Subtype heterogeneous tumors adenocarcinoma. Medical search. Frequent questions

Regardless of the therapeutic approach, the heterogeneity of pancreatic cancer cells and the complexity of its tumor microenvironment contribute to the emergence of drug resistance. (frontiersin.org)
It is considered that the proportional distribution of cells in peripheral blood count may reflect the severity of inflammation in the tumor microenvironment. (researchsquare.com)
The tumor microenvironment typically consists of host components including chronic inflammatory cells, stromal cells, growing vascular cells, and inflammatory infiltrate. (researchsquare.com)
Tumor-associated macrophages (TAMs) are a well-known component of the inflammatory infiltrate in the tumor microenvironment, originating from monocytes. (researchsquare.com)
Simple Summary: The poor prognosis outcome of patients with KRAS mutations (KRASmut) was correlated with an immunosuppressive tumor microenvironment (TME). (nanostring.com)
Wang H , Han G , Chen J , . Heterogeneity of tumor immune microenvironment in malignant and metastatic change in LUAD is revealed by single-cell RNA sequencing. (aging-us.com)
Plenty of research had reported that the tumor immune microenvironment (TIME) impacts cancer progression and metastases, as well as affects patient prognoses and outcomes [ 6 , 7 ], which emphasizes the important role of immune cells, vital components of the tumor microenvironment, impacting on patient survival and tumor progression [ 8 , 9 ]. (aging-us.com)
Cancerous tumors are complex mixtures of malignant and non-malignant cells shaping the tumor microenvironment (TME). (nature.com)
In addition, heterogeneity of the tumor microenvironment was explored, and distinct subtypes of immune cells and fibroblasts in PDAC were characterized. (biomedcentral.com)
Exploring highly expressed pathways in stromal components, such as fibroblasts, will delineate the underlying mechanisms that are pivotal for tumor microenvironment maintenance. (biomedcentral.com)
Stromal fibroblasts are a dominant but heterogenous population within the tumor microenvironment and therapeutic targeting of stromal subsets may have therapeutic utility. (elifesciences.org)
The plasticity and heterogeneity of fibroblasts in the tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) has emerged as a key factor in determining tumor growth and therapeutic response. (elifesciences.org)

These lesions are accessible through endoscopic/endobronchial ultrasound-guided or computed tomography-guided fine-needle aspiration cytology and represent a wide range of primary and metastatic tumors. (allenpress.com)
Tumors metastatic to mediastinal lymph nodes represent the most common mediastinal lesions and must be differentiated from primary lesions. (allenpress.com)
Significant parameters used in the determination of the prognosis and survival of esophageal cancer include tumor stage, surgical margin, and metastatic lymph node status. (researchsquare.com)
Clear cell renal carcinoma (CCRC) is a tumor with great metastatic capacity, although the presence of metastases in the thyroid gland is very uncommon. (scirp.org)
In a widely used mouse model of breast cancer, mammary gland-specific expression of the polyoma middle T (PyMT) oncoprotein under the control of the MMTV promoter/enhancer in transgenic mice (MMTV-PyMT) results in widespread transformation of the mammary epithelium and subsequent development of multifocal mammary adenocarcinomas and metastatic lesions in the lymph nodes and in the lungs [ 2 ]. (biomedcentral.com)
Metastasis-associated in colon cancer-1 (MACC1) was first identified as a transcriptional activator for proto-oncogene c-MET expression, and its overexpression is frequently associated with metastatic progression for multiply tumor types. (biomedcentral.com)
Metastasis-associated in colon cancer-1 (MACC1) was first identified to be overexpressed in primary and metastatic tumor specimens of colon cancer as compared to normal colon mucosa and was found to be indicative of metastasis as well as poor survival of the patients. (biomedcentral.com)
We are also interested in tumour heterogeneity and how this heterogeneity influences metastatic dissemination in lung cancer. (edu.au)
While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)
Most tumors metastatic to the serous membranes are of epithelial origin. (cytojournal.com)
Other rare non-epithelial malignancies that may be encountered in effusion cytology include neuroblastoma, Wilms tumor, and metastatic brain tumors. (cytojournal.com)
Nonfunctioning tumors usually are larger and present because of their size or metastatic spread. (medscape.com)
To identify operable lung cancer patients with risk for metastatic relapse we search for new prognostic biomarkers based on analysis of genome-wide gene expression data and conventional protein marker validation based on analysis of primary tumor tissue. (lu.se)

