Subtype receptor endothelin a. Medical search. Frequent questions

It is an endothelin receptor antagonist selective for subtype A (ETA). (wikipedia.org)
ET-3], as well as the inhibitory effect displayed by BQ123, a specific ETA receptor antagonist, provided evidence for the involvement of the ETA receptor subtype. (aspetjournals.org)
Macitentan, an endothelin-1 receptor antagonist, has the potential to attenuate pulmonary and cardiovascular remodelling. (biomedcentral.com)
The endothelin-1 receptor antagonist macitentan attenuated cardiovascular remodelling in an infant rat model for preterm chronic lung disease. (biomedcentral.com)
More than a decade ago pulmonologists recognized that early detection and treatment of PAH with a dual endothelin receptor antagonist in patients with congenital heart disease improved their exercise capacity and hemodynamic function. (pulmonologyadvisor.com)
The earliest stage product in its pipeline is TMB-003, a formulation of Sitaxsentan, which is a selective endothelin-A receptor antagonist. (td.com)
The ETA receptor antagonist, FR 139317 at a concentration of 10-8M potentiated contractile responses to ET-1 in trachea from control but not chronically hypoxic rats. (gla.ac.uk)
The ETB receptor antagonist, BQ 788, potentiated responses to ET-1 in both control and chronically hypoxic rat trachea. (gla.ac.uk)
It was found that ET-1 responses were only blocked by simultaneous blockade of both ETA and ETB receptors, either by using the non-selective ET receptor antagonist, SB 209670, or by combining BQ 788 and FR 139317. (gla.ac.uk)
Both effects of endothelin-1 were blocked by an antagonist of phospholipase C, suggesting that Ins(1,4,5) P 3 and/or diacylglycerol production was necessary. (biologists.com)
The endothelin-1-mediated spontaneous Ca 2+ transients were abolished by application of 2-aminoethoxydiphenyl borate (2-APB), an antagonist of Ins(1,4,5) P 3 receptors. (biologists.com)

ET receptor antagonists have already been reported to lessen neuropathic and inflammatory discomfort and discomfort in sufferers with metastatic prostate cancers (find [15 16 for testimonials). (exposed-skin-care.net)
Novel targeted agents to treat CRPC have been developed that inhibit either androgen receptor (AR)-mediated signaling (AR antagonists and inhibitors of androgen synthesis) or non-AR-mediated signaling (inhibitors of Src, mammalian target of rapamycin, chaperone proteins, insulin-like growth factor-1 receptor, vascular endothelial growth factor, and endothelin-A receptor) pathways. (escholarship.org)
Objective -To characterize the in vitro response of circular and longitudinal myometrial layers of the uterine horn (CMLH and LMLH, respectively) of horses to endothelin (ET)-1 by use of specific ET A (BQ-123) and ET B (IRL-1038) receptor antagonists. (avma.org)
For these, reasons both leukotriene synthesis inhibitors and leukotriene receptor antagonists have been suggested for inducing beneficial effects at different stages of the atherosclerosis process and may represent a new therapeutic target in the treatment of atherosclerotic vessel diseases, in particular in acute coronary syndrome. (hindawi.com)
Clearly, the magnitude of the pulmonary vasodilator actions of prostanoids, PDE-5 inhibitors, and endothelin antagonists do not account for the degree of clinical benefit observed with these drugs. (medscape.com)

Our pharmacological studies showed that EDNRB2 binds with similar affinity to EDN 1, EDN 2, and EDN 3, further confirming that this receptor belongs to the B type, although it displays a low affinity for sarafotoxin-c, a known EDNRB- selective agonist. (elsevierpure.com)
Hikida T , Yawata S , Yamaguchi T, Danjo T, Sasaoka T, Wang Y, Nakanishi S . Pathway-specific modulation of nucleus accumbens in reward and aversive behavior via selective transmitter receptors. (neurotree.org)
Yawata S , Yamaguchi T, Danjo T, Hikida T , Nakanishi S . Pathway-specific control of reward learning and its flexibility via selective dopamine receptors in the nucleus accumbens. (neurotree.org)
A-61603, a potent α 1 -adrenergic receptor agonist, selective for the α 1A receptor subtype. (rndsystems.com)

