Subunit rab gtp binding proteins. Medical search. Frequent questions

Ras superfamily GTPase activation and inactivation occur by canonical nucleotide exchange and GTP hydrolysis mechanisms. (elifesciences.org)
Despite conservation of active-site residues, the Ras-related Rab GTPase activation pathway differs from Ras and between different Rabs. (elifesciences.org)
The ancestral Rab GTPase Rab18 and both subunits of the Rab3GAP complex are mutated in the human neurological and developmental disorder Warburg Micro syndrome. (ox.ac.uk)
The GTPase Rab11 regulates endosomal protein trafficking and previous work has shown that loss of Rab11 caused intestinal inflammation and hyperplasia in mice and flies. (sdbonline.org)
Similar to other small G proteins, the guanine binding state of Rab3 proteins is regulated by guanine nucleotide exchange proteins or factors (GEPs or GEFs) and GTPase activating proteins (GAPs). (pancreapedia.org)
α subunit has GTPase activity. (nonstopneuron.com)
The subunit is similar to α subunit that is seen in heterotrimeric G proteins ⟶ has GTPase activity. (nonstopneuron.com)
At the Drosophila neuromuscular junction (NMJ), the small GTPase Rab3 controls the distribution of CAZ proteins across release sites, thereby regulating the efficacy of individual AZs. (eneuro.org)
Rho GTPase activating protein 35 [Sour. (gsea-msigdb.org)
Rab GTPases, key regulators of vesicular transport, hydrolyze GTP very slowly unless assisted by Rab GTPase-activating proteins (RabGAPs). (cipsm.de)
ARHGAP21 interacts with RhoA-GTP, and acts as a GAP to increase RhoA GTPase activity. (uth.edu)

The rab family of small, ras-like GTPases regulate membrane trafficking events in the secretory and endocytic pathways. (bl.uk)
These findings highlight plasticity in the activation mechanisms of closely related Rab GTPases. (elifesciences.org)
The Transport Protein Particle (TRAPP) complexes are highly conserved multisubunit complexes that act as nucleotide exchange factors (GEFs) for Rab GTPases. (cam.ac.uk)
We focus on the Rab GTPases that are master regulators of membrane trafficking. (stanford.edu)
Activating mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) cause Parkinson's disease and previously we showed that activated LRRK2 phosphorylates a subset of Rab GTPases (Steger et al. (stanford.edu)
Small G-proteins, monomeric GTPases, or the RAS (Rat sarcoma) superfamily are a large family of small guanine nucleotide-binding proteins with molecular weights ranging from 20 to 30 kDa [ 1 , 2 ]. (oncotarget.com)

For membrane proteins, a third mechanism, based on the interaction of their transmembrane domain (TMD) with lipid microdomains, must also be considered. (biologists.com)
In this Commentary, I review evidence in favor of the idea that partitioning of TMDs into bilayer domains that are endowed with distinct physico-chemical properties plays a pivotal role in the transport of membrane proteins within the early secretory pathway. (biologists.com)
The combination of such self-organizational phenomena with canonical intermolecular interactions is most likely to control the release of membrane proteins from the ER into the secretory pathway. (biologists.com)

Members of the RAB family of RAS-related GTP-binding proteins are important regulators of vesicular transport and are located in specific intracellular compartments. (wikipedia.org)
The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport. (lookformedical.com)
Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS, which move molecules across membranes, by the mode in which the molecules are transported. (lookformedical.com)

Gao S, Yu R, Zhou X. (2016) The Role of Geranylgeranyltransferase I-Mediated Protein Prenylation in the Brain. (guidetopharmacology.org)
Other key interactions include RAC1 (By similarity), NTRK1/TRKA (By similarity), C9orf72 (By similarity), CHM (the substrate-binding subunit of the Rab geranylgeranyltransferase complex), and RILP, as well as PSMA7, RNF115 and FYCO1. (wikipedia.org)
There are three different protein prenyltransferases in humans: farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) share the same motif (the CaaX box) around the cysteine in their substrates, and are thus called CaaX prenyltransferases, whereas geranylgeranyltransferase 2 (GGT2, also called Rab geranylgeranyltransferase) recognizes a different motif and is thus called a non-CaaX prenyltransferase [ 1 ]. (biomedcentral.com)

Secretory proteins exit the endoplasmic reticulum (ER) in coat protein complex II (COPII)-coated vesicles and then progress through the Golgi complex before delivery to their final destination. (biologists.com)

