Subtypes monocytes. Medical search. Frequent questions

Monocytes are further subdivided into dendritic cells and macrophages. (wikipedia.org)
Monocytes, macrophages, and neutrophils are phagocytic. (wikipedia.org)
Recent evidence implicates monocytes/macrophages in the etiopathology of cardiac fibrosis, but giving their heterogeneity and the antagonizing roles of macrophage subtypes in fibrosis, targeting these cells has been challenging. (nature.com)
By using single cell RNA sequencing analysis of immune cells in the same model, we establish the functional heterogeneity of macrophages and define an early pro-fibrogenic phase of NICM that is driven by Ccl5- expressing Ly6c high monocytes. (nature.com)
According to the classical model, it proposes a common myeloid progenitor (CMP) as the precursor of both monocytes/macrophages and DCs. (origene.com)
Monocytes are the largest type of white blood cell and can develop into macrophages that digest debris in our cells. (medicalxpress.com)
Tumor-associated macrophages (TAMs) are a well-known component of the inflammatory infiltrate in the tumor microenvironment, originating from monocytes. (researchsquare.com)
Immunomagnetically selected peripheral blood monocytes are cultured in RPMI 1640 Medium (Catalog #36750) + 10% FBS, M-CSF, and IL-4 for 5 days to generate macrophages. (stemcell.com)
In addition to circulation-derived monocytes, other non-microglial central nervous system (CNS) macrophage subtypes include border-associated meningeal, perivascular and choroid plexus macrophages. (elifesciences.org)
This can be circumvented by administering tamoxifen and then waiting for recombined circulating monocytes to be replaced by non-recombined monocytes from the bone marrow (~15-30 days), so that only resident macrophages (e.g. (elifesciences.org)
Among the host cells recruited into tumor microenvironments, several subtypes of myeloid cells, including macrophages, monocytes, dendritic cells, and granulocytes contribute to tumor development by providing tumor-promoting factors as well as a spectrum of molecules that suppress cytotoxic activities of T lymphocytes. (nih.gov)
Splenectomy decreased the numbers of circulating inflammatory Ly6C hi monocytes in blood, reduced the numbers of proinflammatory cardiac macrophages and significantly improved the post-MI LV function in Hmox1 −/− mice. (springer.com)
Dendritic cells (DCs), 4 monocytes/macrophages, and B cells have been identified as major professional APCs ( 1 , 2 ). (aai.org)
To quantify metabolic dynamics of macrophages within the TME, mouse macrophages or human monocytes (RAW264.7 or THP-1) were cultured alone or with breast cancer cells (mouse polyoma-middle T virus or primary human IDC) in 3D microfluidic platforms. (aacrjournals.org)
Human monocytes and mouse macrophages in tumor cocultures exhibited significantly different FAD mean lifetimes and greater migration than monocultures at 24, 48, and 72 hours postseeding. (aacrjournals.org)
Materials and Methods: We established four different macrophage subtypes through introduction of different culture conditions to THP-1- and U937-derived macrophages. (iiarjournals.org)

These broadest categories can be further divided into the five main types: neutrophils, eosinophils, basophils, lymphocytes, and monocytes. (wikipedia.org)
The other dichotomy is by lineage: Myeloid cells (neutrophils, monocytes, eosinophils and basophils) are distinguished from lymphoid cells (lymphocytes) by hematopoietic lineage (cellular differentiation lineage). (wikipedia.org)
Using a high-throughput mitochondrial phenotyping platform to quantify multiple mitochondrial features among molecularly defined immune cell subtypes, we quantify the natural variation in mitochondrial DNA copy number (mtDNAcn), citrate synthase, and respiratory chain enzymatic activities in human neutrophils, monocytes, B cells, and naïve and memory T lymphocyte subtypes. (nih.gov)
Objectives Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are autoimmune vasculitides associated with antineutrophil cytoplasm antibodies that target proteinase 3 (PR3) or myeloperoxidase (MPO) found within neutrophils and monocytes. (bmj.com)
In this study, we report results of genome-wide association studies (GWAS) and a replication study for the counts of the 5 main WBC subtypes (neutrophils, lymphocytes, monocytes, basophils, and eosinophils) using 14,792 Japanese subjects enrolled in the BioBank Japan Project. (figshare.com)
AAV patients displayed increased frequencies of intermediate monocytes, mature and newly released neutrophils, and an expanded population of CD177 + neutrophils compared to HC. (lu.se)
Paired data from 23 patients demonstrated that active disease was associated with an increased frequency of mature neutrophils and a decreased frequency of monocytes, in particular intermediate monocytes. (lu.se)
The white blood cells (leukocytes) are further divided into phagocytes or myeloid (neutrophils, eosinophils, basophils, monocytes) and immunocytes or lymphoid (lymphocytes). (medscape.com)
Flow cytometric estimation of the apoptotic marker CD95 in peripheral neutrophils, lymphocytes and monocytes was done for 18 infants with non-oedematous protein energy malnutrition (PEM) and 12 oedematous ones, on hospital admission and after supervised nutritional rehabilitation, and compared with 12 matched controls. (who.int)

