Our findings certainly call into question the perception of atherosclerosis as a modern disease. (eurekalert.org)

More research points to how gut microbiome changes have been linked with exacerbating inflammatory skin diseases such as eczema, psoriasis, and more. (express.co.uk)
As psoriasis is an inflammatory disease, people who have the condition would likely benefit from pro and prebiotics. (express.co.uk)
These therapies inhibit the proinflammatory action of TNF-α in common autoimmune diseases such as rheumatoid arthritis, psoriasis, ulcerative colitis, and Crohn's disease. (frontiersin.org)
Psoriasis is a chronic inflammatory disease driven by exaggerated production of pro-inflammatory cytokines and interleukins. (e-ijd.org)
Various genetic polymorphisms including IL-1 are implicated in pathogenesis of psoriasis. (e-ijd.org)
We aimed to study various genetic polymorphisms of IL-1 in psoriasis and their influence on NFκB and histopathological features. (e-ijd.org)
IL-1 genetic polymorphisms may not play a very direct role in pathogenesis of psoriasis. (e-ijd.org)
However, their interaction with NFκB appears to be a significant factor in this direction as NFκB is activated by pro-inflammatory genetic polymorphisms and therefore may influence the severity of psoriasis. (e-ijd.org)
Some diseases like psoriasis or rheumatoid arthritis affect certain people with certain identity tags. (papaa.org)
Psoriasis is a complex, chronic, multifactorial, inflammatory disease that involves hyperproliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate (see the image below). (medscape.com)

The study finds that a higher consumption of healthful plant-based foods can mitigate the risk of NAFLD, even in individuals with genetic susceptibility, while unhealthful plant-based foods increase the risk. (news-medical.net)

Genetic and environmental influences are involved in the pathogenesis. (medscape.com)

Chaitanya Thandra K, Barsouk A, Saginala K, Sukumar Aluru J, Rawla P, Barsouk A. Epidemiology of non-alcoholic fatty liver disease and risk of hepatocellular carcinoma progression. (termedia.pl)
The distribution of lesions and the epidemiology of sarcoids strongly suggest that flies are significant but how the fly and the virus are linked is another matter yet to be established. (arabianlines.com)
Archivos de Bronconeumologia is a scientific journal that preferentially publishes prospective original research articles whose content is based upon results dealing with several aspects of respiratory diseases such as epidemiology, pathophysiology, clinics, surgery, and basic investigation. (archbronconeumol.org)
Predicting disease and mitigating hazard in at-risk populations is an important aim of public health epidemiology, and in preparation for future waves of H1N1 , determining the correlates of disease severity is incredibly important," write Dr. Ryan Zarychanski, University of Manitoba and coauthors. (disabled-world.com)

Etiologies for the development of tumors include long-term exposure to ultraviolet ( UV ) light and a genetic predisposition. (ivis.org)
In pursuing its mandated responsibilities, the Agency for Toxic Substances and Disease Registry (ATSDR) must address public health concerns associated with exposure to carcinogens in the context of all available relevant information. (cdc.gov)
Prospective and longitudinal studies focusing on genetic polymorphisms, objective assessments, and environmental sampling are needed to further delineate the influence of agricultur e exposure in the adult worker. (cdc.gov)
OA, a disease that accounts for nearly 10% of all adult- exposure, suggesting that either exposure route may be onset asthma [2]. (cdc.gov)
Genetic polymorphism studies demonstrated that the can develop immediate, late or dual asthmatic reactions glutathione-S-transferase gene family is associated with after chemical exposure. (cdc.gov)

Epidermolysis bullosa acquisita is a chronic inflammatory disease with periods of partial remissions and exacerbations. (medscape.com)
Study selections: Studies chosen were published in or after 1999 that included adults and asthma and farm ing/ agricultur al work or agricultur al exposures and airway inflammatory disease measurements. (cdc.gov)

Epidermolysis bullosa acquisita (EBA) is a chronic autoimmune subepidermal blistering disease of the skin and mucus membranes. (medscape.com)
Immunization of type VII collagen in athymic nude SJL mice did not induce an autoimmune response, whereas the repletion of T cells from type VII collagen-immunized wild-type mice to the thymic mice showed autoantibody production and resulted in a blistering disease phenotype, supporting the role of T cells in the induction of epidermolysis bullosa acquisita. (medscape.com)

For example, Crohn disease can affect almost any part of the digestive tract, whereas ulcerative colitis almost always affects only the large intestine. (msdmanuals.com)
The tendency to run in families is much higher in Crohn disease than ulcerative colitis. (msdmanuals.com)
The symptoms of inflammatory bowel disease vary depending on which part of the intestine is affected and whether the person has Crohn disease or ulcerative colitis. (msdmanuals.com)

