AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Neoplasm ProteinsPancreatic NeoplasmsProtein SubunitsNeoplasmsMolecular Sequence DataNeoplasms, Cystic, Mucinous, and SerousAmino Acid SequenceMacromolecular SubstancesSkin NeoplasmsNeoplasms, Multiple PrimaryBase SequenceKidney NeoplasmsMutationNeoplasms, Second PrimaryThyroid NeoplasmsAdenocarcinoma, MucinousMyeloproliferative DisordersImmunohistochemistryDNA, NeoplasmLung NeoplasmsBinding SitesProtein BindingParotid NeoplasmsLiver NeoplasmsCystadenomaNeoplasms, Connective and Soft TissueEscherichia coliNeoplasms, Plasma CellCloning, MolecularAppendiceal NeoplasmsOvarian NeoplasmsCystadenoma, MucinousKineticsProton-Translocating ATPasesNeoplasms, ExperimentalEndocrine Gland NeoplasmsProtein ConformationGastrointestinal NeoplasmsMolecular WeightCarcinoma, Pancreatic DuctalSequence Homology, Amino AcidNeoplasms, Vascular TissueEye NeoplasmsNose NeoplasmsSalivary Gland NeoplasmsElectrophoresis, Polyacrylamide GelNeoplasms, Radiation-InducedRecombinant ProteinsAdenocarcinoma, PapillaryTesticular NeoplasmsCarcinoma, PapillaryNeoplasms, Glandular and EpithelialRNA, MessengerProtein Structure, TertiaryNeoplasms, Muscle TissueAdenomaCystadenocarcinoma, MucinousCell LineUterine NeoplasmsLymphomaModels, MolecularSoft Tissue NeoplasmsHematologic NeoplasmsNeoplasm StagingIntestinal NeoplasmsNeoplasms, Adnexal and Skin AppendageVascular NeoplasmsSweat Gland NeoplasmsBone NeoplasmsAntigens, NeoplasmPalatal NeoplasmsNeoplasms, Complex and MixedNeoplasm InvasivenessVaccines, SubunitSaccharomyces cerevisiaeColonic NeoplasmsMandibular NeoplasmsThymus NeoplasmsCystadenocarcinomaVacuolar Proton-Translocating ATPasesBile Duct NeoplasmsTumor Markers, BiologicalMutagenesis, Site-DirectedSplenic NeoplasmsHeart NeoplasmsCystadenoma, SerousPhosphorylationDog DiseasesMaxillary NeoplasmsGlycoprotein Hormones, alpha SubunitAnal Gland NeoplasmsNeoplasms, Germ Cell and EmbryonalBone Marrow NeoplasmsColorectal NeoplasmsRecombinant Fusion ProteinsNeoplasms, Adipose TissueSequence AlignmentMeningeal NeoplasmsDuodenal NeoplasmsAdrenal Cortex Neoplasms
KinaseHumansSignal transductionTranscription FactorsRegulatory subunitsMiceHypoxiaHeterotrimeric G proteiNeoplasticCarcinomaMalignantEncodesGenesRibosomal subunitKinasesBeta subunitSkin NeoplasmsCatalytic subunitsGeneticsDisordersUbiquitin ligaseApoptosisAntigensCellsAlphaMyeloproliferativeMonomericRegulationNovoProtomerFragments
Kinase12
  • The decrease in p27 Kip1 levels is the result of increased proteasome-dependent degradation, mediated and rate-limited by its specific ubiquitin ligase subunits S-phase kinase protein (Skp) 2 and cyclin-dependent kinase subunit (Cks) 1. (haifa.ac.il)
  • cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. (nih.gov)
  • The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. (nih.gov)
  • The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation. (ox.ac.uk)
  • DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a key component of the non-homologous end-joining (NHEJ) pathway, is involved in DNA double-strand break repair, immunocompetence, genomic integrity, and epidermal growth factor receptor signaling. (amegroups.org)
  • The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is the key component of the non-homologous end-joining (NHEJ) pathway for DNA double-strand break (DSB) repair and is required for cellular resistance to ionizing radiation (IR) ( 1 , 2 ). (amegroups.org)
  • The canonical IB kinase (IKK) complicated settings NF-B activation and it is made up of NEMO (IKK) regulatory and IKK and IKK kinase subunits (20,C22). (baxkyardgardener.com)
  • Calcitonin stimulated DNA synthesis of PC-3M cells in a dose-dependent fashion, and also stimulated adenylyl cyclase and protein kinase C activities. (unm.edu)
  • This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)
  • The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. (cancerindex.org)
  • This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)
  • Loss of expression of protein kinase a regulatory subunit 1 alpha in pigmented epithelioid melanocitoma but not in melanoma or other melanocytic lesions. (medigraphic.com)
