• Male infertility refers to a sexually mature male's inability to impregnate a fertile female. (wikipedia.org)
  • Male infertility is commonly due to deficiencies in the semen, and semen quality is used as a surrogate measure of male fecundity. (wikipedia.org)
  • the ratio of DNA-confirmed versus DNA-rejected paternity tests around that age is in agreement with the notion of general male infertility above age 65-66. (wikipedia.org)
  • Factors relating to male infertility include: Antisperm antibodies (ASA) have been considered as infertility cause in around 10-30% of infertile couples. (wikipedia.org)
  • Chromosomal anomalies and genetic mutations account for nearly 10-15% of all male infertility cases. (wikipedia.org)
  • One of the most commonly known causes of infertility is Klinefelter syndrome, which affects one in 500-1000 newborn males. (wikipedia.org)
  • Y chromosomal infertility is a direct cause of male infertility due to its effects on sperm production, occurring in approximately one in 2000 males. (wikipedia.org)
  • This case of infertility occurs during the development of gametes in the male. (wikipedia.org)
  • Mumps Malaria Testicular cancer Defects in USP26 in some cases Acrosomal defects affecting egg penetration Idiopathic oligospermia - unexplained sperm deficiencies account for 30% of male infertility. (wikipedia.org)
  • STUDY QUESTION: We aim to develop, disseminate and implement a minimum data set, known as a core outcome set, for future male infertility research. (bvsalud.org)
  • WHAT IS KNOWN ALREADY: Research into male infertility can be challenging to design, conduct and report. (bvsalud.org)
  • Now, a bespoke core outcome set for male infertility is required to address the unique challenges pertinent to male infertility research. (bvsalud.org)
  • Possible core outcomes will be identified by undertaking a systematic review of randomized controlled trials evaluating potential treatments for male factor infertility. (bvsalud.org)
  • Males with this syndrome carry an extra X chromosome (XXY), meaning they have 47 chromosomes compared to the normal 46 in each cell. (wikipedia.org)
  • Where a normal healthy male will have both an X and a Y chromosome, affected males have genetic deletions in the Y chromosome. (wikipedia.org)
  • if a male is fathered by a man who also exhibited Y chromosome deletions then this trait will be passed down. (wikipedia.org)
  • In human, an array of four DAZ genes ( DAZ 1-4) is located in two clusters on the Y chromosome and mutations of these genes cause severe oligospermia or azospermia [ 1 ]. (ijbs.com)
  • ASA production are directed against surface antigens on sperm, which can interfere with sperm motility and transport through the female reproductive tract, inhibiting capacitation and acrosome reaction, impaired fertilization, influence on the implantation process, and impaired growth and development of the embryo. (wikipedia.org)
  • DAZ family proteins are located in the nucleus and/or in the cytoplasm of male and female germ cells at different developmental stages throughout the gametogenesis. (ijbs.com)
  • Combining with other proteins, DAZ family members play a crucial role in male and female gametogenesis conserved throughout the evolution. (ijbs.com)
  • We also encourage research into epigenetic mechanisms crucial in embryonic development, such as the establishment and maintenance of imprinting patterns, the role of methylation in gametogenesis, the implications of imprinting for assisted reproductive technologies (ART), and the reproductive determinants and consequences of X-inactivation (or the escape from X-inactivation). (nih.gov)
  • We also encourage research into epigenetic mechanisms critical to reproduction, especially areas such as the establishment and maintenance of methylation patterns or imprinted loci in the early embryo, the timing, mechanisms and role of genomic methylation in gametogenesis, the effects of assisted reproductive therapy (ART) on imprinting and genomic methylation, and the reproductive determinants and consequences of X-chromosome inactivation. (nih.gov)
  • ASA production are directed against surface antigens on sperm, which can interfere with sperm motility and transport through the female reproductive tract, inhibiting capacitation and acrosome reaction, impaired fertilization, influence on the implantation process, and impaired growth and development of the embryo. (wikipedia.org)
  • Following meta-analysis, the SMD summary measure with 95% CI for each semen parameter included a concentration of 0.22 (0 0.22); Total sperm count of 0.11 (0.18 0.24);Total motility of 0.02 (0.05 0.09); Volume of 0.02 ( 0.1 0.14); Vitality of 0.55 ( 0.19 0.29), progressive motility of 0.43 ( 0.54 to 0.32); Total motile sperm count of 0.38 ( 0.44 to 0.31); And normal morphology of 0.42 ( 0.54 to 0.3). (bvsalud.org)