Proteins called guanine nucleotide exchange factors, or GEFs for short, activate the Rab protein by promoting the release of GDP and the binding of GTP. (elifesciences.org)
These include four regions participating in guanine nucleotide binding, and effector region corresponding to the effector region in Ras, and a CXC prenylation motif at the C-terminal (45). (pancreapedia.org)
As the Drosophila homologue of mammalian DENN/MADD and Caenorhabditis elegans AEX-3, Rab3-GEF is a guanine nucleotide exchange factor (GEF) for Rab3 that stimulates GDP to GTP exchange. (eneuro.org)

Through a cycle of GTP binding and hydrolysis, rab-effector proteins are recruited to membrane sub-domains in a temporally and spatially specific manner. (bl.uk)
They associate with microtubule bundles (MICROTUBULES) and are believed to produce mechanical force via a process linked to GTP hydrolysis. (lookformedical.com)

The structure of the Rabs changes upon binding GTP and mutant Rab3 species have been described similar to Ras that are locked into active and inactive configurations (6). (pancreapedia.org)
Rab3 GEP is identical to the human DENN/MADD protein and contains a death domain which can bind the TNFR1 (15). (pancreapedia.org)
The second Rab3 GEF, known as GRAB, interacts with inositol hexakisphosphate kinase and Rab3A and its protein expression is primarily in brain (41). (pancreapedia.org)
There is no known specific Rab3 GDI, but rather a common family of Rab GDI isoforms which bind prenylated Rabs in the cytoplasm and participates in insertion and removal from membranes (75). (pancreapedia.org)
Here we identify Rab3-GEF as a second protein that acts in conjunction with Rab3 to control AZ protein composition. (eneuro.org)
A transgenically expressed GTP-locked variant of Rab3 accumulates at the NMJ at wild-type levels and fully rescues the rab3 mutant but is unable to rescue the rab3-GEF mutant. (eneuro.org)
Our results suggest that although Rab3-GEF acts upstream of Rab3 to control Rab3 localization and likely GTP-binding, it also acts downstream to regulate CAZ development, potentially as a Rab3 effector at the synapse. (eneuro.org)
We show here that Rab3-GEF is required for controlling the protein composition of release sites in the Drosophila neuromuscular junction (NMJ). (eneuro.org)
Our results indicate that loss of Rab3-GEF results in the development of NMJs that are structurally and functionally indistinguishable from NMJs that lack the protein Rab3. (eneuro.org)
Our studies reveal that Rab3 and Rab3-GEF act within the same molecular mechanism and support a model wherein Rab3-GEF serves as a Rab3 effector to control active zone protein composition. (eneuro.org)

The process of endocytosis works by folding the cell membrane around a substance outside of the cell (for example a protein) and then forms a vesicle. (wikipedia.org)
The present study unravels a new molecular system for vesicle-based axonal transport of proteins in male and female flies (Drosophila melanogaster). (sdbonline.org)
Proteins that regulate vesicle exocytosis cluster at AZs, composing the cytomatrix at the active zone (CAZ). (eneuro.org)
The vesicle-inducing protein in plastids 1 (Vipp1) is an essential component for thylakoid biogenesis in cyanobacteria and chloroplasts. (cipsm.de)
The coat on the budding vesicle comprises two layers, an inner layer of adaptor proteins (gray ovals) and an outer layer that forms a polyhedral cage. (biologists.com)
A family of high molecular weight GTP phosphohydrolases that play a direct role in vesicle transport. (lookformedical.com)

RILP plays the role of a downstream effector for Rab7 and together both of these proteins act to regulate late endocytic traffic. (wikipedia.org)
Rab40c is a SOCS box-containing protein which binds Cullin5 to form a ubiquitin E3 ligase complex (Rab40c/CRL5) to regulate protein ubiquitylation. (life-science-alliance.org)
Although it did not regulate Rab 2, Rab 5, Rab 10 or Rab 11, a recent study indicates it can act on Rab 27A and 27B (23). (pancreapedia.org)
The combination of growth factors and RTKs can activate the PI3K/AKT signaling pathway and negatively regulate TSC1/2, promoting Rheb to become GTP loaded, which can activate mTORC1. (biomedcentral.com)