We report here that some, but not all, TAS2R agonists decrease [Ca2+]i and relax HASM contracted by G-protein coupled receptors (GPCRs) that stimulate [Ca2+]i. (jefferson.edu)
There was no association between [Ca2+]i inhibition and TAS2R subtype, nor whether [Ca2+]i was increased by Gq- or Gi-coupled GPCRs. (jefferson.edu)
LTs exert their biological effects by activating specific receptors belonging to the superfamily of G protein-coupled receptors (GPCRs) [ 22 - 24 ]. (hindawi.com)

Endothelin 3 (EDN 3) and the endothelin receptor B (EDNRB) are involved in the development of neural crest and particularly of the melanocytes and the enteric nervous system. (elsevierpure.com)
We report here the cloning by reverse transcriptase-PCR of an avian cDNA encoding a subtype of EDNR, which we have called EDNRB2, because its deduced amino acid sequence is more closely related to that of EDNRB than to either the mammalian EDNRA or to the Xenopus EDNRC. (elsevierpure.com)
This syndrome is genetically heterogeneous, composed of three etiological subtypes: WS4-A, WS4-B and WS4-C, caused by mutations in the EDNRB (13q22.3, coding for the endothelin-B receptor), EDN3 (20q13.32, coding for an endothelin receptor ligand) and SOX10 (22q13.1, coding for the SOX10 transcription factor) genes, respectively. (orpha.net)
Both heterozygous and homozygous mutations in the EDNRB (endothelin-B receptor) gene (13q22) occur in patients. (arizona.edu)

In the cardiovascular tissue, the endothelin system-consisting of the receptor subtypes A (ETA R) and B (ETB R) and the mixed agonist endothelin 1 (ET-1)-is a major key player in the regulation of vascular tone and blood pressure. (lscwarsaw.com)
We hypothesise that a first in class agonist is required to activate the apelin receptor in PAH to replace the missing peptide. (cam.ac.uk)
An Alpha-1A Adrenergic Receptor Agonist Prevents Acute dox. (rndsystems.com)
ET-1 acts via at least two G protein-coupled receptor subtypes, termed ETA and ETB- Contractile responses to ET-1 were attenuated in chronically hypoxic rats, whereas responses to sarafotoxin S6c (an ETB receptor agonist) were not altered. (gla.ac.uk)

This trial is comparing a 400-mg dose of sparsentan with a 300-mg daily dose of the angiotensin-receptor blocker irbesartan in 404 randomized patients. (medscape.com)

Yamaguchi T, Goto A, Nakahara I, Yawata S , Hikida T , Matsuda M, Funabiki K , Nakanishi S . Role of PKA signaling in D2 receptor-expressing neurons in the core of the nucleus accumbens in aversive learning. (neurotree.org)
Danjo T, Yoshimi K, Funabiki K , Yawata S , Nakanishi S . Aversive behavior induced by optogenetic inactivation of ventral tegmental area dopamine neurons is mediated by dopamine D2 receptors in the nucleus accumbens. (neurotree.org)
Background Endothelin-1 (ET-1) both stimulates nociceptors and sensitizes these to noxious stimuli an impact probably mediated with the ETA receptor (ETAR) expressed in sensory neurons. (exposed-skin-care.net)
Within this research we looked into ET receptor expression in DRG and using the patch clamp technique the effects of ET-1 on responses to capsaicin in DRG neurons. (exposed-skin-care.net)
Results Endothelin receptors in dorsal root ganglion neurons The expression of endothelin receptor subtypes in the rat lumbar DRG was analyzed in binding experiments using 125I-ET-1 as the radioligand. (exposed-skin-care.net)
RESEARCH:5-HT1A (Serotonin-1A) receptor gene regulation and mental illness:Hypothesis: Down-regulation of the 5-HT1A receptor gene in serotonin neurons is required for the antidepressant actions of therapeutic compounds. (vdocuments.net)