EAC comprises a heterogeneous group of tumors of varying etiology and morphology ( 10 - 12 ). (iiarjournals.org)
Epithelial ovarian cancer comprises a heterogeneous group of tumors. (nih.gov)

Genital warts, which are a form of benign tumor of epithelial cells, are also caused by various strains of HPV. (wikipedia.org)
Hepatocellular adenoma (HCA), or hepatic adenoma, is the third leading benign liver tumor and has bleeding and malignant transformation tendencies. (medscape.com)
Approximately 75%-80% of ovarian tumors are benign, occurring in patients under 40 years of age. (biomedcentral.com)
Benign epithelial tumors (adenoma and cystadenoma) are characterized by the absence of cell proliferation and invasion. (biomedcentral.com)
Benign and malignant smooth-muscle tumors of the esophagus in children account for fewer than 5% of all leiomyomas and leiomyosarcomas. (medscape.com)

Tumor formation and progression in these mice can be divided into four stages: hyperplasia, adenoma/mammary intra-epithelial neoplasia, early carcinoma, and late carcinoma [ 4 ] (we refer to all these four stages as tumor in this study). (biomedcentral.com)
It is mostly seen in obese women between 55 to 65 years old and is a well-differentiated tumor with relatively slow progression and a more favorable outcome 19 . (radiopaedia.org)
Metabolic reprogramming plays an important role in tumor progression and antitumor immunity. (medsci.org)
For instance, RUNX2 is involved in the progression of various tumor types, such as osteosarcoma, renal cell carcinoma, gastric cancer and breast cancer ( 15 - 20 ). (spandidos-publications.com)
Children with long-standing gastroesophageal reflux disease (GERD) are at risk for developing Barrett esophagus, dysplasia, and adenocarcinoma in a progression similar to that seen in adults. (medscape.com)

Objective: Most patients with pancreatic ductal adenocarcinoma (PDAC) will experience recurrence after resection. (nanostring.com)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. (huji.ac.il)
Two recent studies from Dr. Wenming Wu's group at the Department of General Surgery, Peking Union Medical College Hospital (PUMCH), applied single-cell RNA sequencing and whole-genome sequencing (WGS) to delineate heterogeneity of pancreatic tumors, including pancreatic ductal adenocarcinoma (PDAC) and pancreatic neuroendocrine tumor (PanNET). (biomedcentral.com)
Pancreatic ductal adenocarcinoma has a poor clinical outcome and responses to immunotherapy are suboptimal. (elifesciences.org)

It unlocks novel dimensions by uncovering elusive cell populations and tumor heterogeneities for early detection, unraveling mechanisms of treatment resistance, tailoring therapies to individuals, and illuminating metastasis and cachexia pathways, thereby opening fresh avenues for preventive strategies. (frontiersin.org)
however, advanced tumor stages and positive lymph node metastasis were significantly associated with poor overall survival. (biomedcentral.com)
Firstly, the transcriptome landscape of heterogeneous cell types in LUAD was analyzed and memory T cells, NK cells, and helper T cells were revealed to be the common immune cells in tumor, normal, and metastasis tissue, respectively. (aging-us.com)
Next, the results of cell-cell communication analysis suggested that pericytes interact with broad immune cells via MDK-NCL pathways in metastasis samples, MIF-(CD74+CXCR4) and MIF-(CD74+CC44) interaction especially occurred between different cell types in tumor and normal samples. (aging-us.com)
Statistical analysis showed a significant correlation of MACC1 expression with the primary tumor, lymph node metastasis, distant metastasis classifications as well as the clinical staging in breast cancer patients. (biomedcentral.com)

Tumour growth results from an imbalance between cell proliferation and apoptosis. (biomedcentral.com)
Borderline tumors are characterized by cell proliferation and a minor degree of nuclear atypia without stromal invasion. (biomedcentral.com)