The 70 or so members of the Rab subfamily of proteins perform a wide range of important tasks inside cells. (elifesciences.org)
The Rab subfamily of proteins is part of the large Ras superfamily, and all members of this superfamily are activated and inactivated in a similar way, with the binding and unbinding of GDP and GTP taking place at a structure called the G-domain. (elifesciences.org)
ATP binding cassette subfamily D membe. (gsea-msigdb.org)
A constitutively expressed subfamily of the HSP70 heat-shock proteins. (lookformedical.com)

In our lab, we use techniques of protein co-expression in bacteria, insect cells and mammalian cells to produce large multi-subunit IFT complexes for structural and biochemical studies. (au.dk)
The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found. (lookformedical.com)

A search for novel effectors of the trans-Golgi-localised rab protein, rab6, was also made, revealing specific interactions with the dynactin subunit p150glued and the dynactin/dynein accessory proteins BicD1 and BicD2. (bl.uk)
dynactin subunit 1 [Source:HGNC Symbol. (gsea-msigdb.org)

Both complexes share a core of small subunits that form the active site for the exchange of GDP for GTP. (cam.ac.uk)
Combining these findings with functional experiments has allowed the proposal of mechanisms for how the specificity of each complex towards their cognate Rab is determined and for the arrangement of these large complexes on the membrane. (cam.ac.uk)
Our research group studies proteins and protein complexes responsible for such intracellular transport that organizes the inner life of eukaryotic cells. (au.dk)
So far, we have reconstituted IFT protein complexes of up to 15 subunits (Taschner, Weber et al. (au.dk)
We also determined the structures of factors involved in the IFT of large protein complexes known as Outer-Dynein-Arms (ODAs) required for the beating of motile cilia (Taschner et al. (au.dk)

Farnesyltransferase is a dimer, composed of an alpha and beta subunit and requires Mg 2+ and Zn 2+ ions as cofactors. (guidetopharmacology.org)

RAB7A directly interacts with Rubicon when RAB7A is bound to GTP. (wikipedia.org)
The GTP-bound form interacts with OSBPL1A and CLN3. (wikipedia.org)
Clathrin also interacts with cytoskeletal proteins. (lookformedical.com)

Crystal structures have revealed the organisation of the TRAPP core and the mechanism of Rab1 activation, whilst recent cryo-EM structures have unveiled the arrangement of the specific subunits around the core to form each complex. (cam.ac.uk)
In contrast, loss of the specific subunits of TRAPPII, another known Rab11-GEF, does not cause any defects on the eye development nor the transport of rhabdomere proteins, however, simultaneous loss of TRAPPII and Pcs shows severe defects on eye development. (sdbonline.org)

Conserved active-site residues in the Rab switch II region stabilising the nucleotide-free form differentiate these pathways. (elifesciences.org)

download of been proteins appears the architectural subunit of including acids within enzymes and represents the inhibitor gene conjugation SSA to intracellular families that initiate dramatically synaptic from those short at the thyroid beta. (erik-mill.de)
In the trans-Golgi network (TGN), phosphorylated lysosomal enzymes bind to M-6-P receptors, which direct the enzymes into clathrin-coated vesicles. (biomedcentral.com)

Furthermore, Rab1 switch II glutamine mutants refractory to activation by DrrA can be activated by TRAPP, showing that a single Rab can be activated by more than one mechanistically distinct GDP-release pathway. (elifesciences.org)
In addition, each TRAPP complex has distinct large subunits that determine the specificity of each complex towards its substrate Rab and are essential for activity in vivo. (cam.ac.uk)

Trimer of α, β and γ subunit is associated with the receptor. (nonstopneuron.com)
adhesion G protein-coupled receptor E5. (gsea-msigdb.org)

It is now known to have two subunits including a p130 catalytic subunit. (pancreapedia.org)

Each enzyme has two subunits. (biomedcentral.com)
Ran GTP benefits with differentiation, acquiring its enzyme. (evakoch.com)

The structure of the Golgi is maintained by a matrix of proteins, many of which have now been shown to be rab-effector proteins. (bl.uk)
This thesis focuses on Golgi-localised rab proteins and their effector proteins. (bl.uk)
Integrins function as adhesion receptors for extracellular ligands and transduce biochemical signals into the cell, through downstream effector proteins. (mechanobio.info)

The cis-Golgi-localised rab protein, rabl, is shown to interact with the Golgi matrix/golgins GM130 and p115 while rab2 binds GM130 as well as a novel tethering factor named golgin-45. (bl.uk)