Background Endothelin is certainly among the many regional mediators that are essential in pain era as well as the modulation of nociceptor responsiveness to unpleasant stimuli. (exposed-skin-care.net)
p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists. (rndsystems.com)
The effects of endothelin-1 were compared with two other stimuli, isoproterenol and digoxin, which are known to induce inotropy and spontaneous Ca 2+ transients by overloading intracellular Ca 2+ stores. (biologists.com)

This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. (thermofisher.com)
The data indicate that in rat myometrium the ETA receptor is coupled, via two distinct G proteins, to two main signal transduction cascades, which both undergo rapid desensitization. (aspetjournals.org)
Endothelins action on ETA and ETB receptors (ETARs and ETBRs) [6 7 both G protein-coupled receptors that may activate multiple G proteins types and impact several signaling pathways [8]. (exposed-skin-care.net)
Furthermore, we have recently reported that synaptic proteins of the Homer1 family, which interconnect metabotropic glutamate receptors (mGluR1/5) with intracellular calcium stores, are important modulators of inflammatory pain. (uni-heidelberg.de)
PNAS 2006) and addressed the role of proteins interacting with cannabinoid receptors in analgesic tolerance to cannabinoids (Tappe et al. (uni-heidelberg.de)
Understanding the proteins that regulate the 5-HT1A promoter will lead to insights on receptor regulation and provide new therapeutic targets relevant to depression, anxiety, obsessive compulsive disorder and other mental illnesses. (vdocuments.net)

Our results show that AMPA receptors are not mere mediators of fast excitatory neurotransmission in acute pain as previously thought, but are critically required for activity-induced potentiation in pathological states (Hartmann et al. (uni-heidelberg.de)
Neurones, astrocytes, microglia and oligodendrocytes can produce inflammatory mediators, and cytokine receptors are expressed constitutionally throughout the Central Nervous System (CNS), albeit at low levels. (eurekaselect.com)
The arachidonic acid, released by phospholipase A2, is an important substrate for the production of a group of lipid mediators known as leukotrienes, which induce proinflammatory signaling through the activation of specific BLT and CysLT receptors. (hindawi.com)

Vibration white finger is likely driven by somatosympathetic reflex activation, increased á2c adrenergic receptor expression and endothelin-1 release. (cdc.gov)
A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart. (rndsystems.com)
The α-1A Adrenergic Receptor in the Rabbit Heart. (rndsystems.com)
Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure. (rndsystems.com)

While other drugs of this type (sitaxentan, ambrisentan) exploit the vasoconstrictive properties of endothelin and are mainly used for the treatment of pulmonary arterial hypertension, atrasentan blocks endothelin induced cell proliferation. (wikipedia.org)

Treatment involves lifestyle changes and medications, including diuretics, angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers, and calcium channel blockers. (msdmanuals.com)

Endothelin receptor type A signals both the accumulation of inositol phosphates and the inhibition of cyclic AMP generation in rat myometrium: stimulation and desensitization. (aspetjournals.org)
Consistent with the [Ca2+]i inhibition results, chloroquine abolished the cell stiffening response (contraction) evoked by histamine but not by endothelin-1, while aristolochic acid inhibited cell stiffening from endothelin-1, but not from histamine. (jefferson.edu)

This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. (thermofisher.com)
Endothelin produced by vascular endothelial cells is a potent vasoactive peptide that elicits prolonged contraction of vascular smooth muscle cells. (silverchair.com)
Endothelin-1 (ET-1), a potent vasoconstrictive peptide, plays a role in inflammation in mononuclear cells. (omicsdi.org)

Mast cells secrete histamine that inhibits vasoconstriction via H2 receptors on smooth muscle cells. (cdc.gov)
For example, chloroquine inhibits [Ca2+]i increases from histamine, but failed to inhibit [Ca2+]i increases from endothelin-1. (jefferson.edu)
These results suggest that propofol inhibits endothelin-1-induced intracellular signaling in vascular smooth muscle cells. (silverchair.com)

Vasodilatory factors include nitric oxide (NO), prostacyclin (PGl2), and endothelium derived hyperpolarizing factor (EDHF), and vasoconstrictive factors include thromboxane (TXA2), norepinephrine, and endothelin-1 (ET-1). (beckman.com)