The study was conducted using a UK Biobank cohort of 455,405 participants aged 38 to 73 years who were selected based on the number of their genetic variants associated with asthma in. (ajmc.com)
In this study we comprehensively assess the shared genetic basis of impaired lung function and lung cancer risk by conducting genome-wide association analyses in the UK Biobank cohort to identify genetic determinants of three pulmonary phenotypes, forced expiratory volume in 1s (FEV 1 ), forced vital capacity (FVC), and FEV 1 /FVC. (nature.com)

Daily treatment of DPB with macrolide antibiotics such as erythromycin eases symptoms and increases survival time, but the disease currently has no known cure. (wikipedia.org)
She noted that some individuals who have a lower genetic risk score go on to develop ADHD, while some with a higher score never show symptoms. (medscape.com)
By doing so, the doctors of the future will identify diseases, and treat them, long before symptoms appear. (cdc.gov)
Chronic lung disease and subsequent respiratory symptoms. (bmj.com)
Research suggests that certain viral infections may play a role in triggering this autoimmune response, leading to the characteristic symptoms experienced by affected individuals. (myositissupportgroup.org)

The USPSTF relies on clear definitions of the populations that were studied to make recommendations for asymptomatic persons and to stratify recommendations for those who are at average or high risk for particular conditions (such as cardiovascular disease). (uspreventiveservicestaskforce.org)
As this frightening pandemic has spread rapidly throughout the world, the sometimes contradictory reports of its manifestations should be understood in the context of the heterogeneous populations that have been infected, and the immense spectrum of genetic predispositions, coexisting risk factors and pre-existing medications that can hinder cohesive understanding. (nature.com)
Recent attention has focused on genetic public of Iran and populations elsewhere. (who.int)

Life table analyses in extensive colitis gave cumulative risks of 7.2% (CI 3.6-10.8) at 20 years from onset of disease and 16.5% (CI 9.0-24.0) at 30 years from onset. (bmj.com)
An inverse relationship was shown between age at onset of disease and interval from onset of disease to cancer. (bmj.com)
Occupational disease onset of disease [5. (cdc.gov)

So, researchers found a proxy for ADHD: a polygenic risk score that represents the combined genetic likelihood of developing ADHD. (medscape.com)
For the first time, the investigation and identification of polygenic diseases is a realistic proposition. (vin.com)

The common genetic background and similarities in the HLA profile of affected Japanese and Korean individuals were considered in the search for a DPB gene. (wikipedia.org)
4,5) Celiac disease and autoimmune thyroid disease have similarities in pathogenesis. (pediatriconcall.com)
These two diseases have many similarities and sometimes are difficult to distinguish from each other. (msdmanuals.com)

It was suggested that a mutation of a suspected disease-susceptibility gene located somewhere between HLA-B and HLA-A had occurred on an ancestral chromosome carrying both HLA-B54 and HLA-A11. (wikipedia.org)

The aim of this review is to provide broad insight into the role of gut microbiome in the pathophysiology of these diseases. (portlandpress.com)

However, several factors are suspected to be involved with its pathogenesis (the way in which the disease works). (wikipedia.org)
Both genetic predisposition and environmental factors govern the onset of T1D and HT. (portlandpress.com)
Autoimmune thyroid diseases, including GD and Hashimoto's thyroiditis, are due to complex interactions between environmental and genetic factors. (pediatriconcall.com)
Despite the suggestion of a genetic, inflammatory or unknown effect, Drs Thomas and Allam were keen not to discount those risk factors for heart disease which we do know about. (eurekalert.org)
While this may superficially suggest that there is some heritable aspect of the disease it is very important to realize that there are other factors that need to be present for a particular animal to get the disease. (arabianlines.com)
These factors suggest that both cell and host factors are responsible in combination for the variety of forms. (arabianlines.com)
Current research supports that it is caused by a combination of a dysfunction of the immunological system and genetic factors. (rarediseases.org)
A possible role for genetic factors has been suggested by reports of familial clustering of Waldenström macroglobulinemia. (medscape.com)
Environmental, genetic, and immunologic factors appear to play a role. (medscape.com)
However, studies also suggest that agricultur al work and multiple types of livestock are independent risk factors for developing asthma. (cdc.gov)
predisposition to breast cancer [1,2] and on its association with factors relating to modern affluence, including diet and al- cohol consumption [3-5]. (who.int)

Along with DPB, additional forms of primary bronchiolitis include bronchiolitis obliterans, follicular bronchiolitis, respiratory bronchiolitis, mineral dust airway disease, and a number of others. (wikipedia.org)
These diseases are caused by the immune-mediated destruction of hormone-producing endocrine cells, pancreatic beta cells and thyroid follicular cells, respectively. (portlandpress.com)

