• nicotine
  • To evaluate neural correlates associated with emotional processing during nicotine withdrawal preferentially involving the amygdala and associated areas within the corticolimbic and mesolimbic circuitry. (clinicaltrials.gov)
  • We hypothesize that relative to a pre-quit baseline, post-quit nicotine withdrawal will result in increased activity to negative emotional cues, in contrast to other cues, in one or more areas of interest, and particularly in the right cerebral hemisphere. (clinicaltrials.gov)
  • To determine if bupropion and varenicline moderate patterns of brain activation during post-quit nicotine withdrawal. (clinicaltrials.gov)
  • We hypothesize that relative to placebo, bupropion and varenicline will attenuate the effects of post-quit nicotine withdrawal on emotional processing, reducing activation to negative emotional cues, relative to other cues, in one or more areas of interest, and particularly in the right cerebral hemisphere. (clinicaltrials.gov)
  • To determine if genotype (DRD2 TaqA2 allele and the ins variant of the -141C ins/del DRD2) moderates patterns of brain activation during post-quit nicotine withdrawal. (clinicaltrials.gov)
  • The purpose of this study is to determine whether transdermal nicotine replacement therapy is safe and effective for treating nicotine withdrawal symptoms in the critically ill smoking patient. (clinicaltrials.gov)
  • The difference between lozenge use at the designated time-point prior to the stress task and lozenge use in withdrawal symptom response as measured by the Minnesota Nicotine Withdrawal Scale (MNWS) that occurs when smokers are exposed to a stressful task. (clinicaltrials.gov)
  • For instance, GHB, a naturally occurring substance in the central nervous system is considered a drug, and is illegal in many countries, while nicotine is not officially considered a drug in most countries. (wikipedia.org)
  • Symptoms of nicotine withdrawal can become apparent as long as five days after delivery and last for months. (wikipedia.org)
  • The symptoms of nicotine withdrawal in the infant are excitability and hypertonicity. (wikipedia.org)
  • post-acute wi
  • While post-acute withdrawal syndrome has been reported by those in the recovery community, there have been few scientific studies supporting its existence. (wikipedia.org)
  • Cravings may be triggered by seeing objects or experiencing moments that are associated with the drug or usage of it, and this phenomenon, termed post acute withdrawal syndrome, may linger the rest of the life for some drugs. (wikipedia.org)
  • disorders
  • In some cases these substance-induced psychiatric disorders can persist long after detoxification, such as prolonged psychosis or depression after amphetamine or cocaine abuse. (wikipedia.org)
  • In severe cases, the withdrawal reaction may exacerbate or resemble serious psychiatric and medical conditions, such as mania, schizophrenia, and, especially at high doses, seizure disorders. (wikipedia.org)
  • In 2015 substance use disorders resulted in 307,400 deaths, up from 165,000 deaths in 1990. (wikipedia.org)
  • This, along with Substance Abuse are considered Substance Use Disorders. (wikipedia.org)
  • the 2015 VA/DoD guideline on substance use disorders lists gabapentin as a "weak for" and is recommended as a second-line agent. (wikipedia.org)
  • barbiturates
  • A rare adverse reaction to barbiturates is Stevens-Johnson syndrome, which primarily affects the mucous membranes. (wikipedia.org)
  • Patients should never try to tackle the task of discontinuing barbiturates without consulting a doctor due to the high lethality and relatively sudden onset of the withdrawal, attempting to quit "cold turkey" may result in serious neurological damage, severe physical injuries received during convulsions, and even death via glutamatergic excitotoxicity. (wikipedia.org)
  • cannabis
  • Recent studies have established the reliability, validity and time course of the cannabis withdrawal syndrome. (clinicaltrials.gov)
  • Similarly, adopting the view that any (recreational) use of cannabis or substituted amphetamines constitutes drug abuse implies a decision made that the substance is harmful, even in minute quantities. (wikipedia.org)
  • drug withdrawal
  • Thus, there is a need to identify predictive factors of successful drug withdrawal and to define the clinical and histological outcomes of operationally tolerant liver recipients. (clinicaltrials.gov)
  • The main objective of this study is to establish the safety of attempting immunosuppressive (IS) drug withdrawal in stable liver transplant recipients, using standard clinical, biological and histopathological methods, to screen and follow-up patients, and to confirm the benefit of maintaining immunosuppressive drug interruption in patients who are tolerant to their liver transplant. (clinicaltrials.gov)
  • In a diagnostic observational sub-study, peripheral blood and liver tissue samples collected before immunosuppressive drug withdrawal will be employed to validate the diagnostic accuracy of a previously identified set of tolerance biomarkers and to identify potential new biomarkers capable of predicting the outcome of the immunosuppressive withdrawal protocol. (clinicaltrials.gov)
  • This is a long-term, open-label study with a double-blind, placebo-controlled, randomized drug withdrawal period in children with ALGS designed to evaluate the safety and efficacy of LUM001. (clinicaltrials.gov)
  • The study is divided into 5 parts: a 6-week open-label, dose escalation period, a 12-week stable dosing period, a 4-week randomized, double-blind, placebo-controlled drug withdrawal period, a 26-week long-term stable dosing period, and an optional 52 week follow-up treatment period for eligible subjects who choose to stay on treatment with LUM001. (clinicaltrials.gov)
  • Increased expression of AMPA receptors in nucleus accumbens MSNs is a potential mechanism of aversion produced by drug withdrawal. (wikipedia.org)
  • effects
  • This study will investigate the effects of combined treatment of Escitalopram with cognitive-behavior therapy in alleviating the symptoms of the marijuana withdrawal syndrome in regular chronic users of marijuana. (clinicaltrials.gov)
  • Use of short-acting hypnotics, while being effective at initiating sleep, worsen the second half of sleep due to withdrawal effects. (wikipedia.org)
  • Restless
  • Restless legs syndrome (RLS) is a disorder that causes a strong urge to move one's legs. (wikipedia.org)
  • Restless leg syndrome may resolve if the underlying problem is addressed. (wikipedia.org)
  • In a survey among members of the Restless Legs Syndrome Foundation, it was found that up to 45% of patients had their first symptoms before the age of 20 years. (wikipedia.org)
  • Gabapentin, sold under the brand names Neurontin among others, is a medication used to treat epilepsy, neuropathic pain, hot flashes, and restless legs syndrome. (wikipedia.org)