Endothelins and sarafotoxins: physiological regulation, receptor subtypes and transmembrane signaling. (expasy.org)

In estradiol-dominated rat myometrium, endothelin (ET)-1 caused contraction and increased the accumulation of [3H]inositol phosphates (EC50 = 70 nM), with the sequential generation of inositol trisphosphate, inositol bisphosphate, and inositol monophosphate. (aspetjournals.org)
The effects of propofol on the endothelin-1-induced activation of phosphatidylinositol-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D were evaluated by measuring the formation of inositol phosphates and choline, respectively. (silverchair.com)
The endothelin-1-stimulated formation of inositol phosphates was significantly suppressed by propofol. (silverchair.com)

In both layers, ET A receptors mediate contraction but the role of ET B receptors remains unclear. (avma.org)

Other benign and malignant cutaneous proliferative entities where the growth hormone receptor was present included histiocytomas, melanomas and acrochordons. (globale-dermatologie.com)
In several past projects, we have extensively characterized the role of spinal and thalamic NMDA receptors in cutaneous and visceral nociception in rat models using behavioural, pharmacological and electrophysiological methods. (uni-heidelberg.de)

Alveoli, pulmonary vessels, α -smooth muscle actin content in pulmonary arterioles, size of cardiomyocytes, right to left ventricular wall diameter ratio, and endothelin-1 plasma concentrations were assessed. (biomedcentral.com)
Endothelin-1 plasma concentrations were higher compared to placebo (p = 0.015). (biomedcentral.com)
Propofol inhibited the endothelin-1-induced Ca2+ influx, but this was significant only at supuraclinical concentrations. (silverchair.com)
Their concentrations were correlated with receptor expression and compared with the IgG donor's clinical findings. (fu-berlin.de)

The endothelins ET-1 ET-2 and ET-3 are vasoactive peptides originally cloned from endothelial cells [1] but also made by various other cell types including Taladegib some tumor cells [2-5]. (exposed-skin-care.net)
The contributions of vasoactive peptides generated by the luteal endothelin-1 and the renin-angiotensin systems are discussed in context with the function of endothelial cells during corpus luteum formation and regression. (biomedcentral.com)

Primordial endothelial cells specialize into tissue-specific phenotypes of arterial, venous, hemogenic, and lymphatic subtypes with distinct functions for vascular development. (beckman.com)

However, the influence of pharmacological ET-1 receptor blockade on cardiovascular remodelling in the context of BPD has neither been examined in human patients nor in animal models. (biomedcentral.com)

The effects of propofol on endothelin-1-induced intracellular signaling in an aortic smooth muscle cell line, A10 cells, were examined. (silverchair.com)
The effect of propofol on the endothelin-1-induced Ca2+ influx into A10 cells was evaluated by measuring intracellular 45Ca2+. (silverchair.com)

These results described the changes of CH on the CB gene expression profile, affecting a possible interaction in between NOS and ET-1 receptors, as part of the adaptive CB response to CH. (omicsdi.org)

Endothelin-1 and Hypertension" Encyclopedia , https://encyclopedia.pub/entry/14671 (accessed November 30, 2023). (encyclopedia.pub)

Mast cells moderate vasoconstriction by releasing proteases that degrade vasoactive neuropeptides and endothelin-1. (cdc.gov)

Understanding changes in the endothelin axis in hypoxic AMs is a crucial first step to unravel its role in pulmonary circulation. (omicsdi.org)

Einleitung: Patienten mit Systemischer Sklerose (SSc) besitzen funktionelle Autoantikörper gegen den Angiotensin II-Rezeptor Typ 1 (AT1R) sowie gegen den Endothelin-1-Rezeptor Typ A (ETAR). (fu-berlin.de)
Objective: Patients with systemic sclerosis (SSc) present functional autoantibodies against angiotensin II receptor type 1 (AT1R) and endothelin-1 receptor type A (ETAR). (fu-berlin.de)

Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)