Humans4
  • Guanine nucleotide-binding protein G(o) subunit alpha is a protein that in humans is encoded by the GNAO1 gene. (wikipedia.org)
  • In this work, we made use of the inducible SDHD-ESR mouse, a conditional mutant in the SdhD gene, which encodes the small subunit of MCII, and that acts as a tumor suppressor gene in humans. (ed.ac.uk)
  • Four different regulatory subunits and three catalytic subunits have been identified in humans. (nih.gov)
  • The B subunit portion of cholera toxin (CTB) is a safe and effective oral immunizing agent in humans, affording protection against both cholera and diarrhoea caused by enterotoxigenic Escherichia coli producing heat-labile toxin (LT) (Clemens et al. (curehunter.com)
Signal transduction2
Transcription Factors1
  • The adaptive cellular response to low oxygen tensions is mediated by the hypoxia-inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF-α and HIF-β subunits. (york.ac.uk)
Regulatory subunits3
  • cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. (nih.gov)
  • This gene encodes one of the regulatory subunits. (nih.gov)
  • In this study, we identify the zinc finger protein Zbtb18 as a transcriptional repressor that directly binds enhancer/promoter regions of genes encoding class I PI3K regulatory subunits, subsequently limiting their expression, dampening PI3K signaling and suppressing PC responses. (ox.ac.uk)
Mice1
  • Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice. (rush.edu)
Hypoxia6
  • Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Protein (TIP30). (cancerindex.org)
  • Using cDNA arrays and serial analysis of gene expression, we found that hypoxia induces up-regulation of BNIP3 and its homologue, Nip3-like protein X. Analysis of human carcinoma cell lines showed that they are hypoxically regulated in many tumor types, as well as in endothelial cells and macrophages. (ox.ac.uk)
  • Regulation was hypoxia inducible factor-1-dependent, and hypoxia inducible factor-1 expression was suppressed by von Hippel-Lindau protein in normoxic cells. (ox.ac.uk)
  • The von Hippel-Lindau tumour suppressor gene (VHL) targets hypoxia inducible factor (HIF)-alpha subunits for ubiquitin dependent proteolysis. (ox.ac.uk)
  • Genes newly defined as targets of the VHL/hypoxia pathway (conditionally downregulated by VHL in normoxic cells) include aminopeptidase A, collagen type V, alpha 1, cyclin G2, DEC1/Stra13, endothelin 1, low density lipoprotein receptor-related protein 1, MIC2/CD99, and transglutaminase 2. (ox.ac.uk)
  • Regulation occurs principally through the alpha subunits, which are stabilized and activated in hypoxia. (ox.ac.uk)
Heterotrimeric G protei1
  • The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. (curehunter.com)
Neoplastic1
  • Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm. (jefferson.edu)
Carcinoma4
  • Although Hürthle cell carcinoma was previously considered a variant of follicular cell neoplasms, which are generally less aggressive, the 2017 World Health Organization (WHO) classification of endocrine tumors reclassified it as a distinct entity. (medscape.com)
  • The availability of tools to interrogate the transcriptome and proteome, such as expression profiling, have identified a substantial library of products that could aid in distinguishing a well-differentiated pancreatic carcinoma from a benign pancreatic lesion.2 Many of these proteins can be detected immunohistochemically and are thus available to the practicing pathologist (Table 2).3 Some of these markers have been validated on biopsy specimens as well. (coek.info)
  • BACKGROUND: Loss of the cell-cycle inhibitory protein p27 Kip1 is associated with poor prognosis in colorectal carcinoma. (haifa.ac.il)
  • According to the World Health Organization (WHO), these neoplasms are considered a variant of follicular carcinoma of the thyroid and are referred to as follicular carcinoma, oxyphilic type. (medscape.com)
Malignant7