Gallium‐68 ( 68 Ga)‐1,4,7,10‐tetraazacyclo‐dodecane‐1,4,7,10‐tetraacetic acid DOTA‐peptides highlight neuroendocrine tumors ( NETs ) through binding the somatostatin receptors that are overexpressed on the surfaces of their cells. (radiologykey.com)
Pancreatic neuroendocrine tumors may be functional or nonfunctional. (medscape.com)
Overall, the age-adjusted incidence of neuroendocrine tumors increased sixfold from 1973 (1.09 per 100,000) to 2012 ((6.98 per 100,000), possibly because of increased early detection. (medscape.com)

PJS is autosomal-dominant condition caused by mutations of STK11, characterized by gastrointestinal polyposis, mucocutaneous pigmentation, and predisposition to a range of epithelial cancers: including colorectal, gastric, pancreatic, breast, ovarian cancers and sex cord tumors with annular tubules). (cancerindex.org)
Molecular imaging with whole‐body positron emission tomography (PET)/CT or PET/MRI utilizes metabolic and receptor‐based strategies for tumor detection in staging and restaging various cancers. (radiologykey.com)
They represent 30% of all epithelial tumors and 80%-85% of all ovarian cancers. (biomedcentral.com)

In this paper, we propose a method, CSPRV, to improve the cancer subtype prediction by incorporating multi-sources transcriptome expression data and heterogeneous biological networks. (biomedcentral.com)
The proposed method provides an open framework to incorporate transcriptome expression data and biological regulation network to predict cancer subtypes. (biomedcentral.com)
Here, we combine spatial transcriptomics and scRNA-Seq datasets to define the transcriptome of tumor-proximal and tumor-distal cancer-associated fibroblasts (CAFs) and link this to clinical outcome. (elifesciences.org)

Nevertheless, nonresponders had been resistant to all or any ALK inhibitors, regardless of the existence of ALK rearrangement in FISH-positive circulating tumor cells and circulating free of charge DNA and lack of the ALK inhibitor level of resistance mutation. (exposed-skin-care.net)

Duitse onderzoekers publiceren in oktober a.s. het abstract van een aantal laboratoriumstudies en dierstudies die ze gedaan hebben met Herceptin als basis aangevuld met gemcitabine en/of docetaxel bij inoperabele en gevorderde alvleesklierkanker . (kanker-actueel.nl)

Recent developments in technology may make the monitoring of changes in patients' tumour genotypes easier in clinical practice, which may enable patients' treatment regimens to be tailored during the course of their disease, potentially leading to improved patient outcomes. (bmj.com)
A portion of these patients are highly susceptible to DNA damaging therapeutics, however, responses are heterogeneous and clinical resistance evolves. (huji.ac.il)
Our results demonstrate heterogeneous responses to DNA damaging agents/PARPi in BRCA-associated PDX thus reflecting the wide clinical spectrum. (huji.ac.il)
Some authors excluded cystosarcoma phyllodes from their studies due to its epithelial components, but others do not distinguish between other subtypes of breast sarcoma and cystosarcoma because of similar survival and clinical course. (oap-bioscience.org)
There are several variants of cutaneous melanocytic tumors, characterized by differing clinical and pathologic features. (atlasgeneticsoncology.org)
Breast cancer is a heterogeneous disease with a variety of different molecular subtypes and varied clinical outcomes. (biomedcentral.com)
Compared with solid tumor sampling, the bone marrow or peripheral blood of leukemia patients is easier to access, and therefore an accurate and practical prognostic signature for leukemia patients has potential for more direct clinical application. (nature.com)
Since most hematological malignancies are very heterogeneous diseases, robust patient-specific prognostic signatures are required for clinical applications. (nature.com)
Here the authors use innovative approaches to combine spatial profiling with single cell transcriptomics to define tumor-proximal populations of fibroblasts that predict clinical outcome. (elifesciences.org)
An accurate diagnosis of the tumor histology is essential for clinical care. (sttrcancer.org)
Therefore, distinguishing tumor phenotypes has clinical relevance in view of therapeutic response, but the need for a biopsy to diagnose tumor histology can be challenging. (sttrcancer.org)
Tumour classification systems provide the foundation for tumour diagnosis and patient therapy and a critical basis for epidemiological and clinical studies. (ersjournals.com)
Defining the unique therapeutic vulnerabilities of these subtypes of SCLC should help to focus and accelerate therapeutic research, leading to rationally targeted approaches that may ultimately improve clinical outcomes for patients with this disease. (cancerindex.org)
Although nonfunctional islet cell tumors are not uncommon at autopsy, most islet cell tumors with clinical manifestations are functional. (medscape.com)
Functioning tumors produce a clinical syndrome as a result of excessive hormone production. (medscape.com)
Clinical features of the syndrome depend on tumor cell type. (medscape.com)
L ung cancer, the leading cause of cancer death, is divided into several histological subtypes with large differences in molecular alterations, clinical presentation, and patient outcome. (lu.se)