DC subtypes had been further described by Compact disc11c+ (myeloid DC) or Compact disc123+ (plasmacytoid DC). (scienza-under-18.org)
Blood monocyte-derived DCs (B-DCs), as one group of myeloid DCs, can be generated by incubation of monocytes that are isolated from PBMCs with exogenous granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) for 6-7 days [ 3 ]. (biomedcentral.com)
Acute loss of nonclassical monocytes and myeloid DCs, especially CD1c+ DCs, was noted. (cdc.gov)

Unlike other immune cells, dendritic cells are not just a single entity, but a complex assortment of subtypes with varying functions. (origene.com)
These subtypes include conventional dendritic cells (cDC1 and cDC2), plasmacytoid dendritic cells (pDCs), monocyte-derived dendritic cells (moDCs), and Langerhans cells (LCs). (origene.com)
The maturation pathway involves several stages, with differentiating cells passing through a monocyte-like stage before fully maturing into dendritic cells. (origene.com)
In humans and mice, conventional dendritic cells are divided into two main subtypes: cDC1 and cDC2, each with distinct functions and markers [2]. (origene.com)
The objective of this study is to explore the long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) expression profiles of monocyte-derived dendritic cells (DCs) obtained from peripheral blood mononuclear cells (PBMCs). (frontiersin.org)
The cells are new classes of types of white blood cells called dendritic cells and monocytes. (medicalxpress.com)
Researchers have identified two new dendritic cell subtypes and two monocyte subtypes. (medicalxpress.com)
Divya Shah, from Wellcome's Infection and Immunobiology team, says: "Two important white blood cell types in our bodies help defend us from infection - dendritic cells and monocytes. (medicalxpress.com)
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors, Science (2017). (medicalxpress.com)

A tremendous shift from classical to intermediate monocytes was also confirmed in patients with CAD. (nih.gov)
alternate monocytes (Compact disc14?Compact disc16+) and intermediate monocytes. (scienza-under-18.org)
Relapsing MPA patients, on the other hand, showed decreased frequency of intermediate monocytes. (lu.se)
Finally, rituximab treatment was associated with increased frequencies of classical and intermediate monocytes. (lu.se)

granulocytes, lymphocytes and monocytes. (wikipedia.org)

Cell subtype-specific measures among women and men spanning four decades of life indicate potential age- and sex-related differences, including an age-related elevation in mtDNAcn, which are masked or blunted in mixed PBMCs. (nih.gov)
PBMCs include lymphocytes, monocytes, and DCs. (frontiersin.org)
PBMCs are divided into various functional subtypes with respect to the specific cytokine expression profiles, surface markers, and the transcription factors. (frontiersin.org)
Methods We stimulated purified monocytes and whole peripheral blood mononuclear cells (PBMCs) from patients with GPA, patients with MPA or healthy controls with PR3 or MPO and visualised MGC and granuloma-like structure formation using light, confocal and electron microscopy, as well as measuring the cell cytokine production. (bmj.com)
In the first phase of the project cell lines of specific leukocyte subsets (THP-1/monocyte, IM-9/T lymphocyte, H9/B lymphocyte), PBMCs (peripheral blood mononuclear cells) from healthy donors, respectively will be treated in vitro with hgh to identify candidate genes influenced by hghapplication. (wada-ama.org)
To this purpose cell lines of specific leukocyte subsets (THP-1/ monocyte, IM-9/ B- lymphocyte, H9/ T-lymphocyte) and PBMCs (peripheral blood mononuclear cells) from healthy donors, respectively were treated in vitro with hgh to identify candidate hgh-sensitive genes. (wada-ama.org)