  • A benign neoplasm cannot be distinguished from a malignant neoplasm on the basis of cytologic analysis of a fine-needle aspiration (FNA) biopsy specimen. (medscape.com)
  • PANCREATIC DUCTAL ADENOCARCINOMA CLINICAL FEATURES Ductal adenocarcinoma of the pancreas is the most common malignant neoplasm of the pancreas. (coek.info)
  • A benign neoplasm cannot be distinguished from a malignant neoplasm on the basis of cytologic analysis of fine-needle aspiration (FNA) biopsy. (medscape.com)
  • Malignant melanoma with prominent pigment synthesis: animal type melanoma a clinical and histologycal study of six cases with a consideration of other melanocytic neoplasms with prominent pigment synthesis. (medigraphic.com)
  • By using in-depth mass spectrometry-based quantitative proteomics to monitor protein levels in a comprehensive and quantitative manner, our ongoing research aims at defining the fetal- and adult-specific proteomic programs that regulate normal and malignant hematopoiesis. (lu.se)
  • A dermatology work-up was initiated, and the síndrome de Sézary initial diagnosis of malignant T-cell neoplasm was confirmed. (bvsalud.org)
  • subtypes of cutaneous T-cell lymphoma, SS is a malignant neoplasm originating the most common of which are mycosis from T lymphocytes, which involves the fungoides and Sézary syndrome (SS). (bvsalud.org)
Encodes3
  • EZH2 encodes the catalytic subunit of the polycomb repressive complex 2 (PRC2), a histone-modifying enzyme. (medscape.com)
  • Loss-of-function mutations of ASXL1 , which encodes a protein that recruits the PRC2 complex to the histones, is a driver event in some cases of MDS/MPN. (medscape.com)
  • the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. (sergas.gal)
Genes3
  • Splicing factor mutations alter splicing in different ways and affect the expression of different genes involved in RNA splicing, protein synthesis, and mitochondrial function, suggesting common mechanisms of action in MDS. (medscape.com)
  • This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. (nih.gov)
  • Genes that suppress carcinogenesis have been classified as gatekeepers that regulate cellular proliferation and cell death and as caretakers that are primarily encode DNA repair proteins required for the maintenance of genome integrity ( 15 ). (amegroups.org)
Ribosomal subunit2
  • The SBDS protein promotes formation of the mature, translationally active 80S ribosome by cooperating with the GTPase EFL1 to catalyze the removal of EIF6 from the 60S ribosomal subunit. (nature.com)
  • In SDS cells, SBDS deficiency impairs eviction of EIF6 from the nascent 60S subunit, resulting in decreased ribosomal subunit joining and reduced translation efficiency 6 . (nature.com)
Kinases1
Beta subunit3
  • The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. (cancer-genetics.org)
  • The protein encoded by this gene represents the beta subunit and is a type I membrane protein. (cancer-genetics.org)
  • Role of the beta-subunit arginine/lysine finger in integrin heterodimer formation and function. (rush.edu)
Skin Neoplasms1
Catalytic subunits1
  • Since this treatment is known to induce the exchange of the three catalytic subunits of the proteasome to form the immunoproteasome, this result suggested that the processing of this MAGE-3 peptide required the immunoproteasome. (ox.ac.uk)
Genetics3
  • T his is a state-of-the-art review of the molecular genetics of pancreatic neoplasms. (coek.info)
  • INTRODUCTION Pancreatic cancer is the fourth leading cause of cancer death in both men and women in the United States.1 There have been significant advances in our understanding of the genetics of pancreatic neoplasms in the past 2 decades, as well as an explosion of information over the past 3 years, largely because of the availability of whole genome and exome sequencing technologies. (coek.info)
  • This article provides a state-of-the-art review of the molecular genetics of pancreatic neoplasms with a strong emphasis on the relevance of these findings for the practicing surgical pathologist. (coek.info)
Disorders1
  • Myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN) overlap syndromes-disorders that include features of both myelodysplastic syndrome (MDS) and myeloproliferative neoplasm (MPN)-are entities whose diagnosis and management have proved challenging. (medscape.com)
Ubiquitin ligase2
  • The anaphase-promoting complex or cyclosome with the subunit Cdh1 (APC/C(Cdh1)) is an E3 ubiquitin ligase involved in the control of the cell cycle. (ox.ac.uk)
  • We display here that this MCV MC159 proteins interacts using the NEMO subunit from the IKK complicated to avoid NEMO relationships using the cIAP1 E3 ubiquitin ligase. (baxkyardgardener.com)
Apoptosis2
  • Bcl2/adenovirus EIB 19kD-interacting protein 3 (BNIP3) is a cell death factor that is a member of the Bcl-2 proapoptotic family recently shown to induce necrosis rather than apoptosis. (ox.ac.uk)
  • To day, understanding of MCV immune system evasion strategies comes from the manifestation of specific MCV proteins impartial of contamination or during contamination having a surrogate computer virus, and these strategies consist of antagonism of apoptosis (8,C11), NF-B activation (12,C14), interferon regulatory element 3 (IRF3) activation (15), and chemokine (16) and interleukin-18 (IL-18) (17) activities. (baxkyardgardener.com)
Antigens1
Cells6
  • A Hürthle cell neoplasm is defined generally as an encapsulated thyroid lesion comprising at least 75% Hürthle cells. (medscape.com)
  • To test this model the induction of the HIF-1alpha subunit and the HIF target gene, glucose-transporter-1, was examined in a variety of mutant cells that lacked mitochondrial DNA (rho0) or had other genetic defects in mitochondrial respiration. (ox.ac.uk)
  • Role of stimulatory guanine nucleotide binding protein (GSalpha) in proliferation of PC-3M prostate cancer cells. (unm.edu)
  • Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. (jefferson.edu)
  • Altered G Protein Coupling in Olfactory Neuroepithelial Cells From Patients With Schizophrenia. (jefferson.edu)
  • Proteins are the machinery of the cell, responsible for executing the functions essential for cells to operate, survive, differentiate and divide. (lu.se)
Alpha6
  • Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. (wikipedia.org)
  • The HIF DNA binding complex consists of 2 basic-helix-loop-helix PAS proteins designated alpha and beta subunits. (ox.ac.uk)
  • GTP-Binding Protein alpha Subunits" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
  • The GTP-Binding protein alpha subunits are grouped into families according to the type of action they have on second messenger systems. (jefferson.edu)
  • This graph shows the total number of publications written about "GTP-Binding Protein alpha Subunits" by people in this website by year, and whether "GTP-Binding Protein alpha Subunits" was a major or minor topic of these publications. (jefferson.edu)
  • Below are the most recent publications written about "GTP-Binding Protein alpha Subunits" by people in Profiles. (jefferson.edu)
Myeloproliferative1
  • Recently, somatic mutations within SF1 were reported in patients with myelodysplastic syndromes, de novo acute myeloid leukemia and myeloproliferative neoplasms. (fapesp.br)
Monomeric1
  • One or more monomeric subunits may compose a protomer which itself is a subunit structure of a larger assembly. (rush.edu)
Regulation2
  • [ 2 ] Histones are proteins that both provide structural support for DNA (DNA wraps around a core of histones to form nucleosomes) and are involved in the regulation of gene expression. (medscape.com)
  • Short-term regulation of excitation-contraction coupling by the beta1a subunit in adult mouse skeletal muscle. (rush.edu)
Novo2
  • Post-transplant patients reportedly have a higher risk of de novo neoplasms. (bvsalud.org)
  • The choice of treatment, especially invasive treatment, for de novo neoplasms in transplant patients should consider their impaired immunity. (bvsalud.org)
Protomer1
  • It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. (curehunter.com)
Fragments1
  • The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. (curehunter.com)