Diagnosing non-epithelial malignancies in effusion specimens based entirely upon their cytomorphologic features is difficult because these neoplasms often exhibit considerable morphological overlap and their cytomorphology can differ from the original tumor. (cytojournal.com)
Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
Ovarian tumors account for a considerable proportion of clinically relevant neoplasms in females, exhibiting a wide range of age at presentation (from infant to elderly patients). (biomedcentral.com)

The recurrence and drug resistance of breast cancer are intractable due to the presence of breast cancer stem cells (BCSCs), which are adequate to initiate tumor formation and refractory to conventional remedies. (spandidos-publications.com)
They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. (lookformedical.com)

Identification of cancer subtypes is of great importance to facilitate cancer diagnosis and therapy. (biomedcentral.com)
It is crucial to identify cancer subtypes to facilitate the precision of cancer diagnosis and therapy [ 6 ]. (biomedcentral.com)
The differential diagnosis of a malignant effusion is accordingly broad, especially for the small round blue cell tumors that includes not only mesenchymal tumors, but also non-mesenchymal tumors, such as neuroblastoma and Wilms tumor. (cytojournal.com)
Diagnosis is made with ultrasonography and/or computed tomography (CT), which reveal the characteristic heterogenous appearance, including fat, calcifications, and cystic areas. (medscape.com)
Diagnosis of non-Hodgkin lymphoma is by biopsy with histopathologic and immunochemical analysis of tumor cells. (msdmanuals.com)

Note the heterogeneity of the tumor. (medscape.com)

The aim of this study was to identify valuable biomarkers by searching the candidate molecules that contribute to lung adenocarcinoma pathogenesis, especially KC subtype. (cancerindex.org)
Due to the high mortality rate of esophageal cancer, exploration of new prognostic biomarkers for this tumor is of paramount importance. (researchsquare.com)

Clear cell type renal cell carcinoma is a malignant tumor that can metastasize to many locations, but unusually spreads to thyroid. (scirp.org)
Primary breast sarcoma (PBS) is a malignant tumor arising from the mesenchymal tissue of the mammary gland. (oap-bioscience.org)
Lung cancer is the first leading diagnosed malignant tumor globally [ 1 ]. (medsci.org)

Mediastinal tumors/lesions are frequently encountered in daily cytopathology practice. (allenpress.com)
To provide an updated review on the fine-needle aspiration cytology of mediastinal tumors/lesions, with an emphasis on diagnostic challenges. (allenpress.com)
1 The most frequent primary tumor types of anterior mediastinal masses are thymic tumors and lymphoma, with approximate proportions of 35% and 25% among mediastinal lesions, respectively. (allenpress.com)
Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. (biomedcentral.com)

Overall, PUREE is a highly accurate and versatile method for estimating tumor purity and interrogating tumor heterogeneity from bulk tumor gene expression data, which can complement genomics-based approaches or be used in settings where genomic data is unavailable. (nature.com)

I will highlight uses for paired somatic (tumor) and germline (inherited) testing, liquid biopsy, and the intersection with digital pathology and AI. (sttrcancer.org)