At the same time, these effects were mostly observed in individuals with amyloid pathology at baseline, pointing to the genetic risk for ADHD as a susceptibility to damage caused by Alzheimer's," he added. (medscape.com)
While longitudinal profiling of individuals can detect subtle changes in health status and can allow initiation of disease-prevention strategies, the main problem is that "a great deal of work is still needed to determine what parameters should be monitored and how frequently this should occur for a meaningful longitudinal study. (cdc.gov)
Poor sleep quality was associated with increased risk of asthma , especially among individuals with high genetic risk, according to a new study. (ajmc.com)
Although this was a prospective study, and cannot conclude a causal relationship, the researchers of this study believe the results suggest how better sleep management may reduce asthma among individuals, regardless of their genetic predisposition for asthma. (ajmc.com)
By leveraging AI's ability to analyze genetic data, track and analyze health data, and provide personalized guidance through virtual health coaches and chatbots, individuals can receive tailored solutions to improve their overall well-being. (anyuakmedia.com)
Several genetic lines have known predisposition but individuals within those lines may not get sarcoids at all while others may be severely affected. (arabianlines.com)
2 This implies that not all AATD individuals will develop diseases, regardless of their genotypes, even if their plasmatic AAT levels are very low. (archbronconeumol.org)

Diisocyanates, highly reactive low asthma have demonstrated an immunological basis for the molecular weight chemicals, are the leading cause of disease. (cdc.gov)

Inflammatory bowel disease increases the risk of cancer in affected areas of the intestine. (msdmanuals.com)

It may be associated with other extra-intestinal manifestations and autoimmune diseases. (pediatriconcall.com)

Respiratory illness in families of preterm infants with chronic lung disease. (bmj.com)
AIMS--To examine the relation, based on two types of questionnaires, between (1) chronic lung disease of the newborn (CLDN) and lower respiratory illness (LRI) in siblings, and between (2) CLDN and asthma, chronic obstruction pulmonary disease (COPD), or allergy in parents and grandparents. (bmj.com)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in late 2019 in Wuhan, China, as the cause of what is now termed the coronavirus disease 2019 (COVID-19) that rapidly evolved into a global pandemic ( 1 , 2 ). (medrxiv.org)
Since we know that AATD is a genetic condition (and not a disease), which predisposes those who carry it to develop respiratory pathology in the form of emphysema and/or liver involvement in the form of cirrhosis mainly. (archbronconeumol.org)

Highlighting the importance of healthy sleep patterns in the risk of adult asthma under the combined effects of genetic susceptibility: a large-scale prospective cohort study of 455 405 participants. (ajmc.com)

We were very surprised that he had a very strong disposition for cardiovascular disease ," said study co-author Albert Zink, a paleopathologist at the Institute for Mummies and the Iceman at the European Academy of Bozen/Bolzano in Italy. (livescience.com)
In the new study, Zink and his colleagues found that Ötzi had several gene variants associated with cardiovascular disease, including one on the ninth chromosome that is strongly tied to heart troubles, the researchers reported today (July 30) in the journal Global Heart. (livescience.com)
First, that there is still some unknown risk factor for cardiovascular disease, or at least a missing link in our understanding of it. (eurekalert.org)

This potential suggests how a healthy sleep pattern may be beneficial in preventing and managing asthma, regardless of genetic predispositions. (ajmc.com)
In response, the researchers of this study aimed to examine the relationship between poor sleep patterns and increased asthma risk and if improved sleep could relieve the impact of genetic disposition. (ajmc.com)

A clonal disease of B lymphocytes, Waldenström macroglobulinemia is considered to be a lymphoplasmacytic lymphoma, as defined by the Revised European American Lymphoma Classification (REAL) and World Health Organization (WHO) classification. (medscape.com)

The molecular genetic defect is now known for ~60 hereditary disorders in dogs and ~20 in cats. (vin.com)

The disease affects all breeds of horse, mules, donkeys and zebra. (arabianlines.com)
Inflammatory bowel disease affects people of all ages but usually begins before age 30, typically from age 14 to 24. (msdmanuals.com)

Current knowledge suggests that behavioral patterns contribute more to premature death than genetic predisposition, social circumstances, environmental exposures, and health care errors. (uspreventiveservicestaskforce.org)

