• amino acid
  • In order to understand the preference of residues or motifs in these epitopes, we computed and compared amino acid and dipeptide composition of IgG, IgE, IgA inducing epitopes and non-B-cell epitopes. (biomedcentral.com)
  • Based on these observations, we developed models for predicting antibody class-specific B-cell epitopes using various features like amino acid composition, dipeptide composition, and binary profiles. (biomedcentral.com)
  • An alpha-sheet amyloid intermediate is suggested to explain some anomalous features of the amyloid fibrillization process, such as the evident amino acid sequence dependence of amyloidogenesis despite the belief that the amyloid fold is mainly stabilized by the protein backbone. (wikipedia.org)
  • But since ACE is a dipeptide carboxypeptidase, unlike carboxypeptidase A, the distance between the cationic carboxyl-binding site and the zinc atom should be greater, by approximately the length of one amino acid residue. (wikipedia.org)
  • fragment
  • Also the backbone side-chain hydrogen-bonding within the same dipeptide fragment in proteins is less favoured than hydrogen-bonding between side chain and water and between side chain and atoms of other residues. (biochemj.org)
  • Concentration
  • We suggest stress granules are formed by a summation of protein-protein and RNA-RNA interactions, with RNA self-assembly likely to contribute to other RNP assemblies wherever there is a high local concentration of RNA. (pnas.org)
  • Nanostructures can be made by dissolving dipeptides in 1,1,1,3,3, 3-hexafluoro-2-propanol at 100 mg/ml and then diluting it with water for a concentration of less than 2 mg/ml. (wikipedia.org)
  • specifically
  • More specifically, the umami taste found in BMP is generated by the combination of lysine at the N-terminus and the acidic amino acids (Asp-Glu-Glu) in the midsection of the peptide, which suggests that cations and anions play a role in the stimulation of taste receptors to produce the umami taste. (wikipedia.org)
  • mechanism
  • However, biochemical and structural analyses of aminopeptidase (APPro), methionine aminopeptidase (MetAP), and prolidase, all members of the "pita-bread" metalloenzymes, suggest that they share a common mechanism scheme. (wikipedia.org)
  • Analysis showed that transformants that were able to utilize methanol effectively generally yielded higher BMP production, which suggests a relationship between the regulatory mechanism of BMP and methanol. (wikipedia.org)
  • clinical
  • Positive clinical results were suggested to result from rapid and effective DNA-crosslinking following uptake in neoplastic cells, but also from antimetabolic properties of the drug. (diva-portal.org)
  • Our recent pilot data show that GLN dipeptide-supplemented PN decreases nosocomial infections and improves clinical outcomes in SICU patients. (clinicaltrials.gov)
  • Neurofeedback has been suggested as a treatment for temporal lobe epilepsy, and theoretically acts to reduce inappropriate delta wave intrusion, although there has been limited clinical research in this area. (wikipedia.org)
  • different
  • Aminopeptidase N is frequently overexpressed in tumors and has been associated with the growth of different human cancers suggesting it as a suitable target for anti-cancerous therapy. (wikipedia.org)
  • show
  • Furthermore, we show that pathogenic dipeptides increase the propensity of RNA to assemble. (pnas.org)
  • 5. Results show that, within the present experimental conditions, the intravenous administration of dipeptides is as effective as that of the corresponding free amino acids in enriching the tissue pools of amino acids. (clinsci.org)
  • human
  • Dipeptides of glycine and leucine are major components of porcine placenta extracts (PPE) that has been used as an alternative of human placenta extracts. (biomolther.org)
  • strong enough
  • It has excellent stability and is readily soluble in aqueous solutions GLUTAMEAn™ works by providing you a 100% stable dipeptide chemical structure which is strong enough to be mixed in water or other beverages without any degradation or loss to the chemical structure, so your body has to absorb it as is, period! (nutraplanet.com)
  • results
  • These results suggest that the major dipeptides of porcine placenta, Gly-Leu and Leu-Gly, are potentially active ingredients for skin moisturization formulations. (biomolther.org)
  • When Pauling and Corey first proposed the alpha sheet, they suggested that it agreed well with fiber diffraction results from beta-keratin fibers. (wikipedia.org)
  • members
  • There are reports that TTR possesses HAT activity and suggest an evolutionary relationship between TTR and other GNAT members. (wikipedia.org)
  • Studies
  • 1. Studies were performed to investigate the metabolic fate of dipeptides when administered intravenously in rats. (clinsci.org)
  • Early studies suggested that the amino-4-guanidinobutane bound in the S3' subsite and the leucyl group in the S2' subsite, however published crystal structures of E-64 complexed with papain and actinidum indicated that E-64 binds via the S subsites. (wikipedia.org)
  • studies suggest that many transcripts of this gene family may be non-functional or represent pseudogenes. (wikipedia.org)
  • evidence
  • however, some evidence from electron crystallography suggests that at least some amyloid fibrils contain "flat" sheets with only 1-2.5° of twist. (wikipedia.org)
  • No evidence suggests mifamurtide interacts with the studied chemotherapeutics, or with the cytochrome P450 system. (wikipedia.org)
  • found
  • Currently, microfossils within hydrothermal vent precipitates dated from 3.77 to 4.28 billion years old found in Quebec, Canada may be the oldest record of life on Earth, suggesting "an almost instantaneous emergence of life" after ocean formation 4.4 billion years ago. (wikipedia.org)
  • interact
  • These solvation maps suggest that the backbone polar atoms could interact with solvent molecules selectively, depending on the backbone conformation. (biochemj.org)
  • role
  • Position of the amino acids also play a role in taste intensity, as a Glu-Asp dipeptide registers at a threshold value of 3.14 mM, meaning it would need a higher amount of the compound in order for a person to register the umami taste. (wikipedia.org)
  • however
  • However, the authors suggest that these long filaments are unlikely to be physiologically relevant. (wikipedia.org)
  • However, there have been a number of discoveries that suggested the earliest appearance of life on Earth was even earlier. (wikipedia.org)
  • Early
  • The panspermia hypothesis alternatively suggests that microscopic life was distributed to the early Earth by space dust, meteoroids, asteroids and other small Solar System bodies and that life may exist throughout the Universe. (wikipedia.org)