BRCA-associated PDAC comprises a clinically relevant subtype. (huji.ac.il)
applied single-cell RNA sequencing to 24 primary PDAC tumors and 11 control pancreases. (biomedcentral.com)
This elegant study provided valuable resources for deciphering heterogenous cell types in PDAC. (biomedcentral.com)
For this, it may be important to characterize other subtypes, such as the subtype expressing high invasive markers, to further develop new targets of PDAC. (biomedcentral.com)

Tumour-associated activating mutations in EGFR can identify patients with NSCLC who are likely to have a good response to TKIs. (bmj.com)
A number of techniques have been employed for genotypic assessment of tumour-associated DNA to identify EGFR mutations, each of which has advantages and disadvantages. (bmj.com)
Of particular interest in recent years is the detection of acquired chromosomal alterations existing at low intra-sample frequencies, such as when a small proportion of the cells in a heterogeneous mixture exhibit these mutations. (mdanderson.org)
Mutations in this gene have been found in somatic sebaceous tumors. (cancer-genetics.org)

About 90% of cervical cancer cases are squamous cell carcinomas, 10% are adenocarcinoma, and a small number are other types. (wikipedia.org)
Endocervical adenocarcinoma (EAC) accounts for 20-25% of all cervical carcinomas ( 7 ). (iiarjournals.org)
Metaplastic carcinomas and phyllodes tumors were excluded. (oap-bioscience.org)
However, the vast majority of malignant ovarian tumors (80%-85%) are classified as epithelial tumors (carcinomas). (biomedcentral.com)
In contrast, 80%-90% of ovarian carcinomas are detected after the age of 40, and 40% of these tumors are detected after the age of 65. (biomedcentral.com)

Spitz tumors include a group of cutaneous melanocytic tumors that share certain histologic features. (atlasgeneticsoncology.org)
Most cases are B-cell, aggressive, high-grade histologic subtype lymphomas. (msdmanuals.com)

Our findings showed that monocyte count is a prognostic factor affecting disease-free survival in patients with esophageal cancer, regardless of histological subtype. (researchsquare.com)

Evidence has shown that endoscopic ultrasonography (EUS) can be used to accurately diagnose and localize primary endocrine tumors of the pancreas, especially insulinomas and gastrinomas. (medscape.com)

TAMs are known to play an important role in tumor angiogenesis and growth. (researchsquare.com)

Previous studies have shown a relationship between monocyte count and prognosis in some solid tumors. (researchsquare.com)
Accumulating evidence shows that in addition to the characteristics of the tumor, the immune response of the patient is also highly important for determining the prognosis. (researchsquare.com)

Head and neck malignancies consist of a heterogeneous group of neoplasia. (biomedcentral.com)
[ 1 ] In 1960, the incidence of GI malignancies arising from the bowel was estimated at less than 1% of pediatric tumors. (medscape.com)

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. (cancerindex.org)
Conversely, several studies have indicated that CDX2 may act as a tumor suppressor. (biomedcentral.com)
Role of Dusp6 Phosphatase as a Tumor Suppressor in Non-Small Cell Lung Cancer. (cancer-genetics.org)
DUSP6/MKP3 is a dual-specific phosphatase that regulates extracellular regulated kinase ERK1/2 and ERK5 activity, with an increasingly recognized role as tumor suppressor. (cancer-genetics.org)

Despite the declining incidence of cervical carcinoma, the proportion of adenocarcinomas arising from the uterine cervix has risen steadily ( 8 , 9 ). (iiarjournals.org)
Endometrial carcinoma is divided into two subtypes - type I and type II. (radiopaedia.org)
Another change is the subclassification of adenocarcinoma: the definition of bronchioalveolar carcinoma has been restricted to noninvasive tumours. (ersjournals.com)
As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (lookformedical.com)
However, as explained below, recent morphologic findings and molecular analyses have demonstrated that each morphologic subtype of ovarian carcinoma might be derived from a Müllerian-type epithelium. (biomedcentral.com)
[ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)