This means that the indicated PPI was experimentally demonstrated using Arabidopsis thaliana proteins as model of study. (bioinfoguy.net)
The present study characterizes an inhibitor of endomembrane protein trafficking, TE1 (trafficking and endocytosis inhibitor 1/TENin1) that reduces gravitropic root bending in Arabidopsis thaliana seedlings. (portlandpress.com)

Monomeric G proteins. (nonstopneuron.com)
This study tested this hypothesis by determining the effect of the PCAIs on the levels of RAS and related monomeric G-proteins. (oncotarget.com)
These findings implicate the potential role of PCAIs as anticancer agents through their direct interaction with monomeric G-proteins. (oncotarget.com)

Together these proteins form a molecular switch that can be turned on and off. (elifesciences.org)
IFT protein assemblies serve as large adaptors that mediate the recognition of molecular motors and ciliary cargoes required to assemble and maintain functional cilia. (au.dk)
Given that the complete IFT complex has a molecular mass in the MDa range and is composed of up to 30 different protein subunits, the tasks of reconstitution and structure determination represent significant challenges. (au.dk)
The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. (stanford.edu)
Small heat shock proteins (sHsps) are molecular chaperones that prevent the aggregation of nonnative proteins. (cipsm.de)
however, only molecular models of large 50S subunits have been reported for archaea. (cipsm.de)

Several rab proteins localise to the Golgi apparatus, the organelle consisting of stacked, flattened, membrane-bound cisternae through which newly-synthesised proteins are transited and modified, and where proteins and lipids are sorted and packaged for transport to other subcellular destinations. (bl.uk)
A network of membrane compartments, located at the cytoplasmic side of the GOLGI APPARATUS, where proteins and lipids are sorted for transport to various locations in the cell or cell membrane. (lookformedical.com)

Ras-related protein Rab-7a is involved in endocytosis, which is a process that brings substances into a cell. (wikipedia.org)
other download history and gis epistemologies considerations and proteins have normally subsequent and mediate to explore to endocytosis and repair through tyrosine of the ERK and AKT being cells( increased in Parker et al, 2014). (erik-mill.de)

Substrates of the prenyltransferases include Ras, Rho, Rab, other Ras-related small GTP-binding proteins, G-protein γ-subunits, nuclear lamins, centromeric proteins and many proteins involved in visual signal transduction. (guidetopharmacology.org)

Ras-related protein Rab-7a is a protein that in humans is encoded by the RAB7A gene. (wikipedia.org)
the α subunit of FT and GGT1 is encoded by the same gene, FNTA (see Table 1 ). (biomedcentral.com)
Gene structures and chromosomal locations of human protein prenyltransferase subunit genes. (biomedcentral.com)
Due to independent gene duplications, all organisms possess two isoforms, Oxa1 and Oxa2 except gram-negative bacteria, which encode only for one YidC-like protein. (cipsm.de)
allows binding of transcription factors on outer DNA helix gene silencing (NO TRANSCRIPTION)! (freezingblue.com)
So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. (wikidoc.org)

O-linked found in mucous fluids, but can also be present in membrane and secretory proteins, 3 or more sugars linked by N-acetylglalactosamine (GalNAc)--connected to serine, theronine. (freezingblue.com)

Rab proteins constitute the largest family of Ras-related small G proteins and play a role in regulating the specificity of membrane trafficking (63, 78). (pancreapedia.org)

In relation to the causative association between oncogenic Ras proteins and cancer, farnesyltransferase has become an important mechanistic drug discovery target. (guidetopharmacology.org)

They act in both protein secretion and autophagy and have also been proposed to have a role in other processes such as cytokinesis and ciliogenesis. (cam.ac.uk)

Mechanistically, we found that Rab40c binds the protein phosphatase 6 (PP6) complex and ubiquitylates one of its subunits, ankyrin repeat domain 28 (ANKRD28), thus leading to its lysosomal degradation. (life-science-alliance.org)

Guanylate-binding protein 1 (EC 3.6.5. (evpedia.info)

Loss of Pcs impairs Rab11 localization on the trans-side of Golgi units and induces the cytoplasmic accumulation of post-Golgi vesicles bearing rhabdomere proteins, as observed in Rab11-deficiency. (sdbonline.org)
These proteins aggregate at presynaptic active zones (AZs) to form the cytomatrix at the active zone (CAZ), which controls the recruitment, docking, and priming of synaptic vesicles and enhances calcium channel accumulation ( Gundelfinger and Fejtova, 2012 ). (eneuro.org)
The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)
The outer surface of these vesicles is covered with a lattice-like network of the protein CLATHRIN. (lookformedical.com)
An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE. (lookformedical.com)
A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. (lookformedical.com)
The outer surface of these vesicles are covered with a lattice-like network of coat proteins, such as CLATHRIN, coat protein complex proteins, or CAVEOLINS. (lookformedical.com)
A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES. (lookformedical.com)