In this study, we investigated granulocyte and monocyte subsets in a large cohort of AAV patients with emphasis on disease activity and tendency to relapse. (lu.se)

When compared existing libraries, the library identified by IDOL demonstrated significantly better overall discrimination of the entire immune cell landscape ( p = 0.038), and resulted in improved discrimination of 14 out of the 15 pairs of leukocyte subtypes. (biomedcentral.com)
0.99 and root mean square errors ( RMSE s) ranging from [0.97 % to 1.33 %] across leukocyte subtypes. (biomedcentral.com)
A-D) Evaluation from the indicated leukocyte subtypes in the baseline bloodstream sample from the individuals stratified according with their medical response. (scienza-under-18.org)
The percentages of the primary leukocyte subtypes (worth. (scienza-under-18.org)
The differences between your percentages of leukocyte subtypes between progressors and non-progressors had been compared utilizing a two-tailed College students check after Arcsin change of the info. (scienza-under-18.org)

CD14++CD16+, intermediate and CD14 + CD16++, non-classical monocytes). (nih.gov)
The absolute counts of classical monocytes divided in tertiles are predictive of major adverse cardiac events in patients with CAD. (nih.gov)
MPA patients differed from GPA patients in terms of lower frequency of classical monocytes. (lu.se)

Cerebrospinal fluid CD14 ++ CD16 + monocytes in HIV-1 subtype C compared with subtype B. (bvsalud.org)
The monocytes were subdivided into classical (CD14 ++CD16 -), intermediate (CD14 ++CD16 +), and nonclassical (CD14 -CD16 +) monocytes. (lu.se)

Here, we report a microfluidics-based, patient-specific 'GBM-on-a-Chip' microphysiological system to dissect the heterogeneity of immunosuppressive tumor microenvironments and optimize anti-PD-1 immunotherapy for different GBM subtypes. (elifesciences.org)
This study observed reduced breast cancer risk among women with comparatively high OPG concentrations, but given a small number of incident cases ( n = 76), risk by tumor subtypes (e.g., by estrogen (ER) and progesterone (PR) receptor status) was not investigated. (biomedcentral.com)

Our previous research has shown that purified peripheral blood monocytes (PRMo) from individuals who are diagnosed with autism spectrum disorders (ASDs) and have innate immune abnormalities reveal altered interleukin-1ß (IL-1ß)/IL-10 ratios. (frontiersin.org)
Monocyte, an element of the immune system, is a heterogeneous cell showing different responses to different stimuli. (researchsquare.com)
Our clinical and experimental analyses demonstrated that molecularly distinct GBM subtypes have distinct epigenetic and immune signatures that may lead to different immunosuppressive mechanisms. (elifesciences.org)
White blood cells (WBCs) mediate immune systems and consist of various subtypes with distinct roles. (figshare.com)
Elucidation of the mechanism that regulates the counts of the WBC subtypes would provide useful insights into both the etiology of the immune system and disease pathogenesis. (figshare.com)
Immune-related periodontitis subtypes were identified by the NMF algorithm. (researchsquare.com)
Two distinct immune-related periodontitis subtypes were identified and one is characterized by B cell reaction and the other is IL-6 cytokine reactions. (researchsquare.com)

[ 13 ] The hallmark finding in IgA pemphigus is autoantibodies binding to sites containing the monocyte/granulocyte IgA-Fc receptor (CD89), causing intraepidermal neutrophilic pustules. (medscape.com)

estimates the red cells' volume and sorts the WBCs into subtypes. (cdc.gov)

Fate-mapping and developmental analyses have revealed that microglia are derived from the embryonic yolk sac, unlike circulating monocytes, which are derived from the adult bone marrow. (elifesciences.org)
OPG binds RANKL as a decoy receptor, inhibiting the activation of RANK by RANKL and preventing the differentiation of bone marrow precursor (monocyte/macrophage) cells to osteoclasts - cells that are central in the process of bone resorption [ 2 ]. (biomedcentral.com)