  • In brief, the total sperm count was slightly increased post-vaccination, while progressive motility, total motile sperm count, and normal morphology were marginally reduced post-vaccination, according to the meta- analysis. (bvsalud.org)
  • For example, sAC is integral to successful male fertility: sAC activation is required for sperm motility and ability to undergo the acrosome reaction, two processes central to oocyte fertilization. (bvsalud.org)
  • Prenatal BPS exposure reduces sperm motility mediated via impaired PI3K-AKT signaling and increases testicular TEX11 expression in the offspring. (bvsalud.org)
  • Versatile action of picomolar gradients of progesterone on different sperm subpopulations [2] "High step concentrations of progesterone may stimulate various sperm physiological processes, such as priming and the acrosome reaction. (edu.au)
  • The results suggest a versatile role of the gradual distribution of very low doses of progesterone, which selectively stimulate the priming and the acrosome reaction in different sperm subpopulations. (edu.au)
  • However, concerns have been raised that the vaccines could have an adverse effect on sperm function and overall reproductive health. (bvsalud.org)
  • However, little is known about the fetal exposure to BPS compared with BPA and its effects on the reproductive system in the adult male offspring. (bvsalud.org)
  • Exposure of the fetus to BPS interferes developmental programming of the male reproductive system in the offspring. (bvsalud.org)
  • BPS could be an equally potent endocrine disruptor affecting male reproductive functions. (bvsalud.org)
  • Acrosin is essential for sperm penetration through the zona pellucida in hamsters PNAS February 4, 2020 117 (5) 2513-2518 "Mammalian oocytes are surrounded by the zona pellucida , a glycoprotein coat that protects the oocyte and embryo from mechanical damage during their preimplantation development within the oviduct. (edu.au)
  • We thus demonstrated that, at least in hamsters, acrosin is essential for sperm penetration through the zona. (edu.au)
  • Fertilization is the fusion of haploid gametes, egg and sperm, to form the diploid zygote. (edu.au)
  • Juno is the egg Izumo receptor and is essential for mammalian fertilization [3] "Fertilization occurs when sperm and egg recognize each other and fuse to form a new, genetically distinct organism. (edu.au)
  • Here, we investigated the effects of orally administered BPS and BPA (0.4, 4.0, 40.0 µg/kg bw/d) during gestation (gD4-21) on testicular development by evaluating the sperm DNA damage & methylation and testicular functions in the 90 d Wistar rats. (bvsalud.org)
  • Males with this syndrome carry an extra X chromosome (XXY), meaning they have 47 chromosomes compared to the normal 46 in each cell. (wikipedia.org)
  • Where a normal healthy male will have both an X and a Y chromosome, affected males have genetic deletions in the Y chromosome. (wikipedia.org)
  • It is present in 15% of normal men and in about 40% of infertile men. (wikipedia.org)
  • More recently, advance sperm analyses that examine intracellular sperm components are being developed. (wikipedia.org)
  • The process of fertilization involves components of, and signaling between, both sperm ( spermatozoa ) and egg ( oocyte ). (edu.au)
  • DNA was isolated from sperm samples and promoter methylation was assessed using direct. (nih.gov)
  • Methods: A systematic PubMed, Scopus, Google Scholar, Science Direct, LILACS (Literatura Latinoamericana y del Caribe en Ciencias de la Salud), and Scilit database literature search until mid-June 2022 was conducted. (bvsalud.org)
  • Men with this condition may exhibit azoospermia (no sperm production), oligozoospermia (small number of sperm production), or they may produce abnormally shaped sperm (teratozoospermia). (wikipedia.org)
  • Pharmacologic evaluation of existing sAC inhibitors for utility as on-demand, nonhormonal male contraceptives suggested that both high intrinsic potency, fast on and slow dissociation rates are essential design elements for successful male contraceptive applications. (bvsalud.org)
  • Sperm proteases were thought to work as zona lysins, but gene-knockout studies in mice did not support this assumption. (edu.au)
  • The total number of men included was 1551, aged 22.4 48 years. (bvsalud.org)
  • Risk factors for the formation of antisperm antibodies in men include the breakdown of the blood‑testis barrier, trauma and surgery, orchitis, varicocele, infections, prostatitis, testicular cancer, failure of immunosuppression and unprotected receptive anal or oral sex with men. (wikipedia.org)