In addition to these functions, it modulates vascular tone by synthesizing and releasing a number of vasoactive factors that may have vasodilatory effects, such as nitric oxide (NO), prostacyclin (PGI 2 ), and endothelium-derived hyperpolarizing factor, and vasoconstrictor effects, such as thromboxane A 2 and endothelin-1 (ET-1) [ 8 ] . (encyclopedia.pub)

Therefore, an intervention at the ET-1 receptor level might have a positive effect on pulmonary vascular resistance and right ventricular remodelling. (biomedcentral.com)
Although ventricular cardiomyocytes express inositol 1,4,5-trisphosphate [Ins(1,4,5) P 3 ] receptors, it is unclear how these Ca 2+ channels contribute to the effects of Gq-coupled agonists. (biologists.com)
Incubation of electrically-paced ventricular myocytes with a membrane-permeant Ins(1,4,5) P 3 ester provoked the occurrence of spontaneous diastolic Ca 2+ transients with the same characteristics and sensitivity to 2-APB as the events stimulated by endothelin-1. (biologists.com)

Persistent Toll-like receptor 7 stimulation induces behavioral and molecular innate immune tolerance. (harvard.edu)

Markers specific for nerve subtypes are required to relate changes to functional alterations. (cdc.gov)
In the chosen papers the expression of the respective receptors as well as their functional counterparts AT2R and ETBR, their correlation with clinical manifestations of SSc and the autoantibodies' pathological effects mediated through these receptors was analyzed. (fu-berlin.de)

Molecular biology and biochemistry of the endothelins. (expasy.org)

TNF-α expression after stroke stimulates expression of tissue factor and adhesion molecules for leukocytes, release of interleukin-1 (IL-1), nitric oxide, factor VIII/von Willebrand factor, platelet-activating factor and endothelin, suppression of the thrombomodulin-protein C-protein S system, reduction of tissue-plasminogen activator and release of plasminogen activator inhibitor-1. (eurekaselect.com)

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Mucin 5 Subtype B (MUC5B) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (agctsequencing.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Mucin 5 Subtype B (MUC5B) in samples from tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (agctsequencing.com)
Description: Quantitativesandwich ELISA kit for measuring Human mucin-5 subtype B, MUC5B in samples from serum, plasma, tissue homogenates. (agctsequencing.com)

At present, he and his group are investigating the distribution of adrenergic, muscarinic and endothelin receptors in the lower urinary tract of rats and rabbits. (yale.edu)
Tracheal rings (internal diameter ~2mm) isolated from rats exposed to 14 days of chronic hypobaric hypoxia (500-550mBar) produced contractions to methacholine, endothelin-1 (ET-1) and potassium chloride which were significantly less than responses in control rats. (gla.ac.uk)

Moreover, PBMC of healthy donors and patients with SSc were in vitro stimulated with immunglobulin G (IgG) of patients with SSc and healthy donors upon detection of receptor expression. (fu-berlin.de)
Decreased Ambient Oxygen Tension Alters the Expression of Endothelin-1, iNOS and cGMP in Rat Alveolar Macrophages. (omicsdi.org)

Clues to detect tumor necrosis factor receptor-associated periodic syndrome (TRAPS) among patients with idiopathic recurrent acute pericarditis: results of a multicentre study. (cdc.gov)

The endothelins (ETs) are produced from their corresponding approximately 200-residue prepropolypeptides that are encoded by three distinct genes. (encyclopedia.pub)
BLT2 is a pharmacologically distinct receptor, which is ubiquitously expressed and displays low affinity for LTB4 and also binds other eicosanoids [ 26 , 27 ]. (hindawi.com)

By identifying tumors with a characteristic molecular subtype and assigning treatment accordingly, it is hoped that a higher proportion of patients will benefit from targeted therapy. (escholarship.org)

Cellular signaling by peptides of the endothelin gene family. (expasy.org)

receptor system, whose activation in obesity promotes renal inflammation, fibrosis, and injury, and the inducible NOS (iNOS), which generates ROS resulting in oxidative stress. (omicsdi.org)
receptors and iNOS in renal tubules was found in human kidney patients with obesity and other CKDs. (omicsdi.org)