Disease-associated point mutations of conserved residues in either the Rab3GAP1 (T18P and E24V) or Rab3GAP2 (R426C) subunits result in loss of the Rab18 GEF and membrane-targeting activities. (ox.ac.uk)
Here we define the precise Rab29 binding region of the LRRK2 Armadillo domain between residues 360-450 and show that this domain, termed 'Site #1', can also bind additional LRRK2 substrates, Rab8A and Rab10. (stanford.edu)
These proteins share a core structure, the conserved G-box (GDP/GTP) binding domain, of approximately 170 residues [ 3 ]. (oncotarget.com)

Three different protein prenyltransferases (farnesyltransferase and geranylgeranyltransferases I and II) catalyze the attachment of prenyl lipid anchors 15 or 20 carbons long to the carboxyl termini of a variety of eukaryotic proteins. (biomedcentral.com)
The chromosomal locations and number of exons from protein prenyltransferase genes in the major eukaryotic model organisms are shown in Table 2 . (biomedcentral.com)

The α subunits of protein prenyltransferases consist of tetratricopeptide repeats and are part of the tetratricopeptide repeat superfamily [ 5 ], which also includes functionally diverse proteins involved in transcription, co-chaperoning, protein transport, cell-cycle control and phosphorylation. (biomedcentral.com)
2017). Moreover, Golgi-associated Rab29 can recruit LRRK2 to the surface of the Golgi and activate it there for both auto- and Rab substrate phosphorylation. (stanford.edu)
ITCH Phosphorylation p39 loss-of-function MAP2K1( visually activated as MEK1) is a single proneurotrophin and size concept binding that is and appears MAPK3( ERK1)( Ohren et al. (evakoch.com)

On extracellular side: Bind with a ligand. (nonstopneuron.com)
Each integrin heterodimer consists of an alpha (α) and a beta (β) subunit associated by noncovalent interactions forming an extracellular ligand-binding head, two multi-domain `legs', two single-pas s transmembrane helices and two short cytoplasmic tails. (mechanobio.info)
The α subunit leg consists of a thigh and 2 calf domains that support the ligand binding head formed by a β-propeller domain with 7 repeats forming the blades (shown as a cylinder in the figure below). (mechanobio.info)
Similar to αI, the contains βI domain contains a MIDAS site for ligand binding and additional regulatory site "adjacent to MIDAS" or ADMIDAS, inhibited by Ca2+ and activated by Mn2+ [3] for ligand binding. (mechanobio.info)
The βI domain binds ligand together with the β-propeller or with αI (if present) through MIDAS in a Mg2+ dependent fashion [6] at the interface in the headpiece. (mechanobio.info)
The axonemal site of NOTCH1 and the collagen Ligand-binding WD40 cell of 40kDa are different benefits of pumps in accumulation epithelial Endoplasmic development - T-ALL( Welcker and Clurman 2008). (evakoch.com)

Cargoes include both protein factors that are part of the ciliary backbone (known as the axoneme) as well as certain signaling factors such as G-protein coupled receptors (GPCRs) that function in the ciliary membrane to transfer extracellular information to the interior of the cell. (au.dk)
Integrins are proteins that function mechanically, by attaching the cell cytoskeleton to the extracellular matrix (ECM), and biochemically, by sensing whether adhesion has occurred. (mechanobio.info)
Extracellular neuritic plaques are deposits of differently sized small peptides called β-amyloid (Aβ) that are derived via sequential proteolytic cleavages of the β-amyloid precursor protein (APP) [ 6 ]. (biomedcentral.com)
The Aβ domain is unique to the APP protein, though the family shares several other conserved domains such as the E1 and E2 domains in the extracellular sequence. (biomedcentral.com)

Other proteins-known as GAPs-lead to the inactivation of the Rab protein. (elifesciences.org)

create a human Rab protein that cannot be activated by the GEF from the bacteria that cause Listeria, but can still be activated by its normal human GEF. (elifesciences.org)
Members of the Alb3/Oxa1/YidC protein family function as insertases in chloroplasts, mitochondria, and bacteria. (cipsm.de)
high bacteria are as proteins of pathway ATM rise, either as acids for greenhouse initiation or for the dehydrogenase of binding eIF2 disorders. (evakoch.com)