Lung adenocarcinoma (LUAD) is the most common type of non-small cell lung cancer and accounts for approximately 40% of all lung cancer cases. (aging-us.com)
Lung adenocarcinoma (LUAD) is the most common histological type of lung cancer and has the highest cancer mortality rate worldwide [ 1 ]. (aging-us.com)
To unravel the role of the distinct genetic features of lung cancer subtypes among patients, new research opportunities and technologies have arisen that might contribute to different therapeutic decisions [ 4 , 5 ]. (aging-us.com)
Non-small cell lung cancer (NSCLC) accounts for 85-90% of cases, while lung adenocarcinoma (LUAD) is the most common subtype [ 2 ]. (medsci.org)
Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. (cancerindex.org)
By analysis of patient specific alterations in circulating tumor DNA in blood samples we aim to establish blood-based assays for early detection of lung cancer, treatment monitoring, and early detection of relapse in the primary and advanced setting. (lu.se)
The frequency of the type of neoplasm was higher for lung cancer, followed by malignant colon tumor. (cdc.gov)

Here we developed PUREE, which uses a weakly supervised learning approach to infer tumor purity from a tumor gene expression profile. (nature.com)
PUREE was trained on gene expression data and genomic consensus purity estimates from 7864 solid tumor samples. (nature.com)
Gene features of PUREE were further validated using single-cell RNA-seq data from distinct tumor types. (nature.com)
Existing methods that estimate tumor purity from a tumor gene expression profile adopt different analytical strategies (Supplementary Note 1 , 2 ). (nature.com)
Using a robust gene pairing approach, which effectively eliminates batch effects across heterogeneous patient cohorts and transcriptomic data, we developed an immunity and pyroptosis-related prognostic (IPRP) signature that consists of 15 genes. (nature.com)
They mapped out the location of individual fibroblasts in the vicinity of the tumour and analysed their gene activity. (elifesciences.org)

Background/Aim: Gastric-type endocervical adenocarcinoma (GEA) is a rare but distinct histological type of gynecological malignancy. (iiarjournals.org)
The biopsy showed nests of infiltrating tumor cells with frequent atypical mitoses, hyperchromasia, occasionally prominent nucleoli, scant eosinophilic cytoplasm and no distinct cell borders. (pathologyoutlines.com)
PUREE predicted purity with high accuracy across distinct solid tumor types and generalized to tumor samples from unseen tumor types and cohorts. (nature.com)
This finding provides new insight into understanding how distinct tumor types regulate their immune heterogeneity. (biomedcentral.com)
2019). Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma. (edu.au)
Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes. (who.int)
To these data we applied the evolutionary theory of task specialisation (ParetoTI) to identify and characterise distinct archetypes, i.e. molecular subtypes, of LNETs. (who.int)

We have previously characterized HER2/NEU expression in human pancreatic cancer cell lines and studied the anti-tumor activity of Herceptin monotherapy in vitro and in vivo. (kanker-actueel.nl)
relied on tumour samples obtained from pancreatic cancer patients. (elifesciences.org)

Gastric-type EAC (GEA) is the most common subtype of HPVI EAC ( 11 , 16 ). (iiarjournals.org)

State‑of‑the‑art research has indicated the retention of RUNX2 expression in a more invasive subtype of breast cancer, and in particular, triple‑negative breast cancer development and drug resistance are associated with estrogen receptor signaling pathways. (spandidos-publications.com)

Recent research has classified lung adenocarcinoma patients with KRAS mutation into three subtypes by co-occurring genetic events in TP53 (KP subgroup), STK11/LKB1 (KL subgroup) and CDKN2A/B inactivation plus TTF-1 low expression (KC subgroup). (cancerindex.org)
The proportion of malignant cancer cells in the tumor mass, herein referred to as tumor purity, also impacts genomic analysis such as the estimation of clonal composition 6 and tumor mutation burden 7 , critical for predicting treatment outcomes and selecting patients for immunotherapy. (nature.com)

Low-grade tumors may recur and infiltrate adjacent structures. (medscape.com)

Tumors or cancer of the UTERINE CERVIX. (lookformedical.com)

It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)