Recently, we have characterized the role of calcium-permeable AMPA receptors in nociception and chronic inflammatory pain using transgenic mouse models. (uni-heidelberg.de)
iii) The effect of chronic hypoxia on endothelin receptor-mediated responses in rat isolated airways. (gla.ac.uk)
receptor and inducible NOS attenuates obesity-induced chronic kidney disease. (omicsdi.org)

Fewer mast cells means less histamine-induced vasodilation and protease inactivation of NPY and endothelin-1, favoring vasospasm. (cdc.gov)
Conversely, aristolochic acid inhibited [Ca2+]i increases from endothelin-1 but not histamine. (jefferson.edu)

Combining CH and SNAP, iNOS and ETB were significantly up-regulated, whereas the ET-1 receptor A (ETA) was down-regulated, while Tezosentan up-regulated iNOS and ETA and L-NAME induced up-regulation of all NOS. (omicsdi.org)

CMF-019 caused a significant increase in cardiac contractility in vivo without desensitising the apelin receptor. (cam.ac.uk)

TMB-001 is a topical formulation of isotretinoin using its patented IPEG delivery system, completed its Phase IIb clinical trial for the treatment of moderate to severe subtypes of CI. (td.com)
Based on the clinical presentations, four subtypes of the disease are recognized. (bioline.org.br)
[1] Based on the clinical presentations, four subtypes were subsequently described. (bioline.org.br)

Here, glutamate serves as the primary nociceptive neurotransmitter and activates several ionotropic and metabotropic receptors. (uni-heidelberg.de)
Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. (harvard.edu)

Description: A sandwich ELISA kit for detection of Mucin 5 Subtype B from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (agctsequencing.com)

Nakamura, 2001}, there is inactivation of one of the two genes of the Human activated receptor of androgens (HUMARA). (globale-dermatologie.com)
regulators of the rat and human 5-HT1A receptor genes using luciferase reporter fusion constructs transfected in cell lines. (vdocuments.net)

Pleiotropic Effects of Bitter Taste Receptors on [Ca2+]i Mobilization, Hyperpolarization, and Relaxation of Human Airway Smooth Muscle Cells. (jefferson.edu)

These observations prompted us to search for another type of endothelin receptor (EDNR). (elsevierpure.com)

Pleiotropic Effects of Bitter Taste Receptors on [Ca2+]i Mobilization," by Blanca Camoretti-Mercado, Susan H Pauer et al. (jefferson.edu)

that selectively targets the endothelin A receptor and the angiotensin II subtype 1 receptor. (medscape.com)

The following product was used in this experiment: Endothelin A Receptor Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA3-065, RRID AB_11153077. (thermofisher.com)
Western blot was performed using Anti-Endothelin A Receptor Polyclonal Antibody (Product # PA3-065) and a 50kDa band corresponding to Endothelin A Receptor was observed across tissues tested. (thermofisher.com)
By western blot, this antibody detects a 46kDa protein corresponding to mouse Endothelin Receptor A. (thermofisher.com)

PA3-065 detects Endothelin Receptor A from human, mouse, and rat samples. (thermofisher.com)
Description: Quantitative sandwich ELISA for measuring Human Mucin-5 subtype B (MUC5B) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (agctsequencing.com)

Association of leptin and leptin receptor gene polymorphisms with systemic lupus erythematosus in a Chinese population. (cdc.gov)

Receptors responding to Cys-LTs have been cloned in 1999 and termed CysLT1 and CysLT2 [ 22 ]. (hindawi.com)

Anatomy34

Organisms24

Diseases14

Chemicals and Drugs110

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes36

Disciplines and Occupations1

Information Science4

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Antagonists5

Selective4

GPCRs3

EDNRB4

Agonist4

Angiotensin receptor1

Neurons6

Stimuli3

Proteins6

Mediators3

Adrenergic receptor4

Pulmonary arterial hyp1

Inhibitors1

Inhibition2

Potent3

Inhibits3

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Transmembrane1

Inositol phosphates3

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Cutaneous2

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Endothelial cells1

Cardiovascular1

Intracellular2

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Hypertension1

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Hypoxic1

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Phenotypes1

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Tissue3

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