The B7 + monocytes, which are composed of at least two distinct populations, expressed the MHC class II component gene. (aai.org)
To unravel the role of the distinct genetic features of lung cancer subtypes among patients, new research opportunities and technologies have arisen that might contribute to different therapeutic decisions [ 4 , 5 ]. (aging-us.com)

Among cardiac macrophage subtypes, WWP2 dysfunction primarily affects Ly6c high monocytes via modulating Ccl5, and consequentially macrophage infiltration and activation, which contributes to reduced myofibroblast trans -differentiation. (nature.com)
Consequently, a greater post-MI monocyte-derived myocardial macrophage infiltration was noted in Hmox1-deficient individuals. (springer.com)

Using beta subtype selective antagonists (atenolol (beta1) and butoxamine (beta2)), N-caffeoyltyramine was found to increase cAMP mainly via beta 2-adrenoceptor in U937 cells. (usda.gov)
Results In vitro, PR3 promoted monocyte-derived MGC formation using cells from patients with GPA but not from patients with MPA, and this was dependent on soluble interleukin 6 (IL-6), as well as monocyte MAC-1 and protease-activated receptor-2, found to be overexpressed in the cells of patients with GPA. (bmj.com)
THP-1 cells, a model system for monocytes, were least sensitive to the application of hgh due to the lack of insulin-like growth factor 1 (IGF-1) production. (wada-ama.org)
The total white blood cell count is expressed as an absolute number and is further divided into subtypes of white blood cells by a differential WBC count, which is expressed as a percentage and absolute number. (medscape.com)
RVFV-specific CD4 T cells were identified in the liver and spleen following infection and phenotyped as largely Th1 or Tfh subtypes. (cdc.gov)

We assessed phagocytic activity to understand subtype responses to typical macrophage activation factors (MAFs) and the activation mechanisms of serum MAF. (iiarjournals.org)

Given that the monocyte count at the time of diagnosis dynamically reflects the systemic inflammatory response to cancer, studies often measure monocyte count at the time of diagnosis in their patients. (researchsquare.com)
Then, 3-4 days later inflammatory monocytes are recruited into ischemic area of the heart. (springer.com)

We identify a pro-fibrogenic macrophage subtype in non-ischemic cardiomyopathy, and demonstrate that WWP2 is a key regulator of IRF7-mediated Ccl5/Ly6c high monocyte axis in heart fibrosis. (nature.com)
This was accompanied by higher numbers of Ly6C hi monocytes in peripheral blood, as well as higher expression of monocyte chemoattractant protein-1 and adhesion molecules in the hearts of MI-operated Hmox1 −/− mice. (springer.com)

ASD subgroup-specific associations were observed between serum miRNA expression and IL-1ß/IL-10 ratios, mitochondrial respiration, and monocyte cytokine profiles (IL-10, CCL2, and TNF-α). (frontiersin.org)

Subgroups of monocytes predict cardiovascular events in patients with coronary heart disease. (nih.gov)
We compared total numbers of monocyte subgroups stratified by tertiles with the occurrence of the pre-defined combined endpoint (non-fatal myocardial infarction, cardiovascular death and non-haemorrhagic cerebral insult). (nih.gov)
Gene targets of the altered miRNAs in the high and/or low IL-1β/IL-10 ratio ASD subgroups were enriched in pathways critical for monocyte functions and metabolic regulation. (frontiersin.org)

Recent studies have reported conflicting results regarding an association between subtypes of monocytes as defined by the expression of these two surface markers in atherosclerosis. (nih.gov)
Therefore, effects of N-caffeoyltyramine on monocyte activation markers were also investigated in this study. (usda.gov)

Acute tamoxifen administration in Cx3cr1-CreER mice also labels circulating monocytes, which can infiltrate the CNS in the context of injury or disease, thus complicating interpretation. (elifesciences.org)

On the other hand, it is known that the differentiation of monocytes into TAMs is in direct relationship with the severity of prognosis and clinical outcomes. (researchsquare.com)

Classical monocyte proliferation and CD38 upregulation on plasmacytoid DCs coincided with declining viral load. (cdc.gov)

Responses of the cell subtypes were highly different. (wada-ama.org)

The influence of white blood cell (WBC) subtype counts on HCC progression remains unclear. (biomedcentral.com)
Our present study attempted to use MR analysis to identify SNPs strongly related to blood WBC subtype counts to evaluate the causal association between WBC subtypes and HCC risk. (biomedcentral.com)