A genetic predisposition to attention-deficit/hyperactivity disorder (ADHD) may increase risk for cognitive decline and Alzheimer's disease, new research suggests. (medscape.com)
Investigators note that the study, which included more than 200 participants, is the first to show an association between genetic risk for ADHD and odds of developing late-onset Alzheimer's. (medscape.com)
We found that higher genetic risk for ADHD was associated with cognitive decline and development of Alzheimer's pathology, suggesting that it can increase the risk of developing AD," Leffa said. (medscape.com)
Commenting on the findings for Medscape Medical News, Heather Snyder, PhD, vice president of medical and scientific relations with the Alzheimer's Association, said it's important to note that study participants had genetic markers associated with ADHD risk but had not been diagnosed with ADHD. (medscape.com)
This study sought to investigate associations between sleep duration and incident MI, accounting for joint effects with other sleep traits and genetic risk of coronary artery disease, and to assess causality using Mendelian randomization (MR). (nih.gov)
9 h) sleep duration, and examined joint effects with sleep disturbance traits and a coronary artery disease genetic risk score. (nih.gov)
TNF-α blockade quickly became the "standard of care" for these autoimmune diseases due to their effectiveness in controlling disease and decreasing patient's adverse risk profiles compared to broad-spectrum immunosuppressive agents. (frontiersin.org)
However, anti-TNF-α therapies have limitations, including known adverse safety risk, loss of therapeutic efficacy due to drug resistance, and lack of efficacy in numerous autoimmune diseases, including multiple sclerosis. (frontiersin.org)
Whiteness awareness prompted one contributor to ask, "If 28 percent (about three times the current male risk of getting Alzheimer's disease) of U.S. men spent time in prison (instead of the 4 percent of white men who have this experience), would the ethics of correctional healthcare still be a shunned topic? (thenewatlantis.com)
Therefore, researchers are seeking genetic differences that affect the risk of developing this condition. (medlineplus.gov)
Host genetic variation partially drives the immune and biochemical responses to COVID-19 that lead to risk of mortality. (medrxiv.org)
For example, if someone has a genetic predisposition to heart disease, AI can suggest lifestyle changes such as diet and exercise to reduce the risk. (anyuakmedia.com)
They also suggest the increased risk for First Nations peoples may be because of substandard living conditions, low income, diet, additional health issues or lack of access to health care. (disabled-world.com)
Disentangling the role of pulmonary impairment in lung cancer development is important from an etiological perspective, for refining disease susceptibility mechanisms, and for informing precision prevention and risk stratification strategies. (nature.com)
Such studies they had a confirmed pathological primary are of interest because their different risk breast cancer diagnosis from the pathology profiles may help to explain the different department of Bandar Abbas Shahid Mo- occurrence of the disease in different popu- hammadi Hospital, the leading university- lations. (who.int)

In this study, which included all confirmed H1N1 cases in Manitoba, the authors found that longer intervals from symptom onset to eventual treatment with antivirals ( Tamiflu ) were strongly associated with more severe disease necessitating admission to an intensive care unit. (disabled-world.com)
Even though men's FHs improved more than women's, men with XLH remain shorter reflecting a more severe disease phenotype. (bvsalud.org)

Ultrasonography has become the standard modality for screening for moderate to severe fatty liver disease. (termedia.pl)
Is menopausal hormone therapy associated with non-alcoholic fatty liver disease? (news-medical.net)
The effects of menopausal hormone therapy on non-alcoholic fatty liver disease. (news-medical.net)
Dietary patterns, foods, and nutrients to ameliorate nonalcoholic fatty liver disease (NAFLD). (news-medical.net)

The findings suggest that specific lipid subclasses are crucial indicators and potential targets for treatment in human health and various diseases. (news-medical.net)

Anatomy6

Organisms6

Diseases56

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment41

Psychiatry and Psychology11

Phenomena and Processes72

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science6

Named Groups9

Health Care30

Geographicals7

Centers for Diseas2

Incidence9

Familial predisposition2

Genes10

Etiology5

Genetically4

Atopic2

Autoimmune disease6

Inflammation6

Clinical16

Interplay3

Genetics4

Evidence10

Commonly3

Cytokine storm2

Mutations4

Coronary Disease2

Associated with autoimmune diseases3

Development of autoimmune diseases1

Identified in second1

Environmental triggers1

Infection8

Susceptible3

Alzheimer's Disease Neuroimaging Initiative2

Poorly1

Infectious diseases3

Patients14

Clinically2

Atherosclerosis5

Psoriasis10

Mitigate1

Involved in the pathogenesis1

Epidemiology4

Exposure5

Inflammatory disease2

Epidermolysis2

Ulcerative colitis3

Biobank2

Symptoms5

Populations3

Onset of disease3

Polygenic2

Similarities3

Suspected disease-susceptibility1

Pathophysiology1

Factors11

Follicular2

Individuals7

Immunological1

Increases1

Manifestations1

Respiratory4

Adult1

Cardiovascular3

Asthma2

Lymphocytes1

Defect1

Affects2

Exposures1

Risk15

Severe disease2

Fatty liver disease4

Findings suggest1