RAB7A functions as a key regulator in endo-lysosomal trafficking, governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positions, and endosome-lysosome transport through different protein-protein interaction cascades. (wikipedia.org)
Moreover, endosomal sorting complex required for transport (ESCRT)-related proteins and their transcripts are most abundant at early and mid-development. (nature.com)
RAB effector protein involved in melanosome transport. (lu.se)
Steps involved in the intraflagellar transport (IFT) of axonemal subunits such as tubulin are indicated. (au.dk)
A barrier at the base of the cilium separates the organelle from the cell body necessitating active transport of both soluble and membrane associated protein cargoes via IFT. (au.dk)
As an example of the recognition of a cargo destined for the axoneme by the IFT system, we determined the structure of the N-terminal domain of the protein IFT81, which demonstrated a well-conserved tubulin-binding domain that is required for the transport of ab-tubulin hetero-dimers to the tip of the cilium by IFT (Bhogaraju et al. (au.dk)
We also study the NPC1 protein that is essential for cholesterol transport in humans and can lead to Niemann Pick C disease when mutated. (stanford.edu)
opposed factor is and stimulates group of transport proteins to DNA DSBs( Beamish et al. (erik-mill.de)
The cytoskeleton is a highly dynamic network of filamentous proteins that enables the active transport of cellular cargo, transduces force, and when assembled into higher-order structures, forms the basis for motile cellular structures that promote cell movement. (mechanobio.info)
A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK. (lookformedical.com)

Prenylation creates a hydrophobic domain on protein tails which acts as a membrane anchor. (guidetopharmacology.org)
Binds MYO5a via its C-terminal coiled coil domain. (lu.se)
First is the disruption of enterocyte polarity based on staining of the FERM domain protein Coracle . (sdbonline.org)
Integrin α subunit domains: Top: Linear domain arrangement. (mechanobio.info)
The αI domain is present in some subtypes of the α subunit. (mechanobio.info)
The β subunit comprises of 4 cysteine-rich epidermal growth factor (EGF) repeats, a hybrid domain (split in sequence), an I-like domain (βI) and a plexin-sempahorin-integrin (PSI) domain. (mechanobio.info)

However, the exact functions of Rab40c remain to be determined, and what proteins are the targets of Rab40c-Cullin5-mediated ubiquitylation in mammalian cells are unknown. (life-science-alliance.org)

The experiments showed that different amino acids in the active site of the Rab protein are involved when the GEFs mediate the release of the GDP during the activation process. (elifesciences.org)
CCT, chaperonin containing TCP-1), uses a built-in lid to mediate protein folding in an enclosed central cavity. (cipsm.de)

Chloroplast-located proteins which are encoded by the nuclear genome have to be imported from the cytosol into the organelle in a post-translational manner. (cipsm.de)
Among these nuclear-encoded chloroplast proteins are the light-harvesting chlorophyll a/b-binding proteins (LHCPs). (cipsm.de)

2016) Protein prenylation: unique fats make their mark on biology. (guidetopharmacology.org)
Protein prenylation is the posttranslational attachment of either a farnesyl group or a geranylgeranyl group via a thioether linkage (-C-S-C-) to a cysteine at or near the carboxyl terminus of the protein. (biomedcentral.com)

Anatomy26

Organisms9

Chemicals and Drugs143

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes49

Disciplines and Occupations1

Information Science4

GTPase11

GTPases6

Membrane Proteins3

Vesicular transport3

Geranylgeranyltransferase3

Endoplasmic reticulum1

Guanine3

Hydrolysis2

Rab310

Vesicle6

Regulate4

Subfamily4

Multi-subunit2

Dynactin subunit2

Complexes5

Beta subunit1

Interacts3

Specific subunits2

Nucleotide1

Enzymes2

TRAPP2

Receptor2

Catalytic1

Enzyme2

Effector proteins3

Rab21

Arabidopsis2

Monomeric3

Molecular6

Lipids2

Endocytosis2

Signal transduction1

Gene6

Secretory proteins1

Small G proteins1

Oncogenic1

Autophagy1

Phosphatase1

Guanylate-binding1

Vesicles8

Residues3

Eukaryotic2

Phosphorylation3

Ligand6

Extracellular4

Inactivation1

Bacteria3

Transport10

Domain6

Mammalian1

Mediate2

Nuclear2

Prenylation2