Our research studied the lncRNA and mRNA expression profiles of monocyte-derived DCs and demonstrated the functional networks that are involved in monocyte-derived DCs-mediated regulation in AR. (frontiersin.org)
These WBC subtype-related loci demonstrated a variety of patterns of pleiotropic associations within the WBC subtypes, or with total WBC count, platelet count, or red blood cell-related traits (n = 30,454), which suggests unique and common functional roles of these loci in the processes of hematopoiesis. (figshare.com)

This study should contribute to the understanding of the genetic backgrounds of the WBC subtypes and hematological traits. (figshare.com)

This study provides the first prospective data on OPG and breast cancer risk by hormone receptor subtype. (biomedcentral.com)

The aim of this study was to determine the role of Hmox1 in the monocyte/macrophage-mediated cardiac remodeling in a mouse model of MI. (springer.com)

The Receiver Operating Characteristics (ROC) curve analysis determined a cut-off value of 515/μL for the monocyte count assessed at the time of diagnosis. (researchsquare.com)

they can expand in response to injury through the recruitment of circulating monocytes from blood 14 . (nature.com)
The effect of monocyte count assessed in the blood samples taken at the time of diagnosis prior to the initiation of the treatment on disease-free survival was investigated. (researchsquare.com)
The three fugu B7s were expressed on the surface of blood monocytes. (aai.org)

The aim of this study was to evaluate the relationship between the monocyte count assessed at diagnosis and disease-free survival and prognosis in patients with esophageal cancer. (researchsquare.com)
In the present study, we aimed to investigate whether the monocyte count measured at the time of diagnosis can be used as a new prognostic biomarker in predicting disease-free survival in patients with esophageal cancer. (researchsquare.com)

Those with the A+β+ subtype lose their β-cell reserve over time and eventually require lifelong exogenous insulin therapy, whereas the majority of individuals with the A-β+ subgroup can discontinue exogenous insulin therapy and can be managed with oral hypoglycemic agents long term. (medscape.com)
Recently, next-generation sequencing, especially single-cell RNA sequencing is a possible option for the analysis of detailed cell population subtypes of LUAD from bulk tissue samples at single cell level [ 10 , 11 ]. (aging-us.com)

We investigated subtypes of monocytes in n = 994 patients with angiographically documented coronary artery disease (CAD). (nih.gov)
Disease-free survival was 17.3 months (95% CI: 8.4-26.2) in patients with a monocyte count ≥515/μL as opposed to 38.5 months (95% CI: 28. (researchsquare.com)
Our findings showed that monocyte count is a prognostic factor affecting disease-free survival in patients with esophageal cancer, regardless of histological subtype. (researchsquare.com)
In conclusion, AAV patients exhibit a skewing of different neutrophil and monocyte subpopulations that are associated with disease subtypes, disease activity, rituximab treatment, and propensity to relapse. (lu.se)

These results provided possible molecular mechanisms of monocyte-derived DCs in the immunoregulating function and laid the foundation for the molecular therapeutic targets of AR. (frontiersin.org)

We investigated the expression of PR3 binding partners on monocytes and tested the impact of their inhibition. (bmj.com)

[ 10 ] In addition to the SPD and IEN types, four disease subtypes have been described. (medscape.com)

Anatomy36

Organisms19

Diseases9

Chemicals and Drugs118

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes45

Disciplines and Occupations1

Information Science4

Health Care2

Macrophages16

Neutrophils9

Myeloid3

Dendritic9

Intermediate monocytes4

Lymphocytes and monocytes1

PBMCs6

Subsets1

Leukocyte subtypes5

Classical monocytes3

CD162

Tumor2

Immune7

Granulocyte1

WBCs1

Bone marrow2

Distinct2

Macrophage infiltration2

Cells5

Phagocytic1

Inflammatory2

Ly6c2

Cytokine1

Subgroups3

Markers2

Infiltrate1

Differentiation1

Plasmacytoid1

Responses1

Counts2

Functional2

Traits1

Receptor1

Cardiac1

Characteristics1

Blood3

Study2

Cell2

Patients4

Mechanisms1

Expression1

Disease1