Monocyte, an element of the immune system, is a heterogeneous cell showing different responses to different stimuli. (researchsquare.com)
Even though developed for AML patients, our pan-cancer analyses demonstrate a wider application of the IPRP signature for prognostic prediction and analysis of tumor-immune interplay also in multiple solid tumors. (nature.com)
Therefore, cell pyroptosis is closely related to the immune process, but it is also essential for tumor development. (nature.com)
Selective targeting of tumor-proximal subsets, potentially combined with HIF-1α inhibition and immune stimulation, may offer a multi-modal therapeutic approach for this disease. (elifesciences.org)

These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. (biomedcentral.com)
According to the 2014 World Health Organization (WHO) classification and tumor morphology, primary ovarian tumors are subdivided into three categories: epithelial (60%), germ cell (30%), and sex-cord stromal tumors (8%)[ 1 ]. (biomedcentral.com)
Malignant germ cell and sex-cord stromal tumors comprise approximately 10% of all malignant ovarian tumors. (biomedcentral.com)

SNF integrates multiple types of genomic data to identify cancer subtypes, while it uses iterative method to fuse similarity networks between samples, and the model is complex and hard to be interpreted in practice [ 16 ]. (biomedcentral.com)

Ovarian epithelial tumors are subclassified into several categories based on two criteria: 1) the degree of epithelial proliferation and invasion and 2) the histotype of the epithelium composing the tumor. (biomedcentral.com)

Anti-anaplastic lymphoma kinase (ALK)-targeted therapy dramatically improves restorative responses in sufferers with ALK-rearranged lung adenocarcinoma (Ad-LC). (exposed-skin-care.net)
Treatment responses of patients with acute myeloid leukemia (AML) are known to be heterogeneous, posing challenges for risk scoring and treatment stratification. (nature.com)
These studies indicate the importance of the pyroptosis process in tumor development and treatment responses. (nature.com)

The International Endocervical Adenocarcinoma Criteria and Classification (IECC) reliably segregated EACs into human papillomavirus (HPV)-related and HPV-unrelated tumors according to the presence or absence of HPV infection-related morphology (apical mitotic figures and basal apoptotic bodies), which is easily identifiable under scanning magnification ( 12 ). (iiarjournals.org)

Oien] Unfortunately in 20-50% of CUP cases the primary tumor is never found. (biogenex.com)
Primary Brain Lymphomas Primary brain lymphomas, a type of primary central nervous system lymphoma, originate in neural tissue and are usually B-cell tumors. (msdmanuals.com)

Two types of hepatic adenoma have been identified: tumors of bile duct origin and tumors of liver cell origin. (medscape.com)
Two heterogeneous masses that represent hepatic adenomas are seen in the right lobe and are slightly hypointense relative to the liver parenchyma. (medscape.com)
The hepatic adenomas are heterogeneous and slightly hyperintense relative to the fatty liver. (medscape.com)
Patients undergoing yttrium‐90 ( 90 Y)‐microspheres therapy for hepatic tumors must first be evaluated with liver imaging using arterially infused 99m Tc‐ macroaggregated albumin ( MAA ) as part of the planning process for a safe and effective procedure. (radiologykey.com)

Anatomy15

Organisms7

Diseases94

Chemicals and Drugs47

Analytical, Diagnostic and Therapeutic Techniques and Equipment58

Phenomena and Processes37

Disciplines and Occupations1

Information Science6

Health Care17

Microenvironment12

Metastatic14

Group of tumors2

Benign5

Progression5

Ductal4

Metastasis5

Cell Proliferation2

Neuroendocrine tumors3

Cancers3

Transcriptome3

Circulating tumor cells1

Abstract1

Clinical17

Neoplasms3

Recurrence2

Diagnosis5

Heterogeneity of the tumor1

Biomarkers2

Malignant tumor3

Lesions4

Interrogating tumor heterogeneity1

Pathology1

PDAC4

Mutations4

Carcinomas5

Histologic2

Histological subtype1

Endocrine tumors1

Important role in tumor1

Prognosis2

Malignancies2

Suppressor4

Carcinoma7

Lung cancer7

Gene6

Distinct7

Pancreatic cancer2

Common subtype1

Invasive1

Mutation2

Infiltrate1

Uterine cervix1

Epithelial cells1

Immune4

Germ3

Genomic data1

Epithelium1

Responses3

Morphology1

Primary2

Hepatic4